Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97391

- PA2G5_MOUSE

UniProt

P97391 - PA2G5_MOUSE

Protein

Calcium-dependent phospholipase A2

Gene

Pla2g5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol By similarity.By similarity

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Calcium; via carbonyl oxygenBy similarity
    Metal bindingi49 – 491Calcium; via carbonyl oxygenBy similarity
    Metal bindingi51 – 511Calcium; via carbonyl oxygenBy similarity
    Active sitei67 – 671By similarity
    Metal bindingi68 – 681CalciumBy similarity
    Active sitei111 – 1111By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phospholipase A2 activity Source: UniProtKB
    3. receptor binding Source: UniProtKB

    GO - Biological processi

    1. arachidonic acid secretion Source: UniProtKB
    2. lipid catabolic process Source: UniProtKB-KW
    3. phospholipid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-dependent phospholipase A2 (EC:3.1.1.4)
    Alternative name(s):
    Group V phospholipase A2
    PLA2-10
    Phosphatidylcholine 2-acylhydrolase 5
    Gene namesi
    Name:Pla2g5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:101899. Pla2g5.

    Subcellular locationi

    Secreted 1 Publication. Membrane 1 Publication
    Note: Also associated with various membranous organelles including the Golgi apparatus, nuclear envelope, and plasma membrane.

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. extracellular region Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 137117Calcium-dependent phospholipase A2PRO_0000022762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 137By similarity
    Disulfide bondi48 ↔ 64By similarity
    Disulfide bondi63 ↔ 117By similarity
    Disulfide bondi70 ↔ 110By similarity
    Disulfide bondi79 ↔ 103By similarity
    Disulfide bondi97 ↔ 108By similarity

    Post-translational modificationi

    This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP97391.

    Expressioni

    Gene expression databases

    CleanExiMM_PLA2G5.
    GenevestigatoriP97391.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP97391.
    SMRiP97391. Positions 22-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phospholipase A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG330703.
    HOGENOMiHOG000231749.
    HOVERGENiHBG008137.
    KOiK01047.
    PhylomeDBiP97391.

    Family and domain databases

    Gene3Di1.20.90.10. 1 hit.
    InterProiIPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view]
    PANTHERiPTHR11716. PTHR11716. 1 hit.
    PfamiPF00068. Phospholip_A2_1. 1 hit.
    [Graphical view]
    PRINTSiPR00389. PHPHLIPASEA2.
    SMARTiSM00085. PA2c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48619. SSF48619. 1 hit.
    PROSITEiPS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGLLTLAWF LACSVPAVPG GLLELKSMIE KVTGKNAFKN YGFYGCYCGW    50
    GGRGTPKDGT DWCCQMHDRC YGQLEEKDCA IRTQSYDYRY TNGLVICEHD 100
    SFCPMRLCAC DRKLVYCLRR NLWTYNPLYQ YYPNFLC 137
    Length:137
    Mass (Da):15,859
    Last modified:December 5, 2001 - v2
    Checksum:iF08920E1FD1D912A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341G → R in AAC53038. (PubMed:8838795)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66873 mRNA. Translation: AAC53038.1.
    AF162713 mRNA. Translation: AAD45807.1.
    CCDSiCCDS18834.1.
    RefSeqiNP_001116426.1. NM_001122954.1.
    NP_035240.3. NM_011110.4.
    XP_006538722.1. XM_006538659.1.
    XP_006538723.1. XM_006538660.1.
    XP_006538724.1. XM_006538661.1.
    UniGeneiMm.486532.

    Genome annotation databases

    GeneIDi18784.
    KEGGimmu:18784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66873 mRNA. Translation: AAC53038.1 .
    AF162713 mRNA. Translation: AAD45807.1 .
    CCDSi CCDS18834.1.
    RefSeqi NP_001116426.1. NM_001122954.1.
    NP_035240.3. NM_011110.4.
    XP_006538722.1. XM_006538659.1.
    XP_006538723.1. XM_006538660.1.
    XP_006538724.1. XM_006538661.1.
    UniGenei Mm.486532.

    3D structure databases

    ProteinModelPortali P97391.
    SMRi P97391. Positions 22-126.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P97391.
    ChEMBLi CHEMBL4167.

    Proteomic databases

    PRIDEi P97391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18784.
    KEGGi mmu:18784.

    Organism-specific databases

    CTDi 5322.
    MGIi MGI:101899. Pla2g5.

    Phylogenomic databases

    eggNOGi NOG330703.
    HOGENOMi HOG000231749.
    HOVERGENi HBG008137.
    KOi K01047.
    PhylomeDBi P97391.

    Miscellaneous databases

    ChiTaRSi PLA2G5. mouse.
    NextBioi 295048.
    PROi P97391.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PLA2G5.
    Genevestigatori P97391.

    Family and domain databases

    Gene3Di 1.20.90.10. 1 hit.
    InterProi IPR001211. PLipase_A2.
    IPR013090. PLipase_A2_AS.
    IPR016090. PLipase_A2_dom.
    [Graphical view ]
    PANTHERi PTHR11716. PTHR11716. 1 hit.
    Pfami PF00068. Phospholip_A2_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00389. PHPHLIPASEA2.
    SMARTi SM00085. PA2c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48619. SSF48619. 1 hit.
    PROSITEi PS00119. PA2_ASP. 1 hit.
    PS00118. PA2_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human."
      Tischfield J.A., Xia Y.R., Shih D.M., Klisak I., Chen J., Engle S.J., Siakotos A.N., Winstead M.V., Seilhamer J.J., Allamand V., Gyapay G., Lusis A.
      Genomics 32:328-333(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129.
    2. "Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells."
      Bingham C.O. III, Fijneman R.J.A., Friend D.S., Goddeau R.P., Rogers R.A., Austen K.F., Arm J.P.
      J. Biol. Chem. 274:31476-31484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Strain: BALB/c.

    Entry informationi

    Entry nameiPA2G5_MOUSE
    AccessioniPrimary (citable) accession number: P97391
    Secondary accession number(s): Q9QZU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 5, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3