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P97376

- FRG1_MOUSE

UniProt

P97376 - FRG1_MOUSE

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Protein
Protein FRG1
Gene
Frg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be involved in pre-mRNA splicing By similarity.

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. mRNA processing Source: UniProtKB-KW
  3. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FRG1
Alternative name(s):
FSHD region gene 1 protein
Gene namesi
Name:Frg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:893597. Frg1.

Subcellular locationi

NucleusCajal body By similarity. Nucleus speckle By similarity
Note: First expressed in Cajal bodies and nuclear speckles. Nucleus; nucleolus By similarity. As speckle expression diminishes, expression is seen in dense structures (dense fibrillar component and the granular component) of the nucleolus By similarity.

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
  2. catalytic step 2 spliceosome Source: Ensembl
  3. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Protein FRG1
PRO_0000220768Add
BLAST

Proteomic databases

MaxQBiP97376.
PaxDbiP97376.
PRIDEiP97376.

PTM databases

PhosphoSiteiP97376.

Expressioni

Gene expression databases

ArrayExpressiP97376.
BgeeiP97376.
CleanExiMM_FRG1.
GenevestigatoriP97376.

Interactioni

Subunit structurei

Identified in the spliceosome C complex By similarity.

Protein-protein interaction databases

BioGridi199743. 2 interactions.
IntActiP97376. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi47 – 493
Helixi53 – 553
Beta strandi58 – 636
Beta strandi65 – 673
Beta strandi69 – 724
Beta strandi78 – 803
Beta strandi85 – 884
Turni93 – 953
Beta strandi97 – 1015
Beta strandi103 – 1053
Beta strandi107 – 1115
Beta strandi116 – 1194
Beta strandi121 – 1277
Turni134 – 1363
Beta strandi137 – 1415
Beta strandi148 – 1514
Beta strandi156 – 1594
Beta strandi161 – 1633
Beta strandi165 – 1673
Turni174 – 1763
Beta strandi179 – 1824

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUGNMR-A41-188[»]
ProteinModelPortaliP97376.
SMRiP97376. Positions 41-188.

Miscellaneous databases

EvolutionaryTraceiP97376.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 3211Nuclear localization signal Reviewed prediction
Add
BLAST
Motifi235 – 25117Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 3225Lys-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FRG1 family.

Phylogenomic databases

eggNOGiNOG289849.
HOGENOMiHOG000007130.
HOVERGENiHBG018564.
InParanoidiP97376.
KOiK13122.
OMAiNSCFISY.
OrthoDBiEOG7NKKMG.
PhylomeDBiP97376.
TreeFamiTF314108.

Family and domain databases

InterProiIPR008999. Actin_cross-linking.
IPR010414. FRG1.
[Graphical view]
PANTHERiPTHR12928. PTHR12928. 1 hit.
PfamiPF06229. FRG1. 1 hit.
[Graphical view]
SUPFAMiSSF50405. SSF50405. 1 hit.

Sequencei

Sequence statusi: Complete.

P97376-1 [UniParc]FASTAAdd to Basket

« Hide

MAEYSYVKST KLVLKGTKAK SKKKKSKDKK RKREEDEETQ LDIVGIWWTV    50
SNFGEISGTI AIEMDKGAYI HALDNGLFTL GAPHREVDEG PSPPEQFTAV 100
KLSDSRIALK SGYGKYLGIN SDGLVVGRSD AIGPREQWEP VFQDGKMALL 150
ASNSCFIRCN EAGDIEAKNK TAGEEEMIKI RSCAERETKK KDDIPEEDKG 200
SVKQCEINYV KKFQSFQDHK LKISKEDSKI LKKARKDGFL HETLLDRRAK 250
LKADRYCK 258
Length:258
Mass (Da):29,127
Last modified:September 26, 2001 - v2
Checksum:i1D0C07CF83897ACE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401P → Q in AAB39540. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62105 mRNA. Translation: AAB39540.1.
AK079229 mRNA. Translation: BAC37582.1.
BC002027 mRNA. Translation: AAH02027.1.
CCDSiCCDS22263.1.
RefSeqiNP_038550.2. NM_013522.3.
UniGeneiMm.217312.

Genome annotation databases

EnsembliENSMUST00000033999; ENSMUSP00000033999; ENSMUSG00000031590.
GeneIDi14300.
KEGGimmu:14300.
UCSCiuc012gcs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62105 mRNA. Translation: AAB39540.1 .
AK079229 mRNA. Translation: BAC37582.1 .
BC002027 mRNA. Translation: AAH02027.1 .
CCDSi CCDS22263.1.
RefSeqi NP_038550.2. NM_013522.3.
UniGenei Mm.217312.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YUG NMR - A 41-188 [» ]
ProteinModelPortali P97376.
SMRi P97376. Positions 41-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199743. 2 interactions.
IntActi P97376. 1 interaction.

PTM databases

PhosphoSitei P97376.

Proteomic databases

MaxQBi P97376.
PaxDbi P97376.
PRIDEi P97376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033999 ; ENSMUSP00000033999 ; ENSMUSG00000031590 .
GeneIDi 14300.
KEGGi mmu:14300.
UCSCi uc012gcs.1. mouse.

Organism-specific databases

CTDi 2483.
MGIi MGI:893597. Frg1.

Phylogenomic databases

eggNOGi NOG289849.
HOGENOMi HOG000007130.
HOVERGENi HBG018564.
InParanoidi P97376.
KOi K13122.
OMAi NSCFISY.
OrthoDBi EOG7NKKMG.
PhylomeDBi P97376.
TreeFami TF314108.

Miscellaneous databases

EvolutionaryTracei P97376.
NextBioi 285717.
PROi P97376.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97376.
Bgeei P97376.
CleanExi MM_FRG1.
Genevestigatori P97376.

Family and domain databases

InterProi IPR008999. Actin_cross-linking.
IPR010414. FRG1.
[Graphical view ]
PANTHERi PTHR12928. PTHR12928. 1 hit.
Pfami PF06229. FRG1. 1 hit.
[Graphical view ]
SUPFAMi SSF50405. SSF50405. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates."
    Grewal P.K., Todd L.C., van der Maarel S., Frants R.R., Hewitt J.E.
    Gene 216:13-19(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. "Solution structure of mouse Frg1 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 41-188.

Entry informationi

Entry nameiFRG1_MOUSE
AccessioniPrimary (citable) accession number: P97376
Secondary accession number(s): Q99M42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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