Reviewed, UniProtKB/Swiss-Prot P97384 (ANX11_MOUSE)

Names and origin

Protein names

Recommended name:
    Annexin A11
Alternative name(s):
    Annexin-11
    Annexin XI
    Calcyclin-associated annexin 50
      Short name=CAP-50

Gene names

Name:	Anxa11
Synonyms:	Anx11

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to calcyclin in a calcium-dependent manner.
Subcellular location	Nucleus › nucleoplasm By similarity. Melanosome By similarity. Note: Found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus By similarity.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from direct assay. Source: MGI calcium-dependent phospholipid binding Inferred from direct assay. Source: MGI phosphatidylethanolamine binding Inferred from direct assay. Source: MGI protein binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Annexin A11		PRO_0000067511
Regions
	Repeat	207 – 267	61	Annexin 1
	Repeat	279 – 339	61	Annexin 2
	Repeat	363 – 423	61	Annexin 3
	Repeat	438 – 498	61	Annexin 4
Amino acid modifications
	Modified residue	363	1	Phosphotyrosine By similarity
	Modified residue	480	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97384-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 424B1345E0F4EC8A	FASTA	503	54,111
	10 20 30 40 50 60 MSYPGYPPPA GGYPPAAPGG GPWGGAGYPP PSMPPIGLDN VANYAGQFNQ DYLSGMAANM 70 80 90 100 110 120 SGTFGGANMP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP PYGMYPPPGG NPPPGMPSYP 130 140 150 160 170 180 AYPGAPVPGQ PMPPTGQQPP GAYPGQPPMT YPGQSPMPPP GQQPVPSYPG YSGSSTITPA 190 200 210 220 230 240 VPPAQFGNRG TITAASGFDP LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF 250 260 270 280 290 300 KTAYGKDLIK DLKSELSGNF EKTILALMKT PVLFDVYEIK EAIKGAGTDE ACLIEIFASR 310 320 330 340 350 360 SNEHIRELSR AYKTEFQKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV DMSLVQRDVQ 370 380 390 400 410 420 ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT GRDIEKSICR EMSGDLEQGM 430 440 450 460 470 480 LAVVKCLKNT PAFFAERLNK AMRGAGTKDR TLIRIMVSRS ELDLLDIRAE YKRMYGKSLY 490 500 HDITGDTSGD YRKILLKICG GND

References

[1]	"Sequence and chromosomal localization of mouse annexin XI." Fernandez M.-P., Jenkins N.A., Gilbert D.J., Copeland N.G., Morgan R.O. Genomics 37:366-374(1996) [PubMed: 8938449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms." Bances P., Fernandez M.R., Rodriguez-Garcia M.I., Morgan R.O., Fernandez M.-P. Genomics 69:95-103(2000) [PubMed: 11013079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U65986 mRNA. Translation: AAB42012.1. AJ289760 , AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA. Translation: CAB94770.1.
IPI	IPI00124264.
UniGene	Mm.294083
3D structure databases
HSSP	HSSP built from PDB template 1ANN based on UniProtKB P13214.
ModBase	Search...
PTM databases
PhosphoSite	P97384.
2-D gel databases
SWISS-2DPAGE	P97384.
Proteomic databases
PRIDE	P97384.
Genome annotation databases
Ensembl	ENSMUSG00000021866. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:108481. Anxa11.
Phylogenomic databases
HOGENOM	P97384.
HOVERGEN	P97384.
Gene expression databases
ArrayExpress	P97384.
Bgee	P97384.
CleanEx	MM_ANXA11.
GermOnline	ENSMUSG00000021866. Mus musculus.
Family and domain databases
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR015475. Annexin_XI. IPR008157. AnnexinXI_N. [Graphical view]
Gene3D	G3DSA:1.10.220.10. Annexin. 4 hits.
PANTHER	PTHR10502. Annexin. 1 hit. PTHR10502:SF29. Annexin_XI. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01810. ANNEXINXI.
ProDom	PD000143. Annexin. 4 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00335. ANX. 4 hits. [Graphical view]
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ANX11_MOUSE

Accession

Primary (citable) accession number: P97384

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)