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Protein

Serine/threonine-protein kinase Kist

Gene

Uhmk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • mRNA binding Source: GO_Central
  • protein kinase activity Source: BHF-UCL
  • protein serine/threonine kinase activity Source: UniProtKB
  • ribonucleoprotein complex binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
Gene namesi
Name:Uhmk1
Synonyms:Kis, Kist
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1341908. Uhmk1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • dendrite cytoplasm Source: BHF-UCL
  • exon-exon junction complex Source: GO_Central
  • neuronal ribonucleoprotein granule Source: BHF-UCL
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Serine/threonine-protein kinase KistPRO_0000086778Add
BLAST

Proteomic databases

EPDiP97343.
MaxQBiP97343.
PaxDbiP97343.
PRIDEiP97343.

PTM databases

iPTMnetiP97343.
PhosphoSiteiP97343.

Expressioni

Inductioni

By serum growth factors.

Gene expression databases

BgeeiP97343.
CleanExiMM_UHMK1.
ExpressionAtlasiP97343. baseline and differential.
GenevisibleiP97343. MM.

Interactioni

Subunit structurei

Interacts with PAM and CDKN1B/p27Kip1 (By similarity). Interacts with stathmin.By similarity2 Publications

Protein-protein interaction databases

BioGridi200956. 7 interactions.
IntActiP97343. 1 interaction.
STRINGi10090.ENSMUSP00000027979.

Structurei

3D structure databases

ProteinModelPortaliP97343.
SMRiP97343. Positions 23-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 303281Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini323 – 40583RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00790000123065.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiP97343.
KOiK08877.
OMAiDMKEECQ.
PhylomeDBiP97343.
TreeFamiTF331856.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGTPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPG RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEDEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,489
Last modified:January 4, 2005 - v3
Checksum:i3BD3C06A59E22540
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701N → D in CAA57763 (PubMed:7724523).Curated
Sequence conflicti231 – 2311I → T (PubMed:16141072).Curated
Sequence conflicti231 – 2311I → T (PubMed:9287318).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180177 Genomic DNA. Translation: AAO13515.1.
Y10725 mRNA. Translation: CAA71714.2.
BC058732 mRNA. Translation: AAH58732.1.
AK013347 mRNA. Translation: BAB28802.1.
X82320 mRNA. Translation: CAA57763.1.
CCDSiCCDS15468.1.
PIRiI48615.
RefSeqiNP_034763.3. NM_010633.3.
UniGeneiMm.209150.
Mm.389214.

Genome annotation databases

EnsembliENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667.
GeneIDi16589.
KEGGimmu:16589.
UCSCiuc007dma.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180177 Genomic DNA. Translation: AAO13515.1.
Y10725 mRNA. Translation: CAA71714.2.
BC058732 mRNA. Translation: AAH58732.1.
AK013347 mRNA. Translation: BAB28802.1.
X82320 mRNA. Translation: CAA57763.1.
CCDSiCCDS15468.1.
PIRiI48615.
RefSeqiNP_034763.3. NM_010633.3.
UniGeneiMm.209150.
Mm.389214.

3D structure databases

ProteinModelPortaliP97343.
SMRiP97343. Positions 23-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200956. 7 interactions.
IntActiP97343. 1 interaction.
STRINGi10090.ENSMUSP00000027979.

PTM databases

iPTMnetiP97343.
PhosphoSiteiP97343.

Proteomic databases

EPDiP97343.
MaxQBiP97343.
PaxDbiP97343.
PRIDEiP97343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667.
GeneIDi16589.
KEGGimmu:16589.
UCSCiuc007dma.1. mouse.

Organism-specific databases

CTDi127933.
MGIiMGI:1341908. Uhmk1.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00790000123065.
HOGENOMiHOG000013166.
HOVERGENiHBG056149.
InParanoidiP97343.
KOiK08877.
OMAiDMKEECQ.
PhylomeDBiP97343.
TreeFamiTF331856.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Miscellaneous databases

PROiP97343.
SOURCEiSearch...

Gene expression databases

BgeeiP97343.
CleanExiMM_UHMK1.
ExpressionAtlasiP97343. baseline and differential.
GenevisibleiP97343. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000719. Prot_kinase_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Crook M.F., Boehm M., Nabel E.G.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-414.
    Tissue: Brain.
  5. Maucuer A.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 52 AND 68-69.
  6. "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains."
    Maucuer A., Camonis J.H., Sobel A.
    Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-321, INTERACTION WITH STATHMIN.
    Tissue: Embryo.
  7. "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression."
    Boehm M., Yoshimoto T., Crook M.F., Nallamshetty S., True A., Nabel G.J., Nabel E.G.
    EMBO J. 21:3390-3401(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDKN1B, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUHMK1_MOUSE
AccessioniPrimary (citable) accession number: P97343
Secondary accession number(s): Q61775, Q9CYT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.