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Protein

Annexin A11

Gene

Anxa11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner.By similarity

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: MGI
  • calcium-dependent protein binding Source: MGI
  • calcium ion binding Source: MGI
  • MHC class II protein complex binding Source: MGI
  • phosphatidylethanolamine binding Source: MGI
  • RNA binding Source: MGI
  • S100 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division
LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
Gene namesi
Name:Anxa11
Synonyms:Anx11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:108481. Anxa11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675111 – 503Annexin A11Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246N6-acetyllysineBy similarity1
Modified residuei253N6-acetyllysineBy similarity1
Modified residuei477N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP97384.
MaxQBiP97384.
PaxDbiP97384.
PeptideAtlasiP97384.
PRIDEiP97384.

2D gel databases

SWISS-2DPAGEiP97384.

PTM databases

iPTMnetiP97384.
PhosphoSitePlusiP97384.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021866.
CleanExiMM_ANXA11.
ExpressionAtlasiP97384. baseline and differential.
GenevisibleiP97384. MM.

Interactioni

Subunit structurei

Interacts with S100A6. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97384. 1 interactor.
MINTiMINT-4087847.
STRINGi10090.ENSMUSP00000022416.

Structurei

3D structure databases

ProteinModelPortaliP97384.
SMRiP97384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 267Annexin 1Add BLAST61
Repeati279 – 339Annexin 2Add BLAST61
Repeati363 – 423Annexin 3Add BLAST61
Repeati438 – 498Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP97384.
KOiK17095.
OMAiFDAYEIK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR008157. ANX11.
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 4 hits.

Sequencei

Sequence statusi: Complete.

P97384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPPA GGYPPAAPGG GPWGGAGYPP PSMPPIGLDN VANYAGQFNQ
60 70 80 90 100
DYLSGMAANM SGTFGGANVP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP
110 120 130 140 150
PYGMYPPPGG NPPPGMPSYP AYPGAPVPGQ PMPPTGQQPP GAYPGQPPMT
160 170 180 190 200
YPGQSPMPPP GQQPVPSYPG YSGSSTITPA VPPAQFGNRG TITAASGFDP
210 220 230 240 250
LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK
260 270 280 290 300
DLKSELSGNF EKTILALMKT PVLFDVYEIK EAIKGAGTDE ACLIEIFASR
310 320 330 340 350
SNEHIRELSR AYKTEFQKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV
360 370 380 390 400
DMSLVQRDVQ ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT
410 420 430 440 450
GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNK AMRGAGTKDR
460 470 480 490 500
TLIRIMVSRS ELDLLDIRAE YKRMYGKSLY HDITGDTSGD YRKILLKICG

GND
Length:503
Mass (Da):54,079
Last modified:July 27, 2011 - v2
Checksum:i33F3471EE21A0D32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69V → M in AAB42012 (PubMed:8938449).Curated1
Sequence conflicti69V → M in CAB94770 (PubMed:11013079).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65986 mRNA. Translation: AAB42012.1.
AJ289760
, AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA. Translation: CAB94770.1.
AK140375 mRNA. Translation: BAE24363.1.
CT010331 mRNA. Translation: CAJ18539.1.
CH466613 Genomic DNA. Translation: EDL01415.1.
BC012875 mRNA. Translation: AAH12875.1.
CCDSiCCDS26875.1.
RefSeqiNP_038497.2. NM_013469.2.
XP_006518514.1. XM_006518451.3.
UniGeneiMm.294083.

Genome annotation databases

EnsembliENSMUST00000022416; ENSMUSP00000022416; ENSMUSG00000021866.
GeneIDi11744.
KEGGimmu:11744.
UCSCiuc007srv.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiANX11_MOUSE
AccessioniPrimary (citable) accession number: P97384
Secondary accession number(s): Q921F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families