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Protein

Potassium voltage-gated channel subfamily KQT member 1

Gene

Kcnq1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_287159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.15.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 1
Alternative name(s):
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
Voltage-gated potassium channel subunit Kv7.1
Gene namesi
Name:Kcnq1
Synonyms:Kcna9, Kvlqt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108083. Kcnq1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei121 – 14121Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini142 – 1465ExtracellularSequence Analysis
Transmembranei147 – 16721Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini168 – 19528CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini217 – 2248ExtracellularSequence Analysis
Transmembranei225 – 24723Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini248 – 26013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini282 – 29817ExtracellularSequence AnalysisAdd
BLAST
Intramembranei299 – 31921Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini320 – 33011ExtracellularSequence AnalysisAdd
BLAST
Transmembranei331 – 35121Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini352 – 668317CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Potassium voltage-gated channel subfamily KQT member 1PRO_0000054024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97414.
PRIDEiP97414.

PTM databases

PhosphoSiteiP97414.

Expressioni

Tissue specificityi

Expressed in heart, kidney and salivary glands. Detected in the cochlea. Almost undetectable in brain, skeletal muscle and liver. Widely expressed in embryonic and neonatal tissues.1 Publication

Gene expression databases

BgeeiP97414.
ExpressionAtlasiP97414. baseline and differential.
GenevestigatoriP97414.

Interactioni

Subunit structurei

Heterotetramer with KCNE1 (MinK) or KCNE3 (MiRP2). Interacts with CALM (By similarity). Interacts with KCNE5 (By similarity).By similarity

Protein-protein interaction databases

IntActiP97414. 1 interaction.
STRINGi10090.ENSMUSP00000009689.

Structurei

3D structure databases

ProteinModelPortaliP97414.
SMRiP97414. Positions 146-423, 503-534, 584-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili584 – 62037By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi311 – 3166Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The coiled-coil domain mediates tetramerization.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiP97414.
KOiK04926.
OMAiGWGRLPG.
OrthoDBiEOG73804Z.
TreeFamiTF315186.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF109. PTHR11537:SF109. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P97414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY
60 70 80 90 100
APIAPTGAPG LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL
110 120 130 140 150
ARTHIQGRVY NFLERPTGWK CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL
160 170 180 190 200
ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR SKYVGIWGRL RFARKPISII
210 220 230 240 250
DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV DRQGGTWRLL
260 270 280 290 300
GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD
310 320 330 340 350
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF
360 370 380 390 400
ALKVQQKQRQ KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR
410 420 430 440 450
SHTLLSPSPK PKKSVMVKKK KFKLDKDNGM SPGEKMFNVP HITYDPPEDR
460 470 480 490 500
RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR TNSFAEDLDL EGETLLTPIT
510 520 530 540 550
HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV IEQYSQGHLN
560 570 580 590 600
LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ
610 620 630 640 650
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS
660
LPTYEQLTVP QTGPDEGS
Length:668
Mass (Da):74,514
Last modified:July 27, 2011 - v3
Checksum:i8CE35CBA3102B85B
GO
Isoform II (identifier: P97414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: FLERPTGWKCFVYHFTV → MHQLPTSILIPKNMPGG

Show »
Length:557
Mass (Da):62,640
Checksum:i56D3B3EF5F8D0FA0
GO

Sequence cautioni

The sequence AAB36518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731V → L in AAP93874 (PubMed:15004216).Curated
Sequence conflicti473 – 4731V → L in AAB36518 (PubMed:8900282).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform II. CuratedVSP_011748Add
BLAST
Alternative sequencei112 – 12817FLERP…YHFTV → MHQLPTSILIPKNMPGG in isoform II. CuratedVSP_000983Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY331142 mRNA. Translation: AAP93874.1.
AK154244 mRNA. Translation: BAE32460.1.
BC045142 mRNA. Translation: AAH45142.2.
BC055304 mRNA. Translation: AAH55304.1.
U70068 mRNA. Translation: AAB36518.1. Different initiation.
AJ002201 mRNA. Translation: CAA05246.1.
CCDSiCCDS22039.1. [P97414-1]
RefSeqiNP_032460.2. NM_008434.2. [P97414-1]
UniGeneiMm.439769.
Mm.453036.
Mm.453037.

Genome annotation databases

EnsembliENSMUST00000009689; ENSMUSP00000009689; ENSMUSG00000009545. [P97414-1]
GeneIDi16535.
KEGGimmu:16535.
UCSCiuc009kpb.1. mouse. [P97414-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY331142 mRNA. Translation: AAP93874.1.
AK154244 mRNA. Translation: BAE32460.1.
BC045142 mRNA. Translation: AAH45142.2.
BC055304 mRNA. Translation: AAH55304.1.
U70068 mRNA. Translation: AAB36518.1. Different initiation.
AJ002201 mRNA. Translation: CAA05246.1.
CCDSiCCDS22039.1. [P97414-1]
RefSeqiNP_032460.2. NM_008434.2. [P97414-1]
UniGeneiMm.439769.
Mm.453036.
Mm.453037.

3D structure databases

ProteinModelPortaliP97414.
SMRiP97414. Positions 146-423, 503-534, 584-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97414. 1 interaction.
STRINGi10090.ENSMUSP00000009689.

Chemistry

GuidetoPHARMACOLOGYi560.

Protein family/group databases

TCDBi1.A.1.15.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteiP97414.

Proteomic databases

PaxDbiP97414.
PRIDEiP97414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009689; ENSMUSP00000009689; ENSMUSG00000009545. [P97414-1]
GeneIDi16535.
KEGGimmu:16535.
UCSCiuc009kpb.1. mouse. [P97414-1]

Organism-specific databases

CTDi3784.
MGIiMGI:108083. Kcnq1.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiP97414.
KOiK04926.
OMAiGWGRLPG.
OrthoDBiEOG73804Z.
TreeFamiTF315186.

Enzyme and pathway databases

ReactomeiREACT_287159. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSiKcnq1. mouse.
NextBioi289961.
PROiP97414.
SOURCEiSearch...

Gene expression databases

BgeeiP97414.
ExpressionAtlasiP97414. baseline and differential.
GenevestigatoriP97414.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF109. PTHR11537:SF109. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current."
    Knollmann B.C., Casimiro M.C., Katchman A.N., Sirenko S.G., Schober T., Rong Q., Pfeifer K., Ebert S.N.
    J. Pharmacol. Exp. Ther. 310:311-318(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I).
    Strain: 129/SvJ.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Strain: NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Strain: FVB/N.
    Tissue: Colon and Olfactory epithelium.
  4. "K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current."
    Barhanin J., Lesage F., Guillemare E., Fink M., Lazdunski M., Romey G.
    Nature 384:78-80(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-668 (ISOFORM I).
    Tissue: Heart.
  5. "Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5."
    Paulsen M., Davies K.R., Bowden L.M., Villar A.J., Franck O., Fuermann M., Dean W.L., Moore T.F., Rodrigues N., Davies K.E., Hu R.-J., Feinberg A.P., Maher E.R., Reik W., Walter J.
    Hum. Mol. Genet. 7:1149-1159(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM II), TISSUE SPECIFICITY.
    Strain: C57BL/6.

Entry informationi

Entry nameiKCNQ1_MOUSE
AccessioniPrimary (citable) accession number: P97414
Secondary accession number(s): O88702
, Q3U4H1, Q7TNZ1, Q7TPL7, Q80VR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: May 27, 2015
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.