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P97400

- LEG10_MOUSE

UniProt

P97400 - LEG10_MOUSE

Protein

Galectin-10

Gene

Clc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) By similarity.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

    GO - Biological processi

    1. regulation of activated T cell proliferation Source: UniProtKB
    2. regulation of T cell anergy Source: UniProtKB
    3. regulation of T cell cytokine production Source: UniProtKB
    4. T cell apoptotic process Source: UniProtKB

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-10
    Short name:
    Gal-10
    Alternative name(s):
    Charcot-Leyden crystal protein homolog
    Short name:
    CLC
    Gene namesi
    Name:Clc
    Synonyms:Clcp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:891997. Clc.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Cytoplasmic granule By similarity
    Note: Localized in granules from where it may be secreted or transported to other locations in the cell.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›68›68Galectin-10PRO_0000076961Add
    BLAST

    Proteomic databases

    PRIDEiP97400.

    PTM databases

    PhosphoSiteiP97400.

    Expressioni

    Gene expression databases

    GenevestigatoriP97400.

    Interactioni

    Subunit structurei

    Interacts with CEL.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP97400.
    SMRiP97400. Positions 1-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – ›68›68GalectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 galectin domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51304. GALECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P97400-1 [UniParc]FASTAAdd to Basket

    « Hide

    EPYLQVDFHT EMKEDSDIAF HSRVYFGHWV VMNSRVNGAW QYEVTCHNMP   50
    FQDGKPFNLS ISVPPDKY 68
    Length:68
    Mass (Da):8,037
    Last modified:May 1, 1997 - v1
    Checksum:i3B4257F4734F7019
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei68 – 681

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67985 Genomic DNA. Translation: AAB41694.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67985 Genomic DNA. Translation: AAB41694.1 .

    3D structure databases

    ProteinModelPortali P97400.
    SMRi P97400. Positions 1-68.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P97400.

    Proteomic databases

    PRIDEi P97400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:891997. Clc.

    Miscellaneous databases

    PROi P97400.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P97400.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51304. GALECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes."
      Dyer K.D., Handen J.S., Rosenberg H.F.
      Genomics 40:217-221(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLEG10_MOUSE
    AccessioniPrimary (citable) accession number: P97400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3