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P97414 (KCNQ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily KQT member 1
Alternative name(s):
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
Voltage-gated potassium channel subunit Kv7.1
Gene names
Name:Kcnq1
Synonyms:Kcna9, Kvlqt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current.

Subunit structure

Heterotetramer with KCNE1 (MinK) or KCNE3 (MiRP2). Interacts with CALM By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in heart, kidney and salivary glands. Detected in the cochlea. Almost undetectable in brain, skeletal muscle and liver. Widely expressed in embryonic and neonatal tissues. Ref.5

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily. [View classification]

Sequence caution

The sequence AAB36518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentCell membrane
Cytoplasmic vesicle
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandCalmodulin-binding
Potassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

cardiovascular system development

Inferred from mutant phenotype Ref.1. Source: MGI

cellular response to cAMP

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

gene silencing

Inferred from mutant phenotype PubMed 15340049. Source: MGI

male gonad development

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of potassium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

potassium ion export

Inferred from electronic annotation. Source: Ensembl

regulation of atrial cardiac muscle cell membrane repolarization

Inferred from electronic annotation. Source: Ensembl

regulation of gene expression by genetic imprinting

Inferred from mutant phenotype PubMed 12410230PubMed 15340049. Source: MGI

regulation of heart rate by cardiac conduction

Inferred from electronic annotation. Source: Ensembl

regulation of ventricular cardiac muscle cell membrane repolarization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from electronic annotation. Source: Ensembl

late endosome

Inferred from electronic annotation. Source: Ensembl

lysosome

Inferred from electronic annotation. Source: Ensembl

sarcolemma

Inferred from electronic annotation. Source: Ensembl

voltage-gated potassium channel complex

Inferred from electronic annotation. Source: Ensembl

zymogen granule membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiondelayed rectifier potassium channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

outward rectifier potassium channel activity

Inferred from electronic annotation. Source: Ensembl

voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

Inferred from electronic annotation. Source: Ensembl

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform I (identifier: P97414-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform II (identifier: P97414-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: FLERPTGWKCFVYHFTV → MHQLPTSILIPKNMPGG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 668668Potassium voltage-gated channel subfamily KQT member 1
PRO_0000054024

Regions

Transmembrane121 – 14121Helical; Name=Segment S1; Potential
Topological domain142 – 1465Extracellular Potential
Transmembrane147 – 16721Helical; Name=Segment S2; Potential
Topological domain168 – 19528Cytoplasmic Potential
Transmembrane196 – 21621Helical; Name=Segment S3; Potential
Topological domain217 – 2248Extracellular Potential
Transmembrane225 – 24723Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain248 – 26013Cytoplasmic Potential
Transmembrane261 – 28121Helical; Name=Segment S5; Potential
Topological domain282 – 29817Extracellular Potential
Intramembrane299 – 31921Pore-forming; Name=Segment H5; Potential
Topological domain320 – 33011Extracellular Potential
Transmembrane331 – 35121Helical; Name=Segment S6; Potential
Topological domain352 – 668317Cytoplasmic Potential
Motif311 – 3166Selectivity filter By similarity

Amino acid modifications

Glycosylation2881N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 111111Missing in isoform II.
VSP_011748
Alternative sequence112 – 12817FLERP…YHFTV → MHQLPTSILIPKNMPGG in isoform II.
VSP_000983

Experimental info

Sequence conflict4731V → L in AAP93874. Ref.1
Sequence conflict4731V → L in AAB36518. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform I [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 8CE35CBA3102B85B

FASTA66874,514
        10         20         30         40         50         60 
MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY APIAPTGAPG 

        70         80         90        100        110        120 
LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL ARTHIQGRVY NFLERPTGWK 

       130        140        150        160        170        180 
CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR 

       190        200        210        220        230        240 
SKYVGIWGRL RFARKPISII DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV 

       250        260        270        280        290        300 
DRQGGTWRLL GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD 

       310        320        330        340        350        360 
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF ALKVQQKQRQ 

       370        380        390        400        410        420 
KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR SHTLLSPSPK PKKSVMVKKK 

       430        440        450        460        470        480 
KFKLDKDNGM SPGEKMFNVP HITYDPPEDR RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR 

       490        500        510        520        530        540 
TNSFAEDLDL EGETLLTPIT HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV 

       550        560        570        580        590        600 
IEQYSQGHLN LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ 

       610        620        630        640        650        660 
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS LPTYEQLTVP 


QTGPDEGS 

« Hide

Isoform II [UniParc].

Checksum: 56D3B3EF5F8D0FA0
Show »

FASTA55762,640

References

« Hide 'large scale' references
[1]"Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current."
Knollmann B.C., Casimiro M.C., Katchman A.N., Sirenko S.G., Schober T., Rong Q., Pfeifer K., Ebert S.N.
J. Pharmacol. Exp. Ther. 310:311-318(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I).
Strain: 129/SvJ.
Tissue: Heart.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
Strain: NOD.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
Strain: FVB/N.
Tissue: Colon and Olfactory epithelium.
[4]"K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current."
Barhanin J., Lesage F., Guillemare E., Fink M., Lazdunski M., Romey G.
Nature 384:78-80(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-668 (ISOFORM I).
Tissue: Heart.
[5]"Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5."
Paulsen M., Davies K.R., Bowden L.M., Villar A.J., Franck O., Fuermann M., Dean W.L., Moore T.F., Rodrigues N., Davies K.E., Hu R.-J., Feinberg A.P., Maher E.R., Reik W., Walter J.
Hum. Mol. Genet. 7:1149-1159(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM II), TISSUE SPECIFICITY.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY331142 mRNA. Translation: AAP93874.1.
AK154244 mRNA. Translation: BAE32460.1.
BC045142 mRNA. Translation: AAH45142.2.
BC055304 mRNA. Translation: AAH55304.1.
U70068 mRNA. Translation: AAB36518.1. Different initiation.
AJ002201 mRNA. Translation: CAA05246.1.
CCDSCCDS22039.1. [P97414-1]
RefSeqNP_032460.2. NM_008434.2. [P97414-1]
UniGeneMm.439769.
Mm.453036.
Mm.453037.

3D structure databases

ProteinModelPortalP97414.
SMRP97414. Positions 122-377, 584-610.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000009689.

Chemistry

GuidetoPHARMACOLOGY560.

Protein family/group databases

TCDB1.A.1.15.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteP97414.

Proteomic databases

PaxDbP97414.
PRIDEP97414.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009689; ENSMUSP00000009689; ENSMUSG00000009545. [P97414-1]
GeneID16535.
KEGGmmu:16535.
UCSCuc009kpb.1. mouse. [P97414-1]

Organism-specific databases

CTD3784.
MGIMGI:108083. Kcnq1.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00550000074513.
HOGENOMHOG000220839.
HOVERGENHBG059014.
InParanoidQ3U4H1.
KOK04926.
OMAEHHRAAI.
OrthoDBEOG73804Z.
TreeFamTF315186.

Gene expression databases

ArrayExpressP97414.
BgeeP97414.
GenevestigatorP97414.

Family and domain databases

InterProIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF109. PTHR11537:SF109. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetSearch...

Other

NextBio289961.
PROP97414.
SOURCESearch...

Entry information

Entry nameKCNQ1_MOUSE
AccessionPrimary (citable) accession number: P97414
Secondary accession number(s): O88702 expand/collapse secondary AC list , Q3U4H1, Q7TNZ1, Q7TPL7, Q80VR7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot