P97412 (LYST_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosomal-trafficking regulator

Alternative name(s):
Beige protein
CHS1 homolog

Gene names

Name:	Lyst
Synonyms:	Bg, Chs1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3788 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
Subunit structure	Interacts with CENPJ, LIP8 and ZNF521 By similarity.
Subcellular location	Cytoplasm Potential.
Involvement in disease	Defects in Lyst are the cause of beige, an autosomal recessive disorder characterized by hypopigmentation, bleeding, immune cell dysfunction, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types.
Sequence similarities	Contains 1 BEACH domain. Contains 7 WD repeats.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell mediated immunity Inferred from mutant phenotype PubMed 6977094. Source: MGI blood coagulation Inferred from mutant phenotype PubMed 6696991. Source: MGI defense response to bacterium Inferred from mutant phenotype PubMed 4589319PubMed 4601767PubMed 7988496. Source: MGI defense response to protozoan Inferred from mutant phenotype PubMed 6218091. Source: MGI defense response to virus Inferred from mutant phenotype PubMed 6272291. Source: MGI leukocyte chemotaxis Inferred from mutant phenotype PubMed 4589319. Source: MGI lysosome organization Inferred from mutant phenotype PubMed 1113502PubMed 4031470PubMed 4697831PubMed 6170520PubMed 9368050. Source: MGI mast cell secretory granule organization Inferred from mutant phenotype PubMed 624833. Source: MGI melanosome organization Inferred from mutant phenotype PubMed 16518687PubMed 4634048. Source: MGI microtubule-based process Inferred from mutant phenotype PubMed 187062. Source: MGI neutrophil mediated immunity Inferred from mutant phenotype PubMed 7988496. Source: MGI phospholipid homeostasis Inferred from mutant phenotype PubMed 580786. Source: MGI phospholipid metabolic process Inferred from mutant phenotype PubMed 580786. Source: MGI positive regulation of natural killer cell activation Inferred from mutant phenotype PubMed 7089489. Source: MGI response to drug Inferred from mutant phenotype PubMed 2513223. Source: MGI secretion of lysosomal enzymes Inferred from mutant phenotype PubMed 408PubMed 7089489. Source: MGI
Cellular_component	cytosol Inferred from direct assay PubMed 9368050. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P97412-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P97412-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1509-1545: EGDRPEVTESINPGDRLIEDGCIHLISLGSKALMIQV → GMMAGSDLYTKILQIAACLSFKHIWQYFNVFFKCYSP
     1546-3788: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3788	3788	Lysosomal-trafficking regulator		PRO_0000051072
Regions
	Repeat	662 – 700	39	WD 1
	Repeat	1576 – 1620	45	WD 2
	Domain	3126 – 3409	284	BEACH
	Repeat	3550 – 3589	40	WD 3
	Repeat	3601 – 3640	40	WD 4
	Repeat	3643 – 3686	44	WD 5
	Repeat	3687 – 3731	45	WD 6
	Repeat	3736 – 3775	40	WD 7
Amino acid modifications
	Modified residue	1503	1	Phosphoserine Ref.6
	Modified residue	1504	1	Phosphoserine Ref.6
	Modified residue	2099	1	Phosphoserine Ref.6
	Modified residue	2203	1	Phosphoserine Ref.5
	Modified residue	2207	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1509 – 1545	37	EGDRP…LMIQV → GMMAGSDLYTKILQIAACLS FKHIWQYFNVFFKCYSP in isoform 2.		VSP_006783
	Alternative sequence	1546 – 3788	2243	Missing in isoform 2.		VSP_006784

