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P97371

- PSME1_MOUSE

UniProt

P97371 - PSME1_MOUSE

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Protein

Proteasome activator complex subunit 1

Gene

Psme1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

  1. endopeptidase activator activity Source: MGI

GO - Biological processi

  1. antigen processing and presentation of exogenous antigen Source: MGI
  2. positive regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_199105. ER-Phagosome pathway.
REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_199121. Activation of NF-kappaB in B cells.
REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
REACT_203973. Asymmetric localization of PCP proteins.
REACT_207679. Separation of Sister Chromatids.
REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_219129. degradation of AXIN.
REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_227429. degradation of DVL.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 1
Alternative name(s):
11S regulator complex subunit alpha
Short name:
REG-alpha
Activator of multicatalytic protease subunit 1
Proteasome activator 28 subunit alpha
Short name:
PA28a
Short name:
PA28alpha
Gene namesi
Name:Psme1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1096367. Psme1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. proteasome activator complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Proteasome activator complex subunit 1PRO_0000161781Add
BLAST

Proteomic databases

MaxQBiP97371.
PaxDbiP97371.
PRIDEiP97371.

PTM databases

PhosphoSiteiP97371.

Expressioni

Inductioni

By interferon gamma.

Gene expression databases

BgeeiP97371.
CleanExiMM_PSME1.
ExpressionAtlasiP97371. baseline and differential.
GenevestigatoriP97371.

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).By similarity

Protein-protein interaction databases

BioGridi202432. 1 interaction.
IntActiP97371. 3 interactions.
MINTiMINT-1844401.
STRINGi10090.ENSMUSP00000087046.

Structurei

3D structure databases

ProteinModelPortaliP97371.
SMRiP97371. Positions 4-63, 104-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiNOG265006.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
InParanoidiP97371.
KOiK06696.
OMAiTQISKYY.
PhylomeDBiP97371.
TreeFamiTF106236.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view]
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMiSSF47216. SSF47216. 2 hits.

Sequencei

Sequence statusi: Complete.

P97371-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN
60 70 80 90 100
EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP
110 120 130 140 150
CGPVNCNEKI VVLLQRLKPE IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV
160 170 180 190 200
AVQEKVFELM TNLHTKLEGF HTQISKYFSE RGDAVAKAAK QPHVGDYRQL
210 220 230 240
VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
Length:249
Mass (Da):28,673
Last modified:August 29, 2001 - v2
Checksum:i1E2CE09DA44A5346
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171F → L in BAB25712. (PubMed:16141072)Curated
Sequence conflicti97 – 971K → E in BAB25712. (PubMed:16141072)Curated
Sequence conflicti151 – 1511A → S in AAC53295. (PubMed:9162094)Curated
Sequence conflicti156 – 1561V → L in AAC53295. (PubMed:9162094)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87909 mRNA. Translation: BAA22039.1.
U60328 mRNA. Translation: AAC53295.1.
AB007136 Genomic DNA. Translation: BAA28835.1.
AB053120 Genomic DNA. Translation: BAB47403.1.
AK019390 mRNA. Translation: BAB31696.1.
AK008514 mRNA. Translation: BAB25712.1.
CCDSiCCDS36931.1.
RefSeqiNP_035319.1. NM_011189.1.
UniGeneiMm.830.

Genome annotation databases

EnsembliENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216.
GeneIDi19186.
KEGGimmu:19186.
UCSCiuc007tzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87909 mRNA. Translation: BAA22039.1 .
U60328 mRNA. Translation: AAC53295.1 .
AB007136 Genomic DNA. Translation: BAA28835.1 .
AB053120 Genomic DNA. Translation: BAB47403.1 .
AK019390 mRNA. Translation: BAB31696.1 .
AK008514 mRNA. Translation: BAB25712.1 .
CCDSi CCDS36931.1.
RefSeqi NP_035319.1. NM_011189.1.
UniGenei Mm.830.

3D structure databases

ProteinModelPortali P97371.
SMRi P97371. Positions 4-63, 104-242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202432. 1 interaction.
IntActi P97371. 3 interactions.
MINTi MINT-1844401.
STRINGi 10090.ENSMUSP00000087046.

PTM databases

PhosphoSitei P97371.

Proteomic databases

MaxQBi P97371.
PaxDbi P97371.
PRIDEi P97371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000174259 ; ENSMUSP00000134735 ; ENSMUSG00000022216 .
GeneIDi 19186.
KEGGi mmu:19186.
UCSCi uc007tzd.1. mouse.

Organism-specific databases

CTDi 5720.
MGIi MGI:1096367. Psme1.

Phylogenomic databases

eggNOGi NOG265006.
HOGENOMi HOG000282822.
HOVERGENi HBG053745.
InParanoidi P97371.
KOi K06696.
OMAi TQISKYY.
PhylomeDBi P97371.
TreeFami TF106236.

Enzyme and pathway databases

Reactomei REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_199105. ER-Phagosome pathway.
REACT_199114. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_199121. Activation of NF-kappaB in B cells.
REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
REACT_203973. Asymmetric localization of PCP proteins.
REACT_207679. Separation of Sister Chromatids.
REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_219129. degradation of AXIN.
REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_227429. degradation of DVL.

Miscellaneous databases

NextBioi 295890.
PROi P97371.
SOURCEi Search...

Gene expression databases

Bgeei P97371.
CleanExi MM_PSME1.
ExpressionAtlasi P97371. baseline and differential.
Genevestigatori P97371.

Family and domain databases

Gene3Di 1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProi IPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view ]
PANTHERi PTHR10660. PTHR10660. 1 hit.
Pfami PF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF47216. SSF47216. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes."
    Kandil E., Kohda K., Ishibashi T., Tanaka K., Kasahara M.
    Immunogenetics 46:337-344(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  2. "Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki."
    Jiang H., Monaco J.J.
    Immunogenetics 46:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.BR.
  3. "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
    Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
    J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  4. "Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes."
    Yawata M., Murata S., Tanaka K., Ishigatsubo Y., Kasahara M.
    Immunogenetics 53:119-129(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head and Small intestine.

Entry informationi

Entry nameiPSME1_MOUSE
AccessioniPrimary (citable) accession number: P97371
Secondary accession number(s): O35561, Q9D841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3