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P97333

- NRP1_MOUSE

UniProt

P97333 - NRP1_MOUSE

Protein

Neuropilin-1

Gene

Nrp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi195 – 1951CalciumBy similarity
    Metal bindingi209 – 2091CalciumBy similarity
    Metal bindingi250 – 2501CalciumBy similarity

    GO - Molecular functioni

    1. growth factor binding Source: MGI
    2. heparin binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. semaphorin receptor activity Source: MGI
    6. vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
    7. vascular endothelial growth factor binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: BHF-UCL
    2. angiogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
    3. artery morphogenesis Source: BHF-UCL
    4. axonal fasciculation Source: MGI
    5. axon extension involved in axon guidance Source: BHF-UCL
    6. axon guidance Source: MGI
    7. axonogenesis involved in innervation Source: BHF-UCL
    8. branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
    9. cell adhesion Source: InterPro
    10. cell migration Source: MGI
    11. cell migration involved in coronary vasculogenesis Source: BHF-UCL
    12. cell migration involved in sprouting angiogenesis Source: BHF-UCL
    13. cellular response to hepatocyte growth factor stimulus Source: Ensembl
    14. cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
    15. commissural neuron axon guidance Source: BHF-UCL
    16. coronary artery morphogenesis Source: BHF-UCL
    17. cranial ganglion development Source: ParkinsonsUK-UCL
    18. dendrite development Source: MGI
    19. dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
    20. endothelial cell chemotaxis Source: Ensembl
    21. facial nerve structural organization Source: ParkinsonsUK-UCL
    22. ganglion morphogenesis Source: ParkinsonsUK-UCL
    23. gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: BHF-UCL
    24. heart development Source: MGI
    25. hepatocyte growth factor receptor signaling pathway Source: Ensembl
    26. motor neuron axon guidance Source: ParkinsonsUK-UCL
    27. negative regulation of axon extension Source: MGI
    28. negative regulation of axon extension involved in axon guidance Source: MGI
    29. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    30. negative regulation of neuron apoptotic process Source: BHF-UCL
    31. nerve development Source: BHF-UCL
    32. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
    33. neuron development Source: BHF-UCL
    34. neuron migration Source: BHF-UCL
    35. otic placode formation Source: ParkinsonsUK-UCL
    36. patterning of blood vessels Source: BHF-UCL
    37. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    38. positive chemotaxis Source: BHF-UCL
    39. positive regulation of axon extension involved in axon guidance Source: BHF-UCL
    40. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    41. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    42. positive regulation of retinal ganglion cell axon guidance Source: BHF-UCL
    43. protein localization to early endosome Source: BHF-UCL
    44. regulation of axon extension involved in axon guidance Source: MGI
    45. regulation of retinal ganglion cell axon guidance Source: BHF-UCL
    46. renal artery morphogenesis Source: BHF-UCL
    47. response to wounding Source: Ensembl
    48. retinal ganglion cell axon guidance Source: BHF-UCL
    49. retina vasculature morphogenesis in camera-type eye Source: BHF-UCL
    50. semaphorin-plexin signaling pathway Source: MGI
    51. semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
    52. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
    53. sensory neuron axon guidance Source: ParkinsonsUK-UCL
    54. sprouting angiogenesis Source: BHF-UCL
    55. sympathetic ganglion development Source: BHF-UCL
    56. sympathetic nervous system development Source: MGI
    57. sympathetic neuron projection extension Source: BHF-UCL
    58. sympathetic neuron projection guidance Source: BHF-UCL
    59. trigeminal ganglion development Source: ParkinsonsUK-UCL
    60. trigeminal nerve morphogenesis Source: MGI
    61. trigeminal nerve structural organization Source: ParkinsonsUK-UCL
    62. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
    63. VEGF-activated neuropilin signaling pathway Source: BHF-UCL
    64. VEGF-activated neuropilin signaling pathway involved in axon guidance Source: BHF-UCL
    65. vestibulocochlear nerve structural organization Source: ParkinsonsUK-UCL

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Angiogenesis, Differentiation, Neurogenesis

    Keywords - Ligandi

    Calcium, Heparin-binding, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198267. CHL1 interactions.
    REACT_215461. Signal transduction by L1.
    REACT_227870. Neurophilin interactions with VEGF and VEGFR.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropilin-1
    Alternative name(s):
    A5 protein
    CD_antigen: CD304
    Gene namesi
    Name:Nrp1
    Synonyms:Nrp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:106206. Nrp1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: BHF-UCL
    2. cell surface Source: Ensembl
    3. cytosol Source: Ensembl
    4. early endosome Source: BHF-UCL
    5. growth cone Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. neurofilament Source: MGI
    8. neuronal cell body Source: Ensembl
    9. plasma membrane Source: BHF-UCL
    10. sorting endosome Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 923902Neuropilin-1PRO_0000021860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 54Curated
    Disulfide bondi82 ↔ 104Curated
    Disulfide bondi147 ↔ 173By similarity
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 228By similarity
    Glycosylationi261 – 2611N-linked (GlcNAc...)1 Publication
    Disulfide bondi275 ↔ 424By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi431 ↔ 583By similarity
    Glycosylationi522 – 5221N-linked (GlcNAc...)1 Publication
    Glycosylationi612 – 6121O-linked (Xyl...) (chondroitin sulfate); alternateBy similarity
    Glycosylationi612 – 6121O-linked (Xyl...) (heparan sulfate); alternateBy similarity
    Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

    Proteomic databases

    MaxQBiP97333.
    PaxDbiP97333.
    PRIDEiP97333.

    PTM databases

    PhosphoSiteiP97333.

    Expressioni

    Tissue specificityi

    Nervous system.

    Gene expression databases

    ArrayExpressiP97333.
    BgeeiP97333.
    CleanExiMM_NRP1.
    GenevestigatoriP97333.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with NRP2. Binds PLXNB1 By similarity. Interacts with FER.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ptk2P341522EBI-1555129,EBI-77070

    Protein-protein interaction databases

    BioGridi201848. 5 interactions.
    DIPiDIP-39360N.
    IntActiP97333. 12 interactions.
    MINTiMINT-99860.

    Structurei

    Secondary structure

    1
    923
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 326
    Beta strandi37 – 404
    Turni42 – 465
    Beta strandi53 – 597
    Beta strandi67 – 715
    Helixi80 – 823
    Beta strandi84 – 9411
    Beta strandi97 – 1037
    Beta strandi105 – 1073
    Beta strandi115 – 12410
    Beta strandi135 – 1406
    Beta strandi146 – 1516
    Beta strandi153 – 1597
    Turni161 – 1644
    Beta strandi172 – 1787
    Helixi180 – 1823
    Beta strandi185 – 1939
    Beta strandi208 – 21710
    Turni218 – 2203
    Beta strandi223 – 2275
    Beta strandi229 – 2313
    Beta strandi236 – 2383
    Beta strandi240 – 2489
    Beta strandi257 – 2648
    Turni281 – 2833
    Beta strandi284 – 2863
    Helixi288 – 2903
    Beta strandi291 – 2944
    Helixi299 – 3013
    Helixi303 – 3053
    Beta strandi326 – 34217
    Turni347 – 3493
    Beta strandi352 – 36817
    Beta strandi373 – 3786
    Beta strandi385 – 3895
    Beta strandi391 – 41424
    Beta strandi417 – 4248
    Helixi426 – 4283
    Beta strandi429 – 4313
    Turni437 – 4393
    Beta strandi440 – 4423
    Helixi444 – 4463
    Beta strandi447 – 4493
    Turni450 – 4534
    Helixi459 – 4624
    Turni464 – 4663
    Beta strandi471 – 4733
    Beta strandi485 – 50117
    Beta strandi503 – 5075
    Beta strandi512 – 52514
    Beta strandi534 – 5374
    Beta strandi544 – 5474
    Beta strandi550 – 57021
    Beta strandi573 – 58311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GZ9X-ray2.70A22-586[»]
    4GZAX-ray7.00H22-586[»]
    ProteinModelPortaliP97333.
    SMRiP97333. Positions 25-586, 681-801.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 856835ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini880 – 92344CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei857 – 87923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 141115CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 265119CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 424150F5/8 type C 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini431 – 583153F5/8 type C 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini645 – 811167MAMPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

    Sequence similaritiesi

    Belongs to the neuropilin family.Curated
    Contains 2 CUB domains.PROSITE-ProRule annotation
    Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150941.
    GeneTreeiENSGT00740000115053.
    HOGENOMiHOG000039978.
    HOVERGENiHBG000502.
    InParanoidiQ6PAR3.
    KOiK06724.
    OMAiYCACWHN.
    OrthoDBiEOG7ZWD1D.
    TreeFamiTF316506.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    IPR027146. NRP1.
    [Graphical view]
    PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
    PfamiPF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036960. Neuropilin. 1 hit.
    PRINTSiPR00020. MAMDOMAIN.
    SMARTiSM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97333-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP    50
    SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW 100
    GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN 150
    YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP 200
    PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GVLSMVFYTD 250
    SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 300
    WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK 350
    KKYYVKTYRV DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI 400
    TRFVRIKPVS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS 450
    NQADRNWMPE NIRLVTSRTG WALPPSPHPY TNEWLQVDLG DEKIVRGVII 500
    QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF EGNNNYDTPE 550
    LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 600
    DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC 650
    EFGWGSHKTF CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN 700
    QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ 750
    LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI 800
    NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD KNISRKPGNV 850
    LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900
    FELVDGVKLK KDKLNPQSNY SEA 923
    Length:923
    Mass (Da):103,000
    Last modified:July 27, 2011 - v2
    Checksum:i23209818C5C42137
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681M → I in BAA08789. (PubMed:8748368)Curated
    Sequence conflicti170 – 1701S → C in BAA08789. (PubMed:8748368)Curated
    Sequence conflicti601 – 6011D → H in BAA08789. (PubMed:8748368)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50086 mRNA. Translation: BAA08789.1.
    CH466525 Genomic DNA. Translation: EDL11828.1.
    BC060129 mRNA. Translation: AAH60129.1.
    CCDSiCCDS22790.1.
    RefSeqiNP_032763.2. NM_008737.2.
    XP_006530829.1. XM_006530766.1.
    UniGeneiMm.271745.

    Genome annotation databases

    EnsembliENSMUST00000026917; ENSMUSP00000026917; ENSMUSG00000025810.
    GeneIDi18186.
    KEGGimmu:18186.
    UCSCiuc009nzr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50086 mRNA. Translation: BAA08789.1 .
    CH466525 Genomic DNA. Translation: EDL11828.1 .
    BC060129 mRNA. Translation: AAH60129.1 .
    CCDSi CCDS22790.1.
    RefSeqi NP_032763.2. NM_008737.2.
    XP_006530829.1. XM_006530766.1.
    UniGenei Mm.271745.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GZ9 X-ray 2.70 A 22-586 [» ]
    4GZA X-ray 7.00 H 22-586 [» ]
    ProteinModelPortali P97333.
    SMRi P97333. Positions 25-586, 681-801.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201848. 5 interactions.
    DIPi DIP-39360N.
    IntActi P97333. 12 interactions.
    MINTi MINT-99860.

    PTM databases

    PhosphoSitei P97333.

    Proteomic databases

    MaxQBi P97333.
    PaxDbi P97333.
    PRIDEi P97333.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026917 ; ENSMUSP00000026917 ; ENSMUSG00000025810 .
    GeneIDi 18186.
    KEGGi mmu:18186.
    UCSCi uc009nzr.2. mouse.

    Organism-specific databases

    CTDi 8829.
    MGIi MGI:106206. Nrp1.

    Phylogenomic databases

    eggNOGi NOG150941.
    GeneTreei ENSGT00740000115053.
    HOGENOMi HOG000039978.
    HOVERGENi HBG000502.
    InParanoidi Q6PAR3.
    KOi K06724.
    OMAi YCACWHN.
    OrthoDBi EOG7ZWD1D.
    TreeFami TF316506.

    Enzyme and pathway databases

    Reactomei REACT_198267. CHL1 interactions.
    REACT_215461. Signal transduction by L1.
    REACT_227870. Neurophilin interactions with VEGF and VEGFR.

    Miscellaneous databases

    ChiTaRSi NRP1. mouse.
    NextBioi 293506.
    PROi P97333.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97333.
    Bgeei P97333.
    CleanExi MM_NRP1.
    Genevestigatori P97333.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    IPR027146. NRP1.
    [Graphical view ]
    PANTHERi PTHR10127:SF616. PTHR10127:SF616. 1 hit.
    Pfami PF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036960. Neuropilin. 1 hit.
    PRINTSi PR00020. MAMDOMAIN.
    SMARTi SM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system."
      Kawakami A., Kitsukawa T., Takagi S., Fujisawa H.
      J. Neurobiol. 29:1-17(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Embryonic brain.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-522.
      Tissue: Myoblast.
    5. "Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons."
      Jiang S.X., Whitehead S., Aylsworth A., Slinn J., Zurakowski B., Chan K., Li J., Hou S.T.
      J. Biol. Chem. 285:9908-9918(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FER.

    Entry informationi

    Entry nameiNRP1_MOUSE
    AccessioniPrimary (citable) accession number: P97333
    Secondary accession number(s): Q6PAR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3