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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991 Basigin interactions
R-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:Atp1b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107788 Atp1b3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 278ExtracellularSequence analysisAdd BLAST222

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191091 – 278Sodium/potassium-transporting ATPase subunit beta-3Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Disulfide bondi191 ↔ 249By similarity
Glycosylationi197N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP97370
PaxDbiP97370
PeptideAtlasiP97370
PRIDEiP97370

PTM databases

iPTMnetiP97370
PhosphoSitePlusiP97370
SwissPalmiP97370

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000032412
CleanExiMM_ATP1B3
ExpressionAtlasiP97370 baseline and differential
GenevisibleiP97370 MM

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97370 2 interactors.
STRINGi10090.ENSMUSP00000034983

Structurei

3D structure databases

ProteinModelPortaliP97370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 278immunoglobulin-likeBy similarityAdd BLAST93

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP97370
KOiK01540
OMAiLMISPKP
OrthoDBiEOG091G0DJ4
PhylomeDBiP97370
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.16601 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit

Sequencei

Sequence statusi: Complete.

P97370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWA MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP
110 120 130 140 150
QTYKKLVEDL ESFLKPYSVE EQKNLTSCPD GAPFIQHGPD YRACQFPVSL
160 170 180 190 200
LEECSGVTDA NFGYSKGQPC ILVKMNRIID LIPDGYPQIS CLPKEENATI
210 220 230 240 250
ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL NKKEVTVECH
260 270
IAGTRNLKNK NERDKFLGRV SFKVTARA
Length:278
Mass (Da):31,776
Last modified:May 1, 1997 - v1
Checksum:i98A46FF6EDA85AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59761 mRNA Translation: AAC00019.1
CCDSiCCDS23414.1
RefSeqiNP_031528.1, NM_007502.4
UniGeneiMm.424

Genome annotation databases

EnsembliENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412
GeneIDi11933
KEGGimmu:11933
UCSCiuc009rck.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAT1B3_MOUSE
AccessioniPrimary (citable) accession number: P97370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome