P97390 (VPS45_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 45
Short name=mVps45

Gene names

Name:	Vps45
Synonyms:	Vps45a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
Subunit structure	Interacts with ZFYVE20 By similarity. Interacts with STX6. Ref.1
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note: Associated with Golgi/endosomal vesicles and the trans-Golgi network.
Sequence similarities	Belongs to the STXBP/unc-18/SEC1 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endosome Golgi apparatus Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle docking involved in exocytosis Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from direct assay Ref.1. Source: MGI endosome membrane Inferred from direct assay Ref.1. Source: MGI
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Vacuolar protein sorting-associated protein 45		PRO_0000206313
Experimental info
	Sequence conflict	55	1	I → M in AAH12691. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P97390 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: DA704FDE8469F488	FASTA	570	65,053
	10 20 30 40 50 60 MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY LFERIDSQNR 70 80 90 100 110 120 EIMKHLKAIC FLRPTKENVE YLIQELRRPK YSIYFIYFSN VISKSDVKSL AEADEQEVVA 130 140 150 160 170 180 EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS 190 200 210 220 230 240 SEAAKRLGEC VKQVISKEYE LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL 250 260 270 280 290 300 GINNNRIDLS RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKRPK 310 320 330 340 350 360 EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV SEVEQELACQ 370 380 390 400 410 420 NDHSSALQNV KRLLQNPKVT EFDAVRLVML YALHYERHSS NSLPGLIVDL RSKGVAEKYR 430 440 450 460 470 480 KLVSAVVEYG GKRVRGSDLF SPKDAVAITK QFLKGLKGVE NVYTQHQPFL HETLDHLIKG 490 500 510 520 530 540 RLKENLYPYL GPSTLRDRPQ DIIVFIIGGA TYEEALTVYN LNRTTPGVRI VLGGTTIHNT 550 560 570 KSFLEEVLAS GLHSRSRESS QATSRSANRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a mammalian Golgi Sec1p-like protein, mVps45." Tellam J.T., James D.E., Stevens T.H., Piper R.C. J. Biol. Chem. 272:6187-6193(1997) [PubMed: 9045632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH STX6. Strain: Swiss albino. Tissue: Adipocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66865 mRNA. Translation: AAB37577.1. BC012691 mRNA. Translation: AAH12691.1. BC058528 mRNA. Translation: AAH58528.1.
IPI	IPI00124291.
RefSeq	NP_038869.1. NM_013841.3.
UniGene	Mm.263185.
3D structure databases
ProteinModelPortal	P97390.
SMR	P97390. Positions 2-129.
ModBase	Search...
Protein-protein interaction databases
IntAct	P97390. 2 interactions.
STRING	P97390.
PTM databases
PhosphoSite	P97390.
Proteomic databases
PRIDE	P97390.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000015891; ENSMUSP00000015891; ENSMUSG00000015747.
GeneID	22365.
KEGG	mmu:22365.
UCSC	uc008qly.2. mouse.
Organism-specific databases
CTD	11311.
MGI	MGI:891965. Vps45.
Phylogenomic databases
eggNOG	roNOG05944.
HOGENOM	HBG559243.
HOVERGEN	HBG059810.
InParanoid	P97390.
OMA	GTTIHNT.
OrthoDB	EOG4H463H.
PhylomeDB	P97390.
Gene expression databases
ArrayExpress	P97390.
Bgee	P97390.
CleanEx	MM_VPS45.
Genevestigator	P97390.
GermOnline	ENSMUSG00000015747. Mus musculus.
Family and domain databases
InterPro	IPR001619. Sec1-like. [Graphical view]
KO	K12479.
PANTHER	PTHR11679. Sec1-like. 1 hit.
Pfam	PF00995. Sec1. 1 hit. [Graphical view]
SUPFAM	SSF56815. Sec1-like. 1 hit.
ProtoNet	Search...
Other
NextBio	302685.
SOURCE	Search...

Entry information

Entry name

VPS45_MOUSE

Accession

Primary (citable) accession number: P97390
Secondary accession number(s): Q91VK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	May 1, 1997
Last modified:	November 16, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program