Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97370

- AT1B3_MOUSE

UniProt

P97370 - AT1B3_MOUSE

Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sodium:potassium-exchanging ATPase activity Source: Ensembl

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    Potassium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-3
    Alternative name(s):
    Sodium/potassium-dependent ATPase subunit beta-3
    Short name:
    ATPB-3
    CD_antigen: CD298
    Gene namesi
    Name:Atp1b3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:107788. Atp1b3.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. cytoplasm Source: MGI
    3. melanosome Source: UniProtKB-SubCell
    4. sodium:potassium-exchanging ATPase complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Sodium/potassium-transporting ATPase subunit beta-3PRO_0000219109Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
    Disulfide bondi128 ↔ 144By similarity
    Disulfide bondi154 ↔ 170By similarity
    Disulfide bondi191 ↔ 249By similarity
    Glycosylationi197 – 1971N-linked (GlcNAc...)2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP97370.
    PaxDbiP97370.
    PRIDEiP97370.

    PTM databases

    PhosphoSiteiP97370.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiP97370.
    BgeeiP97370.
    CleanExiMM_ATP1B3.
    GenevestigatoriP97370.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP97370.
    SMRiP97370. Positions 16-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 278222ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni186 – 27893immunoglobulin-likeBy similarityAdd
    BLAST

    Domaini

    The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263581.
    HOGENOMiHOG000039248.
    HOVERGENiHBG050603.
    InParanoidiP97370.
    KOiK01540.
    OMAiLMISPKP.
    OrthoDBiEOG7M6D85.
    PhylomeDBiP97370.
    TreeFamiTF314618.

    Family and domain databases

    InterProiIPR000402. Na/K_ATPase_sub_beta.
    [Graphical view]
    PANTHERiPTHR11523. PTHR11523. 1 hit.
    PfamiPF00287. Na_K-ATPase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97370-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL    50
    AALFTFTMWA MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP 100
    QTYKKLVEDL ESFLKPYSVE EQKNLTSCPD GAPFIQHGPD YRACQFPVSL 150
    LEECSGVTDA NFGYSKGQPC ILVKMNRIID LIPDGYPQIS CLPKEENATI 200
    ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL NKKEVTVECH 250
    IAGTRNLKNK NERDKFLGRV SFKVTARA 278
    Length:278
    Mass (Da):31,776
    Last modified:May 1, 1997 - v1
    Checksum:i98A46FF6EDA85AAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59761 mRNA. Translation: AAC00019.1.
    CCDSiCCDS23414.1.
    RefSeqiNP_031528.1. NM_007502.4.
    UniGeneiMm.424.

    Genome annotation databases

    EnsembliENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412.
    GeneIDi11933.
    KEGGimmu:11933.
    UCSCiuc009rck.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59761 mRNA. Translation: AAC00019.1 .
    CCDSi CCDS23414.1.
    RefSeqi NP_031528.1. NM_007502.4.
    UniGenei Mm.424.

    3D structure databases

    ProteinModelPortali P97370.
    SMRi P97370. Positions 16-278.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P97370.

    Proteomic databases

    MaxQBi P97370.
    PaxDbi P97370.
    PRIDEi P97370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034983 ; ENSMUSP00000034983 ; ENSMUSG00000032412 .
    GeneIDi 11933.
    KEGGi mmu:11933.
    UCSCi uc009rck.2. mouse.

    Organism-specific databases

    CTDi 483.
    MGIi MGI:107788. Atp1b3.

    Phylogenomic databases

    eggNOGi NOG263581.
    HOGENOMi HOG000039248.
    HOVERGENi HBG050603.
    InParanoidi P97370.
    KOi K01540.
    OMAi LMISPKP.
    OrthoDBi EOG7M6D85.
    PhylomeDBi P97370.
    TreeFami TF314618.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    ChiTaRSi ATP1B3. mouse.
    NextBioi 280025.
    PROi P97370.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97370.
    Bgeei P97370.
    CleanExi MM_ATP1B3.
    Genevestigatori P97370.

    Family and domain databases

    InterProi IPR000402. Na/K_ATPase_sub_beta.
    [Graphical view ]
    PANTHERi PTHR11523. PTHR11523. 1 hit.
    Pfami PF00287. Na_K-ATPase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01107. Na_K_ATPase_bet. 1 hit.
    PROSITEi PS00390. ATPASE_NA_K_BETA_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel beta 3 isoform of the Na,K-ATPase beta subunit from mouse retina."
      Besirli C.G., Gong T.-W.L., Lomax M.I.
      Biochim. Biophys. Acta 1350:21-26(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Retina.
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 18-31, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197.
      Tissue: Myoblast.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-197.

    Entry informationi

    Entry nameiAT1B3_MOUSE
    AccessioniPrimary (citable) accession number: P97370
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3