Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Plakophilin-1

Gene

Pkp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a role in junctional plaques.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-1
Gene namesi
Name:Pkp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1328359. Pkp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Plakophilin-1PRO_0000064285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97350.
PaxDbiP97350.
PeptideAtlasiP97350.
PRIDEiP97350.

PTM databases

iPTMnetiP97350.
PhosphoSiteiP97350.

Expressioni

Gene expression databases

BgeeiP97350.
CleanExiMM_PKP1.
ExpressionAtlasiP97350. baseline and differential.
GenevisibleiP97350. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202212. 4 interactions.
IntActiP97350. 4 interactions.
MINTiMINT-4997007.
STRINGi10090.ENSMUSP00000027667.

Structurei

3D structure databases

ProteinModelPortaliP97350.
SMRiP97350. Positions 245-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati244 – 27532ARM 1Add
BLAST
Repeati276 – 31742ARM 2Add
BLAST
Repeati318 – 36043ARM 3Add
BLAST
Repeati361 – 41252ARM 4Add
BLAST
Repeati413 – 44331ARM 5Add
BLAST
Repeati505 – 53632ARM 6Add
BLAST
Repeati537 – 58347ARM 7Add
BLAST
Repeati584 – 62946ARM 8Add
BLAST
Repeati630 – 69465ARM 9Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000060193.
HOVERGENiHBG096389.
InParanoidiP97350.
KOiK10387.
OMAiAYECFQD.
OrthoDBiEOG7QVM31.
PhylomeDBiP97350.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK
60 70 80 90 100
RQKSKSSQSS TLSHSNRGSM YDGLADNYNN YGTTSRSSYF SKFQAGNGSW
110 120 130 140 150
GYPIYNGTLK REPDNRRFSS YSQMENWSRH YPRGSCATPG AGSDICFMQK
160 170 180 190 200
IKASRSEPDL YCDPRGTLRK GTLGSKGHKT TQNRCSFYST CSGQKAVKKC
210 220 230 240 250
PVRPPSCTSK QDPVYVPPIS CNKDLSFGHS RASSKICSED IECSGLTIPK
260 270 280 290 300
AVQYLCSQDE KYQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP
310 320 330 340 350
NQNVQQAAAG ALRNLVFRST PNKLETRRQN GIREAVSLLR RSGSTEIQKQ
360 370 380 390 400
LTGLLWNLSS TDELKEELVA DALPVLTDRV IIPFSGWCDG NSNMSREVVD
410 420 430 440 450
PEVFFNATGC LRNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK
460 470 480 490 500
SVENCMCILH NLSYRLDAEV PTRYRQLEYN TRNAYTEKSS TGCFSNRGDK
510 520 530 540 550
MMNNNYDCPL PEEETNPKGS SWLYHSDAIR TYLNLMGKSK KDATLEACAG
560 570 580 590 600
ALQNLTASKG LMSNGMSQLI GIKEKGLPQI ARLLQSGNSD VVRSGASLLS
610 620 630 640 650
NMSRHPVLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMT
660 670 680 690 700
SQPQMAKQYF SNSMLNNVFN LCRNTASSPK AAEAARLLLS DMWASKELQS
710 720
VLRQQGFDRN MMGNIAGANN LRNFTSRF
Length:728
Mass (Da):80,896
Last modified:May 1, 1997 - v1
Checksum:iBDAC5BA7B4118AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07941 mRNA. Translation: CAA69240.1.
BC139041 mRNA. Translation: AAI39042.1.
BC139042 mRNA. Translation: AAI39043.1.
CCDSiCCDS15322.1.
RefSeqiNP_001300630.1. NM_001313701.1.
NP_062619.1. NM_019645.3.
UniGeneiMm.4494.

Genome annotation databases

EnsembliENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413.
ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413.
GeneIDi18772.
KEGGimmu:18772.
UCSCiuc007cub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07941 mRNA. Translation: CAA69240.1.
BC139041 mRNA. Translation: AAI39042.1.
BC139042 mRNA. Translation: AAI39043.1.
CCDSiCCDS15322.1.
RefSeqiNP_001300630.1. NM_001313701.1.
NP_062619.1. NM_019645.3.
UniGeneiMm.4494.

3D structure databases

ProteinModelPortaliP97350.
SMRiP97350. Positions 245-702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202212. 4 interactions.
IntActiP97350. 4 interactions.
MINTiMINT-4997007.
STRINGi10090.ENSMUSP00000027667.

PTM databases

iPTMnetiP97350.
PhosphoSiteiP97350.

Proteomic databases

MaxQBiP97350.
PaxDbiP97350.
PeptideAtlasiP97350.
PRIDEiP97350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027667; ENSMUSP00000027667; ENSMUSG00000026413.
ENSMUST00000163260; ENSMUSP00000128418; ENSMUSG00000026413.
GeneIDi18772.
KEGGimmu:18772.
UCSCiuc007cub.1. mouse.

Organism-specific databases

CTDi5317.
MGIiMGI:1328359. Pkp1.

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOGENOMiHOG000060193.
HOVERGENiHBG096389.
InParanoidiP97350.
KOiK10387.
OMAiAYECFQD.
OrthoDBiEOG7QVM31.
PhylomeDBiP97350.
TreeFamiTF321877.

Miscellaneous databases

ChiTaRSiPkp1. mouse.
PROiP97350.
SOURCEiSearch...

Gene expression databases

BgeeiP97350.
CleanExiMM_PKP1.
ExpressionAtlasiP97350. baseline and differential.
GenevisibleiP97350. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028432. Plakophilin-1.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 1 hit.
PTHR10372:SF3. PTHR10372:SF3. 1 hit.
PfamiPF00514. Arm. 2 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Nimmrich V., Hunziker A.H., Franke W.W.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Liver and Pancreas.

Entry informationi

Entry nameiPKP1_MOUSE
AccessioniPrimary (citable) accession number: P97350
Secondary accession number(s): B2RSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.