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Protein

Transcription factor ETV6

Gene

Etv6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi335 – 416ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • hematopoietic stem cell proliferation Source: UniProtKB
  • mesenchymal cell apoptotic process Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neurogenesis Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • vitellogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor ETV6
Alternative name(s):
ETS translocation variant 6
ETS-related protein Tel1
Short name:
Tel
Gene namesi
Name:Etv6
Synonyms:Tel, Tel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109336. Etv6.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041221 – 485Transcription factor ETV6Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-acetyllysine; alternateBy similarity1
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei18PhosphothreonineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei165PhosphothreonineCombined sources1
Modified residuei215PhosphoserineBy similarity1
Modified residuei240PhosphoserineCombined sources1
Modified residuei251PhosphoserineBy similarity1
Cross-linki284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei298N6-acetyllysineBy similarity1
Modified residuei319PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97360.
MaxQBiP97360.
PaxDbiP97360.
PeptideAtlasiP97360.
PRIDEiP97360.

PTM databases

iPTMnetiP97360.
PhosphoSitePlusiP97360.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030199.
CleanExiMM_ETV6.
ExpressionAtlasiP97360. baseline and differential.
GenevisibleiP97360. MM.

Interactioni

Subunit structurei

Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199540. 5 interactors.
STRINGi10090.ENSMUSP00000079818.

Structurei

Secondary structure

1485
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi337 – 345Combined sources9
Helixi348 – 350Combined sources3
Turni351 – 353Combined sources3
Beta strandi354 – 358Combined sources5
Turni359 – 362Combined sources4
Beta strandi363 – 367Combined sources5
Helixi369 – 379Combined sources11
Helixi387 – 399Combined sources13
Beta strandi402 – 405Combined sources4
Beta strandi412 – 417Combined sources6
Helixi419 – 422Combined sources4
Turni423 – 429Combined sources7
Helixi430 – 433Combined sources4
Beta strandi451 – 453Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LF7NMR-A335-436[»]
2LF8NMR-A335-458[»]
2MD5NMR-A329-426[»]
4MHGX-ray2.20A329-426[»]
ProteinModelPortaliP97360.
SMRiP97360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 125PNTPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000012982.
HOVERGENiHBG005617.
InParanoidiP97360.
KOiK03211.
OMAiHQEPYPL.
OrthoDBiEOG091G05Q3.
PhylomeDBiP97360.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH
60 70 80 90 100
LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK
110 120 130 140 150
EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH
160 170 180 190 200
QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ
210 220 230 240 250
RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS
260 270 280 290 300
SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI
310 320 330 340 350
NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY
360 370 380 390 400
ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL
410 420 430 440 450
NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI
460 470 480
ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE
Length:485
Mass (Da):56,406
Last modified:May 1, 1997 - v1
Checksum:iECFCDFEC88EA0424
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07915 mRNA. Translation: CAA69220.1.
CCDSiCCDS39677.1.
RefSeqiNP_031987.3. NM_007961.4.
UniGeneiMm.269995.

Genome annotation databases

EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
GeneIDi14011.
KEGGimmu:14011.
UCSCiuc009eke.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07915 mRNA. Translation: CAA69220.1.
CCDSiCCDS39677.1.
RefSeqiNP_031987.3. NM_007961.4.
UniGeneiMm.269995.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LF7NMR-A335-436[»]
2LF8NMR-A335-458[»]
2MD5NMR-A329-426[»]
4MHGX-ray2.20A329-426[»]
ProteinModelPortaliP97360.
SMRiP97360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199540. 5 interactors.
STRINGi10090.ENSMUSP00000079818.

PTM databases

iPTMnetiP97360.
PhosphoSitePlusiP97360.

Proteomic databases

EPDiP97360.
MaxQBiP97360.
PaxDbiP97360.
PeptideAtlasiP97360.
PRIDEiP97360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081028; ENSMUSP00000079818; ENSMUSG00000030199.
GeneIDi14011.
KEGGimmu:14011.
UCSCiuc009eke.2. mouse.

Organism-specific databases

CTDi2120.
MGIiMGI:109336. Etv6.

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000012982.
HOVERGENiHBG005617.
InParanoidiP97360.
KOiK03211.
OMAiHQEPYPL.
OrthoDBiEOG091G05Q3.
PhylomeDBiP97360.
TreeFamiTF318679.

Miscellaneous databases

ChiTaRSiEtv6. mouse.
PROiP97360.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030199.
CleanExiMM_ETV6.
ExpressionAtlasiP97360. baseline and differential.
GenevisibleiP97360. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETV6_MOUSE
AccessioniPrimary (citable) accession number: P97360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.