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Protein

Voltage-gated potassium channel subunit beta-3

Gene

Kcnab3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv2.2 but not Kv2.1.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
Gene namesi
Name:Kcnab3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1336208. Kcnab3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487511 – 249Voltage-gated potassium channel subunit beta-3Add BLAST249

Proteomic databases

MaxQBiP97382.
PaxDbiP97382.
PRIDEiP97382.

PTM databases

iPTMnetiP97382.
PhosphoSitePlusiP97382.

Expressioni

Tissue specificityi

Strong expression in brain, with highest levels in neocortical and allocortical regions, hippocampus, olfactory bulb and cerebellum. Also strong in kidney. Weak expression in lung, skeletal muscle and heart.1 Publication

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
Panx1Q9JIP42EBI-7261133,EBI-6272917

Protein-protein interaction databases

IntActiP97382. 1 interactor.
MINTiMINT-7260826.
STRINGi10090.ENSMUSP00000018614.

Structurei

3D structure databases

ProteinModelPortaliP97382.
SMRiP97382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1575. Eukaryota.
COG0667. LUCA.
HOVERGENiHBG052216.
InParanoidiP97382.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

P97382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGYGLIFS LKVVFTFLSL PHPPGLQGSL DRLQLEYVDI VFANRSDPNS
60 70 80 90 100
PMEEIVRAMT YVINQGLALY WGTSRWSAAE IMEAYSMARQ FNLIPPVCEQ
110 120 130 140 150
AENHFFQREK VEMQLPELYH KIGVGSVTWS PLACGLITSK YDGRVPDTCK
160 170 180 190 200
ATVKGYQWLK EKVQSEEGKK QQARVMDLLP TARQLGCTVG QLAIAWCLRS
210 220 230 240
EGVSSVLLGV SSAEQLMEHL GSLQVLSQLT PQTVVEIDAL LGNKSHSKK
Length:249
Mass (Da):27,749
Last modified:May 1, 1997 - v1
Checksum:i614844B35161D2EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65593 mRNA. Translation: AAB37264.1.
UniGeneiMm.232472.

Genome annotation databases

UCSCiuc007jpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65593 mRNA. Translation: AAB37264.1.
UniGeneiMm.232472.

3D structure databases

ProteinModelPortaliP97382.
SMRiP97382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97382. 1 interactor.
MINTiMINT-7260826.
STRINGi10090.ENSMUSP00000018614.

PTM databases

iPTMnetiP97382.
PhosphoSitePlusiP97382.

Proteomic databases

MaxQBiP97382.
PaxDbiP97382.
PRIDEiP97382.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007jpt.1. mouse.

Organism-specific databases

MGIiMGI:1336208. Kcnab3.

Phylogenomic databases

eggNOGiKOG1575. Eukaryota.
COG0667. LUCA.
HOVERGENiHBG052216.
InParanoidiP97382.

Miscellaneous databases

PROiP97382.
SOURCEiSearch...

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCAB3_MOUSE
AccessioniPrimary (citable) accession number: P97382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.