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: F01BE837C676A750	FASTA	3,788	425,287
	10 20 30 40 50 60 MSTDSNSLAR EFLIDVNQLC NAVVQRAEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 70 80 90 100 110 120 IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL SSDIILTKEK NSSLQKSTQG 130 140 150 160 170 180 KLYLEGSAPS GQVSAKVNLF RKIRRQRKST HRYSVRDARK TQLSTSDSEG NSDEKSTVVS 190 200 210 220 230 240 KHRRLHALPR FLTQSPKEGH LVAKPDPSAT KEQVLSDTMS VENSREVILR QDSNGDILSE 250 260 270 280 290 300 PAALSILSNM NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LALSVVPTLT EFLAGFGDCC 310 320 330 340 350 360 NQSDTLEGQL VSAGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR KNLTELLRAA 370 380 390 400 410 420 LKIRACLEKQ PEPFSPRQKK TLQEVQEGFV FSKYRHRALL LPELLEGVLQ LLISCLQSAA 430 440 450 460 470 480 SNPFYFSQAM DLVQEFIQHQ GFNLFGTAVL QMEWLLTRDG VPSEAAEHLK ALINSVIKIM 490 500 510 520 530 540 STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD 550 560 570 580 590 600 VQYPERCCCI AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIAPLLHAFK 610 620 630 640 650 660 LPALKAFQQH ILNVLSKLLV DQLGGAELSP RIKKAACNIC TVDSDQLAKL GETLQGTLCG 670 680 690 700 710 720 AGPTSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV FQEDRLHNIQ IANHICNLLQ 730 740 750 760 770 780 KGNVVVQWKL YNYIFNPVLQ RGVELVHHCQ QLSIPSAQTH MCSQLKQYLP QEVLQIYLKT 790 800 810 820 830 840 LPVLLKSRVI RDLFLSCNGV NHIIELNYLD GIRSHSLKAF ETLIVSLGEQ QKDAAVLDVD 850 860 870 880 890 900 GLDIQQELPS LSVGPSLHKQ QASSDSPCSL RKFYASLREP DPKKRKTIHQ DVHINTINLF 910 920 930 940 950 960 LCVAFLCVSK EADSDRESAN ESEDTSGYDS PPSEPLSHML PCLSLEDVVL PSPECLHHAA 970 980 990 1000 1010 1020 DIWSMCRWIY MLNSVFQKQF HRLGGFQVCH ELIFMIIQKL FRSHTEDQGR RQGEMSRNEN 1030 1040 1050 1060 1070 1080 QELIRISYPE LTLKGDVSSA TAPDLGFLRK SADSVRGFQS QPVLPTSAEQ IVATESVPGE 1090 1100 1110 1120 1130 1140 RKAFMSQQSE TSLQSIRLLE SLLDICLHSA RACQQKMELE LPSQGLSVEN ILCELREHLS 1150 1160 1170 1180 1190 1200 QSKVAETELA KPLFDALLRV ALGNHSADLG PGDAVTEKSH PSEEELLSQP GDFSEEAEDS 1210 1220 1230 1240 1250 1260 QCCSLKLLGE EEGYEADSES NPEDVDTQDD GVELNPEAEG FSGSIVSNNL LENLTHGEII 1270 1280 1290 1300 1310 1320 YPEICMLGLN LLSASKAKLD VLAHVFESFL KIVRQKEKNI SLLIQQGTVK ILLGGFLNIL 1330 1340 1350 1360 1370 1380 TQTNSDFQAC QRVLVDLLVS LMSSRTCSED LTLLWRIFLE KSPCTEILLL GIHKIVESDF 1390 1400 1410 1420 1430 1440 TMSPSQCLTF PFLHTPSLSN GVLSQKPPGI LNSKALGLLR RARISRGKKE ADRESFPYRL 1450 1460 1470 1480 1490 1500 LSSWHIAPIH LPLLGQNCWP HLSEGFSVSL VGLMWNTSNE SESAAERGKR VKKRNKPSVL 1510 1520 1530 1540 1550 1560 EDSSFEGAEG DRPEVTESIN PGDRLIEDGC IHLISLGSKA LMIQVWADPH SGTFIFRVCM 1570 1580 1590 1600 1610 1620 DSNDDTKAVS LAQVESQENI FFPSKWQHLV LTYIQHPQGK KNVHGEISIW VSGQRKTDVI 1630 1640 1650 1660 1670 1680 LDFVLPRKTS LSSDSNKTFC MIGHCLTSQE ESLQLAGKWD LGNLLLFNGA KIGSQEAFFL 1690 1700 1710 1720 1730 1740 YACGPNYTSI MPCKYGQPVI DYSKYINKDI LRCDEIRDLF MTKKEVDVGL LIESLSVVYT 1750 1760 1770 1780 1790 1800 TCCPAQYTIY EPVIRLKGQV KTQPSQRPFS SKEAQSILLE PSQLKGLQPT ECKAIQGILH 1810 1820 1830 1840 1850 1860 EIGGAGTFVF LFARVVELSS CEETQALALR VILSLIKYSQ QRTQELENCN GLSMIHQVLV 1870 1880 1890 1900 1910 1920 KQKCIVGFHI LKTLLEGCCG EEVIHVSEHG EFKLDVESHA IIQDVKLLQE LLLDWKIWNK 1930 1940 1950 1960 1970 1980 AEQGVWETLL AALEVLIRVE HHQQQFNIKQ LLNAHVVHHF LLTCQVLQEH REGQLTSMPR 1990 2000 2010 2020 2030 2040 EVCRSFVKII AEVLGSPPDL ELLTVIFNFL LAVHPPTNTY VCHNPTNFYF SLHIDGKIFQ 2050 2060 2070 2080 2090 2100 EKVQSLAYLR HSSSGGQAFP SPGFLVISPS AFTAAPPEGT SSSNIVPQRM AAQMVRSRSL 2110 2120 2130 2140 2150 2160 PAFPTYLPLI RAQKLAASLG FSVDKLQNIA DANPEKQNLL GRPYALKTSK EEAFISSCES 2170 2180 2190 2200 2210 2220 AKTVCEMEAL LGAHASANGV SRGSPRFPRA RVDHKDVGTE PRSDDDSPGD ESYPRRPDNL 2230 2240 2250 2260 2270 2280 KGLASFQRSQ STVASLGLAF PSQNGSAVAS RWPSLVDRNA DDWENFTFSP AYEASYNRAT 2290 2300 2310 2320 2330 2340 STHSVIEDCL IPICCGLYEL LSGVLLVLPD AMLEDVMDRI IQADILLVLV NHPSPAIQQG 2350 2360 2370 2380 2390 2400 VIKLLHAYIN RASKEQKDKF LKNRGFSLLA NQLYLHRGTQ ELLECFVEMF FGRPIGLDEE 2410 2420 2430 2440 2450 2460 FDLEEVKHME LFQKWSVIPV LGLIETSLYD NVLLHNALLL LLQVLNSCSK VADMLLDNGL 2470 2480 2490 2500 2510 2520 LYVLCNTVAA LNGLEKNIPV NEYKLLACDI QQLFIAVTIH ACSSSGTQYF RVIEDLIVLL 2530 2540 2550 2560 2570 2580 GYLHNSKNKR TQNMALALQL RVLQAALEFI RSTANHDSES PVHSPSAHRH SVPPKRRSIA 2590 2600 2610 2620 2630 2640 GSRKFPLAQT ESLLMKMRSV ASDELHSMMQ RRMSQEHPSQ ASEAELAQRL QRLTILAVNR 2650 2660 2670 2680 2690 2700 IIYQELNSDI IDILRTPENT SQSKTSVSQT EISEEDMHHE QPSVYNPFQK EMLTYLLDGF 2710 2720 2730 2740 2750 2760 KVCIGSSKTS VSKQQWTKIL GSCKETLRDQ LGRLLAHILS PTHTVQERKQ ILEIVHEPAH 2770 2780 2790 2800 2810 2820 QDILRDCLSP SPQHGAKLVL YLSELIHNHQ DELSEEEMDT AELLMNALKL CGHKCIPPSA 2830 2840 2850 2860 2870 2880 PSKPELIKII REEQKKYESE ESVSKGSWQK TVNNNQQSLF QRLDFKSKDI SKIAADITQA 2890 2900 2910 2920 2930 2940 VSLSQGIERK KVIQHIRGMY KVDLSASRHW QECIQQLTHD RAVWYDPIYY PTSWQLDPTE 2950 2960 2970 2980 2990 3000 GPNRERRRLQ RCYLTIPNKY LLRDRQKSEG VLRPPLSYLF EDKTHSSFSS TVKDKAASES 3010 3020 3030 3040 3050 3060 IRVNRRCISV APSRETAGEL LLGKCGMYFV EDNASDAVES SSLQGELEPA SFSWTYEEIK 3070 3080 3090 3100 3110 3120 EVHRRWWQLR DNAVEIFLTN GRTLLLAFDN NKVRDDVYQS ILTNNLPNLL EYGNITALTN 3130 3140 3150 3160 3170 3180 LWYSGQITNF EYLTHLNKHA GRSFNDLMQY PVFPFILSDY VSETLDLNDP SIYRNLSKPI 3190 3200 3210 3220 3230 3240 AVQYKEKEDR YVDTYKYLEE EYRKGAREDD PMPPVQPYHY GSHYSNSGTV LHFLVRMPPF 3250 3260 3270 3280 3290 3300 TKMFLAYQDQ SFDIPDRTFH STNTTWRLSS FESMTDVKEL IPEFFYLPEF LVNREGFDFG 3310 3320 3330 3340 3350 3360 VRQNGERVNH VNLPPWARND PRLFILIHRQ ALESDHVSQN ICHWIDLVFG YKQKGKASVQ 3370 3380 3390 3400 3410 3420 AINVFHPATY FGMDVSAVED PVQRRALETM IKTYGQTPRQ LFHTAHASRP GAKLNIEGEL 3430 3440 3450 3460 3470 3480 PAAVGLLVQF AFRETREPVK EVTHPSPLSW IKGLKWGEYV GSPSAPVPVV CFSQPHGERF 3490 3500 3510 3520 3530 3540 GSLQALPTRA ICGLSRNFCL LMTYNKEQGV RSMNNTNIQW SAILSWGYAD NILRLKSKQS 3550 3560 3570 3580 3590 3600 EPPINFIQSS QQHQVTSCAW VPDSCQLFTG SKCGVITAYT NRLTSSTPSE IEMESQMHLY 3610 3620 3630 3640 3650 3660 GHTEEITGLC VCKPYSVMIS VSRDGTCIVW DLNRLCYVQS LAGHKSPVTA VSASETSGDI 3670 3680 3690 3700 3710 3720 ATVCDSAGGG SDLRLWTVNG DLVGHVHCRE IICSVAFSNQ PEGVSINVIA GGLENGIVRL 3730 3740 3750 3760 3770 3780 WSTWDLKPVR EITFPKSNKP IISLTFSCDG HHLYTANSEG TVIAWCRKDQ QRVKLPMFYS FLSSYAAG
