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P97370 (AT1B3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name=ATPB-3
CD_antigen=CD298
Gene names
Name:Atp1b3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma.

Subcellular location

Cell membrane; Single-pass type II membrane protein. Melanosome By similarity.

Tissue specificity

Widely expressed.

Domain

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties By similarity.

Sequence similarities

Belongs to the X(+)/potassium ATPases subunit beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Sodium/potassium-transporting ATPase subunit beta-3
PRO_0000219109

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain57 – 278222Extracellular Potential
Region186 – 27893immunoglobulin-like By similarity

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Ref.4
Glycosylation1971N-linked (GlcNAc...) Ref.3 Ref.4
Disulfide bond128 ↔ 144 By similarity
Disulfide bond154 ↔ 170 By similarity
Disulfide bond191 ↔ 249 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97370 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 98A46FF6EDA85AAC

FASTA27831,776
        10         20         30         40         50         60 
MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL AALFTFTMWA 

        70         80         90        100        110        120 
MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP QTYKKLVEDL ESFLKPYSVE 

       130        140        150        160        170        180 
EQKNLTSCPD GAPFIQHGPD YRACQFPVSL LEECSGVTDA NFGYSKGQPC ILVKMNRIID 

       190        200        210        220        230        240 
LIPDGYPQIS CLPKEENATI ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL 

       250        260        270 
NKKEVTVECH IAGTRNLKNK NERDKFLGRV SFKVTARA 

« Hide

References

« Hide 'large scale' references
[1]"Novel beta 3 isoform of the Na,K-ATPase beta subunit from mouse retina."
Besirli C.G., Gong T.-W.L., Lomax M.I.
Biochim. Biophys. Acta 1350:21-26(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Retina.
[2]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 18-31, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[3]"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197.
Tissue: Myoblast.
[4]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-197.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59761 mRNA. Translation: AAC00019.1.
CCDSCCDS23414.1.
RefSeqNP_031528.1. NM_007502.4.
UniGeneMm.424.

3D structure databases

ProteinModelPortalP97370.
SMRP97370. Positions 16-278.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP97370.

Proteomic databases

MaxQBP97370.
PaxDbP97370.
PRIDEP97370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412.
GeneID11933.
KEGGmmu:11933.
UCSCuc009rck.2. mouse.

Organism-specific databases

CTD483.
MGIMGI:107788. Atp1b3.

Phylogenomic databases

eggNOGNOG263581.
HOGENOMHOG000039248.
HOVERGENHBG050603.
InParanoidP97370.
KOK01540.
OMALMISPKP.
OrthoDBEOG7M6D85.
PhylomeDBP97370.
TreeFamTF314618.

Gene expression databases

ArrayExpressP97370.
BgeeP97370.
CleanExMM_ATP1B3.
GenevestigatorP97370.

Family and domain databases

InterProIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERPTHR11523. PTHR11523. 1 hit.
PfamPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP1B3. mouse.
NextBio280025.
PROP97370.
SOURCESearch...

Entry information

Entry nameAT1B3_MOUSE
AccessionPrimary (citable) accession number: P97370
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot