P97353 (SEC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Galactoside 2-alpha-L-fucosyltransferase 3 EC=2.4.1.69 Alternative name(s): Alpha(1,2)FT 3 Fucosyltransferase 10 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3 Secretory blood group protein 1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 368 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. |
| Pathway | |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity. |
| Miscellaneous | In mouse, there are three genes (Fut1, Fut2 and Sec1) which encode galactoside 2-L-fucosyltransferase. |
| Sequence similarities | Belongs to the glycosyltransferase 11 family. |
| Caution | Was originally thought to be Fut2. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein glycosylation Inferred from direct assay Ref.3. Source: UniProtKB |
| Cellular component | Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | galactoside 2-alpha-L-fucosyltransferase activity Inferred from direct assay Ref.3. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 368 | 368 | Galactoside 2-alpha-L-fucosyltransferase 3 | PRO_0000149115 | |||||
Regions | |||||||||
| Topological domain | 1 – 20 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 21 – 41 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
| Topological domain | 42 – 368 | 327 | Lumenal Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 195 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 289 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 315 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 46 | 1 | G → S in strain: BFM/2Msf, C57BL/10SnJ and pgn2. | ||||||
| Natural variant | 50 | 1 | A → G in strain: BFM/2Msf, C57BL/10SnJ and pgn2. | ||||||
| Natural variant | 62 | 1 | P → A in strain: CAST/Ei. | ||||||
| Natural variant | 150 | 1 | H → Q in strain: BFM/2Msf and C57BL/10SnJ. | ||||||
| Natural variant | 214 | 1 | R → H in strain: pgn2. | ||||||
Sequences
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References
| [1] | "Molecular cloning and expression of a mouse GDP-L-Fucose: beta-D-galactoside 2-alpha-L-Fucosyltransferase." Hitoshi S., Kusunoki S., Kanazawa I., Tsuji S. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ICR. |
| [2] | "GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide." Lin B., Hayashi Y., Saito M., Sakakibara Y., Yanagisawa M., Iwamori M. Biochim. Biophys. Acta 1487:275-285(2000) [PubMed: 11018479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ICR. Tissue: Gastrointestinal tract. |
| [3] | "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract." Domino S.E., Zhang L., Lowe J.B. J. Biol. Chem. 276:23748-23756(2001) [PubMed: 11323419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Ola. |
| [4] | "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf. |
| + | Additional computationally mapped references. |
Web resources
| Functional Glycomics Gateway - GTase Secretory blood group protein 1 |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y09882 Genomic DNA. Translation: CAA71008.1. AF113532 mRNA. Translation: AAD25351.1. AF214657 Genomic DNA. Translation: AAF45147.1. AF214658 Genomic DNA. Translation: AAF45148.1. AB039204 Genomic DNA. Translation: BAB68728.1. AB039205 Genomic DNA. Translation: BAB68729.1. AB039206 Genomic DNA. Translation: BAB68730.1. AB039207 Genomic DNA. Translation: BAB68731.1. AB039208 Genomic DNA. Translation: BAB68732.1. AB039209 Genomic DNA. Translation: BAB68733.1. AB039210 Genomic DNA. Translation: BAB68734.1. AB039211 Genomic DNA. Translation: BAB68735.1. AB039212 Genomic DNA. Translation: BAB68736.1. |
| IPI | IPI00311940. |
| RefSeq | NP_064318.2. NM_019934.2. |
| UniGene | Mm.56914. |
3D structure databases | |
| ProteinModelPortal | P97353. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P97353. |
Protein family/group databases | |
| CAZy | GT11. Glycosyltransferase Family 11. |
Proteomic databases | |
| PRIDE | P97353. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 56546. |
| KEGG | mmu:56546. |
Organism-specific databases | |
| CTD | 653677. |
| MGI | MGI:1928893. Sec1. |
Phylogenomic databases | |
| eggNOG | roNOG17828. |
| HOVERGEN | HBG004338. |
| InParanoid | P97353. |
| OrthoDB | EOG4BK545. |
Gene expression databases | |
| ArrayExpress | P97353. |
| Bgee | P97353. |
| CleanEx | MM_FUT10. MM_SEC1. |
| Genevestigator | P97353. |
| GermOnline | ENSMUSG00000040364. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002516. Glyco_trans_11. [Graphical view] |
| KO | K00718. |
| PANTHER | PTHR11927. Glyco_trans_11. 1 hit. |
| Pfam | PF01531. Glyco_transf_11. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | SEC1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P97353 Secondary accession number(s): Q91V73, Q920T3, Q920T4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with