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Protein

Protein S100-A13

Gene

S100a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi24 – 37141By similarityAdd
BLAST
Calcium bindingi64 – 75122By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Calcium, Copper, Lipid-binding, Metal-binding

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A13
Alternative name(s):
S100 calcium-binding protein A13
Gene namesi
Name:S100a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109581. S100a13.

Subcellular locationi

  • Cytoplasm
  • Secreted

  • Note: Secretion is mediated by exposure to stress and requires copper ions.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Protein S100-A13PRO_0000144020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97352.
MaxQBiP97352.
PaxDbiP97352.
PRIDEiP97352.
TopDownProteomicsiP97352.

PTM databases

iPTMnetiP97352.
PhosphoSiteiP97352.

Expressioni

Gene expression databases

BgeeiP97352.
CleanExiMM_S100A13.

Interactioni

Subunit structurei

Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97352. 1 interaction.
MINTiMINT-4133637.
STRINGi10090.ENSMUSP00000047737.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 1910Combined sources
Helixi21 – 266Combined sources
Beta strandi27 – 326Combined sources
Helixi37 – 404Combined sources
Helixi41 – 455Combined sources
Helixi56 – 6510Combined sources
Turni66 – 683Combined sources
Beta strandi69 – 746Combined sources
Helixi77 – 804Combined sources
Helixi82 – 9312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CXJNMR-A/B1-98[»]
ProteinModelPortaliP97352.
SMRiP97352. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5336EF-handAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 1 EF-hand domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZIJ. Eukaryota.
ENOG410ZHGQ. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP97352.
OrthoDBiEOG71P2D8.
PhylomeDBiP97352.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view]
PANTHERiPTHR11639:SF57. PTHR11639:SF57. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

P97352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAETLTELE AAIETVVSTF FTFAGREGRK GSLNINEFKE LATQQLPHLL
60 70 80 90
KDVGSLDEKM KTLDVNQDSE LRFSEYWRLI GELAKEVRKE KALGIRKK
Length:98
Mass (Da):11,158
Last modified:May 1, 1997 - v1
Checksum:i0A8CE8DA822BD530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA. Translation: CAA68189.1.
BC005687 mRNA. Translation: AAH05687.1.
PIRiJC5065.
UniGeneiMm.6523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA. Translation: CAA68189.1.
BC005687 mRNA. Translation: AAH05687.1.
PIRiJC5065.
UniGeneiMm.6523.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CXJNMR-A/B1-98[»]
ProteinModelPortaliP97352.
SMRiP97352. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97352. 1 interaction.
MINTiMINT-4133637.
STRINGi10090.ENSMUSP00000047737.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

PTM databases

iPTMnetiP97352.
PhosphoSiteiP97352.

Proteomic databases

EPDiP97352.
MaxQBiP97352.
PaxDbiP97352.
PRIDEiP97352.
TopDownProteomicsiP97352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109581. S100a13.

Phylogenomic databases

eggNOGiENOG410IZIJ. Eukaryota.
ENOG410ZHGQ. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP97352.
OrthoDBiEOG71P2D8.
PhylomeDBiP97352.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP97352.
PROiP97352.
SOURCEiSearch...

Gene expression databases

BgeeiP97352.
CleanExiMM_S100A13.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view]
PANTHERiPTHR11639:SF57. PTHR11639:SF57. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family."
    Wicki R., Schaefer B.W., Erne P., Heizmann C.W.
    Biochem. Biophys. Res. Commun. 227:594-599(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export."
    Prudovsky I., Bagala C., Tarantini F., Mandinova A., Soldi R., Bellum S., Maciag T.
    J. Cell Biol. 158:201-208(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells."
    Mandinova A., Soldi R., Graziani I., Bagala C., Bellum S., Landriscina M., Tarantini F., Prudovsky I., Maciag T.
    J. Cell Sci. 116:2687-2696(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "S100A13-lipid interactions-role in the non-classical release of the acidic fibroblast growth factor."
    Kathir K.M., Ibrahim K., Rajalingam D., Prudovsky I., Yu C., Kumar T.K.
    Biochim. Biophys. Acta 1768:3080-3089(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LIPID VESICLES.
  6. "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress."
    Landriscina M., Bagala C., Mandinova A., Soldi R., Micucci I., Bellum S., Prudovsky I., Maciag T.
    J. Biol. Chem. 276:25549-25557(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SYT1 AND FGF1, COPPER BINDING, IDENTIFICATION IN A COPPER-DEPENDENT MULTIPROTEIN COMPLEX CONTAINING SYT1; FGF1 AND S100A13.
  7. Cited for: SUBCELLULAR LOCATION.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung and Spleen.
  9. "Three-dimensional solution structure of S100A13."
    Vaithiyalingam S., Kumar T.K.S., Yu C.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR, SUBUNIT.

Entry informationi

Entry nameiS10AD_MOUSE
AccessioniPrimary (citable) accession number: P97352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.