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Protein

Selenide, water dikinase 2

Gene

Sephs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Synthesizes selenophosphate from selenide and ATP.

Catalytic activityi

ATP + selenide + H2O = AMP + selenophosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Sequence analysis1
Sitei66Important for catalytic activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 328ATPSequence analysis7

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • selenide, water dikinase activity Source: MGI

GO - Biological processi

  • selenium compound metabolic process Source: MGI
  • selenocysteine biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Selenium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14949.
BRENDAi2.7.9.3. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenide, water dikinase 2 (EC:2.7.9.3)
Alternative name(s):
Selenium donor protein 2
Selenophosphate synthase 2
Gene namesi
Name:Sephs2
Synonyms:Sps2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108388. Sephs2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001276512 – 452Selenide, water dikinase 2Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP97364.
MaxQBiP97364.
PaxDbiP97364.
PeptideAtlasiP97364.
PRIDEiP97364.

2D gel databases

REPRODUCTION-2DPAGEIPI00124181.

PTM databases

iPTMnetiP97364.
PhosphoSitePlusiP97364.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049091.
CleanExiMM_SEPHS2.
GenevisibleiP97364. MM.

Interactioni

Protein-protein interaction databases

IntActiP97364. 2 interactors.
MINTiMINT-1865888.
STRINGi10090.ENSMUSP00000081009.

Structurei

3D structure databases

ProteinModelPortaliP97364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 9Poly-Ala8
Compositional biasi433 – 440Poly-Ala8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3939. Eukaryota.
COG0709. LUCA.
GeneTreeiENSGT00390000000950.
HOGENOMiHOG000219301.
HOVERGENiHBG001207.
InParanoidiP97364.
KOiK01008.
OMAiSVSQKMN.
OrthoDBiEOG091G0B7N.
PhylomeDBiP97364.
TreeFamiTF313811.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004536. SPS/SelD.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAAAAGAS GETMAALVAA EGSLGPAGWS AGRSFSNYRP FEPQTLGFSP
60 70 80 90 100
SWRLTSFSGM KGUGCKVPQE TLLKLLEGLT RPALQPPLTS GLVGGQEETV
110 120 130 140 150
QEGGLSTRPG PGSAFPSLSI GMDSCVIPLR HGGLSLVQTT DFFYPLVEDP
160 170 180 190 200
YMMGRIACAN VLSDLYAMGI TECDNMLMLL SVSQSMSEKE REKVTPLMIK
210 220 230 240 250
GFRDAAEEGG TAVTGGQTVV NPWIIIGGVA TVVCQQNEFI MPDSAVVGDV
260 270 280 290 300
LVLTKPLGTQ VAANAHQWLD NPEKWNKIKM VVSREEVELA YQEAMFNMAT
310 320 330 340 350
LNRTAAGLMH TFNAHAATDI TGFGILGHSQ NLAKQQKNEV SFVIHNLPII
360 370 380 390 400
AKMAAISKAS GRFGLLQGTS AETSGGLLIC LPREQAARFC SEIKSSKYGE
410 420 430 440 450
GHQAWIVGIV EKGNRTARII DKPRVIEVLP RGASAAAAAA PDNSNAASEP

SS
Length:452
Mass (Da):47,834
Last modified:February 26, 2008 - v3
Checksum:iCF82585D01ABE3BF
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei63Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43285 mRNA. Translation: AAC53024.2.
AK149516 mRNA. Translation: BAE28931.1.
AK168722 mRNA. Translation: BAE40564.1.
AK168965 mRNA. Translation: BAE40770.1.
BC016508 mRNA. Translation: AAH16508.1.
BC028966 mRNA. Translation: AAH28966.1.
BC043334 mRNA. Translation: AAH43334.2.
CCDSiCCDS21863.1.
RefSeqiNP_033292.2. NM_009266.3.
UniGeneiMm.20294.

Genome annotation databases

EnsembliENSMUST00000082428; ENSMUSP00000081009; ENSMUSG00000049091.
GeneIDi20768.
KEGGimmu:20768.
UCSCiuc009jux.2. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43285 mRNA. Translation: AAC53024.2.
AK149516 mRNA. Translation: BAE28931.1.
AK168722 mRNA. Translation: BAE40564.1.
AK168965 mRNA. Translation: BAE40770.1.
BC016508 mRNA. Translation: AAH16508.1.
BC028966 mRNA. Translation: AAH28966.1.
BC043334 mRNA. Translation: AAH43334.2.
CCDSiCCDS21863.1.
RefSeqiNP_033292.2. NM_009266.3.
UniGeneiMm.20294.

3D structure databases

ProteinModelPortaliP97364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97364. 2 interactors.
MINTiMINT-1865888.
STRINGi10090.ENSMUSP00000081009.

PTM databases

iPTMnetiP97364.
PhosphoSitePlusiP97364.

2D gel databases

REPRODUCTION-2DPAGEIPI00124181.

Proteomic databases

EPDiP97364.
MaxQBiP97364.
PaxDbiP97364.
PeptideAtlasiP97364.
PRIDEiP97364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082428; ENSMUSP00000081009; ENSMUSG00000049091.
GeneIDi20768.
KEGGimmu:20768.
UCSCiuc009jux.2. mouse.

Organism-specific databases

CTDi22928.
MGIiMGI:108388. Sephs2.

Phylogenomic databases

eggNOGiKOG3939. Eukaryota.
COG0709. LUCA.
GeneTreeiENSGT00390000000950.
HOGENOMiHOG000219301.
HOVERGENiHBG001207.
InParanoidiP97364.
KOiK01008.
OMAiSVSQKMN.
OrthoDBiEOG091G0B7N.
PhylomeDBiP97364.
TreeFamiTF313811.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14949.
BRENDAi2.7.9.3. 3474.

Miscellaneous databases

PROiP97364.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049091.
CleanExiMM_SEPHS2.
GenevisibleiP97364. MM.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
InterProiIPR010918. AIR_synth_C_dom.
IPR016188. PurM-like_N.
IPR004536. SPS/SelD.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00476. selD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPS2_MOUSE
AccessioniPrimary (citable) accession number: P97364
Secondary accession number(s): Q3TGI4, Q80ZY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.