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Protein

40S ribosomal protein S3a

Gene

Rps3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Alternative name(s):
Protein TU-11
Gene namesi
Name:Rps3a
Synonyms:Rps3a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1202063. Rps3a1.

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Nucleus UniRule annotation1 Publication

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.UniRule annotation

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • cytosolic small ribosomal subunit Source: UniProtKB-HAMAP
  • extracellular exosome Source: Ensembl
  • extracellular matrix Source: Ensembl
  • focal adhesion Source: Ensembl
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleolus Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001535252 – 26440S ribosomal protein S3aAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei249N6-acetyllysine; alternateBy similarity1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei256PhosphotyrosineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97351.
PaxDbiP97351.
PeptideAtlasiP97351.
PRIDEiP97351.
TopDownProteomicsiP97351.

PTM databases

iPTMnetiP97351.
PhosphoSitePlusiP97351.
SwissPalmiP97351.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028081.
CleanExiMM_RPS3A.
ExpressionAtlasiP97351. baseline and differential.
GenevisibleiP97351. MM.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi203010. 7 interactors.
IntActiP97351. 6 interactors.
MINTiMINT-1859558.
STRINGi10090.ENSMUSP00000029722.

Structurei

3D structure databases

ProteinModelPortaliP97351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S3Ae family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
GeneTreeiENSGT00390000018433.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.
InParanoidiP97351.
KOiK02984.
OMAiGQNAYTK.
OrthoDBiEOG091G0HTU.
PhylomeDBiP97351.
TreeFamiTF300037.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGGSSGK AAGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,885
Last modified:January 23, 2007 - v3
Checksum:iF50037AE0C1E359C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83368 Genomic DNA. Translation: CAB05955.1.
AK088113 mRNA. Translation: BAC40152.1.
BC039659 mRNA. Translation: AAH39659.1.
BC081451 mRNA. Translation: AAH81451.1.
BC083338 mRNA. Translation: AAH83338.1.
BC084675 mRNA. Translation: AAH84675.1.
CCDSiCCDS17446.1.
RefSeqiNP_058655.3. NM_016959.4.
UniGeneiMm.391785.
Mm.399829.

Genome annotation databases

EnsembliENSMUST00000029722; ENSMUSP00000029722; ENSMUSG00000028081.
GeneIDi20091.
KEGGimmu:20091.
UCSCiuc008prc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83368 Genomic DNA. Translation: CAB05955.1.
AK088113 mRNA. Translation: BAC40152.1.
BC039659 mRNA. Translation: AAH39659.1.
BC081451 mRNA. Translation: AAH81451.1.
BC083338 mRNA. Translation: AAH83338.1.
BC084675 mRNA. Translation: AAH84675.1.
CCDSiCCDS17446.1.
RefSeqiNP_058655.3. NM_016959.4.
UniGeneiMm.391785.
Mm.399829.

3D structure databases

ProteinModelPortaliP97351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203010. 7 interactors.
IntActiP97351. 6 interactors.
MINTiMINT-1859558.
STRINGi10090.ENSMUSP00000029722.

PTM databases

iPTMnetiP97351.
PhosphoSitePlusiP97351.
SwissPalmiP97351.

Proteomic databases

EPDiP97351.
PaxDbiP97351.
PeptideAtlasiP97351.
PRIDEiP97351.
TopDownProteomicsiP97351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029722; ENSMUSP00000029722; ENSMUSG00000028081.
GeneIDi20091.
KEGGimmu:20091.
UCSCiuc008prc.2. mouse.

Organism-specific databases

CTDi20091.
MGIiMGI:1202063. Rps3a1.

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
GeneTreeiENSGT00390000018433.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.
InParanoidiP97351.
KOiK02984.
OMAiGQNAYTK.
OrthoDBiEOG091G0HTU.
PhylomeDBiP97351.
TreeFamiTF300037.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP97351.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028081.
CleanExiMM_RPS3A.
ExpressionAtlasiP97351. baseline and differential.
GenevisibleiP97351. MM.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS3A_MOUSE
AccessioniPrimary (citable) accession number: P97351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.