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P97348 (RHOD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoD
Gene names
Name:Rhod
Synonyms:Arhd, Rhom
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.

Subunit structure

Interacts with PAK7/PAK5 By similarity.

Subcellular location

Cell membrane. Early endosome.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Rho-related GTP-binding protein RhoD
PRO_0000198864
Propeptide208 – 2103Removed in mature form By similarity
PRO_0000223366

Regions

Nucleotide binding24 – 318GTP By similarity
Nucleotide binding71 – 755GTP By similarity
Nucleotide binding129 – 1324GTP By similarity
Motif46 – 549Effector region Potential

Amino acid modifications

Modified residue2071Cysteine methyl ester By similarity
Lipidation2071S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P97348 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0D9C1C39AA6D56E9

FASTA21023,562
        10         20         30         40         50         60 
MNASQVAGEE APQSGHSVKV VLVGDGGCGK TSLMMVFAKG AFPESYSPTV FERYNATLQM 

        70         80         90        100        110        120 
KGKPVHLQIW DTAGQDDYDR LRPLFYPDAN VLLLCFDVTN PNSFDNVSNR WYPEVTHFCK 

       130        140        150        160        170        180 
GVPIIVVGCK IDLRKDKVLV NNLRKKRLEP VTYHRGHDMA RSVGAVAYLE CSARLHDNVE 

       190        200        210 
AVFQEAAEVA LSSRRHNFWR RITQNCCLAT 

« Hide

References

« Hide 'large scale' references
[1]"Endosome dynamics regulated by a Rho protein."
Murphy C., Saffrich R., Grummt M., Gournier H., Rybin V., Rubino M., Auvinen P., Luetcke A., Parton R.G., Zerial M.
Nature 384:427-432(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton."
Matsumoto K., Asano T., Endo T.
Oncogene 15:2409-2417(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84325 mRNA. Translation: CAA59064.1.
D89821 mRNA. Translation: BAA14023.1.
BC047989 mRNA. Translation: AAH47989.1.
RefSeqNP_031511.1. NM_007485.4.
UniGeneMm.27701.

3D structure databases

ProteinModelPortalP97348.
SMRP97348. Positions 17-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198198. 6 interactions.
MINTMINT-1340205.
STRING10090.ENSMUSP00000036031.

PTM databases

PhosphoSiteP97348.

Proteomic databases

PaxDbP97348.
PRIDEP97348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048197; ENSMUSP00000036031; ENSMUSG00000041845.
GeneID11854.
KEGGmmu:11854.
UCSCuc008gaa.1. mouse.

Organism-specific databases

CTD29984.
MGIMGI:108446. Rhod.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidP97348.
KOK07530.
OMAAGQVDYD.
OrthoDBEOG74TX0S.
PhylomeDBP97348.
TreeFamTF331746.

Gene expression databases

ArrayExpressP97348.
BgeeP97348.
CleanExMM_RHOD.
GenevestigatorP97348.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279833.
PROP97348.
SOURCESearch...

Entry information

Entry nameRHOD_MOUSE
AccessionPrimary (citable) accession number: P97348
Secondary accession number(s): O09104
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot