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P97334

- NKX23_MOUSE

UniProt

P97334 - NKX23_MOUSE

Protein

Homeobox protein Nkx-2.3

Gene

Nkx2-3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (02 Aug 2002)
      Previous versions | rss
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    Functioni

    Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi145 – 20460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. B cell differentiation Source: MGI
    2. CD4-positive, alpha-beta T cell differentiation Source: MGI
    3. digestive tract development Source: MGI
    4. gland morphogenesis Source: MGI
    5. immune response Source: MGI
    6. leukocyte homeostasis Source: MGI
    7. leukocyte migration Source: MGI
    8. lymph node development Source: MGI
    9. macrophage differentiation Source: MGI
    10. mucosal-associated lymphoid tissue development Source: MGI
    11. odontogenesis of dentin-containing tooth Source: MGI
    12. Peyer's patch development Source: MGI
    13. plasma cell differentiation Source: MGI
    14. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    15. post-embryonic development Source: MGI
    16. post-embryonic digestive tract morphogenesis Source: MGI
    17. regulation of cell proliferation Source: MGI
    18. spleen development Source: MGI
    19. transcription, DNA-templated Source: UniProtKB-KW
    20. triglyceride metabolic process Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-2.3
    Alternative name(s):
    Homeobox protein NK-2 homolog 3
    Homeobox protein NK-2 homolog C
    Nkx2-C
    Gene namesi
    Name:Nkx2-3
    Synonyms:Nkx-2.3, Nkx2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:97348. Nkx2-3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Homeobox protein Nkx-2.3PRO_0000048934Add
    BLAST

    Proteomic databases

    PRIDEiP97334.

    PTM databases

    PhosphoSiteiP97334.

    Expressioni

    Tissue specificityi

    Expressed in spleen and intestine. Also expressed in salivary gland and tongue.1 Publication

    Developmental stagei

    Expressed in gut mesenchyme during pre- and postnatal development. Expressed as well in the pharyngeal floor and pouches, and in the oral and branchial arch ectoderm. Expression persisted in the developing thyroid until birth, in mucous forming cells of salivary glands and in odontogenic epithelium of the mandible.

    Gene expression databases

    BgeeiP97334.
    GenevestigatoriP97334.

    Interactioni

    Protein-protein interaction databases

    BioGridi201777. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP97334.
    SMRiP97334. Positions 145-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 679Poly-Glu
    Compositional biasi216 – 2205Poly-Pro
    Compositional biasi268 – 28316Poly-AlaAdd
    BLAST
    Compositional biasi295 – 3028Poly-Gly

    Sequence similaritiesi

    Belongs to the NK-2 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG310976.
    GeneTreeiENSGT00720000108380.
    HOGENOMiHOG000231923.
    HOVERGENiHBG006689.
    InParanoidiP97334.
    KOiK09343.
    OMAiPCVTPSA.
    OrthoDBiEOG769ZK0.
    TreeFamiTF351204.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97334-1 [UniParc]FASTAAdd to Basket

