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Protein

Rho-related GTP-binding protein RhoD

Gene

Rhod

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: MGI
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-5663220 RHO GTPases Activate Formins

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoD
Gene namesi
Name:Rhod
Synonyms:Arhd, Rhom
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:108446 Rhod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988641 – 207Rho-related GTP-binding protein RhoDAdd BLAST207
PropeptideiPRO_0000223366208 – 210Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207Cysteine methyl esterBy similarity1
Lipidationi207S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP97348
PRIDEiP97348

PTM databases

iPTMnetiP97348
PhosphoSitePlusiP97348
SwissPalmiP97348

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000041845
CleanExiMM_RHOD
ExpressionAtlasiP97348 baseline and differential
GenevisibleiP97348 MM

Interactioni

Subunit structurei

Interacts with PAK5. Interacts (in GTP-bound form) with DAPK3, FILIP1 and WHAMM. Interacts (independent of GTP-loaded status) with ANKFY1.3 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198198, 6 interactors
IntActiP97348, 7 interactors
MINTiP97348
STRINGi10090.ENSMUSP00000036031

Structurei

3D structure databases

ProteinModelPortaliP97348
SMRiP97348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP97348
KOiK07530
OMAiAGQVDYD
OrthoDBiEOG091G0KNI
PhylomeDBiP97348
TreeFamiTF331746

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASQVAGEE APQSGHSVKV VLVGDGGCGK TSLMMVFAKG AFPESYSPTV
60 70 80 90 100
FERYNATLQM KGKPVHLQIW DTAGQDDYDR LRPLFYPDAN VLLLCFDVTN
110 120 130 140 150
PNSFDNVSNR WYPEVTHFCK GVPIIVVGCK IDLRKDKVLV NNLRKKRLEP
160 170 180 190 200
VTYHRGHDMA RSVGAVAYLE CSARLHDNVE AVFQEAAEVA LSSRRHNFWR
210
RITQNCCLAT
Length:210
Mass (Da):23,562
Last modified:May 1, 1997 - v1
Checksum:i0D9C1C39AA6D56E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84325 mRNA Translation: CAA59064.1
D89821 mRNA Translation: BAA14023.1
BC047989 mRNA Translation: AAH47989.1
CCDSiCCDS29427.1
RefSeqiNP_031511.1, NM_007485.5
UniGeneiMm.27701

Genome annotation databases

EnsembliENSMUST00000048197; ENSMUSP00000036031; ENSMUSG00000041845
GeneIDi11854
KEGGimmu:11854
UCSCiuc008gaa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRHOD_MOUSE
AccessioniPrimary (citable) accession number: P97348
Secondary accession number(s): O09104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health