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Protein

Ras GTPase-activating protein-binding protein 2

Gene

G3bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable scaffold protein that may be involved in mRNA transport.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein-binding protein 2
Short name:
G3BP-2
Alternative name(s):
GAP SH3 domain-binding protein 2
Gene namesi
Name:G3bp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2442040 G3bp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948011 – 482Ras GTPase-activating protein-binding protein 2Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei392N6-succinyllysineCombined sources1
Modified residuei457Omega-N-methylarginine; alternateBy similarity1
Modified residuei457Omega-N-methylated arginine; alternateBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei468Omega-N-methylarginine; alternateCombined sources1
Modified residuei468Omega-N-methylated arginine; alternateBy similarity1
Isoform B (identifier: P97379-2)
Modified residuei225PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP97379
PeptideAtlasiP97379
PRIDEiP97379

PTM databases

iPTMnetiP97379
PhosphoSitePlusiP97379
SwissPalmiP97379

Expressioni

Gene expression databases

BgeeiENSMUSG00000029405
ExpressionAtlasiP97379 baseline and differential
GenevisibleiP97379 MM

Interactioni

Protein-protein interaction databases

BioGridi204773, 4 interactors
IntActiP97379, 4 interactors
MINTiP97379
STRINGi10090.ENSMUSP00000128244

Structurei

3D structure databases

ProteinModelPortaliP97379
SMRiP97379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 133NTF2PROSITE-ProRule annotationAdd BLAST123
Domaini331 – 409RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 223Glu-richAdd BLAST90
Compositional biasi419 – 479Gly-richAdd BLAST61

Phylogenomic databases

eggNOGiKOG0116 Eukaryota
ENOG410YV57 LUCA
GeneTreeiENSGT00390000011365
HOGENOMiHOG000220838
HOVERGENiHBG007211
InParanoidiP97379
OMAiGEFNYRS
OrthoDBiEOG091G0GAN
PhylomeDBiP97379
TreeFamiTF325464

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd12464 RRM_G3BP2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034377 G3BP2
IPR034376 G3BP2_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10693:SF10 PTHR10693:SF10, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P97379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK
60 70 80 90 100
PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN
110 120 130 140 150
SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE
160 170 180 190 200
DEVEEEQEDR QPSPEPVQEN ANSAYYDAHP VTNGIEEPLE ESSHEPEPEP
210 220 230 240 250
ESETKTEELK PQVEEKHLEE LEEKSATPPP AEPASLPQEP PKAFSWASVT
260 270 280 290 300
SKNLPPSGTV SSSGIPPHVK APVSQPRVDA KPEVQSQPPR VREQRPRERP
310 320 330 340 350
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF
360 370 380 390 400
FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV
410 420 430 440 450
RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD
460 470 480
GRGPPPRGGM TQKLGSGRGT GQMEGRFTGQ RR
Length:482
Mass (Da):54,088
Last modified:July 11, 2001 - v2
Checksum:iFB8BC2086123A5CE
GO
Isoform B (identifier: P97379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-275: Missing.

Show »
Length:449
Mass (Da):50,784
Checksum:i2C98E40121E1901D
GO

Sequence cautioni

The sequence BAE26595 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476 – 482RFTGQRR → TLHRTASLKSHCWQFWQWYL THRVCILVKFFWLWNVTQPF in AAC53553 (PubMed:9575347).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003606243 – 275Missing in isoform B. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65313 mRNA Translation: AAC53553.1
AF145285 mRNA Translation: AAD51933.1
AK145697 mRNA Translation: BAE26595.1 Different initiation.
CCDSiCCDS19427.1 [P97379-1]
CCDS39149.1 [P97379-2]
RefSeqiNP_001074263.1, NM_001080794.2 [P97379-1]
NP_001074266.1, NM_001080797.2 [P97379-1]
NP_035946.2, NM_011816.4 [P97379-1]
XP_006534990.1, XM_006534927.3
XP_006534991.1, XM_006534928.3
UniGeneiMm.290530

Genome annotation databases

EnsembliENSMUST00000113127; ENSMUSP00000108752; ENSMUSG00000029405 [P97379-2]
ENSMUST00000164378; ENSMUSP00000128353; ENSMUSG00000029405 [P97379-1]
ENSMUST00000167918; ENSMUSP00000132469; ENSMUSG00000029405 [P97379-2]
ENSMUST00000169094; ENSMUSP00000128244; ENSMUSG00000029405 [P97379-1]
ENSMUST00000202258; ENSMUSP00000144456; ENSMUSG00000029405 [P97379-1]
GeneIDi23881
KEGGimmu:23881
UCSCiuc008ycg.2 mouse [P97379-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiG3BP2_MOUSE
AccessioniPrimary (citable) accession number: P97379
Secondary accession number(s): Q3UL55, Q9R1B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 11, 2001
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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