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    MMLPSPVTST PFSVKDILNL EQQRHFHGAH LQAELEQHFH SAPCMLATAE    50
    GTQFSDAGEE DEEEEGEKLS YLNSLAAAEG HGDSGLCPQS YVHTVLRDAC 100
    SGPKEQEEEV VSERSQKSCQ LKKSLEAAGD CKTSEDGERP KPRSRRKPRV 150
    LFSQAQVFEL ERRFKQQRYL SAPEREHLAS SLKLTSTQVK IWFQNRRYKC 200
    KRQRQDKSLE LGTHAPPPPP RRVAVPVLVR DGKPCVTPSA QTYGSPYGVG 250
    AGAYSYNSFP AYGYGNSAAA AAAAAAAAAA AAAYSGSYGC AYPTGGGGGG 300
    GGTASAATTA MQPACSATGG GSFVNVSNLG GFGSGGGAQP LHQGAAAGSA 350
    CTQGTLQGIR AW 362
    Length:362
    Mass (Da):38,090
    Last modified:August 2, 2002 - v2
    Checksum:i48886528EC3E1622
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441C → R in CAA72002. (PubMed:9142493)Curated
    Sequence conflicti61 – 611D → E in CAA72002. (PubMed:9142493)Curated
    Sequence conflicti132 – 1321K → R in CAA72002. (PubMed:9142493)Curated
    Sequence conflicti248 – 2503GVG → RC in CAA72002. (PubMed:9142493)Curated
    Sequence conflicti261 – 35797AYGYG…QGTLQ → TATGTRPPQPLQPPQPQQQG LQRQLRLAYRPVAAVVVAAR PPRRPPPCNPPAAPPGDLRV TAGIEAFVPLVR in CAA72002. (PubMed:9142493)CuratedAdd
    BLAST
    Sequence conflicti349 – 3491S → A in AAD38415. (PubMed:10926756)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11117 mRNA. Translation: CAA72002.1.
    AF202036 mRNA. Translation: AAF08008.1.
    AF155583 Genomic DNA. Translation: AAD38415.1.
    BC072614 mRNA. Translation: AAH72614.1.
    CCDSiCCDS29833.1.
    RefSeqiNP_032725.1. NM_008699.2.
    XP_006526807.1. XM_006526744.1.
    UniGeneiMm.56994.

    Genome annotation databases

    EnsembliENSMUST00000057178; ENSMUSP00000050933; ENSMUSG00000044220.
    GeneIDi18089.
    KEGGimmu:18089.
    UCSCiuc008hok.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11117 mRNA. Translation: CAA72002.1 .
    AF202036 mRNA. Translation: AAF08008.1 .
    AF155583 Genomic DNA. Translation: AAD38415.1 .
    BC072614 mRNA. Translation: AAH72614.1 .
    CCDSi CCDS29833.1.
    RefSeqi NP_032725.1. NM_008699.2.
    XP_006526807.1. XM_006526744.1.
    UniGenei Mm.56994.

    3D structure databases

    ProteinModelPortali P97334.
    SMRi P97334. Positions 145-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201777. 2 interactions.

    PTM databases

    PhosphoSitei P97334.

    Proteomic databases

    PRIDEi P97334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057178 ; ENSMUSP00000050933 ; ENSMUSG00000044220 .
    GeneIDi 18089.
    KEGGi mmu:18089.
    UCSCi uc008hok.1. mouse.

    Organism-specific databases

    CTDi 159296.
    MGIi MGI:97348. Nkx2-3.

    Phylogenomic databases

    eggNOGi NOG310976.
    GeneTreei ENSGT00720000108380.
    HOGENOMi HOG000231923.
    HOVERGENi HBG006689.
    InParanoidi P97334.
    KOi K09343.
    OMAi PCVTPSA.
    OrthoDBi EOG769ZK0.
    TreeFami TF351204.

    Miscellaneous databases

    ChiTaRSi NKX2-3. mouse.
    NextBioi 293231.
    PROi P97334.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97334.
    Genevestigatori P97334.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development."
      Pabst O., Schneider A., Brand T., Arnold H.-H.
      Dev. Dyn. 209:29-35(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129.
      Tissue: Liver.
    2. "Homeodomain factor Nkx2-3 is required for normal development of the gut-associated lymphoid tissue and the spleen."
      Wang C.-C., Biben C., Robb R., Tarlinton D., Nassir F., Davidson N.O., Harvey R.P.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129.
    3. "Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera."
      Wang C.-C., Biben C., Robb L., Nassir F., Barnett L., Davidson N.O., Koentgen F., Tarlinton D., Harvey R.P.
      Dev. Biol. 224:152-167(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue."
      Pabst O., Foerster R., Lipp M., Engel H., Arnold H.-H.
      EMBO J. 19:2015-2023(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis."
      Biben C., Wang C.-C., Harvey R.P.
      Int. J. Dev. Biol. 46:415-422(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNKX23_MOUSE
    AccessioniPrimary (citable) accession number: P97334
    Secondary accession number(s): Q9QZ60, Q9WV67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: August 2, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3