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Protein

Islet cell autoantigen 1

Gene

Ica1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neurotransmitter secretion.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Islet cell autoantigen 1
Alternative name(s):
69 kDa islet cell autoantigen
Short name:
ICA69
Islet cell autoantigen p69
Short name:
ICAp69
Short name:
p69
Gene namesi
Name:Ica1Imported
Synonyms:Icap69
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96391. Ica1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: UniProtKB
  • secretory granule membrane Source: UniProtKB
  • synaptic vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

129/SvJ mice lacking Ica1 do not display an obvious phenotype and age normally, while NOD mice without Ica1 develop diabetes and display sudden mid-life lethality but are resistant to cyclophosphamide-induced disease acceleration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841311 – 478Islet cell autoantigen 1Add BLAST478

Proteomic databases

MaxQBiP97411.
PaxDbiP97411.
PRIDEiP97411.

PTM databases

PhosphoSitePlusiP97411.

Expressioni

Tissue specificityi

Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000062995.
CleanExiMM_ICA1.
ExpressionAtlasiP97411. baseline and differential.
GenevisibleiP97411. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-60170N.
STRINGi10090.ENSMUSP00000040062.

Structurei

3D structure databases

ProteinModelPortaliP97411.
SMRiP97411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 253AHPROSITE-ProRule annotationAdd BLAST204

Sequence similaritiesi

Contains 1 AH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3891. Eukaryota.
ENOG410YJKW. LUCA.
GeneTreeiENSGT00390000005530.
HOGENOMiHOG000006612.
HOVERGENiHBG061005.
InParanoidiP97411.
KOiK19863.
OMAiVQEPSQL.
OrthoDBiEOG091G0BDC.
TreeFamiTF317186.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030796. ICA1.
IPR024114. Islet_autoAg_Ica1/Ica1-like.
IPR006723. Islet_autoAg_Ica1_C.
[Graphical view]
PANTHERiPTHR10164. PTHR10164. 1 hit.
PTHR10164:SF3. PTHR10164:SF3. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
PF04629. ICA69. 2 hits.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
SM01237. ICA69. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 11 Publication (identifier: P97411-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGHKCYSWE LQDRFAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA
60 70 80 90 100
SDADLDAKLE LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ
110 120 130 140 150
GFQDKTRAGK MMQATGKALC FSSQQRLALR NPLCRFHQEV ETFRHRAISD
160 170 180 190 200
TWLTVNRMEQ YRTEYRGALL WMKDVSQELD PDLYKQMEKF RKVQTQVRLA
210 220 230 240 250
KKNFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF WEKTSHTMAA
260 270 280 290 300
IHESFKGYQP YEFTTLKSLQ DPMKKLVEKE GKKTSWRENR EAVAPEPRQL
310 320 330 340 350
ISLEDEHKDS SAYKTEEGTS VLSSVDKGSV HDTCSGPIDE LLDGKPEEAC
360 370 380 390 400
LGPTAGTPEP ESGDKDDLLL LNEIFSTSCL DEGEFSREWA AVFGDDQLKE
410 420 430 440 450
PAPMGAQGEP DPKPQIGSGF LPSQLLDQNM KDLQASLQEP AKAASDLTAW
460 470
FSLFADLDPL SNPDAVGKTD KEHELLNA
Length:478
Mass (Da):54,324
Last modified:July 27, 2011 - v3
Checksum:iB7B1EE18AC39E2F9
GO
Isoform 21 Publication (identifier: P97411-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: T → R
     316-336: Missing.

Show »
Length:457
Mass (Da):52,303
Checksum:i06645C68B867D942
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170L → F in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAC52992 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAC52993 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAB40939 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAH02030 (PubMed:15489334).Curated1
Sequence conflicti312A → T in AAC99989 (Ref. 5) Curated1
Sequence conflicti397Q → R in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAC52992 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAC52993 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAB40939 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAH02030 (PubMed:15489334).Curated1
Sequence conflicti397Q → R in AAC99989 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050425315T → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_050426316 – 336Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26459 mRNA. Translation: AAC52992.1.
U26460 mRNA. Translation: AAB40939.1.
U26461 mRNA. Translation: AAC52993.1.
U37186
, U37013, U37014, U37015, U37082, U37083, U37084, U37085, U37086, U37184, U37185 Genomic DNA. Translation: AAB19182.1.
AC158670 Genomic DNA. No translation available.
BC002030 mRNA. Translation: AAH02030.1.
U34595 mRNA. Translation: AAC99989.1.
CCDSiCCDS19911.1. [P97411-1]
RefSeqiNP_001239195.1. NM_001252266.1. [P97411-2]
NP_034622.3. NM_010492.3. [P97411-1]
XP_006505056.1. XM_006504993.3. [P97411-1]
XP_006505057.1. XM_006504994.3. [P97411-1]
XP_006505058.1. XM_006504995.3. [P97411-2]
UniGeneiMm.275683.

Genome annotation databases

EnsembliENSMUST00000038403; ENSMUSP00000040062; ENSMUSG00000062995. [P97411-1]
ENSMUST00000115520; ENSMUSP00000111182; ENSMUSG00000062995. [P97411-1]
GeneIDi15893.
KEGGimmu:15893.
UCSCiuc009axx.1. mouse. [P97411-2]
uc009axy.1. mouse. [P97411-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26459 mRNA. Translation: AAC52992.1.
U26460 mRNA. Translation: AAB40939.1.
U26461 mRNA. Translation: AAC52993.1.
U37186
, U37013, U37014, U37015, U37082, U37083, U37084, U37085, U37086, U37184, U37185 Genomic DNA. Translation: AAB19182.1.
AC158670 Genomic DNA. No translation available.
BC002030 mRNA. Translation: AAH02030.1.
U34595 mRNA. Translation: AAC99989.1.
CCDSiCCDS19911.1. [P97411-1]
RefSeqiNP_001239195.1. NM_001252266.1. [P97411-2]
NP_034622.3. NM_010492.3. [P97411-1]
XP_006505056.1. XM_006504993.3. [P97411-1]
XP_006505057.1. XM_006504994.3. [P97411-1]
XP_006505058.1. XM_006504995.3. [P97411-2]
UniGeneiMm.275683.

3D structure databases

ProteinModelPortaliP97411.
SMRiP97411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60170N.
STRINGi10090.ENSMUSP00000040062.

PTM databases

PhosphoSitePlusiP97411.

Proteomic databases

MaxQBiP97411.
PaxDbiP97411.
PRIDEiP97411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038403; ENSMUSP00000040062; ENSMUSG00000062995. [P97411-1]
ENSMUST00000115520; ENSMUSP00000111182; ENSMUSG00000062995. [P97411-1]
GeneIDi15893.
KEGGimmu:15893.
UCSCiuc009axx.1. mouse. [P97411-2]
uc009axy.1. mouse. [P97411-1]

Organism-specific databases

CTDi3382.
MGIiMGI:96391. Ica1.

Phylogenomic databases

eggNOGiKOG3891. Eukaryota.
ENOG410YJKW. LUCA.
GeneTreeiENSGT00390000005530.
HOGENOMiHOG000006612.
HOVERGENiHBG061005.
InParanoidiP97411.
KOiK19863.
OMAiVQEPSQL.
OrthoDBiEOG091G0BDC.
TreeFamiTF317186.

Miscellaneous databases

ChiTaRSiIca1. mouse.
PROiP97411.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062995.
CleanExiMM_ICA1.
ExpressionAtlasiP97411. baseline and differential.
GenevisibleiP97411. MM.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030796. ICA1.
IPR024114. Islet_autoAg_Ica1/Ica1-like.
IPR006723. Islet_autoAg_Ica1_C.
[Graphical view]
PANTHERiPTHR10164. PTHR10164. 1 hit.
PTHR10164:SF3. PTHR10164:SF3. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
PF04629. ICA69. 2 hits.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
SM01237. ICA69. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICA69_MOUSE
AccessioniPrimary (citable) accession number: P97411
Secondary accession number(s): E9QLS3
, P97362, P97954, Q99M40, Q9R2C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.