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Protein

Transcription factor ETV6

Gene

Etv6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi335 – 41682ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein domain specific binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  5. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  7. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. regulation of transcription, DNA-templated Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor ETV6
Alternative name(s):
ETS translocation variant 6
ETS-related protein Tel1
Short name:
Tel
Gene namesi
Name:Etv6
Synonyms:Tel, Tel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109336. Etv6.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleolus Source: MGI
  3. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 485484Transcription factor ETV6PRO_0000204122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei11 – 111N6-acetyllysineBy similarity
Modified residuei18 – 181PhosphothreonineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei215 – 2151PhosphoserineBy similarity
Modified residuei251 – 2511PhosphoserineBy similarity
Modified residuei298 – 2981N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97360.
PaxDbiP97360.
PRIDEiP97360.

PTM databases

PhosphoSiteiP97360.

Expressioni

Gene expression databases

BgeeiP97360.
CleanExiMM_ETV6.
ExpressionAtlasiP97360. baseline and differential.
GenevestigatoriP97360.

Interactioni

Subunit structurei

Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199540. 5 interactions.

Structurei

Secondary structure

1
485
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi337 – 3459Combined sources
Helixi348 – 3503Combined sources
Turni351 – 3533Combined sources
Beta strandi354 – 3585Combined sources
Turni359 – 3624Combined sources
Beta strandi363 – 3675Combined sources
Helixi369 – 37911Combined sources
Helixi387 – 39913Combined sources
Beta strandi402 – 4054Combined sources
Beta strandi412 – 4176Combined sources
Helixi419 – 4224Combined sources
Turni423 – 4297Combined sources
Helixi430 – 4334Combined sources
Beta strandi451 – 4533Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LF7NMR-A335-436[»]
2LF8NMR-A335-458[»]
2MD5NMR-A329-426[»]
4MHGX-ray2.20A329-426[»]
ProteinModelPortaliP97360.
SMRiP97360. Positions 21-124, 335-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12585PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG270606.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000012982.
HOVERGENiHBG005617.
InParanoidiP97360.
KOiK03211.
OMAiHQEPYPL.
OrthoDBiEOG7R2BJB.
PhylomeDBiP97360.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH
60 70 80 90 100
LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK
110 120 130 140 150
EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH
160 170 180 190 200
QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ
210 220 230 240 250
RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS
260 270 280 290 300
SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI
310 320 330 340 350
NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY
360 370 380 390 400
ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL
410 420 430 440 450
NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI
460 470 480
ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE
Length:485
Mass (Da):56,406
Last modified:April 30, 1997 - v1
Checksum:iECFCDFEC88EA0424
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07915 mRNA. Translation: CAA69220.1.
CCDSiCCDS39677.1.
RefSeqiNP_031987.3. NM_007961.4.
UniGeneiMm.269995.

Genome annotation databases

EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
GeneIDi14011.
KEGGimmu:14011.
UCSCiuc009eke.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07915 mRNA. Translation: CAA69220.1.
CCDSiCCDS39677.1.
RefSeqiNP_031987.3. NM_007961.4.
UniGeneiMm.269995.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LF7NMR-A335-436[»]
2LF8NMR-A335-458[»]
2MD5NMR-A329-426[»]
4MHGX-ray2.20A329-426[»]
ProteinModelPortaliP97360.
SMRiP97360. Positions 21-124, 335-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199540. 5 interactions.

PTM databases

PhosphoSiteiP97360.

Proteomic databases

MaxQBiP97360.
PaxDbiP97360.
PRIDEiP97360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
GeneIDi14011.
KEGGimmu:14011.
UCSCiuc009eke.1. mouse.

Organism-specific databases

CTDi2120.
MGIiMGI:109336. Etv6.

Phylogenomic databases

eggNOGiNOG270606.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000012982.
HOVERGENiHBG005617.
InParanoidiP97360.
KOiK03211.
OMAiHQEPYPL.
OrthoDBiEOG7R2BJB.
PhylomeDBiP97360.
TreeFamiTF318679.

Miscellaneous databases

ChiTaRSiEtv6. mouse.
NextBioi284920.
PROiP97360.
SOURCEiSearch...

Gene expression databases

BgeeiP97360.
CleanExiMM_ETV6.
ExpressionAtlasiP97360. baseline and differential.
GenevestigatoriP97360.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Bernard O.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiETV6_MOUSE
AccessioniPrimary (citable) accession number: P97360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: April 30, 1997
Last modified: March 31, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.