	Isoform 2 [UniParc]. Checksum: A346094C0E5C419A	FASTA	1,545	172,458
	10 20 30 40 50 60 MSTDSNSLAR EFLIDVNQLC NAVVQRAEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 70 80 90 100 110 120 IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL SSDIILTKEK NSSLQKSTQG 130 140 150 160 170 180 KLYLEGSAPS GQVSAKVNLF RKIRRQRKST HRYSVRDARK TQLSTSDSEG NSDEKSTVVS 190 200 210 220 230 240 KHRRLHALPR FLTQSPKEGH LVAKPDPSAT KEQVLSDTMS VENSREVILR QDSNGDILSE 250 260 270 280 290 300 PAALSILSNM NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LALSVVPTLT EFLAGFGDCC 310 320 330 340 350 360 NQSDTLEGQL VSAGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR KNLTELLRAA 370 380 390 400 410 420 LKIRACLEKQ PEPFSPRQKK TLQEVQEGFV FSKYRHRALL LPELLEGVLQ LLISCLQSAA 430 440 450 460 470 480 SNPFYFSQAM DLVQEFIQHQ GFNLFGTAVL QMEWLLTRDG VPSEAAEHLK ALINSVIKIM 490 500 510 520 530 540 STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD 550 560 570 580 590 600 VQYPERCCCI AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIAPLLHAFK 610 620 630 640 650 660 LPALKAFQQH ILNVLSKLLV DQLGGAELSP RIKKAACNIC TVDSDQLAKL GETLQGTLCG 670 680 690 700 710 720 AGPTSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV FQEDRLHNIQ IANHICNLLQ 730 740 750 760 770 780 KGNVVVQWKL YNYIFNPVLQ RGVELVHHCQ QLSIPSAQTH MCSQLKQYLP QEVLQIYLKT 790 800 810 820 830 840 LPVLLKSRVI RDLFLSCNGV NHIIELNYLD GIRSHSLKAF ETLIVSLGEQ QKDAAVLDVD 850 860 870 880 890 900 GLDIQQELPS LSVGPSLHKQ QASSDSPCSL RKFYASLREP DPKKRKTIHQ DVHINTINLF 910 920 930 940 950 960 LCVAFLCVSK EADSDRESAN ESEDTSGYDS PPSEPLSHML PCLSLEDVVL PSPECLHHAA 970 980 990 1000 1010 1020 DIWSMCRWIY MLNSVFQKQF HRLGGFQVCH ELIFMIIQKL FRSHTEDQGR RQGEMSRNEN 1030 1040 1050 1060 1070 1080 QELIRISYPE LTLKGDVSSA TAPDLGFLRK SADSVRGFQS QPVLPTSAEQ IVATESVPGE 1090 1100 1110 1120 1130 1140 RKAFMSQQSE TSLQSIRLLE SLLDICLHSA RACQQKMELE LPSQGLSVEN ILCELREHLS 1150 1160 1170 1180 1190 1200 QSKVAETELA KPLFDALLRV ALGNHSADLG PGDAVTEKSH PSEEELLSQP GDFSEEAEDS 1210 1220 1230 1240 1250 1260 QCCSLKLLGE EEGYEADSES NPEDVDTQDD GVELNPEAEG FSGSIVSNNL LENLTHGEII 1270 1280 1290 1300 1310 1320 YPEICMLGLN LLSASKAKLD VLAHVFESFL KIVRQKEKNI SLLIQQGTVK ILLGGFLNIL 1330 1340 1350 1360 1370 1380 TQTNSDFQAC QRVLVDLLVS LMSSRTCSED LTLLWRIFLE KSPCTEILLL GIHKIVESDF 1390 1400 1410 1420 1430 1440 TMSPSQCLTF PFLHTPSLSN GVLSQKPPGI LNSKALGLLR RARISRGKKE ADRESFPYRL 1450 1460 1470 1480 1490 1500 LSSWHIAPIH LPLLGQNCWP HLSEGFSVSL VGLMWNTSNE SESAAERGKR VKKRNKPSVL 1510 1520 1530 1540 EDSSFEGAGM MAGSDLYTKI LQIAACLSFK HIWQYFNVFF KCYSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse." Barbosa M.D.F.S., Barrat F.J., Tchernev V.T., Nguyen Q.A., Mishra V.S., Colman S.D., Pastural E., Dufourcq-Lagelouse R., Fischer A., Holcombe R.F., Wallace M.R., Brandt S.J., De Saint Basile G., Kingsmore S.F. Hum. Mol. Genet. 