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Protein

Protein S100-A13

Gene

S100a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 371By similarityAdd BLAST14
Calcium bindingi64 – 752By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Calcium, Copper, Lipid-binding, Metal-binding

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A13
Alternative name(s):
S100 calcium-binding protein A13
Gene namesi
Name:S100a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109581. S100a13.

Subcellular locationi

  • Cytoplasm
  • Secreted

  • Note: Secretion is mediated by exposure to stress and requires copper ions.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440201 – 98Protein S100-A13Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97352.
MaxQBiP97352.
PaxDbiP97352.
PeptideAtlasiP97352.
PRIDEiP97352.
TopDownProteomicsiP97352.

PTM databases

iPTMnetiP97352.
PhosphoSitePlusiP97352.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042312.
CleanExiMM_S100A13.

Interactioni

Subunit structurei

Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97352. 1 interactor.
MINTiMINT-4133637.
STRINGi10090.ENSMUSP00000047737.

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 19Combined sources10
Helixi21 – 26Combined sources6
Beta strandi27 – 32Combined sources6
Helixi37 – 40Combined sources4
Helixi41 – 45Combined sources5
Helixi56 – 65Combined sources10
Turni66 – 68Combined sources3
Beta strandi69 – 74Combined sources6
Helixi77 – 80Combined sources4
Helixi82 – 93Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXJNMR-A/B1-98[»]
ProteinModelPortaliP97352.
SMRiP97352.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97352.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-handAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 1 EF-hand domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZIJ. Eukaryota.
ENOG410ZHGQ. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP97352.
PhylomeDBiP97352.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view]
PANTHERiPTHR11639:SF57. PTHR11639:SF57. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

P97352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAETLTELE AAIETVVSTF FTFAGREGRK GSLNINEFKE LATQQLPHLL
60 70 80 90
KDVGSLDEKM KTLDVNQDSE LRFSEYWRLI GELAKEVRKE KALGIRKK
Length:98
Mass (Da):11,158
Last modified:May 1, 1997 - v1
Checksum:i0A8CE8DA822BD530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA. Translation: CAA68189.1.
BC005687 mRNA. Translation: AAH05687.1.
PIRiJC5065.
UniGeneiMm.6523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA. Translation: CAA68189.1.
BC005687 mRNA. Translation: AAH05687.1.
PIRiJC5065.
UniGeneiMm.6523.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXJNMR-A/B1-98[»]
ProteinModelPortaliP97352.
SMRiP97352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97352. 1 interactor.
MINTiMINT-4133637.
STRINGi10090.ENSMUSP00000047737.

Protein family/group databases

TCDBi9.A.48.1.1. the unconventional protein secretion (ups) system.

PTM databases

iPTMnetiP97352.
PhosphoSitePlusiP97352.

Proteomic databases

EPDiP97352.
MaxQBiP97352.
PaxDbiP97352.
PeptideAtlasiP97352.
PRIDEiP97352.
TopDownProteomicsiP97352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109581. S100a13.

Phylogenomic databases

eggNOGiENOG410IZIJ. Eukaryota.
ENOG410ZHGQ. LUCA.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP97352.
PhylomeDBiP97352.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP97352.
PROiP97352.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042312.
CleanExiMM_S100A13.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028487. S100A13.
[Graphical view]
PANTHERiPTHR11639:SF57. PTHR11639:SF57. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10AD_MOUSE
AccessioniPrimary (citable) accession number: P97352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.