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Protein

Plakophilin-1

Gene

Pkp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a role in junctional plaques.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-1
Gene namesi
Name:Pkp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1328359. Pkp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642851 – 728Plakophilin-1Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97350.
PaxDbiP97350.
PeptideAtlasiP97350.
PRIDEiP97350.

PTM databases

iPTMnetiP97350.
PhosphoSitePlusiP97350.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026413.
CleanExiMM_PKP1.
ExpressionAtlasiP97350. baseline and differential.
GenevisibleiP97350. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202212. 4 interactors.
IntActiP97350. 5 interactors.
MINTiMINT-4997007.
STRINGi10090.ENSMUSP00000027667.

Structurei

3D structure databases

ProteinModelPortaliP97350.
SMRiP97350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati244 – 275ARM 1Add BLAST32
Repeati276 – 317ARM 2Add BLAST42
Repeati318 – 360ARM 3Add BLAST43
Repeati361 – 412ARM 4Add BLAST52
Repeati413 – 443ARM 5Add BLAST31
Repeati505 – 536ARM 6Add BLAST32
Repeati537 – 583ARM 7Add BLAST47
Repeati584 – 629ARM 8Add BLAST46
Repeati630 – 694ARM 9Add BLAST65

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000060193.
HOVERGENiHBG096389.
InParanoidiP97350.
KOiK10387.
OMAiAYECFQD.
OrthoDBiEOG091G02GJ.
PhylomeDBiP97350.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK
60 70 80 90 100
RQKSKSSQSS TLSHSNRGSM YDGLADNYNN YGTTSRSSYF SKFQAGNGSW
110 120 130 140 150
GYPIYNGTLK REPDNRRFSS YSQMENWSRH YPRGSCATPG AGSDICFMQK
160 170 180 190 200
IKASRSEPDL YCDPRGTLRK GTLGSKGHKT TQNRCSFYST CSGQKAVKKC
210 220 230 240 250
PVRPPSCTSK QDPVYVPPIS CNKDLSFGHS RASSKICSED IECSGLTIPK
260 270 280 290 300
AVQYLCSQDE KYQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
310 320 330 340 350
NQNVQQAAAG ALRNLVFRST PNKLETRRQN GIREAVSLLR RSGSTEIQKQ
360 370 380 390 400
LTGLLWNLSS TDELKEELVA DALPVLTDRV IIPFSGWCDG NSNMSREVVD
410 420 430 440 450
PEVFFNATGC LRNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK
460 470 480 490 500
SVENCMCILH NLSYRLDAEV PTRYRQLEYN TRNAYTEKSS TGCFSNRGDK
510 520 530 540 550
MMNNNYDCPL PEEETNPKGS SWLYHSDAIR TYLNLMGKSK KDATLEACAG
560 570 580 590 600
ALQNLTASKG LMSNGMSQLI GIKEKGLPQI ARLLQSGNSD VVRSGASLLS
610 620 630 640 650
NMSRHPVLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMT
660 670 680 690 700
SQPQMAKQYF SNSMLNNVFN LCRNTASSPK AAEAARLLLS DMWASKELQS
710 720
VLRQQGFDRN MMGNIAGANN LRNFTSRF
Length:728
Mass (Da):80,896
Last modified:May 1, 1997 - v1
Checksum:iBDAC5BA7B4118AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07941 mRNA. Translation: CAA69240.1.
BC139041 mRNA. Translation: AAI39042.1.
BC139042 mRNA. Translation: AAI39043.1.
CCDSiCCDS15322.1.
RefSeqiNP_001300630.1. NM_001313701.1.
NP_062619.1. NM_019645.3.
UniGeneiMm.4494.

Genome annotation databases

EnsembliENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413.
ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413.
GeneIDi18772.
KEGGimmu:18772.
UCSCiuc007cub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07941 mRNA. Translation: CAA69240.1.
BC139041 mRNA. Translation: AAI39042.1.
BC139042 mRNA. Translation: AAI39043.1.
CCDSiCCDS15322.1.
RefSeqiNP_001300630.1. NM_001313701.1.
NP_062619.1. NM_019645.3.
UniGeneiMm.4494.

3D structure databases

ProteinModelPortaliP97350.
SMRiP97350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202212. 4 interactors.
IntActiP97350. 5 interactors.
MINTiMINT-4997007.
STRINGi10090.ENSMUSP00000027667.

PTM databases

iPTMnetiP97350.
PhosphoSitePlusiP97350.

Proteomic databases

MaxQBiP97350.
PaxDbiP97350.
PeptideAtlasiP97350.
PRIDEiP97350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413.
ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413.
GeneIDi18772.
KEGGimmu:18772.
UCSCiuc007cub.1. mouse.

Organism-specific databases

CTDi5317.
MGIiMGI:1328359. Pkp1.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000060193.
HOVERGENiHBG096389.
InParanoidiP97350.
KOiK10387.
OMAiAYECFQD.
OrthoDBiEOG091G02GJ.
PhylomeDBiP97350.
TreeFamiTF321877.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiPkp1. mouse.
PROiP97350.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026413.
CleanExiMM_PKP1.
ExpressionAtlasiP97350. baseline and differential.
GenevisibleiP97350. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKP1_MOUSE
AccessioniPrimary (citable) accession number: P97350
Secondary accession number(s): B2RSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.