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P97414

- KCNQ1_MOUSE

UniProt

P97414 - KCNQ1_MOUSE

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Protein
Potassium voltage-gated channel subfamily KQT member 1
Gene
Kcnq1, Kcna9, Kvlqt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. outward rectifier potassium channel activity Source: Ensembl
  3. voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: Ensembl
  4. voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Source: Ensembl

GO - Biological processi

  1. cardiac muscle contraction Source: Ensembl
  2. cardiovascular system development Source: MGI
  3. cellular response to cAMP Source: Ensembl
  4. cellular response to drug Source: Ensembl
  5. gene silencing Source: MGI
  6. male gonad development Source: Ensembl
  7. negative regulation of insulin secretion Source: Ensembl
  8. positive regulation of gastric acid secretion Source: Ensembl
  9. positive regulation of potassium ion transmembrane transport Source: Ensembl
  10. potassium ion export Source: Ensembl
  11. regulation of atrial cardiac muscle cell membrane repolarization Source: Ensembl
  12. regulation of gene expression by genetic imprinting Source: MGI
  13. regulation of heart rate by cardiac conduction Source: Ensembl
  14. regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Calmodulin-binding, Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.15.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 1
Alternative name(s):
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
Voltage-gated potassium channel subunit Kv7.1
Gene namesi
Name:Kcnq1
Synonyms:Kcna9, Kvlqt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:108083. Kcnq1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei121 – 14121Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Topological domaini142 – 1465Extracellular Reviewed prediction
Transmembranei147 – 16721Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini168 – 19528Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Topological domaini217 – 2248Extracellular Reviewed prediction
Transmembranei225 – 24723Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini248 – 26013Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Topological domaini282 – 29817Extracellular Reviewed prediction
Add
BLAST
Intramembranei299 – 31921Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Topological domaini320 – 33011Extracellular Reviewed prediction
Add
BLAST
Transmembranei331 – 35121Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini352 – 668317Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. early endosome Source: Ensembl
  3. late endosome Source: Ensembl
  4. lysosome Source: Ensembl
  5. sarcolemma Source: Ensembl
  6. voltage-gated potassium channel complex Source: Ensembl
  7. zymogen granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Potassium voltage-gated channel subfamily KQT member 1
PRO_0000054024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP97414.
PRIDEiP97414.

PTM databases

PhosphoSiteiP97414.

Expressioni

Tissue specificityi

Expressed in heart, kidney and salivary glands. Detected in the cochlea. Almost undetectable in brain, skeletal muscle and liver. Widely expressed in embryonic and neonatal tissues.1 Publication

Gene expression databases

ArrayExpressiP97414.
BgeeiP97414.
GenevestigatoriP97414.

Interactioni

Subunit structurei

Heterotetramer with KCNE1 (MinK) or KCNE3 (MiRP2). Interacts with CALM By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009689.

Structurei

3D structure databases

ProteinModelPortaliP97414.
SMRiP97414. Positions 122-377, 584-610.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili584 – 62037 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi311 – 3166Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The coiled-coil domain mediates tetramerization By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiQ3U4H1.
KOiK04926.
OMAiEHHRAAI.
OrthoDBiEOG73804Z.
TreeFamiTF315186.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF109. PTHR11537:SF109. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform I (identifier: P97414-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY    50
APIAPTGAPG LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL 100
ARTHIQGRVY NFLERPTGWK CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL 150
ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR SKYVGIWGRL RFARKPISII 200
DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV DRQGGTWRLL 250
GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD 300
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF 350
ALKVQQKQRQ KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR 400
SHTLLSPSPK PKKSVMVKKK KFKLDKDNGM SPGEKMFNVP HITYDPPEDR 450
RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR TNSFAEDLDL EGETLLTPIT 500
HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV IEQYSQGHLN 550
LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ 600
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS 650
LPTYEQLTVP QTGPDEGS 668
Length:668
Mass (Da):74,514
Last modified:July 27, 2011 - v3
Checksum:i8CE35CBA3102B85B
GO
Isoform II (identifier: P97414-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: FLERPTGWKCFVYHFTV → MHQLPTSILIPKNMPGG

Show »
Length:557
Mass (Da):62,640
Checksum:i56D3B3EF5F8D0FA0
GO

Sequence cautioni

The sequence AAB36518.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform II.
VSP_011748Add
BLAST
Alternative sequencei112 – 12817FLERP…YHFTV → MHQLPTSILIPKNMPGG in isoform II.
VSP_000983Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731V → L in AAP93874. 1 Publication
Sequence conflicti473 – 4731V → L in AAB36518. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY331142 mRNA. Translation: AAP93874.1.
AK154244 mRNA. Translation: BAE32460.1.
BC045142 mRNA. Translation: AAH45142.2.
BC055304 mRNA. Translation: AAH55304.1.
U70068 mRNA. Translation: AAB36518.1. Different initiation.
AJ002201 mRNA. Translation: CAA05246.1.
CCDSiCCDS22039.1. [P97414-1]
RefSeqiNP_032460.2. NM_008434.2. [P97414-1]
UniGeneiMm.439769.
Mm.453036.
Mm.453037.

Genome annotation databases

EnsembliENSMUST00000009689; ENSMUSP00000009689; ENSMUSG00000009545. [P97414-1]
GeneIDi16535.
KEGGimmu:16535.
UCSCiuc009kpb.1. mouse. [P97414-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY331142 mRNA. Translation: AAP93874.1 .
AK154244 mRNA. Translation: BAE32460.1 .
BC045142 mRNA. Translation: AAH45142.2 .
BC055304 mRNA. Translation: AAH55304.1 .
U70068 mRNA. Translation: AAB36518.1 . Different initiation.
AJ002201 mRNA. Translation: CAA05246.1 .
CCDSi CCDS22039.1. [P97414-1 ]
RefSeqi NP_032460.2. NM_008434.2. [P97414-1 ]
UniGenei Mm.439769.
Mm.453036.
Mm.453037.

3D structure databases

ProteinModelPortali P97414.
SMRi P97414. Positions 122-377, 584-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000009689.

Chemistry

GuidetoPHARMACOLOGYi 560.

Protein family/group databases

TCDBi 1.A.1.15.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei P97414.

Proteomic databases

PaxDbi P97414.
PRIDEi P97414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009689 ; ENSMUSP00000009689 ; ENSMUSG00000009545 . [P97414-1 ]
GeneIDi 16535.
KEGGi mmu:16535.
UCSCi uc009kpb.1. mouse. [P97414-1 ]

Organism-specific databases

CTDi 3784.
MGIi MGI:108083. Kcnq1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00550000074513.
HOGENOMi HOG000220839.
HOVERGENi HBG059014.
InParanoidi Q3U4H1.
KOi K04926.
OMAi EHHRAAI.
OrthoDBi EOG73804Z.
TreeFami TF315186.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289961.
PROi P97414.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97414.
Bgeei P97414.
Genevestigatori P97414.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR005827. K_chnl_volt-dep_KCQN1.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF109. PTHR11537:SF109. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01460. KCNQ1CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current."
    Knollmann B.C., Casimiro M.C., Katchman A.N., Sirenko S.G., Schober T., Rong Q., Pfeifer K., Ebert S.N.
    J. Pharmacol. Exp. Ther. 310:311-318(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I).
    Strain: 129/SvJ.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Strain: NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    Strain: FVB/N.
    Tissue: Colon and Olfactory epithelium.
  4. "K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current."
    Barhanin J., Lesage F., Guillemare E., Fink M., Lazdunski M., Romey G.
    Nature 384:78-80(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-668 (ISOFORM I).
    Tissue: Heart.
  5. "Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5."
    Paulsen M., Davies K.R., Bowden L.M., Villar A.J., Franck O., Fuermann M., Dean W.L., Moore T.F., Rodrigues N., Davies K.E., Hu R.-J., Feinberg A.P., Maher E.R., Reik W., Walter J.
    Hum. Mol. Genet. 7:1149-1159(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM II), TISSUE SPECIFICITY.
    Strain: C57BL/6.

Entry informationi

Entry nameiKCNQ1_MOUSE
AccessioniPrimary (citable) accession number: P97414
Secondary accession number(s): O88702
, Q3U4H1, Q7TNZ1, Q7TPL7, Q80VR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi