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P97400 (LEG10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-10

Short name=Gal-10
Alternative name(s):
Charcot-Leyden crystal protein homolog
Short name=CLC
Gene names
Name:Clc
Synonyms:Clcp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length68 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) By similarity.

Subunit structure

Interacts with CEL By similarity.

Subcellular location

Cytoplasmcytosol By similarity. Cytoplasmic granule By similarity. Note: Localized in granules from where it may be secreted or transported to other locations in the cell By similarity.

Sequence similarities

Contains 1 galectin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›68›68Galectin-10
PRO_0000076961

Regions

Domain‹1 – ›68›68Galectin

Experimental info

Non-terminal residue11
Non-terminal residue681

Sequences

Sequence LengthMass (Da)Tools
P97400 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 3B4257F4734F7019

FASTA688,037
        10         20         30         40         50         60 
EPYLQVDFHT EMKEDSDIAF HSRVYFGHWV VMNSRVNGAW QYEVTCHNMP FQDGKPFNLS 


ISVPPDKY 

« Hide

References

[1]"The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes."
Dyer K.D., Handen J.S., Rosenberg H.F.
Genomics 40:217-221(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67985 Genomic DNA. Translation: AAB41694.1.

3D structure databases

ProteinModelPortalP97400.
SMRP97400. Positions 1-68.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP97400.

Proteomic databases

PRIDEP97400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:891997. Clc.

Gene expression databases

GenevestigatorP97400.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP97400.
SOURCESearch...

Entry information

Entry nameLEG10_MOUSE
AccessionPrimary (citable) accession number: P97400
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: January 22, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot