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P97400

- LEG10_MOUSE

UniProt

P97400 - LEG10_MOUSE

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Protein

Galectin-10

Gene

Clc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  1. regulation of activated T cell proliferation Source: UniProtKB
  2. regulation of T cell anergy Source: UniProtKB
  3. regulation of T cell cytokine production Source: UniProtKB
  4. T cell apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-10
Short name:
Gal-10
Alternative name(s):
Charcot-Leyden crystal protein homolog
Short name:
CLC
Gene namesi
Name:Clc
Synonyms:Clcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:891997. Clc.

Subcellular locationi

Cytoplasmcytosol By similarity. Cytoplasmic granule By similarity
Note: Localized in granules from where it may be secreted or transported to other locations in the cell.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›68›68Galectin-10PRO_0000076961Add
BLAST

Proteomic databases

PRIDEiP97400.

PTM databases

PhosphoSiteiP97400.

Expressioni

Gene expression databases

GenevestigatoriP97400.

Interactioni

Subunit structurei

Interacts with CEL.By similarity

Structurei

3D structure databases

ProteinModelPortaliP97400.
SMRiP97400. Positions 1-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›68›68GalectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP97400.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P97400-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EPYLQVDFHT EMKEDSDIAF HSRVYFGHWV VMNSRVNGAW QYEVTCHNMP
60
FQDGKPFNLS ISVPPDKY
Length:68
Mass (Da):8,037
Last modified:May 1, 1997 - v1
Checksum:i3B4257F4734F7019
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei68 – 681

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67985 Genomic DNA. Translation: AAB41694.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67985 Genomic DNA. Translation: AAB41694.1 .

3D structure databases

ProteinModelPortali P97400.
SMRi P97400. Positions 1-68.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P97400.

Proteomic databases

PRIDEi P97400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:891997. Clc.

Phylogenomic databases

InParanoidi P97400.

Miscellaneous databases

PROi P97400.
SOURCEi Search...

Gene expression databases

Genevestigatori P97400.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view ]
Pfami PF00337. Gal-bind_lectin. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51304. GALECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes."
    Dyer K.D., Handen J.S., Rosenberg H.F.
    Genomics 40:217-221(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLEG10_MOUSE
AccessioniPrimary (citable) accession number: P97400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3