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P97376 (FRG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FRG1
Alternative name(s):
FSHD region gene 1 protein
Gene names
Name:Frg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be involved in pre-mRNA splicing By similarity.

Subunit structure

Identified in the spliceosome C complex By similarity.

Subcellular location

NucleusCajal body By similarity. Nucleus speckle By similarity. Note: First expressed in Cajal bodies and nuclear speckles. Nucleus; nucleolus By similarity. As speckle expression diminishes, expression is seen in dense structures (dense fibrillar component and the granular component) of the nucleolus By similarity.

Sequence similarities

Belongs to the FRG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Protein FRG1
PRO_0000220768

Regions

Motif22 – 3211Nuclear localization signal Potential
Motif235 – 25117Bipartite nuclear localization signal Potential
Compositional bias8 – 3225Lys-rich

Experimental info

Sequence conflict1401P → Q in AAB39540. Ref.1

Secondary structure

.......................................... 258
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P97376 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: 1D0C07CF83897ACE

FASTA25829,127
        10         20         30         40         50         60 
MAEYSYVKST KLVLKGTKAK SKKKKSKDKK RKREEDEETQ LDIVGIWWTV SNFGEISGTI 

        70         80         90        100        110        120 
AIEMDKGAYI HALDNGLFTL GAPHREVDEG PSPPEQFTAV KLSDSRIALK SGYGKYLGIN 

       130        140        150        160        170        180 
SDGLVVGRSD AIGPREQWEP VFQDGKMALL ASNSCFIRCN EAGDIEAKNK TAGEEEMIKI 

       190        200        210        220        230        240 
RSCAERETKK KDDIPEEDKG SVKQCEINYV KKFQSFQDHK LKISKEDSKI LKKARKDGFL 

       250 
HETLLDRRAK LKADRYCK 

« Hide

References

« Hide 'large scale' references
[1]"FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates."
Grewal P.K., Todd L.C., van der Maarel S., Frants R.R., Hewitt J.E.
Gene 216:13-19(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"Solution structure of mouse Frg1 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (APR-2008) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 41-188.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62105 mRNA. Translation: AAB39540.1.
AK079229 mRNA. Translation: BAC37582.1.
BC002027 mRNA. Translation: AAH02027.1.
CCDSCCDS22263.1.
RefSeqNP_038550.2. NM_013522.3.
UniGeneMm.217312.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUGNMR-A41-188[»]
ProteinModelPortalP97376.
SMRP97376. Positions 41-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199743. 2 interactions.
IntActP97376. 1 interaction.

PTM databases

PhosphoSiteP97376.

Proteomic databases

MaxQBP97376.
PaxDbP97376.
PRIDEP97376.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033999; ENSMUSP00000033999; ENSMUSG00000031590.
GeneID14300.
KEGGmmu:14300.
UCSCuc012gcs.1. mouse.

Organism-specific databases

CTD2483.
MGIMGI:893597. Frg1.

Phylogenomic databases

eggNOGNOG289849.
HOGENOMHOG000007130.
HOVERGENHBG018564.
InParanoidP97376.
KOK13122.
OMANSCFISY.
OrthoDBEOG7NKKMG.
PhylomeDBP97376.
TreeFamTF314108.

Gene expression databases

ArrayExpressP97376.
BgeeP97376.
CleanExMM_FRG1.
GenevestigatorP97376.

Family and domain databases

InterProIPR008999. Actin_cross-linking.
IPR010414. FRG1.
[Graphical view]
PANTHERPTHR12928. PTHR12928. 1 hit.
PfamPF06229. FRG1. 1 hit.
[Graphical view]
SUPFAMSSF50405. SSF50405. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP97376.
NextBio285717.
PROP97376.
SOURCESearch...

Entry information

Entry nameFRG1_MOUSE
AccessionPrimary (citable) accession number: P97376
Secondary accession number(s): Q99M42
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot