SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P97360

- ETV6_MOUSE

UniProt

P97360 - ETV6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcription factor ETV6

Gene
Etv6, Tel, Tel1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi335 – 41682ETSAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  5. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. regulation of transcription, DNA-templated Source: MGI
  3. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  4. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor ETV6
Alternative name(s):
ETS translocation variant 6
ETS-related protein Tel1
Short name:
Tel
Gene namesi
Name:Etv6
Synonyms:Tel, Tel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:109336. Etv6.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 485484Transcription factor ETV6PRO_0000204122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei11 – 111N6-acetyllysine By similarity
Modified residuei18 – 181Phosphothreonine By similarity
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei215 – 2151Phosphoserine By similarity
Modified residuei251 – 2511Phosphoserine By similarity
Modified residuei298 – 2981N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97360.
PaxDbiP97360.
PRIDEiP97360.

PTM databases

PhosphoSiteiP97360.

Expressioni

Gene expression databases

ArrayExpressiP97360.
BgeeiP97360.
CleanExiMM_ETV6.
GenevestigatoriP97360.

Interactioni

Subunit structurei

Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9 By similarity.

Protein-protein interaction databases

BioGridi199540. 5 interactions.

Structurei

Secondary structure

1
485
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi337 – 3459
Helixi348 – 3503
Turni351 – 3533
Beta strandi354 – 3585
Turni359 – 3624
Beta strandi363 – 3675
Helixi369 – 37911
Helixi387 – 39913
Beta strandi402 – 4054
Beta strandi412 – 4176
Helixi419 – 4224
Turni423 – 4297
Helixi430 – 4334
Beta strandi451 – 4533

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LF7NMR-A335-436[»]
2LF8NMR-A335-458[»]
2MD5NMR-A329-426[»]
4MHGX-ray2.20A329-426[»]
ProteinModelPortaliP97360.
SMRiP97360. Positions 48-124, 335-458.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12585PNTAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG270606.
GeneTreeiENSGT00750000117271.
HOGENOMiHOG000012982.
HOVERGENiHBG005617.
InParanoidiP97360.
KOiK03211.
OMAiHQEPYPL.
OrthoDBiEOG7R2BJB.
PhylomeDBiP97360.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97360-1 [UniParc]FASTAAdd to Basket

« Hide

MSETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH    50
LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK 100
EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH 150
QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ 200
RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS 250
SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI 300
NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY 350
ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL 400
NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI 450
ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE 485
Length:485
Mass (Da):56,406
Last modified:May 1, 1997 - v1
Checksum:iECFCDFEC88EA0424
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07915 mRNA. Translation: CAA69220.1.
CCDSiCCDS39677.1.
RefSeqiNP_031987.3. NM_007961.3.
UniGeneiMm.269995.

Genome annotation databases

EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
GeneIDi14011.
KEGGimmu:14011.
UCSCiuc009eke.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07915 mRNA. Translation: CAA69220.1 .
CCDSi CCDS39677.1.
RefSeqi NP_031987.3. NM_007961.3.
UniGenei Mm.269995.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LF7 NMR - A 335-436 [» ]
2LF8 NMR - A 335-458 [» ]
2MD5 NMR - A 329-426 [» ]
4MHG X-ray 2.20 A 329-426 [» ]
ProteinModelPortali P97360.
SMRi P97360. Positions 48-124, 335-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199540. 5 interactions.

PTM databases

PhosphoSitei P97360.

Proteomic databases

MaxQBi P97360.
PaxDbi P97360.
PRIDEi P97360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081028 ; ENSMUSP00000079818 ; ENSMUSG00000030199 .
GeneIDi 14011.
KEGGi mmu:14011.
UCSCi uc009eke.1. mouse.

Organism-specific databases

CTDi 2120.
MGIi MGI:109336. Etv6.

Phylogenomic databases

eggNOGi NOG270606.
GeneTreei ENSGT00750000117271.
HOGENOMi HOG000012982.
HOVERGENi HBG005617.
InParanoidi P97360.
KOi K03211.
OMAi HQEPYPL.
OrthoDBi EOG7R2BJB.
PhylomeDBi P97360.
TreeFami TF318679.

Miscellaneous databases

ChiTaRSi ETV6. mouse.
NextBioi 284920.
PROi P97360.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97360.
Bgeei P97360.
CleanExi MM_ETV6.
Genevestigatori P97360.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Bernard O.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiETV6_MOUSE
AccessioniPrimary (citable) accession number: P97360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi