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Protein

TATA box-binding protein-associated factor RNA polymerase I subunit A

Gene

Taf1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-associated factor RNA polymerase I subunit A
Alternative name(s):
RNA polymerase I-specific TBP-associated factor 48 kDa
Short name:
TAFI48
TATA box-binding protein-associated factor 1A
Short name:
TBP-associated factor 1A
Transcription initiation factor SL1/TIF-IB subunit A
Gene namesi
Name:Taf1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109578. Taf1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453TATA box-binding protein-associated factor RNA polymerase I subunit APRO_0000227988Add
BLAST

Proteomic databases

EPDiP97357.
MaxQBiP97357.
PaxDbiP97357.
PeptideAtlasiP97357.
PRIDEiP97357.

PTM databases

iPTMnetiP97357.
PhosphoSiteiP97357.

Interactioni

Subunit structurei

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT (By similarity). Interacts with CEBPA (isoform 1 and isoform 4) (By similarity).By similarity

Protein-protein interaction databases

BioGridi203956. 6 interactions.
DIPiDIP-60267N.
STRINGi10090.ENSMUSP00000094808.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEFS. Eukaryota.
ENOG410YWVA. LUCA.
HOVERGENiHBG053462.
InParanoidiP97357.
KOiK15212.
PhylomeDBiP97357.

Family and domain databases

InterProiIPR016629. RNA_pol_I_TAF1A/TAFI48.
[Graphical view]
PIRSFiPIRSF015161. TAFI48. 1 hit.

Sequencei

Sequence statusi: Complete.

P97357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSDFGEELT KLAVAEDNPE TSVLSKTGMH FPWLHKHVEA VVTGGKKRKD
60 70 80 90 100
FAQTTSACLS FIQEALLKHQ WQQAAEYMHS YLQTLEDSDT DKRQAAPEII
110 120 130 140 150
WKLGSEILFY HPKSNVETFN SFADRMKNIG VLNYLKISLQ HALYLLHHGM
160 170 180 190 200
LDDANRNLSK AETWRYGEKS SSQEVLINLV QAYKGLLQYY TWTRKKMELS
210 220 230 240 250
KLDEDDYAYA AKTRTMLSQS CKTSTNICAL VKTPGVWDPF VKSYVEMLEF
260 270 280 290 300
YGDQDGAREM LTNYAYDEKF PSNPNAHVYL YEFLKREKAP RAKLISVLKI
310 320 330 340 350
LHEIVPSHTL MLEFHTLLRK SDTEEHQKLG LSVLFEVLDF AGCNKNITAW
360 370 380 390 400
KYLAKYLKQI LVGSHHEWVE EEWKSRRNWW PAFHFSFFWA KSDWKADTDL
410 420 430 440 450
ACEKAFVAGV LLGKGCKYFR YILKQDHETL KKKIKRMKKS VKKYTIVNPG

VHT
Length:453
Mass (Da):52,718
Last modified:May 1, 1997 - v1
Checksum:i36FAB970FBC5956F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09972 mRNA. Translation: CAA71091.1.
AK132811 mRNA. Translation: BAE21371.1.
BC061106 mRNA. Translation: AAH61106.1.
RefSeqiNP_001264886.1. NM_001277957.1.
NP_001264887.1. NM_001277958.1.
NP_001264888.1. NM_001277959.1.
NP_067441.1. NM_021466.3.
UniGeneiMm.383556.

Genome annotation databases

GeneIDi21339.
KEGGimmu:21339.
UCSCiuc008ida.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09972 mRNA. Translation: CAA71091.1.
AK132811 mRNA. Translation: BAE21371.1.
BC061106 mRNA. Translation: AAH61106.1.
RefSeqiNP_001264886.1. NM_001277957.1.
NP_001264887.1. NM_001277958.1.
NP_001264888.1. NM_001277959.1.
NP_067441.1. NM_021466.3.
UniGeneiMm.383556.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203956. 6 interactions.
DIPiDIP-60267N.
STRINGi10090.ENSMUSP00000094808.

PTM databases

iPTMnetiP97357.
PhosphoSiteiP97357.

Proteomic databases

EPDiP97357.
MaxQBiP97357.
PaxDbiP97357.
PeptideAtlasiP97357.
PRIDEiP97357.

Protocols and materials databases

DNASUi21339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21339.
KEGGimmu:21339.
UCSCiuc008ida.2. mouse.

Organism-specific databases

CTDi9015.
MGIiMGI:109578. Taf1a.

Phylogenomic databases

eggNOGiENOG410IEFS. Eukaryota.
ENOG410YWVA. LUCA.
HOVERGENiHBG053462.
InParanoidiP97357.
KOiK15212.
PhylomeDBiP97357.

Enzyme and pathway databases

ReactomeiR-MMU-427359. SIRT1 negatively regulates rRNA Expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

PROiP97357.
SOURCEiSearch...

Family and domain databases

InterProiIPR016629. RNA_pol_I_TAF1A/TAFI48.
[Graphical view]
PIRSFiPIRSF015161. TAFI48. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1A_MOUSE
AccessioniPrimary (citable) accession number: P97357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.