Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97348

- RHOD_MOUSE

UniProt

P97348 - RHOD_MOUSE

Protein

Rho-related GTP-binding protein RhoD

Gene

Rhod

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi71 – 755GTPBy similarity
    Nucleotide bindingi129 – 1324GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: MGI

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related GTP-binding protein RhoD
    Gene namesi
    Name:Rhod
    Synonyms:Arhd, Rhom
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:108446. Rhod.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Rho-related GTP-binding protein RhoDPRO_0000198864Add
    BLAST
    Propeptidei208 – 2103Removed in mature formBy similarityPRO_0000223366

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071Cysteine methyl esterBy similarity
    Lipidationi207 – 2071S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP97348.
    PRIDEiP97348.

    PTM databases

    PhosphoSiteiP97348.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiP97348.
    BgeeiP97348.
    CleanExiMM_RHOD.
    GenevestigatoriP97348.

    Interactioni

    Subunit structurei

    Interacts with PAK7/PAK5.By similarity

    Protein-protein interaction databases

    BioGridi198198. 6 interactions.
    MINTiMINT-1340205.
    STRINGi10090.ENSMUSP00000036031.

    Structurei

    3D structure databases

    ProteinModelPortaliP97348.
    SMRiP97348. Positions 17-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 549Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233974.
    HOVERGENiHBG009351.
    InParanoidiP97348.
    KOiK07530.
    OMAiAGQVDYD.
    OrthoDBiEOG74TX0S.
    PhylomeDBiP97348.
    TreeFamiTF331746.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNASQVAGEE APQSGHSVKV VLVGDGGCGK TSLMMVFAKG AFPESYSPTV    50
    FERYNATLQM KGKPVHLQIW DTAGQDDYDR LRPLFYPDAN VLLLCFDVTN 100
    PNSFDNVSNR WYPEVTHFCK GVPIIVVGCK IDLRKDKVLV NNLRKKRLEP 150
    VTYHRGHDMA RSVGAVAYLE CSARLHDNVE AVFQEAAEVA LSSRRHNFWR 200
    RITQNCCLAT 210
    Length:210
    Mass (Da):23,562
    Last modified:May 1, 1997 - v1
    Checksum:i0D9C1C39AA6D56E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84325 mRNA. Translation: CAA59064.1.
    D89821 mRNA. Translation: BAA14023.1.
    BC047989 mRNA. Translation: AAH47989.1.
    CCDSiCCDS29427.1.
    RefSeqiNP_031511.1. NM_007485.4.
    UniGeneiMm.27701.

    Genome annotation databases

    EnsembliENSMUST00000048197; ENSMUSP00000036031; ENSMUSG00000041845.
    GeneIDi11854.
    KEGGimmu:11854.
    UCSCiuc008gaa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84325 mRNA. Translation: CAA59064.1 .
    D89821 mRNA. Translation: BAA14023.1 .
    BC047989 mRNA. Translation: AAH47989.1 .
    CCDSi CCDS29427.1.
    RefSeqi NP_031511.1. NM_007485.4.
    UniGenei Mm.27701.

    3D structure databases

    ProteinModelPortali P97348.
    SMRi P97348. Positions 17-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198198. 6 interactions.
    MINTi MINT-1340205.
    STRINGi 10090.ENSMUSP00000036031.

    PTM databases

    PhosphoSitei P97348.

    Proteomic databases

    PaxDbi P97348.
    PRIDEi P97348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048197 ; ENSMUSP00000036031 ; ENSMUSG00000041845 .
    GeneIDi 11854.
    KEGGi mmu:11854.
    UCSCi uc008gaa.1. mouse.

    Organism-specific databases

    CTDi 29984.
    MGIi MGI:108446. Rhod.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233974.
    HOVERGENi HBG009351.
    InParanoidi P97348.
    KOi K07530.
    OMAi AGQVDYD.
    OrthoDBi EOG74TX0S.
    PhylomeDBi P97348.
    TreeFami TF331746.

    Enzyme and pathway databases

    Reactomei REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    NextBioi 279833.
    PROi P97348.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97348.
    Bgeei P97348.
    CleanExi MM_RHOD.
    Genevestigatori P97348.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton."
      Matsumoto K., Asano T., Endo T.
      Oncogene 15:2409-2417(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiRHOD_MOUSE
    AccessioniPrimary (citable) accession number: P97348
    Secondary accession number(s): O09104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3