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P97371 (PSME1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome activator complex subunit 1
Alternative name(s):
11S regulator complex subunit alpha
Short name=REG-alpha
Activator of multicatalytic protease subunit 1
Proteasome activator 28 subunit alpha
Short name=PA28a
Short name=PA28alpha
Gene names
Name:Psme1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

Subunit structure

Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers By similarity.

Induction

By interferon gamma.

Sequence similarities

Belongs to the PA28 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Proteasome activator complex subunit 1
PRO_0000161781

Experimental info

Sequence conflict171F → L in BAB25712. Ref.5
Sequence conflict971K → E in BAB25712. Ref.5
Sequence conflict1511A → S in AAC53295. Ref.2
Sequence conflict1561V → L in AAC53295. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P97371 [UniParc].

Last modified August 29, 2001. Version 2.
Checksum: 1E2CE09DA44A5346

FASTA24928,673
        10         20         30         40         50         60 
MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP 

        70         80         90        100        110        120 
LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP CGPVNCNEKI VVLLQRLKPE 

       130        140        150        160        170        180 
IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TNLHTKLEGF HTQISKYFSE 

       190        200        210        220        230        240 
RGDAVAKAAK QPHVGDYRQL VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP 


RGETKGMIY 

« Hide

References

« Hide 'large scale' references
[1]"PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes."
Kandil E., Kohda K., Ishibashi T., Tanaka K., Kasahara M.
Immunogenetics 46:337-344(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Spleen.
[2]"Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki."
Jiang H., Monaco J.J.
Immunogenetics 46:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.BR.
[3]"Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes."
Kohda K., Ishibashi T., Shimbara N., Tanaka K., Matsuda Y., Kasahara M.
J. Immunol. 160:4923-4935(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[4]"Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes."
Yawata M., Murata S., Tanaka K., Ishigatsubo Y., Kasahara M.
Immunogenetics 53:119-129(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic head and Small intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87909 mRNA. Translation: BAA22039.1.
U60328 mRNA. Translation: AAC53295.1.
AB007136 Genomic DNA. Translation: BAA28835.1.
AB053120 Genomic DNA. Translation: BAB47403.1.
AK019390 mRNA. Translation: BAB31696.1.
AK008514 mRNA. Translation: BAB25712.1.
CCDSCCDS36931.1.
RefSeqNP_035319.1. NM_011189.1.
UniGeneMm.830.

3D structure databases

ProteinModelPortalP97371.
SMRP97371. Positions 4-63, 104-242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202432. 1 interaction.
IntActP97371. 3 interactions.
MINTMINT-1844401.
STRING10090.ENSMUSP00000087046.

PTM databases

PhosphoSiteP97371.

Proteomic databases

MaxQBP97371.
PaxDbP97371.
PRIDEP97371.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216.
GeneID19186.
KEGGmmu:19186.
UCSCuc007tzd.1. mouse.

Organism-specific databases

CTD5720.
MGIMGI:1096367. Psme1.

Phylogenomic databases

eggNOGNOG265006.
HOGENOMHOG000282822.
HOVERGENHBG053745.
InParanoidP97371.
KOK06696.
OMATQISKYY.
PhylomeDBP97371.
TreeFamTF106236.

Gene expression databases

ArrayExpressP97371.
BgeeP97371.
CleanExMM_PSME1.
GenevestigatorP97371.

Family and domain databases

Gene3D1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProIPR009077. Proteasome_activ_pa28.
IPR003186. Proteasome_activ_pa28_C.
IPR003185. Proteasome_activ_pa28_N.
[Graphical view]
PANTHERPTHR10660. PTHR10660. 1 hit.
PfamPF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
[Graphical view]
SUPFAMSSF47216. SSF47216. 2 hits.
ProtoNetSearch...

Other

NextBio295890.
PROP97371.
SOURCESearch...

Entry information

Entry namePSME1_MOUSE
AccessionPrimary (citable) accession number: P97371
Secondary accession number(s): O35561, Q9D841
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot