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Protein

Annexin A11

Gene

Anxa11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner.By similarity

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: MGI
  • calcium-dependent protein binding Source: MGI
  • calcium ion binding Source: MGI
  • MHC class II protein complex binding Source: MGI
  • phosphatidylethanolamine binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • S100 protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
Gene namesi
Name:Anxa11
Synonyms:Anx11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:108481. Anxa11.

Subcellular locationi

  • Cytoplasm By similarity
  • Melanosome By similarity
  • Nucleus envelope By similarity
  • Nucleusnucleoplasm By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Annexin A11PRO_0000067511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei246 – 2461N6-acetyllysineBy similarity
Modified residuei253 – 2531N6-acetyllysineBy similarity
Modified residuei477 – 4771N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP97384.
MaxQBiP97384.
PaxDbiP97384.
PeptideAtlasiP97384.
PRIDEiP97384.

2D gel databases

SWISS-2DPAGEP97384.

PTM databases

iPTMnetiP97384.
PhosphoSiteiP97384.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021866.
CleanExiMM_ANXA11.
ExpressionAtlasiP97384. baseline and differential.
GenevisibleiP97384. MM.

Interactioni

Subunit structurei

Interacts with S100A6. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97384. 1 interaction.
MINTiMINT-4087847.
STRINGi10090.ENSMUSP00000022416.

Structurei

3D structure databases

ProteinModelPortaliP97384.
SMRiP97384. Positions 195-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati207 – 26761Annexin 1Add
BLAST
Repeati279 – 33961Annexin 2Add
BLAST
Repeati363 – 42361Annexin 3Add
BLAST
Repeati438 – 49861Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP97384.
KOiK17095.
OMAiDIRMEYK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYPGYPPPA GGYPPAAPGG GPWGGAGYPP PSMPPIGLDN VANYAGQFNQ
60 70 80 90 100
DYLSGMAANM SGTFGGANVP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP
110 120 130 140 150
PYGMYPPPGG NPPPGMPSYP AYPGAPVPGQ PMPPTGQQPP GAYPGQPPMT
160 170 180 190 200
YPGQSPMPPP GQQPVPSYPG YSGSSTITPA VPPAQFGNRG TITAASGFDP
210 220 230 240 250
LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK
260 270 280 290 300
DLKSELSGNF EKTILALMKT PVLFDVYEIK EAIKGAGTDE ACLIEIFASR
310 320 330 340 350
SNEHIRELSR AYKTEFQKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV
360 370 380 390 400
DMSLVQRDVQ ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT
410 420 430 440 450
GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNK AMRGAGTKDR
460 470 480 490 500
TLIRIMVSRS ELDLLDIRAE YKRMYGKSLY HDITGDTSGD YRKILLKICG

GND
Length:503
Mass (Da):54,079
Last modified:July 27, 2011 - v2
Checksum:i33F3471EE21A0D32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691V → M in AAB42012 (PubMed:8938449).Curated
Sequence conflicti69 – 691V → M in CAB94770 (PubMed:11013079).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65986 mRNA. Translation: AAB42012.1.
AJ289760
, AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA. Translation: CAB94770.1.
AK140375 mRNA. Translation: BAE24363.1.
CT010331 mRNA. Translation: CAJ18539.1.
CH466613 Genomic DNA. Translation: EDL01415.1.
BC012875 mRNA. Translation: AAH12875.1.
CCDSiCCDS26875.1.
RefSeqiNP_038497.2. NM_013469.2.
XP_006518514.1. XM_006518451.2.
UniGeneiMm.294083.

Genome annotation databases

EnsembliENSMUST00000022416; ENSMUSP00000022416; ENSMUSG00000021866.
GeneIDi11744.
KEGGimmu:11744.
UCSCiuc007srv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65986 mRNA. Translation: AAB42012.1.
AJ289760
, AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA. Translation: CAB94770.1.
AK140375 mRNA. Translation: BAE24363.1.
CT010331 mRNA. Translation: CAJ18539.1.
CH466613 Genomic DNA. Translation: EDL01415.1.
BC012875 mRNA. Translation: AAH12875.1.
CCDSiCCDS26875.1.
RefSeqiNP_038497.2. NM_013469.2.
XP_006518514.1. XM_006518451.2.
UniGeneiMm.294083.

3D structure databases

ProteinModelPortaliP97384.
SMRiP97384. Positions 195-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97384. 1 interaction.
MINTiMINT-4087847.
STRINGi10090.ENSMUSP00000022416.

PTM databases

iPTMnetiP97384.
PhosphoSiteiP97384.

2D gel databases

SWISS-2DPAGEP97384.

Proteomic databases

EPDiP97384.
MaxQBiP97384.
PaxDbiP97384.
PeptideAtlasiP97384.
PRIDEiP97384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022416; ENSMUSP00000022416; ENSMUSG00000021866.
GeneIDi11744.
KEGGimmu:11744.
UCSCiuc007srv.2. mouse.

Organism-specific databases

CTDi311.
MGIiMGI:108481. Anxa11.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP97384.
KOiK17095.
OMAiDIRMEYK.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Miscellaneous databases

ChiTaRSiAnxa11. mouse.
PROiP97384.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021866.
CleanExiMM_ANXA11.
ExpressionAtlasiP97384. baseline and differential.
GenevisibleiP97384. MM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 3 hits.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANX11_MOUSE
AccessioniPrimary (citable) accession number: P97384
Secondary accession number(s): Q921F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.