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Protein

Neuropilin-1

Gene

Nrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi195 – 1951CalciumBy similarity
Metal bindingi209 – 2091CalciumBy similarity
Metal bindingi250 – 2501CalciumBy similarity

GO - Molecular functioni

  • growth factor binding Source: MGI
  • heparin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • semaphorin receptor activity Source: MGI
  • vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
  • vascular endothelial growth factor binding Source: BHF-UCL

GO - Biological processi

  • angiogenesis Source: BHF-UCL
  • angiogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
  • artery morphogenesis Source: BHF-UCL
  • axonal fasciculation Source: MGI
  • axon extension involved in axon guidance Source: BHF-UCL
  • axon guidance Source: MGI
  • axonogenesis involved in innervation Source: BHF-UCL
  • branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
  • cell migration Source: MGI
  • cell migration involved in coronary vasculogenesis Source: BHF-UCL
  • cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • cellular response to hepatocyte growth factor stimulus Source: MGI
  • cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
  • commissural neuron axon guidance Source: BHF-UCL
  • coronary artery morphogenesis Source: BHF-UCL
  • dendrite development Source: MGI
  • dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  • endothelial cell chemotaxis Source: MGI
  • facial nerve structural organization Source: ParkinsonsUK-UCL
  • facioacoustic ganglion development Source: ParkinsonsUK-UCL
  • ganglion morphogenesis Source: ParkinsonsUK-UCL
  • gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: BHF-UCL
  • heart development Source: MGI
  • hepatocyte growth factor receptor signaling pathway Source: MGI
  • motor neuron axon guidance Source: ParkinsonsUK-UCL
  • negative regulation of axon extension Source: MGI
  • negative regulation of axon extension involved in axon guidance Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of neuron apoptotic process Source: BHF-UCL
  • nerve development Source: BHF-UCL
  • neural crest cell migration involved in autonomic nervous system development Source: ParkinsonsUK-UCL
  • neuron development Source: BHF-UCL
  • neuron migration Source: BHF-UCL
  • otic placode formation Source: ParkinsonsUK-UCL
  • patterning of blood vessels Source: BHF-UCL
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive chemotaxis Source: BHF-UCL
  • positive regulation of axon extension involved in axon guidance Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of retinal ganglion cell axon guidance Source: BHF-UCL
  • protein localization to early endosome Source: BHF-UCL
  • regulation of axon extension involved in axon guidance Source: MGI
  • regulation of retinal ganglion cell axon guidance Source: BHF-UCL
  • renal artery morphogenesis Source: BHF-UCL
  • retinal ganglion cell axon guidance Source: BHF-UCL
  • retina vasculature morphogenesis in camera-type eye Source: BHF-UCL
  • semaphorin-plexin signaling pathway Source: MGI
  • semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
  • semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
  • sensory neuron axon guidance Source: ParkinsonsUK-UCL
  • sprouting angiogenesis Source: BHF-UCL
  • sympathetic ganglion development Source: BHF-UCL
  • sympathetic nervous system development Source: MGI
  • sympathetic neuron projection extension Source: BHF-UCL
  • sympathetic neuron projection guidance Source: BHF-UCL
  • toxin transport Source: MGI
  • trigeminal ganglion development Source: ParkinsonsUK-UCL
  • trigeminal nerve morphogenesis Source: MGI
  • trigeminal nerve structural organization Source: ParkinsonsUK-UCL
  • vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  • VEGF-activated neuropilin signaling pathway Source: BHF-UCL
  • VEGF-activated neuropilin signaling pathway involved in axon guidance Source: BHF-UCL
  • ventral trunk neural crest cell migration Source: ParkinsonsUK-UCL
  • vestibulocochlear nerve structural organization Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_307441. Sema3A PAK dependent Axon repulsion.
REACT_314392. CRMPs in Sema3A signaling.
REACT_329019. CHL1 interactions.
REACT_336251. Neurophilin interactions with VEGF and VEGFR.
REACT_340782. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_353319. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
A5 protein
CD_antigen: CD304
Gene namesi
Name:Nrp1
Synonyms:Nrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106206. Nrp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 856835ExtracellularSequence AnalysisAdd
BLAST
Transmembranei857 – 87923HelicalSequence AnalysisAdd
BLAST
Topological domaini880 – 92344CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • axon Source: BHF-UCL
  • cytosol Source: MGI
  • early endosome Source: BHF-UCL
  • extracellular space Source: MGI
  • focal adhesion Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • neurofilament Source: MGI
  • plasma membrane Source: BHF-UCL
  • sorting endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 923902Neuropilin-1PRO_0000021860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54Curated
Disulfide bondi82 ↔ 104Curated
Disulfide bondi147 ↔ 173By similarity
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi206 ↔ 228By similarity
Glycosylationi261 – 2611N-linked (GlcNAc...)1 Publication
Disulfide bondi275 ↔ 424By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi431 ↔ 583By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...)1 Publication
Glycosylationi612 – 6121O-linked (Xyl...) (chondroitin sulfate); alternateBy similarity
Glycosylationi612 – 6121O-linked (Xyl...) (heparan sulfate); alternateBy similarity
Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

MaxQBiP97333.
PaxDbiP97333.
PRIDEiP97333.

PTM databases

PhosphoSiteiP97333.

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiP97333.
CleanExiMM_NRP1.
ExpressionAtlasiP97333. baseline and differential.
GenevisibleiP97333. MM.

Interactioni

Subunit structurei

Homodimer, and heterodimer with NRP2. Binds PLXNB1 (By similarity). Interacts with FER.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ptk2P341522EBI-1555129,EBI-77070

Protein-protein interaction databases

BioGridi201848. 5 interactions.
DIPiDIP-39360N.
IntActiP97333. 12 interactions.
MINTiMINT-99860.
STRINGi10090.ENSMUSP00000026917.

Structurei

Secondary structure

1
923
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 326Combined sources
Beta strandi37 – 404Combined sources
Turni42 – 465Combined sources
Beta strandi53 – 597Combined sources
Beta strandi67 – 715Combined sources
Helixi80 – 823Combined sources
Beta strandi84 – 9411Combined sources
Beta strandi97 – 1037Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi115 – 12410Combined sources
Beta strandi135 – 1406Combined sources
Beta strandi146 – 1516Combined sources
Beta strandi153 – 1597Combined sources
Turni161 – 1644Combined sources
Beta strandi172 – 1787Combined sources
Helixi180 – 1823Combined sources
Beta strandi185 – 1939Combined sources
Beta strandi208 – 21710Combined sources
Turni218 – 2203Combined sources
Beta strandi223 – 2275Combined sources
Beta strandi229 – 2313Combined sources
Beta strandi236 – 2383Combined sources
Beta strandi240 – 2489Combined sources
Beta strandi257 – 2648Combined sources
Turni281 – 2833Combined sources
Beta strandi284 – 2863Combined sources
Helixi288 – 2903Combined sources
Beta strandi291 – 2944Combined sources
Helixi299 – 3013Combined sources
Helixi303 – 3053Combined sources
Beta strandi326 – 34217Combined sources
Turni347 – 3493Combined sources
Beta strandi352 – 36817Combined sources
Beta strandi373 – 3786Combined sources
Beta strandi385 – 3895Combined sources
Beta strandi391 – 41424Combined sources
Beta strandi417 – 4248Combined sources
Helixi426 – 4283Combined sources
Beta strandi429 – 4313Combined sources
Turni437 – 4393Combined sources
Beta strandi440 – 4423Combined sources
Helixi444 – 4463Combined sources
Beta strandi447 – 4493Combined sources
Turni450 – 4534Combined sources
Helixi459 – 4624Combined sources
Turni464 – 4663Combined sources
Beta strandi471 – 4733Combined sources
Beta strandi485 – 50117Combined sources
Beta strandi503 – 5075Combined sources
Beta strandi512 – 52514Combined sources
Beta strandi534 – 5374Combined sources
Beta strandi544 – 5474Combined sources
Beta strandi550 – 57021Combined sources
Beta strandi573 – 58311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GZ9X-ray2.70A22-586[»]
4GZAX-ray7.00H22-586[»]
ProteinModelPortaliP97333.
SMRiP97333. Positions 25-586, 681-801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 141115CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 265119CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 424150F5/8 type C 1PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 583153F5/8 type C 2PROSITE-ProRule annotationAdd
BLAST
Domaini645 – 811167MAMPROSITE-ProRule annotationAdd
BLAST

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150941.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiP97333.
KOiK06724.
OMAiYCACWHN.
OrthoDBiEOG7ZWD1D.
TreeFamiTF316506.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP
60 70 80 90 100
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW
110 120 130 140 150
GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN
160 170 180 190 200
YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP
210 220 230 240 250
PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GVLSMVFYTD
260 270 280 290 300
SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN
310 320 330 340 350
WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK
360 370 380 390 400
KKYYVKTYRV DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI
410 420 430 440 450
TRFVRIKPVS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS
460 470 480 490 500
NQADRNWMPE NIRLVTSRTG WALPPSPHPY TNEWLQVDLG DEKIVRGVII
510 520 530 540 550
QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF EGNNNYDTPE
560 570 580 590 600
LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV
610 620 630 640 650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC
660 670 680 690 700
EFGWGSHKTF CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN
710 720 730 740 750
QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ
760 770 780 790 800
LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI
810 820 830 840 850
NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD KNISRKPGNV
860 870 880 890 900
LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN
910 920
FELVDGVKLK KDKLNPQSNY SEA
Length:923
Mass (Da):103,000
Last modified:July 27, 2011 - v2
Checksum:i23209818C5C42137
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681M → I in BAA08789 (PubMed:8748368).Curated
Sequence conflicti170 – 1701S → C in BAA08789 (PubMed:8748368).Curated
Sequence conflicti601 – 6011D → H in BAA08789 (PubMed:8748368).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50086 mRNA. Translation: BAA08789.1.
CH466525 Genomic DNA. Translation: EDL11828.1.
BC060129 mRNA. Translation: AAH60129.1.
CCDSiCCDS22790.1.
RefSeqiNP_032763.2. NM_008737.2.
XP_006530829.1. XM_006530766.2.
UniGeneiMm.271745.

Genome annotation databases

EnsembliENSMUST00000026917; ENSMUSP00000026917; ENSMUSG00000025810.
GeneIDi18186.
KEGGimmu:18186.
UCSCiuc009nzr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50086 mRNA. Translation: BAA08789.1.
CH466525 Genomic DNA. Translation: EDL11828.1.
BC060129 mRNA. Translation: AAH60129.1.
CCDSiCCDS22790.1.
RefSeqiNP_032763.2. NM_008737.2.
XP_006530829.1. XM_006530766.2.
UniGeneiMm.271745.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GZ9X-ray2.70A22-586[»]
4GZAX-ray7.00H22-586[»]
ProteinModelPortaliP97333.
SMRiP97333. Positions 25-586, 681-801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201848. 5 interactions.
DIPiDIP-39360N.
IntActiP97333. 12 interactions.
MINTiMINT-99860.
STRINGi10090.ENSMUSP00000026917.

PTM databases

PhosphoSiteiP97333.

Proteomic databases

MaxQBiP97333.
PaxDbiP97333.
PRIDEiP97333.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026917; ENSMUSP00000026917; ENSMUSG00000025810.
GeneIDi18186.
KEGGimmu:18186.
UCSCiuc009nzr.2. mouse.

Organism-specific databases

CTDi8829.
MGIiMGI:106206. Nrp1.

Phylogenomic databases

eggNOGiNOG150941.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiP97333.
KOiK06724.
OMAiYCACWHN.
OrthoDBiEOG7ZWD1D.
TreeFamiTF316506.

Enzyme and pathway databases

ReactomeiREACT_307441. Sema3A PAK dependent Axon repulsion.
REACT_314392. CRMPs in Sema3A signaling.
REACT_329019. CHL1 interactions.
REACT_336251. Neurophilin interactions with VEGF and VEGFR.
REACT_340782. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_353319. Signal transduction by L1.

Miscellaneous databases

ChiTaRSiNrp1. mouse.
NextBioi293506.
PROiP97333.
SOURCEiSearch...

Gene expression databases

BgeeiP97333.
CleanExiMM_NRP1.
ExpressionAtlasiP97333. baseline and differential.
GenevisibleiP97333. MM.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system."
    Kawakami A., Kitsukawa T., Takagi S., Fujisawa H.
    J. Neurobiol. 29:1-17(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Embryonic brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-522.
    Tissue: Myoblast.
  5. "Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons."
    Jiang S.X., Whitehead S., Aylsworth A., Slinn J., Zurakowski B., Chan K., Li J., Hou S.T.
    J. Biol. Chem. 285:9908-9918(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FER.

Entry informationi

Entry nameiNRP1_MOUSE
AccessioniPrimary (citable) accession number: P97333
Secondary accession number(s): Q6PAR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.