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Protein

Ras GTPase-activating protein-binding protein 2

Gene

G3bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable scaffold protein that may be involved in mRNA transport.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein-binding protein 2
Short name:
G3BP-2
Alternative name(s):
GAP SH3 domain-binding protein 2
Gene namesi
Name:G3bp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442040. G3bp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 482481Ras GTPase-activating protein-binding protein 2PRO_0000194801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411PhosphoserineCombined sources
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei227 – 2271PhosphothreonineCombined sources
Cross-linki281 – 281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei392 – 3921N6-succinyllysineCombined sources
Modified residuei457 – 4571Omega-N-methylated arginineBy similarity
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei468 – 4681Omega-N-methylated arginineBy similarity
Isoform B (identifier: P97379-2)
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei227 – 2271PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP97379.
PeptideAtlasiP97379.
PRIDEiP97379.

PTM databases

iPTMnetiP97379.
PhosphoSiteiP97379.
SwissPalmiP97379.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029405.
ExpressionAtlasiP97379. baseline and differential.
GenevisibleiP97379. MM.

Interactioni

Protein-protein interaction databases

BioGridi204773. 2 interactions.
IntActiP97379. 2 interactions.
MINTiMINT-1858459.
STRINGi10090.ENSMUSP00000128244.

Structurei

3D structure databases

ProteinModelPortaliP97379.
SMRiP97379. Positions 1-138, 308-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 133123NTF2PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 40979RRMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi134 – 22390Glu-richAdd
BLAST
Compositional biasi419 – 47961Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0116. Eukaryota.
ENOG410YV57. LUCA.
GeneTreeiENSGT00390000011365.
HOGENOMiHOG000220838.
HOVERGENiHBG007211.
InParanoidiP97379.
OMAiANSAYYD.
OrthoDBiEOG091G0GAN.
PhylomeDBiP97379.
TreeFamiTF325464.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P97379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK
60 70 80 90 100
PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN
110 120 130 140 150
SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE
160 170 180 190 200
DEVEEEQEDR QPSPEPVQEN ANSAYYDAHP VTNGIEEPLE ESSHEPEPEP
210 220 230 240 250
ESETKTEELK PQVEEKHLEE LEEKSATPPP AEPASLPQEP PKAFSWASVT
260 270 280 290 300
SKNLPPSGTV SSSGIPPHVK APVSQPRVDA KPEVQSQPPR VREQRPRERP
310 320 330 340 350
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF
360 370 380 390 400
FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV
410 420 430 440 450
RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD
460 470 480
GRGPPPRGGM TQKLGSGRGT GQMEGRFTGQ RR
Length:482
Mass (Da):54,088
Last modified:July 11, 2001 - v2
Checksum:iFB8BC2086123A5CE
GO
Isoform B (identifier: P97379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-275: Missing.

Show »
Length:449
Mass (Da):50,784
Checksum:i2C98E40121E1901D
GO

Sequence cautioni

The sequence BAE26595 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti476 – 4827RFTGQRR → TLHRTASLKSHCWQFWQWYL THRVCILVKFFWLWNVTQPF in AAC53553 (PubMed:9575347).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei243 – 27533Missing in isoform B. 2 PublicationsVSP_003606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65313 mRNA. Translation: AAC53553.1.
AF145285 mRNA. Translation: AAD51933.1.
AK145697 mRNA. Translation: BAE26595.1. Different initiation.
CCDSiCCDS19427.1. [P97379-1]
CCDS39149.1. [P97379-2]
RefSeqiNP_001074263.1. NM_001080794.2. [P97379-1]
NP_001074266.1. NM_001080797.2. [P97379-1]
NP_035946.2. NM_011816.4. [P97379-1]
XP_006534990.1. XM_006534927.2. [P97379-1]
XP_006534991.1. XM_006534928.2. [P97379-1]
UniGeneiMm.290530.

Genome annotation databases

EnsembliENSMUST00000113127; ENSMUSP00000108752; ENSMUSG00000029405. [P97379-2]
ENSMUST00000164378; ENSMUSP00000128353; ENSMUSG00000029405. [P97379-1]
ENSMUST00000167918; ENSMUSP00000132469; ENSMUSG00000029405. [P97379-2]
ENSMUST00000169094; ENSMUSP00000128244; ENSMUSG00000029405. [P97379-1]
ENSMUST00000202258; ENSMUSP00000144456; ENSMUSG00000029405. [P97379-1]
GeneIDi23881.
KEGGimmu:23881.
UCSCiuc008ycg.2. mouse. [P97379-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65313 mRNA. Translation: AAC53553.1.
AF145285 mRNA. Translation: AAD51933.1.
AK145697 mRNA. Translation: BAE26595.1. Different initiation.
CCDSiCCDS19427.1. [P97379-1]
CCDS39149.1. [P97379-2]
RefSeqiNP_001074263.1. NM_001080794.2. [P97379-1]
NP_001074266.1. NM_001080797.2. [P97379-1]
NP_035946.2. NM_011816.4. [P97379-1]
XP_006534990.1. XM_006534927.2. [P97379-1]
XP_006534991.1. XM_006534928.2. [P97379-1]
UniGeneiMm.290530.

3D structure databases

ProteinModelPortaliP97379.
SMRiP97379. Positions 1-138, 308-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204773. 2 interactions.
IntActiP97379. 2 interactions.
MINTiMINT-1858459.
STRINGi10090.ENSMUSP00000128244.

PTM databases

iPTMnetiP97379.
PhosphoSiteiP97379.
SwissPalmiP97379.

Proteomic databases

PaxDbiP97379.
PeptideAtlasiP97379.
PRIDEiP97379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113127; ENSMUSP00000108752; ENSMUSG00000029405. [P97379-2]
ENSMUST00000164378; ENSMUSP00000128353; ENSMUSG00000029405. [P97379-1]
ENSMUST00000167918; ENSMUSP00000132469; ENSMUSG00000029405. [P97379-2]
ENSMUST00000169094; ENSMUSP00000128244; ENSMUSG00000029405. [P97379-1]
ENSMUST00000202258; ENSMUSP00000144456; ENSMUSG00000029405. [P97379-1]
GeneIDi23881.
KEGGimmu:23881.
UCSCiuc008ycg.2. mouse. [P97379-1]

Organism-specific databases

CTDi9908.
MGIiMGI:2442040. G3bp2.

Phylogenomic databases

eggNOGiKOG0116. Eukaryota.
ENOG410YV57. LUCA.
GeneTreeiENSGT00390000011365.
HOGENOMiHOG000220838.
HOVERGENiHBG007211.
InParanoidiP97379.
OMAiANSAYYD.
OrthoDBiEOG091G0GAN.
PhylomeDBiP97379.
TreeFamiTF325464.

Miscellaneous databases

ChiTaRSiG3bp2. mouse.
PROiP97379.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029405.
ExpressionAtlasiP97379. baseline and differential.
GenevisibleiP97379. MM.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3BP2_MOUSE
AccessioniPrimary (citable) accession number: P97379
Secondary accession number(s): Q3UL55, Q9R1B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.