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P97372 (PSME2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome activator complex subunit 2
Alternative name(s):
11S regulator complex subunit beta
Short name=REG-beta
Activator of multicatalytic protease subunit 2
Proteasome activator 28 subunit beta
Short name=PA28b
Short name=PA28beta
Gene names
Name:Psme2
Synonyms:Pa28b1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Subunit structure

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

Induction

By interferon gamma.

Sequence similarities

Belongs to the PA28 family.

Ontologies

Keywords
   Cellular componentProteasome
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentproteasome activator complex

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 239238Proteasome activator complex subunit 2
PRO_0000161786

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue101Phosphoserine By similarity

Experimental info

Sequence conflict1521A → P in AAC53296. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P97372 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: D8BB90F78CB0DD7C

FASTA23927,057
        10         20         30         40         50         60 
MAKPCGVRLS GEARKQVDVF RQNLFQEADD FLCTFLPRKI ISLSQLLQED SLNVADLSSL 

        70         80         90        100        110        120 
RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGYLPGNEKL LALLALVKPE VWTLKEKCIL 

       130        140        150        160        170        180 
VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK 

       190        200        210        220        230 
DTHVMDYRAL VHERDEAAYG ALRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY

« Hide

References

« Hide 'large scale' references
[1]"Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki."
Jiang H., Monaco J.J.
Immunogenetics 46:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.BR.
[2]"Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"Characterization of the mouse proteasome regulator PA28b gene."
Li Y., Chambers J., Pang J., Ngo K., Peterson P.A., Leung W.P., Yang Y.
Immunogenetics 49:149-157(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[4]"Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes."
Yawata M., Murata S., Tanaka K., Ishigatsubo Y., Kasahara M.
Immunogenetics 53:119-129(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U60329 mRNA. Translation: AAC53296.1.
AB007138 Genomic DNA. Translation: BAA28837.1.
AF060195 Genomic DNA. Translation: AAC83999.1.
AB053120 Genomic DNA. Translation: BAB47405.1.
AK012344 mRNA. Translation: BAB28175.1.
BC005680 mRNA. Translation: AAH05680.1.
BC057859 mRNA. Translation: AAH57859.1.
IPIIPI00124225.
RefSeqNP_001025026.1. NM_001029855.1.
NP_035320.1. NM_011190.3.
UniGeneMm.371573.

3D structure databases

ProteinModelPortalP97372.
SMRP97372. Positions 7-66, 97-232.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000100564.

PTM databases

PhosphoSiteP97372.

Proteomic databases

PaxDbP97372.
PRIDEP97372.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000104958; ENSMUSP00000100564; ENSMUSG00000078153.
ENSMUST00000161807; ENSMUSP00000123798; ENSMUSG00000079197.
GeneID19188.
KEGGmmu:19188.

Organism-specific databases

CTD5721.
MGIMGI:1096365. Psme2.

Phylogenomic databases

eggNOGNOG280316.
HOGENOMHOG000282822.
HOVERGENHBG053745.
InParanoidP97372.
KOK06697.
OMADIRGFYA.
OrthoDBEOG402WT1.

Gene expression databases

ArrayExpressP97372.
BgeeP97372.
CleanExMM_PSME2.
GenevestigatorP97372.

Family and domain databases

Gene3D1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProIPR003185. Proteasome_activ_REG_asu.
IPR009077. Proteasome_activ_REG_asu/bsu.
IPR003186. Proteasome_activ_REG_bsu.
[Graphical view]
PANTHERPTHR10660. PTHR10660. 1 hit.
PfamPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMSSF47216. Prot_act_regA. 1 hit.
ProtoNetSearch...

Other

NextBio295894.
SOURCESearch...

Entry information

Entry namePSME2_MOUSE
AccessionPrimary (citable) accession number: P97372
Secondary accession number(s): O35562
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents