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Protein

Protein FRG1

Gene

Frg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, Myogenesis, Ribosome biogenesis, rRNA processing

Keywords - Ligandi

Actin-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FRG1
Alternative name(s):
FSHD region gene 1 protein
Gene namesi
Name:Frg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:893597. Frg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207681 – 258Protein FRG1Add BLAST258

Proteomic databases

EPDiP97376.
PaxDbiP97376.
PeptideAtlasiP97376.
PRIDEiP97376.

PTM databases

iPTMnetiP97376.
PhosphoSitePlusiP97376.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031590.
CleanExiMM_FRG1.
ExpressionAtlasiP97376. baseline and differential.
GenevisibleiP97376. MM.

Interactioni

Subunit structurei

Homodimer and homotetramer in solution. Identified in the spliceosome C complex. Interacts (via N-terminus) with KPNA2 and NXF1/TAP. Interacts with F-actin with a stoichiometry of 2:1 (By similarity). Interacts with KMT5B (via C-terminus).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199743. 2 interactors.
IntActiP97376. 2 interactors.
STRINGi10090.ENSMUSP00000033999.

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi47 – 49Combined sources3
Helixi53 – 55Combined sources3
Beta strandi58 – 63Combined sources6
Beta strandi65 – 67Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi78 – 80Combined sources3
Beta strandi85 – 88Combined sources4
Turni93 – 95Combined sources3
Beta strandi97 – 101Combined sources5
Beta strandi103 – 105Combined sources3
Beta strandi107 – 111Combined sources5
Beta strandi116 – 119Combined sources4
Beta strandi121 – 127Combined sources7
Turni134 – 136Combined sources3
Beta strandi137 – 141Combined sources5
Beta strandi148 – 151Combined sources4
Beta strandi156 – 159Combined sources4
Beta strandi161 – 163Combined sources3
Beta strandi165 – 167Combined sources3
Turni174 – 176Combined sources3
Beta strandi179 – 182Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUGNMR-A41-188[»]
ProteinModelPortaliP97376.
SMRiP97376.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97376.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 32Nuclear localization signalSequence analysisAdd BLAST11
Motifi235 – 251Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 32Lys-richAdd BLAST25

Sequence similaritiesi

Belongs to the FRG1 family.Curated

Phylogenomic databases

eggNOGiKOG3962. Eukaryota.
ENOG411009G. LUCA.
GeneTreeiENSGT00390000004552.
HOGENOMiHOG000007130.
HOVERGENiHBG018564.
InParanoidiP97376.
KOiK13122.
OMAiNSCFISY.
OrthoDBiEOG091G0M4K.
PhylomeDBiP97376.
TreeFamiTF314108.

Family and domain databases

InterProiIPR008999. Actin_cross-linking.
IPR010414. FRG1.
[Graphical view]
PfamiPF06229. FRG1. 1 hit.
[Graphical view]
SUPFAMiSSF50405. SSF50405. 1 hit.

Sequencei

Sequence statusi: Complete.

P97376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEYSYVKST KLVLKGTKAK SKKKKSKDKK RKREEDEETQ LDIVGIWWTV
60 70 80 90 100
SNFGEISGTI AIEMDKGAYI HALDNGLFTL GAPHREVDEG PSPPEQFTAV
110 120 130 140 150
KLSDSRIALK SGYGKYLGIN SDGLVVGRSD AIGPREQWEP VFQDGKMALL
160 170 180 190 200
ASNSCFIRCN EAGDIEAKNK TAGEEEMIKI RSCAERETKK KDDIPEEDKG
210 220 230 240 250
SVKQCEINYV KKFQSFQDHK LKISKEDSKI LKKARKDGFL HETLLDRRAK

LKADRYCK
Length:258
Mass (Da):29,127
Last modified:September 26, 2001 - v2
Checksum:i1D0C07CF83897ACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140P → Q in AAB39540 (PubMed:9714712).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62105 mRNA. Translation: AAB39540.1.
AK079229 mRNA. Translation: BAC37582.1.
BC002027 mRNA. Translation: AAH02027.1.
CCDSiCCDS22263.1.
RefSeqiNP_038550.2. NM_013522.3.
XP_017168059.1. XM_017312570.1.
UniGeneiMm.217312.

Genome annotation databases

EnsembliENSMUST00000033999; ENSMUSP00000033999; ENSMUSG00000031590.
GeneIDi14300.
KEGGimmu:14300.
UCSCiuc012gcs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62105 mRNA. Translation: AAB39540.1.
AK079229 mRNA. Translation: BAC37582.1.
BC002027 mRNA. Translation: AAH02027.1.
CCDSiCCDS22263.1.
RefSeqiNP_038550.2. NM_013522.3.
XP_017168059.1. XM_017312570.1.
UniGeneiMm.217312.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUGNMR-A41-188[»]
ProteinModelPortaliP97376.
SMRiP97376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199743. 2 interactors.
IntActiP97376. 2 interactors.
STRINGi10090.ENSMUSP00000033999.

PTM databases

iPTMnetiP97376.
PhosphoSitePlusiP97376.

Proteomic databases

EPDiP97376.
PaxDbiP97376.
PeptideAtlasiP97376.
PRIDEiP97376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033999; ENSMUSP00000033999; ENSMUSG00000031590.
GeneIDi14300.
KEGGimmu:14300.
UCSCiuc012gcs.1. mouse.

Organism-specific databases

CTDi2483.
MGIiMGI:893597. Frg1.

Phylogenomic databases

eggNOGiKOG3962. Eukaryota.
ENOG411009G. LUCA.
GeneTreeiENSGT00390000004552.
HOGENOMiHOG000007130.
HOVERGENiHBG018564.
InParanoidiP97376.
KOiK13122.
OMAiNSCFISY.
OrthoDBiEOG091G0M4K.
PhylomeDBiP97376.
TreeFamiTF314108.

Miscellaneous databases

EvolutionaryTraceiP97376.
PROiP97376.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031590.
CleanExiMM_FRG1.
ExpressionAtlasiP97376. baseline and differential.
GenevisibleiP97376. MM.

Family and domain databases

InterProiIPR008999. Actin_cross-linking.
IPR010414. FRG1.
[Graphical view]
PfamiPF06229. FRG1. 1 hit.
[Graphical view]
SUPFAMiSSF50405. SSF50405. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFRG1_MOUSE
AccessioniPrimary (citable) accession number: P97376
Secondary accession number(s): Q99M42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of Frg1 leads to development of facioscapulohumeral muscular dystrophy (FSHD1)-like symptoms such as kyphosis, progressive muscle dystrophy and skeletal muscle atrophy. It also causes aberrant pre-mRNA splicing of Tnnt3 and Mtmr1, affects the localization and activity of KMT5B, and leads to increased levels of Eid3, resulting in inhibited muscle differentiation. These results suggest that human FSHD1 results from inappropriate overexpression of FRG1 which leads to abnormal alternative splicing of specific pre-mRNAs (PubMed:16341202, PubMed:23720823).2 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.