6:1091-1098(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification of the homologous beige and Chediak-Higashi syndrome genes." Barbosa M.D.F.S., Nguyen Q.A., Tchernev V.T., Ashley J.A., Detter J.C., Blaydes S.M., Brandt S.J., Chotai D., Hodgman C., Solari R.C.E.S., Lovett M., Kingsmore S.F. Nature 382:262-265(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: C57BL/6J.
[3]	Erratum Barbosa M.D.F.S., Nguyen Q.A., Tchernev V.T., Ashley J.A., Detter J.C., Blaydes S.M., Brandt S.J., Chotai D., Hodgman C., Solari R.C.E.S., Lovett M., Kingsmore S.F. Nature 385:97-97(1997)
[4]	"Identification of the murine beige gene by YAC complementation and positional cloning." Perou C.M., Moore K.J., Nagle D.L., Misumi D.J., Woolf E.A., McGrail S.H., Holmgren L., Brody T.B., Dussault B.J., Monroe C.A., Duyk G.M., Pryor R.J., Li L., Justice M.J., Kaplan J. Nat. Genet. 13:303-308(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1428-3788 (ISOFORM 1). Strain: C57BL/6J.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2203 AND SER-2207, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1503; SER-1504 AND SER-2099, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U70015 mRNA. Translation: AAC53011.1. L77884 mRNA. Translation: AAL40134.1. U52461 mRNA. Translation: AAB60778.1.
IPI	IPI00227912. IPI00399954.
PIR	T30851.
RefSeq	NP_034878.2. NM_010748.2.
UniGene	Mm.342337.
3D structure databases
ProteinModelPortal	P97412.
SMR	P97412. Positions 3010-3409, 3549-3770.
ModBase	Search...
PTM databases
PhosphoSite	P97412.
Proteomic databases
PaxDb	P97412.
PRIDE	P97412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	17101.
KEGG	mmu:17101.
UCSC	uc007pmj.1. mouse.
Organism-specific databases
CTD	1130.
MGI	MGI:107448. Lyst.
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000113425.
HOVERGEN	HBG006300.
OrthoDB	EOG418BMF.
Gene expression databases
CleanEx	MM_LYST.
Genevestigator	P97412.
GermOnline	ENSMUSG00000019726. Mus musculus.
Family and domain databases
Gene3D	1.10.1540.10. 1 hit. 2.130.10.10. 1 hit. 2.30.29.40. 1 hit.
InterPro	IPR000409. BEACH_dom. IPR023362. PH-BEACH_dom. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF02138. Beach. 1 hit. PF00400. WD40. 2 hits. [Graphical view]
SMART	SM01026. Beach. 1 hit. SM00320. WD40. 4 hits. [Graphical view]
SUPFAM	SSF81837. Beige_BEACH. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS50197. BEACH. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LYST. mouse.
NextBio	291244.
SOURCE	Search...

Entry information

Entry name

LYST_MOUSE

Accession

Primary (citable) accession number: P97412
Secondary accession number(s): Q62403, Q8VBS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program