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P97370

- AT1B3_MOUSE

UniProt

P97370 - AT1B3_MOUSE

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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

  1. sodium:potassium-exchanging ATPase activity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiREACT_211508. Basigin interactions.
REACT_250224. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:Atp1b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:107788. Atp1b3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini57 – 278222ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. sodium:potassium-exchanging ATPase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Sodium/potassium-transporting ATPase subunit beta-3PRO_0000219109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Disulfide bondi191 ↔ 249By similarity
Glycosylationi197 – 1971N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP97370.
PaxDbiP97370.
PRIDEiP97370.

PTM databases

PhosphoSiteiP97370.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiP97370.
CleanExiMM_ATP1B3.
ExpressionAtlasiP97370. baseline and differential.
GenevestigatoriP97370.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP97370.
SMRiP97370. Positions 16-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 27893immunoglobulin-likeBy similarityAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263581.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP97370.
KOiK01540.
OMAiLMISPKP.
OrthoDBiEOG7M6D85.
PhylomeDBiP97370.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97370-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWA MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP
110 120 130 140 150
QTYKKLVEDL ESFLKPYSVE EQKNLTSCPD GAPFIQHGPD YRACQFPVSL
160 170 180 190 200
LEECSGVTDA NFGYSKGQPC ILVKMNRIID LIPDGYPQIS CLPKEENATI
210 220 230 240 250
ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL NKKEVTVECH
260 270
IAGTRNLKNK NERDKFLGRV SFKVTARA
Length:278
Mass (Da):31,776
Last modified:May 1, 1997 - v1
Checksum:i98A46FF6EDA85AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59761 mRNA. Translation: AAC00019.1.
CCDSiCCDS23414.1.
RefSeqiNP_031528.1. NM_007502.4.
UniGeneiMm.424.

Genome annotation databases

EnsembliENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412.
GeneIDi11933.
KEGGimmu:11933.
UCSCiuc009rck.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59761 mRNA. Translation: AAC00019.1 .
CCDSi CCDS23414.1.
RefSeqi NP_031528.1. NM_007502.4.
UniGenei Mm.424.

3D structure databases

ProteinModelPortali P97370.
SMRi P97370. Positions 16-278.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P97370.

Proteomic databases

MaxQBi P97370.
PaxDbi P97370.
PRIDEi P97370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034983 ; ENSMUSP00000034983 ; ENSMUSG00000032412 .
GeneIDi 11933.
KEGGi mmu:11933.
UCSCi uc009rck.2. mouse.

Organism-specific databases

CTDi 483.
MGIi MGI:107788. Atp1b3.

Phylogenomic databases

eggNOGi NOG263581.
HOGENOMi HOG000039248.
HOVERGENi HBG050603.
InParanoidi P97370.
KOi K01540.
OMAi LMISPKP.
OrthoDBi EOG7M6D85.
PhylomeDBi P97370.
TreeFami TF314618.

Enzyme and pathway databases

Reactomei REACT_211508. Basigin interactions.
REACT_250224. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi Atp1b3. mouse.
NextBioi 280025.
PROi P97370.
SOURCEi Search...

Gene expression databases

Bgeei P97370.
CleanExi MM_ATP1B3.
ExpressionAtlasi P97370. baseline and differential.
Genevestigatori P97370.

Family and domain databases

InterProi IPR000402. Na/K_ATPase_sub_beta.
[Graphical view ]
PANTHERi PTHR11523. PTHR11523. 1 hit.
Pfami PF00287. Na_K-ATPase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel beta 3 isoform of the Na,K-ATPase beta subunit from mouse retina."
    Besirli C.G., Gong T.-W.L., Lomax M.I.
    Biochim. Biophys. Acta 1350:21-26(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Retina.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 18-31, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197.
    Tissue: Myoblast.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-197.

Entry informationi

Entry nameiAT1B3_MOUSE
AccessioniPrimary (citable) accession number: P97370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3