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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

Atp1b3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name:
ATPB-3
CD_antigen: CD298
Gene namesi
Name:Atp1b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107788. Atp1b3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini57 – 278ExtracellularSequence analysisAdd BLAST222

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191091 – 278Sodium/potassium-transporting ATPase subunit beta-3Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)1 Publication1
Disulfide bondi128 ↔ 144By similarity
Disulfide bondi154 ↔ 170By similarity
Disulfide bondi191 ↔ 249By similarity
Glycosylationi197N-linked (GlcNAc...)2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP97370.
PaxDbiP97370.
PeptideAtlasiP97370.
PRIDEiP97370.

PTM databases

iPTMnetiP97370.
PhosphoSitePlusiP97370.
SwissPalmiP97370.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000032412.
CleanExiMM_ATP1B3.
ExpressionAtlasiP97370. baseline and differential.
GenevisibleiP97370. MM.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034983.

Structurei

3D structure databases

ProteinModelPortaliP97370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 278immunoglobulin-likeBy similarityAdd BLAST93

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP97370.
KOiK01540.
OMAiHQSLAEW.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP97370.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWA MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP
110 120 130 140 150
QTYKKLVEDL ESFLKPYSVE EQKNLTSCPD GAPFIQHGPD YRACQFPVSL
160 170 180 190 200
LEECSGVTDA NFGYSKGQPC ILVKMNRIID LIPDGYPQIS CLPKEENATI
210 220 230 240 250
ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL NKKEVTVECH
260 270
IAGTRNLKNK NERDKFLGRV SFKVTARA
Length:278
Mass (Da):31,776
Last modified:May 1, 1997 - v1
Checksum:i98A46FF6EDA85AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59761 mRNA. Translation: AAC00019.1.
CCDSiCCDS23414.1.
RefSeqiNP_031528.1. NM_007502.4.
UniGeneiMm.424.

Genome annotation databases

EnsembliENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412.
GeneIDi11933.
KEGGimmu:11933.
UCSCiuc009rck.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59761 mRNA. Translation: AAC00019.1.
CCDSiCCDS23414.1.
RefSeqiNP_031528.1. NM_007502.4.
UniGeneiMm.424.

3D structure databases

ProteinModelPortaliP97370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034983.

PTM databases

iPTMnetiP97370.
PhosphoSitePlusiP97370.
SwissPalmiP97370.

Proteomic databases

EPDiP97370.
PaxDbiP97370.
PeptideAtlasiP97370.
PRIDEiP97370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034983; ENSMUSP00000034983; ENSMUSG00000032412.
GeneIDi11933.
KEGGimmu:11933.
UCSCiuc009rck.2. mouse.

Organism-specific databases

CTDi483.
MGIiMGI:107788. Atp1b3.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP97370.
KOiK01540.
OMAiHQSLAEW.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP97370.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp1b3. mouse.
PROiP97370.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032412.
CleanExiMM_ATP1B3.
ExpressionAtlasiP97370. baseline and differential.
GenevisibleiP97370. MM.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B3_MOUSE
AccessioniPrimary (citable) accession number: P97370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.