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P97371

- PSME1_MOUSE

UniProt

P97371 - PSME1_MOUSE

Protein

Proteasome activator complex subunit 1

Gene

Psme1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

    GO - Molecular functioni

    1. endopeptidase activator activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation of exogenous antigen Source: MGI
    2. positive regulation of endopeptidase activity Source: GOC

    Enzyme and pathway databases

    ReactomeiREACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_199105. ER-Phagosome pathway.
    REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_199121. Activation of NF-kappaB in B cells.
    REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_203973. Asymmetric localization of PCP proteins.
    REACT_207679. Separation of Sister Chromatids.
    REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_219129. degradation of AXIN.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_227429. degradation of DVL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome activator complex subunit 1
    Alternative name(s):
    11S regulator complex subunit alpha
    Short name:
    REG-alpha
    Activator of multicatalytic protease subunit 1
    Proteasome activator 28 subunit alpha
    Short name:
    PA28a
    Short name:
    PA28alpha
    Gene namesi
    Name:Psme1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1096367. Psme1.

    Subcellular locationi

    GO - Cellular componenti

    1. proteasome activator complex Source: InterPro

    Keywords - Cellular componenti

    Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Proteasome activator complex subunit 1PRO_0000161781Add
    BLAST

    Proteomic databases

    MaxQBiP97371.
    PaxDbiP97371.
    PRIDEiP97371.

    PTM databases

    PhosphoSiteiP97371.

    Expressioni

    Inductioni

    By interferon gamma.

    Gene expression databases

    ArrayExpressiP97371.
    BgeeiP97371.
    CleanExiMM_PSME1.
    GenevestigatoriP97371.

    Interactioni

    Subunit structurei

    Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers By similarity.By similarity

    Protein-protein interaction databases

    BioGridi202432. 1 interaction.
    IntActiP97371. 3 interactions.
    MINTiMINT-1844401.
    STRINGi10090.ENSMUSP00000087046.

    Structurei

    3D structure databases

    ProteinModelPortaliP97371.
    SMRiP97371. Positions 4-63, 104-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PA28 family.Curated

    Phylogenomic databases

    eggNOGiNOG265006.
    HOGENOMiHOG000282822.
    HOVERGENiHBG053745.
    InParanoidiP97371.
    KOiK06696.
    OMAiTQISKYY.
    PhylomeDBiP97371.
    TreeFamiTF106236.

    Family and domain databases

    Gene3Di1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProiIPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view]
    PANTHERiPTHR10660. PTHR10660. 1 hit.
    PfamiPF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF47216. SSF47216. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P97371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN    50
    EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP 100
    CGPVNCNEKI VVLLQRLKPE IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV 150
    AVQEKVFELM TNLHTKLEGF HTQISKYFSE RGDAVAKAAK QPHVGDYRQL 200
    VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY 249
    Length:249
    Mass (Da):28,673
    Last modified:August 29, 2001 - v2
    Checksum:i1E2CE09DA44A5346
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171F → L in BAB25712. (PubMed:16141072)Curated
    Sequence conflicti97 – 971K → E in BAB25712. (PubMed:16141072)Curated
    Sequence conflicti151 – 1511A → S in AAC53295. (PubMed:9162094)Curated
    Sequence conflicti156 – 1561V → L in AAC53295. (PubMed:9162094)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87909 mRNA. Translation: BAA22039.1.
    U60328 mRNA. Translation: AAC53295.1.
    AB007136 Genomic DNA. Translation: BAA28835.1.
    AB053120 Genomic DNA. Translation: BAB47403.1.
    AK019390 mRNA. Translation: BAB31696.1.
    AK008514 mRNA. Translation: BAB25712.1.
    CCDSiCCDS36931.1.
    RefSeqiNP_035319.1. NM_011189.1.
    UniGeneiMm.830.

    Genome annotation databases

    EnsembliENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216.
    GeneIDi19186.
    KEGGimmu:19186.
    UCSCiuc007tzd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87909 mRNA. Translation: BAA22039.1 .
    U60328 mRNA. Translation: AAC53295.1 .
    AB007136 Genomic DNA. Translation: BAA28835.1 .
    AB053120 Genomic DNA. Translation: BAB47403.1 .
    AK019390 mRNA. Translation: BAB31696.1 .
    AK008514 mRNA. Translation: BAB25712.1 .
    CCDSi CCDS36931.1.
    RefSeqi NP_035319.1. NM_011189.1.
    UniGenei Mm.830.

    3D structure databases

    ProteinModelPortali P97371.
    SMRi P97371. Positions 4-63, 104-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202432. 1 interaction.
    IntActi P97371. 3 interactions.
    MINTi MINT-1844401.
    STRINGi 10090.ENSMUSP00000087046.

    PTM databases

    PhosphoSitei P97371.

    Proteomic databases

    MaxQBi P97371.
    PaxDbi P97371.
    PRIDEi P97371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000174259 ; ENSMUSP00000134735 ; ENSMUSG00000022216 .
    GeneIDi 19186.
    KEGGi mmu:19186.
    UCSCi uc007tzd.1. mouse.

    Organism-specific databases

    CTDi 5720.
    MGIi MGI:1096367. Psme1.

    Phylogenomic databases

    eggNOGi NOG265006.
    HOGENOMi HOG000282822.
    HOVERGENi HBG053745.
    InParanoidi P97371.
    KOi K06696.
    OMAi TQISKYY.
    PhylomeDBi P97371.
    TreeFami TF106236.

    Enzyme and pathway databases

    Reactomei REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_199105. ER-Phagosome pathway.
    REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_199121. Activation of NF-kappaB in B cells.
    REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_203973. Asymmetric localization of PCP proteins.
    REACT_207679. Separation of Sister Chromatids.
    REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_219129. degradation of AXIN.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_227429. degradation of DVL.

    Miscellaneous databases

    NextBioi 295890.
    PROi P97371.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97371.
    Bgeei P97371.
    CleanExi MM_PSME1.
    Genevestigatori P97371.

    Family and domain databases

    Gene3Di 1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProi IPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view ]
    PANTHERi PTHR10660. PTHR10660. 1 hit.
    Pfami PF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47216. SSF47216. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes."
      Kandil E., Kohda K., Ishibashi T., Tanaka K., Kasahara M.
      Immunogenetics 46:337-344(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Spleen.
    2. "Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki."
      Jiang H., Monaco J.J.
      Immunogenetics 46:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.BR.
    3. "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
      Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
      J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    4. "Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes."
      Yawata M., Murata S., Tanaka K., Ishigatsubo Y., Kasahara M.
      Immunogenetics 53:119-129(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head and Small intestine.

    Entry informationi

    Entry nameiPSME1_MOUSE
    AccessioniPrimary (citable) accession number: P97371
    Secondary accession number(s): O35561, Q9D841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3