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Reviewed, UniProtKB/Swiss-Prot P97333 (NRP1_MOUSE)

Last modified June 16, 2009. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Neuropilin-1
Alternative name(s):
    A5 protein
    CD_antigen=CD304
Gene names
Name: Nrp1
Synonyms: Nrp
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis By similarity.

Subunit structure

Heterodimer with NRP2 Probable. Binds PLXNB1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Nervous system.

Sequence similarities

Belongs to the neuropilin family.

Contains 2 CUB domains.

Contains 2 F5/8 type C domains.

Contains 1 MAM domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-1555129,EBI-1555129

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 923902Neuropilin-1
PRO_0000021860

Regions

Topological domain22 – 856835Extracellular Potential
Transmembrane857 – 87923 Potential
Topological domain880 – 92344Cytoplasmic Potential
Domain27 – 141115CUB 1
Domain147 – 265119CUB 2
Domain275 – 424150F5/8 type C 1
Domain431 – 583153F5/8 type C 2
Domain645 – 811167MAM

Amino acid modifications

Modified residue9201Phosphotyrosine By similarity
Glycosylation1501N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Potential
Glycosylation6121O-linked (Xyl...) (chondroitin sulfate); alternate By similarity
Glycosylation6121O-linked (Xyl...) (heparan sulfate); alternate By similarity
Glycosylation8421N-linked (GlcNAc...) Potential
Disulfide bond27 ↔ 54 Probable
Disulfide bond82 ↔ 104 Probable
Disulfide bond147 ↔ 173 Probable
Disulfide bond206 ↔ 228 Probable
Disulfide bond275 ↔ 424 By similarity
Disulfide bond431 ↔ 583 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97333-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0644B8A170796808

FASTA923103,020
        10         20         30         40         50         60 
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA 

        70         80         90        100        110        120 
PEPYQRIIIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW GKFCGKIAPS PVVSSGPFLF 

       130        140        150        160        170        180 
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPTGVIKS PGFPEKYPNC LECTYIIFAP 

       190        200        210        220        230        240 
KMSEIILEFE SFDLEQDSNP PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS 

       250        260        270        280        290        300 
GVLSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 

       310        320        330        340        350        360 
WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV 

       370        380        390        400        410        420 
DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI TRFVRIKPVS WETGISMRFE 

       430        440        450        460        470        480 
VYGCKITDYP CSGMLGMVSG LISDSQITAS NQADRNWMPE NIRLVTSRTG WALPPSPHPY 

       490        500        510        520        530        540 
TNEWLQVDLG DEKIVRGVII QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF 

       550        560        570        580        590        600 
EGNNNYDTPE LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 

       610        620        630        640        650        660 
HECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF 

       670        680        690        700        710        720 
CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH 

       730        740        750        760        770        780 
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI 

       790        800        810        820        830        840 
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD 

       850        860        870        880        890        900 
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 

       910        920 
FELVDGVKLK KDKLNPQSNY SEA 

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References

[1]"Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system."
Kawakami A., Kitsukawa T., Takagi S., Fujisawa H.
J. Neurobiol. 29:1-17(1996) [PubMed: 8748368] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

D50086 mRNA. Translation: BAA08789.1.
IPIIPI00123996.
RefSeqNP_032763.1.
UniGeneMm.271745
Mm.423531

3D structure databases

HSSPHSSP built from PDB template 1KEX based on UniProtKB O14786.
SMRP97333. Positions 274-586.
ModBaseSearch...

Protein-protein interaction databases

IntActP97333. 1 interaction.

PTM databases

PhosphoSiteP97333.

Proteomic databases

PRIDEP97333.

Genome annotation databases

EnsemblENSMUSG00000025810. Mus musculus. [Contig view]
GeneID18186.
KEGGmmu:18186.

Organism-specific databases

MGIMGI:106206. Nrp1.

Phylogenomic databases

HOGENOMP97333.
HOVERGENP97333.

Gene expression databases

ArrayExpressP97333.
BgeeP97333.
CleanExMM_NRP1.
GermOnlineENSMUSG00000025810. Mus musculus.

Family and domain databases

InterProIPR000421. Coagulation_factor_5/8-type_C.
IPR000859. CUB.
IPR000998. MAM.
IPR014648. Neuropilin.
[Graphical view]
Gene3DG3DSA:2.60.120.290. CUB. 2 hits.
PfamPF00431. CUB. 2 hits.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFPIRSF036960. Neuropilin. 1 hit.
PRINTSPR00020. MAMDOMAIN.
SMARTSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
PROSITEPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio293506.
SOURCESearch...

Entry information

Entry nameNRP1_MOUSE
AccessionPrimary (citable) accession number: P97333
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 16, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents