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P97360

- ETV6_MOUSE

UniProt

P97360 - ETV6_MOUSE

Protein

Transcription factor ETV6

Gene

Etv6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi335 – 41682ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    3. regulation of transcription, DNA-templated Source: MGI
    4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor ETV6
    Alternative name(s):
    ETS translocation variant 6
    ETS-related protein Tel1
    Short name:
    Tel
    Gene namesi
    Name:Etv6
    Synonyms:Tel, Tel1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:109336. Etv6.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 485484Transcription factor ETV6PRO_0000204122Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei11 – 111N6-acetyllysineBy similarity
    Modified residuei18 – 181PhosphothreonineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei215 – 2151PhosphoserineBy similarity
    Modified residuei251 – 2511PhosphoserineBy similarity
    Modified residuei298 – 2981N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP97360.
    PaxDbiP97360.
    PRIDEiP97360.

    PTM databases

    PhosphoSiteiP97360.

    Expressioni

    Gene expression databases

    ArrayExpressiP97360.
    BgeeiP97360.
    CleanExiMM_ETV6.
    GenevestigatoriP97360.

    Interactioni

    Subunit structurei

    Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199540. 5 interactions.

    Structurei

    Secondary structure

    1
    485
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi337 – 3459
    Helixi348 – 3503
    Turni351 – 3533
    Beta strandi354 – 3585
    Turni359 – 3624
    Beta strandi363 – 3675
    Helixi369 – 37911
    Helixi387 – 39913
    Beta strandi402 – 4054
    Beta strandi412 – 4176
    Helixi419 – 4224
    Turni423 – 4297
    Helixi430 – 4334
    Beta strandi451 – 4533

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LF7NMR-A335-436[»]
    2LF8NMR-A335-458[»]
    2MD5NMR-A329-426[»]
    4MHGX-ray2.20A329-426[»]
    ProteinModelPortaliP97360.
    SMRiP97360. Positions 48-124, 335-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 12585PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG270606.
    GeneTreeiENSGT00750000117271.
    HOGENOMiHOG000012982.
    HOVERGENiHBG005617.
    InParanoidiP97360.
    KOiK03211.
    OMAiHQEPYPL.
    OrthoDBiEOG7R2BJB.
    PhylomeDBiP97360.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97360-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH    50
    LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK 100
    EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH 150
    QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ 200
    RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS 250
    SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI 300
    NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY 350
    ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL 400
    NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI 450
    ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE 485
    Length:485
    Mass (Da):56,406
    Last modified:May 1, 1997 - v1
    Checksum:iECFCDFEC88EA0424
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07915 mRNA. Translation: CAA69220.1.
    CCDSiCCDS39677.1.
    RefSeqiNP_031987.3. NM_007961.3.
    UniGeneiMm.269995.

    Genome annotation databases

    EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
    GeneIDi14011.
    KEGGimmu:14011.
    UCSCiuc009eke.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07915 mRNA. Translation: CAA69220.1 .
    CCDSi CCDS39677.1.
    RefSeqi NP_031987.3. NM_007961.3.
    UniGenei Mm.269995.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LF7 NMR - A 335-436 [» ]
    2LF8 NMR - A 335-458 [» ]
    2MD5 NMR - A 329-426 [» ]
    4MHG X-ray 2.20 A 329-426 [» ]
    ProteinModelPortali P97360.
    SMRi P97360. Positions 48-124, 335-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199540. 5 interactions.

    PTM databases

    PhosphoSitei P97360.

    Proteomic databases

    MaxQBi P97360.
    PaxDbi P97360.
    PRIDEi P97360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081028 ; ENSMUSP00000079818 ; ENSMUSG00000030199 .
    GeneIDi 14011.
    KEGGi mmu:14011.
    UCSCi uc009eke.1. mouse.

    Organism-specific databases

    CTDi 2120.
    MGIi MGI:109336. Etv6.

    Phylogenomic databases

    eggNOGi NOG270606.
    GeneTreei ENSGT00750000117271.
    HOGENOMi HOG000012982.
    HOVERGENi HBG005617.
    InParanoidi P97360.
    KOi K03211.
    OMAi HQEPYPL.
    OrthoDBi EOG7R2BJB.
    PhylomeDBi P97360.
    TreeFami TF318679.

    Miscellaneous databases

    ChiTaRSi ETV6. mouse.
    NextBioi 284920.
    PROi P97360.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97360.
    Bgeei P97360.
    CleanExi MM_ETV6.
    Genevestigatori P97360.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Bernard O.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiETV6_MOUSE
    AccessioniPrimary (citable) accession number: P97360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3