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Protein

Proteasome activator complex subunit 1

Gene

Psme1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

  • endopeptidase activator activity Source: MGI

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-382556. ABC-family proteins mediated transport.
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 1
Alternative name(s):
11S regulator complex subunit alpha
Short name:
REG-alpha
Activator of multicatalytic protease subunit 1
Proteasome activator 28 subunit alpha
Short name:
PA28a
Short name:
PA28alpha
Gene namesi
Name:Psme1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1096367. Psme1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617811 – 249Proteasome activator complex subunit 1Add BLAST249

Proteomic databases

EPDiP97371.
PaxDbiP97371.
PRIDEiP97371.

PTM databases

iPTMnetiP97371.
PhosphoSitePlusiP97371.

Expressioni

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSMUSG00000022216.
CleanExiMM_PSME1.
ExpressionAtlasiP97371. baseline and differential.
GenevisibleiP97371. MM.

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).By similarity

Protein-protein interaction databases

BioGridi202432. 1 interactor.
IntActiP97371. 3 interactors.
MINTiMINT-1844401.
STRINGi10090.ENSMUSP00000134735.

Structurei

3D structure databases

ProteinModelPortaliP97371.
SMRiP97371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiKOG4470. Eukaryota.
ENOG410XQVX. LUCA.
GeneTreeiENSGT00510000046374.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
InParanoidiP97371.
KOiK06696.
OMAiTQISKYY.
OrthoDBiEOG091G0GX7.
PhylomeDBiP97371.
TreeFamiTF106236.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view]
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 2 hits.

Sequencei

Sequence statusi: Complete.

P97371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN
60 70 80 90 100
EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP
110 120 130 140 150
CGPVNCNEKI VVLLQRLKPE IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV
160 170 180 190 200
AVQEKVFELM TNLHTKLEGF HTQISKYFSE RGDAVAKAAK QPHVGDYRQL
210 220 230 240
VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
Length:249
Mass (Da):28,673
Last modified:August 29, 2001 - v2
Checksum:i1E2CE09DA44A5346
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17F → L in BAB25712 (PubMed:16141072).Curated1
Sequence conflicti97K → E in BAB25712 (PubMed:16141072).Curated1
Sequence conflicti151A → S in AAC53295 (PubMed:9162094).Curated1
Sequence conflicti156V → L in AAC53295 (PubMed:9162094).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87909 mRNA. Translation: BAA22039.1.
U60328 mRNA. Translation: AAC53295.1.
AB007136 Genomic DNA. Translation: BAA28835.1.
AB053120 Genomic DNA. Translation: BAB47403.1.
AK019390 mRNA. Translation: BAB31696.1.
AK008514 mRNA. Translation: BAB25712.1.
CCDSiCCDS36931.1.
RefSeqiNP_035319.1. NM_011189.1.
UniGeneiMm.830.

Genome annotation databases

EnsembliENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216.
GeneIDi19186.
KEGGimmu:19186.
UCSCiuc007tzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87909 mRNA. Translation: BAA22039.1.
U60328 mRNA. Translation: AAC53295.1.
AB007136 Genomic DNA. Translation: BAA28835.1.
AB053120 Genomic DNA. Translation: BAB47403.1.
AK019390 mRNA. Translation: BAB31696.1.
AK008514 mRNA. Translation: BAB25712.1.
CCDSiCCDS36931.1.
RefSeqiNP_035319.1. NM_011189.1.
UniGeneiMm.830.

3D structure databases

ProteinModelPortaliP97371.
SMRiP97371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202432. 1 interactor.
IntActiP97371. 3 interactors.
MINTiMINT-1844401.
STRINGi10090.ENSMUSP00000134735.

PTM databases

iPTMnetiP97371.
PhosphoSitePlusiP97371.

Proteomic databases

EPDiP97371.
PaxDbiP97371.
PRIDEiP97371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216.
GeneIDi19186.
KEGGimmu:19186.
UCSCiuc007tzd.1. mouse.

Organism-specific databases

CTDi5720.
MGIiMGI:1096367. Psme1.

Phylogenomic databases

eggNOGiKOG4470. Eukaryota.
ENOG410XQVX. LUCA.
GeneTreeiENSGT00510000046374.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
InParanoidiP97371.
KOiK06696.
OMAiTQISKYY.
OrthoDBiEOG091G0GX7.
PhylomeDBiP97371.
TreeFamiTF106236.

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-MMU-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-MMU-195253. Degradation of beta-catenin by the destruction complex.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-MMU-350562. Regulation of ornithine decarboxylase (ODC).
R-MMU-382556. ABC-family proteins mediated transport.
R-MMU-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-MMU-4608870. Asymmetric localization of PCP proteins.
R-MMU-4641257. Degradation of AXIN.
R-MMU-4641258. Degradation of DVL.
R-MMU-5358346. Hedgehog ligand biogenesis.
R-MMU-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5610780. Degradation of GLI1 by the proteasome.
R-MMU-5610785. GLI3 is processed to GLI3R by the proteasome.
R-MMU-5632684. Hedgehog 'on' state.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676590. NIK-->noncanonical NF-kB signaling.
R-MMU-5687128. MAPK6/MAPK4 signaling.
R-MMU-5689603. UCH proteinases.
R-MMU-5689880. Ub-specific processing proteases.
R-MMU-68827. CDT1 association with the CDC6:ORC:origin complex.
R-MMU-68949. Orc1 removal from chromatin.
R-MMU-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-MMU-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-MMU-69481. G2/M Checkpoints.
R-MMU-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-MMU-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiP97371.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022216.
CleanExiMM_PSME1.
ExpressionAtlasiP97371. baseline and differential.
GenevisibleiP97371. MM.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view]
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPSME1_MOUSE
AccessioniPrimary (citable) accession number: P97371
Secondary accession number(s): O35561, Q9D841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.