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P97329

- KI20A_MOUSE

UniProt

P97329 - KI20A_MOUSE

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Protein

Kinesin-like protein KIF20A

Gene
Kif20a, Rab6kifl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle By similarity. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi159 – 1668ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro

GO - Biological processi

  1. cytokinesis Source: UniProtKB
  2. microtubule-based movement Source: InterPro
  3. microtubule bundle formation Source: UniProtKB
  4. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF20A
Alternative name(s):
Kinesin-like protein 174
Rab6-interacting kinesin-like protein
Rabkinesin-6
Gene namesi
Name:Kif20a
Synonyms:Rab6kifl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1201682. Kif20a.

Subcellular locationi

Golgi apparatus By similarity. Cytoplasmcytoskeletonspindle Inferred 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
  4. spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 887886Kinesin-like protein KIF20APRO_0000125461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei7 – 71Phosphoserine By similarity
Modified residuei14 – 141Phosphoserine By similarity
Modified residuei21 – 211Phosphoserine By similarity
Modified residuei527 – 5271Phosphoserine; by PLK1 By similarity
Modified residuei823 – 8231Phosphoserine By similarity
Modified residuei855 – 8551Phosphothreonine By similarity
Modified residuei865 – 8651Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by PLK1 at Ser-527 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97329.
PaxDbiP97329.
PRIDEiP97329.

PTM databases

PhosphoSiteiP97329.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in spleen and testis.1 Publication

Gene expression databases

BgeeiP97329.
CleanExiMM_KIF20A.
GenevestigatoriP97329.

Interactioni

Protein-protein interaction databases

BioGridi202552. 2 interactions.
IntActiP97329. 1 interaction.
STRINGi10090.ENSMUSP00000003877.

Structurei

3D structure databases

ProteinModelPortaliP97329.
SMRiP97329. Positions 59-541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 506444Kinesin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni805 – 88783Globular Reviewed predictionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili559 – 804246 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00530000063172.
HOGENOMiHOG000054207.
HOVERGENiHBG052246.
InParanoidiP97329.
KOiK10402.
OMAiRLCEDQN.
OrthoDBiEOG74BJR9.
PhylomeDBiP97329.
TreeFamiTF105232.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR027326. KIF20A.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF352. PTHR24115:SF352. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97329-1 [UniParc]FASTAAdd to Basket

« Hide

MSHRILSPPA GLLSDEDVVD SPILESTAAD LRSVVRKDLL SDCSVISASL    50
EDKQALLEDT SEKVKVYLRI RPFLTSELDR QEDQGCVCIE NTETLVLQAP 100
KDSFALKSNE RGVGQATHKF TFSQIFGPEV GQVAFFNLTM KEMVKDVLKG 150
QNWLIYTYGV TNSGKTYTIQ GTSKDAGILP QSLALIFNSL QGQLHPTPDL 200
KPLLSNEVIW LDSKQIRQEE MKKLSLLIGG LQEEELSTSV KKRVHTESRI 250
GASNSFDSGV AGLSSTSQFT SSSQLDETSQ LWAQPDTVPV SVPADIRFSV 300
WISFFEIYNE LLYDLLEPPS HQHKRQTLRL CEDQNGNPYV KDLNWIHVRD 350
VEEAWKLLKV GRKNQSFAST HMNQQSSRSH SIFSIRILHL QGEGDIVPKI 400
SELSLCDLAG SERCKHQKSG ERLKEAGNIN TSLHTLGRCI AALRQNQQNR 450
SKQNLIPFRD SKLTRVFQGF FTGRGRSCMI VNVNPCASTY DETLHAAKFS 500
ALASQLVHAP PVHLGIPSLH SFIKKHSPQV GPGLEKEDKA DSDLEDSPED 550
EADVSVYGKE ELLQVVEAMK ALLLKERQEK LQLEIQLREE ICNEMVEQMQ 600
QREQWCSERL DNQKELMEEL YEEKLKILKE SLTTFYQEQI QERDEKIEEL 650
ETLLQEAKQQ PAAQQSGGLS LLRRSQRLAA SASTQQFQEV KAELEQCKTE 700
LSSTTAELHK YQQVLKPPPP AKPFTIDVDK KLEEGQKNIR LLRTELQKLG 750
QSLQSAERAC CHSTGAGKLR QALTNCDDIL IKQNQTLAEL QNNMVLVKLD 800
LQKKAACIAE QYHTVLKLQG QASAKKRLGA NQENQQPNHQ PPGKKPFLRN 850
LLPRTPTCQS STDSSPYARI LRSRHSPLLK SPFGKKY 887
Length:887
Mass (Da):99,876
Last modified:May 1, 1997 - v1
Checksum:i7143CCB261A4EA15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09632 mRNA. Translation: CAA70845.1.
AK083412 mRNA. Translation: BAC38906.1.
AK084732 mRNA. Translation: BAC39267.1.
AK144844 mRNA. Translation: BAE26095.1.
BC060608 mRNA. Translation: AAH60608.1.
CCDSiCCDS29131.1.
RefSeqiNP_001159878.1. NM_001166406.1.
NP_001159879.1. NM_001166407.1.
NP_033030.1. NM_009004.4.
UniGeneiMm.258846.

Genome annotation databases

EnsembliENSMUST00000166044; ENSMUSP00000132659; ENSMUSG00000003779.
ENSMUST00000167161; ENSMUSP00000130045; ENSMUSG00000003779.
GeneIDi19348.
KEGGimmu:19348.
UCSCiuc008ela.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09632 mRNA. Translation: CAA70845.1 .
AK083412 mRNA. Translation: BAC38906.1 .
AK084732 mRNA. Translation: BAC39267.1 .
AK144844 mRNA. Translation: BAE26095.1 .
BC060608 mRNA. Translation: AAH60608.1 .
CCDSi CCDS29131.1.
RefSeqi NP_001159878.1. NM_001166406.1.
NP_001159879.1. NM_001166407.1.
NP_033030.1. NM_009004.4.
UniGenei Mm.258846.

3D structure databases

ProteinModelPortali P97329.
SMRi P97329. Positions 59-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202552. 2 interactions.
IntActi P97329. 1 interaction.
STRINGi 10090.ENSMUSP00000003877.

PTM databases

PhosphoSitei P97329.

Proteomic databases

MaxQBi P97329.
PaxDbi P97329.
PRIDEi P97329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000166044 ; ENSMUSP00000132659 ; ENSMUSG00000003779 .
ENSMUST00000167161 ; ENSMUSP00000130045 ; ENSMUSG00000003779 .
GeneIDi 19348.
KEGGi mmu:19348.
UCSCi uc008ela.2. mouse.

Organism-specific databases

CTDi 10112.
MGIi MGI:1201682. Kif20a.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00530000063172.
HOGENOMi HOG000054207.
HOVERGENi HBG052246.
InParanoidi P97329.
KOi K10402.
OMAi RLCEDQN.
OrthoDBi EOG74BJR9.
PhylomeDBi P97329.
TreeFami TF105232.

Miscellaneous databases

NextBioi 296373.
PROi P97329.
SOURCEi Search...

Gene expression databases

Bgeei P97329.
CleanExi MM_KIF20A.
Genevestigatori P97329.

Family and domain databases

Gene3Di 3.40.850.10. 2 hits.
InterProi IPR027326. KIF20A.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
PTHR24115:SF352. PTHR24115:SF352. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of a Golgi-associated kinesin-like protein with Rab6."
    Echard A., Jollivet F., Martinez O., Lacapere J.-J., Rousselet A., Janoueix-Lerosey I., Goud B.
    Science 279:580-585(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiKI20A_MOUSE
AccessioniPrimary (citable) accession number: P97329
Secondary accession number(s): Q542M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi