Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar protein sorting-associated protein 45

Gene

Vps45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 45
Short name:
mVps45
Gene namesi
Name:Vps45
Synonyms:Vps45a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:891965. Vps45.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: MGI
  • Golgi membrane Source: MGI
  • integral component of membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Vacuolar protein sorting-associated protein 45PRO_0000206313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei307 – 3071PhosphoserineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97390.
MaxQBiP97390.
PaxDbiP97390.
PeptideAtlasiP97390.
PRIDEiP97390.

PTM databases

iPTMnetiP97390.
PhosphoSiteiP97390.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015747.
CleanExiMM_VPS45.
GenevisibleiP97390. MM.

Interactioni

Subunit structurei

Interacts with ZFYVE20 (By similarity). Interacts with STX6.By similarity1 Publication

Protein-protein interaction databases

BioGridi204535. 3 interactions.
IntActiP97390. 4 interactions.
MINTiMINT-1870278.
STRINGi10090.ENSMUSP00000015891.

Structurei

3D structure databases

ProteinModelPortaliP97390.
SMRiP97390. Positions 23-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1299. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00550000075028.
HOGENOMiHOG000200803.
HOVERGENiHBG059810.
InParanoidiP97390.
KOiK12479.
OMAiQFKHTKS.
OrthoDBiEOG091G05OR.
PhylomeDBiP97390.
TreeFamiTF300407.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

P97390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY
60 70 80 90 100
LFERIDSQNR EIMKHLKAIC FLRPTKENVE YLIQELRRPK YSIYFIYFSN
110 120 130 140 150
VISKSDVKSL AEADEQEVVA EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW
160 170 180 190 200
DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS SEAAKRLGEC VKQVISKEYE
210 220 230 240 250
LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL GINNNRIDLS
260 270 280 290 300
RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKRPK
310 320 330 340 350
EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV
360 370 380 390 400
SEVEQELACQ NDHSSALQNV KRLLQNPKVT EFDAVRLVML YALHYERHSS
410 420 430 440 450
NSLPGLIVDL RSKGVAEKYR KLVSAVVEYG GKRVRGSDLF SPKDAVAITK
460 470 480 490 500
QFLKGLKGVE NVYTQHQPFL HETLDHLIKG RLKENLYPYL GPSTLRDRPQ
510 520 530 540 550
DIIVFIIGGA TYEEALTVYN LNRTTPGVRI VLGGTTIHNT KSFLEEVLAS
560 570
GLHSRSRESS QATSRSANRR
Length:570
Mass (Da):65,053
Last modified:May 1, 1997 - v1
Checksum:iDA704FDE8469F488
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551I → M in AAH12691 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66865 mRNA. Translation: AAB37577.1.
BC012691 mRNA. Translation: AAH12691.1.
BC058528 mRNA. Translation: AAH58528.1.
CCDSiCCDS17628.1.
RefSeqiNP_038869.1. NM_013841.3.
UniGeneiMm.263185.

Genome annotation databases

EnsembliENSMUST00000015891; ENSMUSP00000015891; ENSMUSG00000015747.
GeneIDi22365.
KEGGimmu:22365.
UCSCiuc008qly.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66865 mRNA. Translation: AAB37577.1.
BC012691 mRNA. Translation: AAH12691.1.
BC058528 mRNA. Translation: AAH58528.1.
CCDSiCCDS17628.1.
RefSeqiNP_038869.1. NM_013841.3.
UniGeneiMm.263185.

3D structure databases

ProteinModelPortaliP97390.
SMRiP97390. Positions 23-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204535. 3 interactions.
IntActiP97390. 4 interactions.
MINTiMINT-1870278.
STRINGi10090.ENSMUSP00000015891.

PTM databases

iPTMnetiP97390.
PhosphoSiteiP97390.

Proteomic databases

EPDiP97390.
MaxQBiP97390.
PaxDbiP97390.
PeptideAtlasiP97390.
PRIDEiP97390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015891; ENSMUSP00000015891; ENSMUSG00000015747.
GeneIDi22365.
KEGGimmu:22365.
UCSCiuc008qly.2. mouse.

Organism-specific databases

CTDi11311.
MGIiMGI:891965. Vps45.

Phylogenomic databases

eggNOGiKOG1299. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00550000075028.
HOGENOMiHOG000200803.
HOVERGENiHBG059810.
InParanoidiP97390.
KOiK12479.
OMAiQFKHTKS.
OrthoDBiEOG091G05OR.
PhylomeDBiP97390.
TreeFamiTF300407.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiP97390.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015747.
CleanExiMM_VPS45.
GenevisibleiP97390. MM.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
PIRSFiPIRSF005715. VPS45_Sec1. 1 hit.
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVPS45_MOUSE
AccessioniPrimary (citable) accession number: P97390
Secondary accession number(s): Q91VK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.