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P97364

- SPS2_MOUSE

UniProt

P97364 - SPS2_MOUSE

Protein

Selenide, water dikinase 2

Gene

Sephs2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Synthesizes selenophosphate from selenide and ATP.

    Catalytic activityi

    ATP + selenide + H2O = AMP + selenophosphate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Sequence Analysis
    Sitei66 – 661Important for catalytic activityBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi322 – 3287ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. selenide, water dikinase activity Source: MGI

    GO - Biological processi

    1. selenium compound metabolic process Source: MGI
    2. selenocysteine biosynthetic process Source: MGI

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, Selenium

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14949.
    BRENDAi2.7.9.3. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Selenide, water dikinase 2 (EC:2.7.9.3)
    Alternative name(s):
    Selenium donor protein 2
    Selenophosphate synthase 2
    Gene namesi
    Name:Sephs2
    Synonyms:Sps2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:108388. Sephs2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 452451Selenide, water dikinase 2PRO_0000127651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP97364.
    PaxDbiP97364.
    PRIDEiP97364.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00124181.

    PTM databases

    PhosphoSiteiP97364.

    Expressioni

    Gene expression databases

    BgeeiP97364.
    CleanExiMM_SEPHS2.
    GenevestigatoriP97364.

    Interactioni

    Protein-protein interaction databases

    IntActiP97364. 2 interactions.
    MINTiMINT-1865888.

    Structurei

    3D structure databases

    ProteinModelPortaliP97364.
    SMRiP97364. Positions 41-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 98Poly-Ala
    Compositional biasi433 – 4408Poly-Ala

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0709.
    GeneTreeiENSGT00390000000950.
    HOGENOMiHOG000219301.
    HOVERGENiHBG001207.
    InParanoidiP97364.
    KOiK01008.
    OMAiSVSQKMN.
    OrthoDBiEOG7SR4MT.
    PhylomeDBiP97364.
    TreeFamiTF313811.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR016188. PurM_N-like.
    IPR004536. SelD.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00476. selD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97364-1 [UniParc]FASTAAdd to Basket

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    MAEAAAAGAS GETMAALVAA EGSLGPAGWS AGRSFSNYRP FEPQTLGFSP    50
    SWRLTSFSGM KGUGCKVPQE TLLKLLEGLT RPALQPPLTS GLVGGQEETV 100
    QEGGLSTRPG PGSAFPSLSI GMDSCVIPLR HGGLSLVQTT DFFYPLVEDP 150
    YMMGRIACAN VLSDLYAMGI TECDNMLMLL SVSQSMSEKE REKVTPLMIK 200
    GFRDAAEEGG TAVTGGQTVV NPWIIIGGVA TVVCQQNEFI MPDSAVVGDV 250
    LVLTKPLGTQ VAANAHQWLD NPEKWNKIKM VVSREEVELA YQEAMFNMAT 300
    LNRTAAGLMH TFNAHAATDI TGFGILGHSQ NLAKQQKNEV SFVIHNLPII 350
    AKMAAISKAS GRFGLLQGTS AETSGGLLIC LPREQAARFC SEIKSSKYGE 400
    GHQAWIVGIV EKGNRTARII DKPRVIEVLP RGASAAAAAA PDNSNAASEP 450
    SS 452
    Length:452
    Mass (Da):47,834
    Last modified:February 26, 2008 - v3
    Checksum:iCF82585D01ABE3BF
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei63 – 631Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43285 mRNA. Translation: AAC53024.2.
    AK149516 mRNA. Translation: BAE28931.1.
    AK168722 mRNA. Translation: BAE40564.1.
    AK168965 mRNA. Translation: BAE40770.1.
    BC016508 mRNA. Translation: AAH16508.1.
    BC028966 mRNA. Translation: AAH28966.1.
    BC043334 mRNA. Translation: AAH43334.2.
    CCDSiCCDS21863.1.
    RefSeqiNP_033292.2. NM_009266.3.
    UniGeneiMm.20294.

    Genome annotation databases

    EnsembliENSMUST00000082428; ENSMUSP00000081009; ENSMUSG00000049091.
    GeneIDi20768.
    KEGGimmu:20768.
    UCSCiuc009jux.2. mouse.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43285 mRNA. Translation: AAC53024.2 .
    AK149516 mRNA. Translation: BAE28931.1 .
    AK168722 mRNA. Translation: BAE40564.1 .
    AK168965 mRNA. Translation: BAE40770.1 .
    BC016508 mRNA. Translation: AAH16508.1 .
    BC028966 mRNA. Translation: AAH28966.1 .
    BC043334 mRNA. Translation: AAH43334.2 .
    CCDSi CCDS21863.1.
    RefSeqi NP_033292.2. NM_009266.3.
    UniGenei Mm.20294.

    3D structure databases

    ProteinModelPortali P97364.
    SMRi P97364. Positions 41-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97364. 2 interactions.
    MINTi MINT-1865888.

    PTM databases

    PhosphoSitei P97364.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00124181.

    Proteomic databases

    MaxQBi P97364.
    PaxDbi P97364.
    PRIDEi P97364.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082428 ; ENSMUSP00000081009 ; ENSMUSG00000049091 .
    GeneIDi 20768.
    KEGGi mmu:20768.
    UCSCi uc009jux.2. mouse.

    Organism-specific databases

    CTDi 22928.
    MGIi MGI:108388. Sephs2.

    Phylogenomic databases

    eggNOGi COG0709.
    GeneTreei ENSGT00390000000950.
    HOGENOMi HOG000219301.
    HOVERGENi HBG001207.
    InParanoidi P97364.
    KOi K01008.
    OMAi SVSQKMN.
    OrthoDBi EOG7SR4MT.
    PhylomeDBi P97364.
    TreeFami TF313811.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14949.
    BRENDAi 2.7.9.3. 3474.

    Miscellaneous databases

    NextBioi 299475.
    PROi P97364.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97364.
    CleanExi MM_SEPHS2.
    Genevestigatori P97364.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR016188. PurM_N-like.
    IPR004536. SelD.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00476. selD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies."
      Guimaraes M.J., Bazan J.F., Zlotnik A., Wiles M.V., Grimaldi J.C., Lee F., McClanahan T.
      Development 121:3335-3346(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?"
      Guimaraes M.J., Peterson D., Vicari A., Cocks B.G., Copeland N.G., Gilbert D.J., Jenkins N.A., Ferrick D.A., Kastelein R., Bazan J.F., Zlotnik A.
      Proc. Natl. Acad. Sci. U.S.A. 93:15086-15091(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Kidney and Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver and Salivary gland.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 353-362, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiSPS2_MOUSE
    AccessioniPrimary (citable) accession number: P97364
    Secondary accession number(s): Q3TGI4, Q80ZY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3