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P97412

- LYST_MOUSE

UniProt

P97412 - LYST_MOUSE

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Protein

Lysosomal-trafficking regulator

Gene

Lyst

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.

GO - Biological processi

  1. blood coagulation Source: MGI
  2. defense response to bacterium Source: MGI
  3. defense response to protozoan Source: MGI
  4. defense response to virus Source: MGI
  5. leukocyte chemotaxis Source: MGI
  6. lysosome organization Source: MGI
  7. mast cell secretory granule organization Source: MGI
  8. melanosome organization Source: MGI
  9. microtubule-based process Source: MGI
  10. neutrophil mediated immunity Source: MGI
  11. phospholipid homeostasis Source: MGI
  12. phospholipid metabolic process Source: MGI
  13. pigmentation Source: MGI
  14. pigment granule organization Source: MGI
  15. positive regulation of natural killer cell activation Source: MGI
  16. response to drug Source: MGI
  17. secretion of lysosomal enzymes Source: MGI
  18. T cell mediated immunity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-trafficking regulator
Alternative name(s):
Beige protein
CHS1 homolog
Gene namesi
Name:Lyst
Synonyms:Bg, Chs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107448. Lyst.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytosol Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in Lyst are the cause of beige, an autosomal recessive disorder characterized by hypopigmentation, bleeding, immune cell dysfunction, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37883788Lysosomal-trafficking regulatorPRO_0000051072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2099 – 20991PhosphoserineBy similarity
Modified residuei2203 – 22031Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97412.
PaxDbiP97412.
PRIDEiP97412.

PTM databases

PhosphoSiteiP97412.

Expressioni

Gene expression databases

CleanExiMM_LYST.
GenevestigatoriP97412.

Interactioni

Subunit structurei

Interacts with CENPJ, LIP8 and ZNF521.By similarity

Protein-protein interaction databases

IntActiP97412. 1 interaction.
MINTiMINT-4100871.

Structurei

3D structure databases

ProteinModelPortaliP97412.
SMRiP97412. Positions 3010-3409, 3522-3770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati662 – 70039WD 1Add
BLAST
Repeati1576 – 162045WD 2Add
BLAST
Domaini3126 – 3409284BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati3550 – 358940WD 3Add
BLAST
Repeati3601 – 364040WD 4Add
BLAST
Repeati3643 – 368644WD 5Add
BLAST
Repeati3687 – 373145WD 6Add
BLAST
Repeati3736 – 377540WD 7Add
BLAST

Sequence similaritiesi

Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000113425.
HOVERGENiHBG006300.
InParanoidiP97412.
PhylomeDBiP97412.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P97412-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTDSNSLAR EFLIDVNQLC NAVVQRAEAR EEEEEETHMA TLGQYLVHGR
60 70 80 90 100
GFLLLTKLNS IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL
110 120 130 140 150
SSDIILTKEK NSSLQKSTQG KLYLEGSAPS GQVSAKVNLF RKIRRQRKST
160 170 180 190 200
HRYSVRDARK TQLSTSDSEG NSDEKSTVVS KHRRLHALPR FLTQSPKEGH
210 220 230 240 250
LVAKPDPSAT KEQVLSDTMS VENSREVILR QDSNGDILSE PAALSILSNM
260 270 280 290 300
NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LALSVVPTLT EFLAGFGDCC
310 320 330 340 350
NQSDTLEGQL VSAGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR
360 370 380 390 400
KNLTELLRAA LKIRACLEKQ PEPFSPRQKK TLQEVQEGFV FSKYRHRALL
410 420 430 440 450
LPELLEGVLQ LLISCLQSAA SNPFYFSQAM DLVQEFIQHQ GFNLFGTAVL
460 470 480 490 500
QMEWLLTRDG VPSEAAEHLK ALINSVIKIM STVKKVKSEQ LHHSMCTRKR
510 520 530 540 550
HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD VQYPERCCCI
560 570 580 590 600
AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIAPLLHAFK
610 620 630 640 650
LPALKAFQQH ILNVLSKLLV DQLGGAELSP RIKKAACNIC TVDSDQLAKL
660 670 680 690 700
GETLQGTLCG AGPTSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV
710 720 730 740 750
FQEDRLHNIQ IANHICNLLQ KGNVVVQWKL YNYIFNPVLQ RGVELVHHCQ
760 770 780 790 800
QLSIPSAQTH MCSQLKQYLP QEVLQIYLKT LPVLLKSRVI RDLFLSCNGV
810 820 830 840 850
NHIIELNYLD GIRSHSLKAF ETLIVSLGEQ QKDAAVLDVD GLDIQQELPS
860 870 880 890 900
LSVGPSLHKQ QASSDSPCSL RKFYASLREP DPKKRKTIHQ DVHINTINLF
910 920 930 940 950
LCVAFLCVSK EADSDRESAN ESEDTSGYDS PPSEPLSHML PCLSLEDVVL
960 970 980 990 1000
PSPECLHHAA DIWSMCRWIY MLNSVFQKQF HRLGGFQVCH ELIFMIIQKL
1010 1020 1030 1040 1050
FRSHTEDQGR RQGEMSRNEN QELIRISYPE LTLKGDVSSA TAPDLGFLRK
1060 1070 1080 1090 1100
SADSVRGFQS QPVLPTSAEQ IVATESVPGE RKAFMSQQSE TSLQSIRLLE
1110 1120 1130 1140 1150
SLLDICLHSA RACQQKMELE LPSQGLSVEN ILCELREHLS QSKVAETELA
1160 1170 1180 1190 1200
KPLFDALLRV ALGNHSADLG PGDAVTEKSH PSEEELLSQP GDFSEEAEDS
1210 1220 1230 1240 1250
QCCSLKLLGE EEGYEADSES NPEDVDTQDD GVELNPEAEG FSGSIVSNNL
1260 1270 1280 1290 1300
LENLTHGEII YPEICMLGLN LLSASKAKLD VLAHVFESFL KIVRQKEKNI
1310 1320 1330 1340 1350
SLLIQQGTVK ILLGGFLNIL TQTNSDFQAC QRVLVDLLVS LMSSRTCSED
1360 1370 1380 1390 1400
LTLLWRIFLE KSPCTEILLL GIHKIVESDF TMSPSQCLTF PFLHTPSLSN
1410 1420 1430 1440 1450
GVLSQKPPGI LNSKALGLLR RARISRGKKE ADRESFPYRL LSSWHIAPIH
1460 1470 1480 1490 1500
LPLLGQNCWP HLSEGFSVSL VGLMWNTSNE SESAAERGKR VKKRNKPSVL
1510 1520 1530 1540 1550
EDSSFEGAEG DRPEVTESIN PGDRLIEDGC IHLISLGSKA LMIQVWADPH
1560 1570 1580 1590 1600
SGTFIFRVCM DSNDDTKAVS LAQVESQENI FFPSKWQHLV LTYIQHPQGK
1610 1620 1630 1640 1650
KNVHGEISIW VSGQRKTDVI LDFVLPRKTS LSSDSNKTFC MIGHCLTSQE
1660 1670 1680 1690 1700
ESLQLAGKWD LGNLLLFNGA KIGSQEAFFL YACGPNYTSI MPCKYGQPVI
1710 1720 1730 1740 1750
DYSKYINKDI LRCDEIRDLF MTKKEVDVGL LIESLSVVYT TCCPAQYTIY
1760 1770 1780 1790 1800
EPVIRLKGQV KTQPSQRPFS SKEAQSILLE PSQLKGLQPT ECKAIQGILH
1810 1820 1830 1840 1850
EIGGAGTFVF LFARVVELSS CEETQALALR VILSLIKYSQ QRTQELENCN
1860 1870 1880 1890 1900
GLSMIHQVLV KQKCIVGFHI LKTLLEGCCG EEVIHVSEHG EFKLDVESHA
1910 1920 1930 1940 1950
IIQDVKLLQE LLLDWKIWNK AEQGVWETLL AALEVLIRVE HHQQQFNIKQ
1960 1970 1980 1990 2000
LLNAHVVHHF LLTCQVLQEH REGQLTSMPR EVCRSFVKII AEVLGSPPDL
2010 2020 2030 2040 2050
ELLTVIFNFL LAVHPPTNTY VCHNPTNFYF SLHIDGKIFQ EKVQSLAYLR
2060 2070 2080 2090 2100
HSSSGGQAFP SPGFLVISPS AFTAAPPEGT SSSNIVPQRM AAQMVRSRSL
2110 2120 2130 2140 2150
PAFPTYLPLI RAQKLAASLG FSVDKLQNIA DANPEKQNLL GRPYALKTSK
2160 2170 2180 2190 2200
EEAFISSCES AKTVCEMEAL LGAHASANGV SRGSPRFPRA RVDHKDVGTE
2210 2220 2230 2240 2250
PRSDDDSPGD ESYPRRPDNL KGLASFQRSQ STVASLGLAF PSQNGSAVAS
2260 2270 2280 2290 2300
RWPSLVDRNA DDWENFTFSP AYEASYNRAT STHSVIEDCL IPICCGLYEL
2310 2320 2330 2340 2350
LSGVLLVLPD AMLEDVMDRI IQADILLVLV NHPSPAIQQG VIKLLHAYIN
2360 2370 2380 2390 2400
RASKEQKDKF LKNRGFSLLA NQLYLHRGTQ ELLECFVEMF FGRPIGLDEE
2410 2420 2430 2440 2450
FDLEEVKHME LFQKWSVIPV LGLIETSLYD NVLLHNALLL LLQVLNSCSK
2460 2470 2480 2490 2500
VADMLLDNGL LYVLCNTVAA LNGLEKNIPV NEYKLLACDI QQLFIAVTIH
2510 2520 2530 2540 2550
ACSSSGTQYF RVIEDLIVLL GYLHNSKNKR TQNMALALQL RVLQAALEFI
2560 2570 2580 2590 2600
RSTANHDSES PVHSPSAHRH SVPPKRRSIA GSRKFPLAQT ESLLMKMRSV
2610 2620 2630 2640 2650
ASDELHSMMQ RRMSQEHPSQ ASEAELAQRL QRLTILAVNR IIYQELNSDI
2660 2670 2680 2690 2700
IDILRTPENT SQSKTSVSQT EISEEDMHHE QPSVYNPFQK EMLTYLLDGF
2710 2720 2730 2740 2750
KVCIGSSKTS VSKQQWTKIL GSCKETLRDQ LGRLLAHILS PTHTVQERKQ
2760 2770 2780 2790 2800
ILEIVHEPAH QDILRDCLSP SPQHGAKLVL YLSELIHNHQ DELSEEEMDT
2810 2820 2830 2840 2850
AELLMNALKL CGHKCIPPSA PSKPELIKII REEQKKYESE ESVSKGSWQK
2860 2870 2880 2890 2900
TVNNNQQSLF QRLDFKSKDI SKIAADITQA VSLSQGIERK KVIQHIRGMY
2910 2920 2930 2940 2950
KVDLSASRHW QECIQQLTHD RAVWYDPIYY PTSWQLDPTE GPNRERRRLQ
2960 2970 2980 2990 3000
RCYLTIPNKY LLRDRQKSEG VLRPPLSYLF EDKTHSSFSS TVKDKAASES
3010 3020 3030 3040 3050
IRVNRRCISV APSRETAGEL LLGKCGMYFV EDNASDAVES SSLQGELEPA
3060 3070 3080 3090 3100
SFSWTYEEIK EVHRRWWQLR DNAVEIFLTN GRTLLLAFDN NKVRDDVYQS
3110 3120 3130 3140 3150
ILTNNLPNLL EYGNITALTN LWYSGQITNF EYLTHLNKHA GRSFNDLMQY
3160 3170 3180 3190 3200
PVFPFILSDY VSETLDLNDP SIYRNLSKPI AVQYKEKEDR YVDTYKYLEE
3210 3220 3230 3240 3250
EYRKGAREDD PMPPVQPYHY GSHYSNSGTV LHFLVRMPPF TKMFLAYQDQ
3260 3270 3280 3290 3300
SFDIPDRTFH STNTTWRLSS FESMTDVKEL IPEFFYLPEF LVNREGFDFG
3310 3320 3330 3340 3350
VRQNGERVNH VNLPPWARND PRLFILIHRQ ALESDHVSQN ICHWIDLVFG
3360 3370 3380 3390 3400
YKQKGKASVQ AINVFHPATY FGMDVSAVED PVQRRALETM IKTYGQTPRQ
3410 3420 3430 3440 3450
LFHTAHASRP GAKLNIEGEL PAAVGLLVQF AFRETREPVK EVTHPSPLSW
3460 3470 3480 3490 3500
IKGLKWGEYV GSPSAPVPVV CFSQPHGERF GSLQALPTRA ICGLSRNFCL
3510 3520 3530 3540 3550
LMTYNKEQGV RSMNNTNIQW SAILSWGYAD NILRLKSKQS EPPINFIQSS
3560 3570 3580 3590 3600
QQHQVTSCAW VPDSCQLFTG SKCGVITAYT NRLTSSTPSE IEMESQMHLY
3610 3620 3630 3640 3650
GHTEEITGLC VCKPYSVMIS VSRDGTCIVW DLNRLCYVQS LAGHKSPVTA
3660 3670 3680 3690 3700
VSASETSGDI ATVCDSAGGG SDLRLWTVNG DLVGHVHCRE IICSVAFSNQ
3710 3720 3730 3740 3750
PEGVSINVIA GGLENGIVRL WSTWDLKPVR EITFPKSNKP IISLTFSCDG
3760 3770 3780
HHLYTANSEG TVIAWCRKDQ QRVKLPMFYS FLSSYAAG
Length:3,788
Mass (Da):425,287
Last modified:May 1, 1997 - v1
Checksum:iF01BE837C676A750
GO
Isoform 2 (identifier: P97412-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1509-1545: EGDRPEVTESINPGDRLIEDGCIHLISLGSKALMIQV → GMMAGSDLYTKILQIAACLSFKHIWQYFNVFFKCYSP
     1546-3788: Missing.

Show »
Length:1,545
Mass (Da):172,458
Checksum:iA346094C0E5C419A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1509 – 154537EGDRP…LMIQV → GMMAGSDLYTKILQIAACLS FKHIWQYFNVFFKCYSP in isoform 2. 1 PublicationVSP_006783Add
BLAST
Alternative sequencei1546 – 37882243Missing in isoform 2. 1 PublicationVSP_006784Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70015 mRNA. Translation: AAC53011.1.
L77884 mRNA. Translation: AAL40134.1.
U52461 mRNA. Translation: AAB60778.1.
PIRiT30851.
RefSeqiNP_034878.2. NM_010748.2.
UniGeneiMm.342337.

Genome annotation databases

GeneIDi17101.
KEGGimmu:17101.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70015 mRNA. Translation: AAC53011.1 .
L77884 mRNA. Translation: AAL40134.1 .
U52461 mRNA. Translation: AAB60778.1 .
PIRi T30851.
RefSeqi NP_034878.2. NM_010748.2.
UniGenei Mm.342337.

3D structure databases

ProteinModelPortali P97412.
SMRi P97412. Positions 3010-3409, 3522-3770.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97412. 1 interaction.
MINTi MINT-4100871.

PTM databases

PhosphoSitei P97412.

Proteomic databases

MaxQBi P97412.
PaxDbi P97412.
PRIDEi P97412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17101.
KEGGi mmu:17101.

Organism-specific databases

CTDi 1130.
MGIi MGI:107448. Lyst.

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000113425.
HOVERGENi HBG006300.
InParanoidi P97412.
PhylomeDBi P97412.

Miscellaneous databases

ChiTaRSi LYST. mouse.
NextBioi 291244.
PROi P97412.
SOURCEi Search...

Gene expression databases

CleanExi MM_LYST.
Genevestigatori P97412.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1428-3788 (ISOFORM 1).
    Strain: C57BL/6J.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiLYST_MOUSE
AccessioniPrimary (citable) accession number: P97412
Secondary accession number(s): Q62403, Q8VBS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3