P97348 (RHOD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoD

Gene names

Name:	Rhod
Synonyms:	Arhd, Rhom

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.
Subunit structure	Interacts with PAK7/PAK5 By similarity.
Subcellular location	Cell membrane. Early endosome.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
Cellular component	Cell membrane Endosome Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from direct assay PubMed 19543268. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Rho-related GTP-binding protein RhoD		PRO_0000198864
	Propeptide	208 – 210	3	Removed in mature form By similarity		PRO_0000223366
Regions
	Nucleotide binding	24 – 31	8	GTP By similarity
	Nucleotide binding	71 – 75	5	GTP By similarity
	Nucleotide binding	129 – 132	4	GTP By similarity
	Motif	46 – 54	9	Effector region Potential
Amino acid modifications
	Modified residue	207	1	Cysteine methyl ester By similarity
	Lipidation	207	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97348 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0D9C1C39AA6D56E9	FASTA	210	23,562
	10 20 30 40 50 60 MNASQVAGEE APQSGHSVKV VLVGDGGCGK TSLMMVFAKG AFPESYSPTV FERYNATLQM 70 80 90 100 110 120 KGKPVHLQIW DTAGQDDYDR LRPLFYPDAN VLLLCFDVTN PNSFDNVSNR WYPEVTHFCK 130 140 150 160 170 180 GVPIIVVGCK IDLRKDKVLV NNLRKKRLEP VTYHRGHDMA RSVGAVAYLE CSARLHDNVE 190 200 210 AVFQEAAEVA LSSRRHNFWR RITQNCCLAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Endosome dynamics regulated by a Rho protein." Murphy C., Saffrich R., Grummt M., Gournier H., Rybin V., Rubino M., Auvinen P., Luetcke A., Parton R.G., Zerial M. Nature 384:427-432(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton." Matsumoto K., Asano T., Endo T. Oncogene 15:2409-2417(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X84325 mRNA. Translation: CAA59064.1. D89821 mRNA. Translation: BAA14023.1. BC047989 mRNA. Translation: AAH47989.1.
IPI	IPI00124081.
RefSeq	NP_031511.1. NM_007485.4.
UniGene	Mm.27701.
3D structure databases
ProteinModelPortal	P97348.
SMR	P97348. Positions 17-193.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1340205.
STRING	10090.ENSMUSP00000036031.
PTM databases
PhosphoSite	P97348.
Proteomic databases
PaxDb	P97348.
PRIDE	P97348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000048197; ENSMUSP00000036031; ENSMUSG00000041845.
GeneID	11854.
KEGG	mmu:11854.
Organism-specific databases
CTD	29984.
MGI	MGI:108446. Rhod.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233974.
HOVERGEN	HBG009351.
InParanoid	P97348.
KO	K07530.
OMA	AGQVDYD.
OrthoDB	EOG4P5KB3.
Gene expression databases
ArrayExpress	P97348.
Bgee	P97348.
CleanEx	MM_RHOD.
Genevestigator	P97348.
GermOnline	ENSMUSG00000041845. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279833.
SOURCE	Search...

Entry information

Entry name

RHOD_MOUSE

Accession

Primary (citable) accession number: P97348
Secondary accession number(s): O09104

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program