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Protein

Plakophilin-1

Gene

Pkp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play a role in junctional plaques.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-351906 Apoptotic cleavage of cell adhesion proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-1
Gene namesi
Name:Pkp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1328359 Pkp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642851 – 728Plakophilin-1Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97350
PaxDbiP97350
PeptideAtlasiP97350
PRIDEiP97350

PTM databases

iPTMnetiP97350
PhosphoSitePlusiP97350

Expressioni

Gene expression databases

BgeeiENSMUSG00000026413
CleanExiMM_PKP1
ExpressionAtlasiP97350 baseline and differential
GenevisibleiP97350 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202212, 5 interactors
IntActiP97350, 6 interactors
MINTiP97350
STRINGi10090.ENSMUSP00000027667

Structurei

3D structure databases

ProteinModelPortaliP97350
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati244 – 275ARM 1Add BLAST32
Repeati276 – 317ARM 2Add BLAST42
Repeati318 – 360ARM 3Add BLAST43
Repeati361 – 412ARM 4Add BLAST52
Repeati413 – 443ARM 5Add BLAST31
Repeati505 – 536ARM 6Add BLAST32
Repeati537 – 583ARM 7Add BLAST47
Repeati584 – 629ARM 8Add BLAST46
Repeati630 – 694ARM 9Add BLAST65

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOGENOMiHOG000060193
HOVERGENiHBG096389
InParanoidiP97350
KOiK10387
OMAiQVMMTVK
OrthoDBiEOG091G02GJ
PhylomeDBiP97350
TreeFamiTF321877

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028432 Plakophilin-1
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF3 PTHR10372:SF3, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

Sequencei

Sequence statusi: Complete.

P97350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK
60 70 80 90 100
RQKSKSSQSS TLSHSNRGSM YDGLADNYNN YGTTSRSSYF SKFQAGNGSW
110 120 130 140 150
GYPIYNGTLK REPDNRRFSS YSQMENWSRH YPRGSCATPG AGSDICFMQK
160 170 180 190 200
IKASRSEPDL YCDPRGTLRK GTLGSKGHKT TQNRCSFYST CSGQKAVKKC
210 220 230 240 250
PVRPPSCTSK QDPVYVPPIS CNKDLSFGHS RASSKICSED IECSGLTIPK
260 270 280 290 300
AVQYLCSQDE KYQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
310 320 330 340 350
NQNVQQAAAG ALRNLVFRST PNKLETRRQN GIREAVSLLR RSGSTEIQKQ
360 370 380 390 400
LTGLLWNLSS TDELKEELVA DALPVLTDRV IIPFSGWCDG NSNMSREVVD
410 420 430 440 450
PEVFFNATGC LRNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK
460 470 480 490 500
SVENCMCILH NLSYRLDAEV PTRYRQLEYN TRNAYTEKSS TGCFSNRGDK
510 520 530 540 550
MMNNNYDCPL PEEETNPKGS SWLYHSDAIR TYLNLMGKSK KDATLEACAG
560 570 580 590 600
ALQNLTASKG LMSNGMSQLI GIKEKGLPQI ARLLQSGNSD VVRSGASLLS
610 620 630 640 650
NMSRHPVLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMT
660 670 680 690 700
SQPQMAKQYF SNSMLNNVFN LCRNTASSPK AAEAARLLLS DMWASKELQS
710 720
VLRQQGFDRN MMGNIAGANN LRNFTSRF
Length:728
Mass (Da):80,896
Last modified:May 1, 1997 - v1
Checksum:iBDAC5BA7B4118AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07941 mRNA Translation: CAA69240.1
BC139041 mRNA Translation: AAI39042.1
BC139042 mRNA Translation: AAI39043.1
CCDSiCCDS15322.1
RefSeqiNP_001300630.1, NM_001313701.1
NP_062619.1, NM_019645.3
UniGeneiMm.4494

Genome annotation databases

EnsembliENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413
ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413
GeneIDi18772
KEGGimmu:18772
UCSCiuc007cub.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPKP1_MOUSE
AccessioniPrimary (citable) accession number: P97350
Secondary accession number(s): B2RSX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health