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Protein

Calcium-dependent phospholipase A2

Gene

Pla2g5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Calcium; via carbonyl oxygenBy similarity
Metal bindingi49 – 491Calcium; via carbonyl oxygenBy similarity
Metal bindingi51 – 511Calcium; via carbonyl oxygenBy similarity
Active sitei67 – 671By similarity
Metal bindingi68 – 681CalciumBy similarity
Active sitei111 – 1111By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • phospholipase A2 activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent phospholipase A2 (EC:3.1.1.4)
Alternative name(s):
Group V phospholipase A2
PLA2-10
Phosphatidylcholine 2-acylhydrolase 5
Gene namesi
Name:Pla2g5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:101899. Pla2g5.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 137117Calcium-dependent phospholipase A2PRO_0000022762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 137By similarity
Disulfide bondi48 ↔ 64By similarity
Disulfide bondi63 ↔ 117By similarity
Disulfide bondi70 ↔ 110By similarity
Disulfide bondi79 ↔ 103By similarity
Disulfide bondi97 ↔ 108By similarity

Post-translational modificationi

This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP97391.
PRIDEiP97391.

Expressioni

Gene expression databases

CleanExiMM_PLA2G5.

Interactioni

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030524.

Chemistry

BindingDBiP97391.

Structurei

3D structure databases

ProteinModelPortaliP97391.
SMRiP97391. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiP97391.
KOiK01047.
PhylomeDBiP97391.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLLTLAWF LACSVPAVPG GLLELKSMIE KVTGKNAFKN YGFYGCYCGW
60 70 80 90 100
GGRGTPKDGT DWCCQMHDRC YGQLEEKDCA IRTQSYDYRY TNGLVICEHD
110 120 130
SFCPMRLCAC DRKLVYCLRR NLWTYNPLYQ YYPNFLC
Length:137
Mass (Da):15,859
Last modified:December 5, 2001 - v2
Checksum:iF08920E1FD1D912A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341G → R in AAC53038 (PubMed:8838795).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66873 mRNA. Translation: AAC53038.1.
AF162713 mRNA. Translation: AAD45807.1.
CCDSiCCDS18834.1.
RefSeqiNP_001116426.1. NM_001122954.1.
NP_035240.3. NM_011110.4.
XP_006538721.2. XM_006538658.2.
XP_011248510.1. XM_011250208.1.
UniGeneiMm.486532.

Genome annotation databases

GeneIDi18784.
KEGGimmu:18784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66873 mRNA. Translation: AAC53038.1.
AF162713 mRNA. Translation: AAD45807.1.
CCDSiCCDS18834.1.
RefSeqiNP_001116426.1. NM_001122954.1.
NP_035240.3. NM_011110.4.
XP_006538721.2. XM_006538658.2.
XP_011248510.1. XM_011250208.1.
UniGeneiMm.486532.

3D structure databases

ProteinModelPortaliP97391.
SMRiP97391. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030524.

Chemistry

BindingDBiP97391.
ChEMBLiCHEMBL4167.

Proteomic databases

PaxDbiP97391.
PRIDEiP97391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18784.
KEGGimmu:18784.

Organism-specific databases

CTDi5322.
MGIiMGI:101899. Pla2g5.

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiP97391.
KOiK01047.
PhylomeDBiP97391.

Miscellaneous databases

ChiTaRSiPla2g5. mouse.
PROiP97391.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PLA2G5.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR033112. PLipase_A2_Asp_AS.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PANTHERiPTHR11716. PTHR11716. 1 hit.
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00119. PA2_ASP. 1 hit.
PS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA2G5_MOUSE
AccessioniPrimary (citable) accession number: P97391
Secondary accession number(s): Q9QZU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 5, 2001
Last modified: June 8, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.