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P97348

- RHOD_MOUSE

UniProt

P97348 - RHOD_MOUSE

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Protein

Rho-related GTP-binding protein RhoD

Gene
Rhod, Arhd, Rhom
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTP By similarity
Nucleotide bindingi71 – 755GTP By similarity
Nucleotide bindingi129 – 1324GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: MGI

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoD
Gene namesi
Name:Rhod
Synonyms:Arhd, Rhom
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:108446. Rhod.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Rho-related GTP-binding protein RhoDPRO_0000198864Add
BLAST
Propeptidei208 – 2103Removed in mature form By similarityPRO_0000223366

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei207 – 2071Cysteine methyl ester By similarity
Lipidationi207 – 2071S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP97348.
PRIDEiP97348.

PTM databases

PhosphoSiteiP97348.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiP97348.
BgeeiP97348.
CleanExiMM_RHOD.
GenevestigatoriP97348.

Interactioni

Subunit structurei

Interacts with PAK7/PAK5 By similarity.

Protein-protein interaction databases

BioGridi198198. 6 interactions.
MINTiMINT-1340205.
STRINGi10090.ENSMUSP00000036031.

Structurei

3D structure databases

ProteinModelPortaliP97348.
SMRiP97348. Positions 17-193.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 549Effector region Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiP97348.
KOiK07530.
OMAiAGQVDYD.
OrthoDBiEOG74TX0S.
PhylomeDBiP97348.
TreeFamiTF331746.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97348-1 [UniParc]FASTAAdd to Basket

« Hide

MNASQVAGEE APQSGHSVKV VLVGDGGCGK TSLMMVFAKG AFPESYSPTV    50
FERYNATLQM KGKPVHLQIW DTAGQDDYDR LRPLFYPDAN VLLLCFDVTN 100
PNSFDNVSNR WYPEVTHFCK GVPIIVVGCK IDLRKDKVLV NNLRKKRLEP 150
VTYHRGHDMA RSVGAVAYLE CSARLHDNVE AVFQEAAEVA LSSRRHNFWR 200
RITQNCCLAT 210
Length:210
Mass (Da):23,562
Last modified:May 1, 1997 - v1
Checksum:i0D9C1C39AA6D56E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84325 mRNA. Translation: CAA59064.1.
D89821 mRNA. Translation: BAA14023.1.
BC047989 mRNA. Translation: AAH47989.1.
CCDSiCCDS29427.1.
RefSeqiNP_031511.1. NM_007485.4.
UniGeneiMm.27701.

Genome annotation databases

EnsembliENSMUST00000048197; ENSMUSP00000036031; ENSMUSG00000041845.
GeneIDi11854.
KEGGimmu:11854.
UCSCiuc008gaa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84325 mRNA. Translation: CAA59064.1 .
D89821 mRNA. Translation: BAA14023.1 .
BC047989 mRNA. Translation: AAH47989.1 .
CCDSi CCDS29427.1.
RefSeqi NP_031511.1. NM_007485.4.
UniGenei Mm.27701.

3D structure databases

ProteinModelPortali P97348.
SMRi P97348. Positions 17-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198198. 6 interactions.
MINTi MINT-1340205.
STRINGi 10090.ENSMUSP00000036031.

PTM databases

PhosphoSitei P97348.

Proteomic databases

PaxDbi P97348.
PRIDEi P97348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048197 ; ENSMUSP00000036031 ; ENSMUSG00000041845 .
GeneIDi 11854.
KEGGi mmu:11854.
UCSCi uc008gaa.1. mouse.

Organism-specific databases

CTDi 29984.
MGIi MGI:108446. Rhod.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi P97348.
KOi K07530.
OMAi AGQVDYD.
OrthoDBi EOG74TX0S.
PhylomeDBi P97348.
TreeFami TF331746.

Enzyme and pathway databases

Reactomei REACT_210090. Rho GTPase cycle.

Miscellaneous databases

NextBioi 279833.
PROi P97348.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97348.
Bgeei P97348.
CleanExi MM_RHOD.
Genevestigatori P97348.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton."
    Matsumoto K., Asano T., Endo T.
    Oncogene 15:2409-2417(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiRHOD_MOUSE
AccessioniPrimary (citable) accession number: P97348
Secondary accession number(s): O09104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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