Kinesin-like protein KIF20A - Mus musculus (Mouse)

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P97329 (KI20A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF20A

Alternative name(s):
Kinesin-like protein 174
Rab6-interacting kinesin-like protein
Rabkinesin-6

Gene names

Name:	Kif20a
Synonyms:	Rab6kifl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	887 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle By similarity. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Ref.1
Subcellular location	Golgi apparatus By similarity. Cytoplasm › cytoskeleton › spindle Probable Ref.1.
Tissue specificity	Ubiquitously expressed, with highest levels in spleen and testis. Ref.1
Post-translational modification	Phosphorylated by PLK1 at Ser-527 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle By similarity.
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Microtubule
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB microtubule bundle formation Inferred from sequence or structural similarity. Source: UniProtKB microtubule-based movement Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro spindle Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 887

886

Kinesin-like protein KIF20A

PRO_0000125461

Regions

Domain

69 – 494

426

Kinesin-motor

Nucleotide binding

159 – 166

ATP By similarity

Region

805 – 887

Globular Potential

Coiled coil

559 – 804

246

Potential

Amino acid modifications

Modified residue

N-acetylserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine By similarity

Modified residue

527

Phosphoserine; by PLK1 By similarity

Modified residue

823

Phosphoserine By similarity

Modified residue

855

Phosphothreonine By similarity

Modified residue

865

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P97329 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 7143CCB261A4EA15
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FASTA

887

99,876

        10         20         30         40         50         60 
MSHRILSPPA GLLSDEDVVD SPILESTAAD LRSVVRKDLL SDCSVISASL EDKQALLEDT 

        70         80         90        100        110        120 
SEKVKVYLRI RPFLTSELDR QEDQGCVCIE NTETLVLQAP KDSFALKSNE RGVGQATHKF 

       130        140        150        160        170        180 
TFSQIFGPEV GQVAFFNLTM KEMVKDVLKG QNWLIYTYGV TNSGKTYTIQ GTSKDAGILP 

       190        200        210        220        230        240 
QSLALIFNSL QGQLHPTPDL KPLLSNEVIW LDSKQIRQEE MKKLSLLIGG LQEEELSTSV 

       250        260        270        280        290        300 
KKRVHTESRI GASNSFDSGV AGLSSTSQFT SSSQLDETSQ LWAQPDTVPV SVPADIRFSV 

       310        320        330        340        350        360 
WISFFEIYNE LLYDLLEPPS HQHKRQTLRL CEDQNGNPYV KDLNWIHVRD VEEAWKLLKV 

       370        380        390        400        410        420 
GRKNQSFAST HMNQQSSRSH SIFSIRILHL QGEGDIVPKI SELSLCDLAG SERCKHQKSG 

       430        440        450        460        470        480 
ERLKEAGNIN TSLHTLGRCI AALRQNQQNR SKQNLIPFRD SKLTRVFQGF FTGRGRSCMI 

       490        500        510        520        530        540 
VNVNPCASTY DETLHAAKFS ALASQLVHAP PVHLGIPSLH SFIKKHSPQV GPGLEKEDKA 

       550        560        570        580        590        600 
DSDLEDSPED EADVSVYGKE ELLQVVEAMK ALLLKERQEK LQLEIQLREE ICNEMVEQMQ 

       610        620        630        640        650        660 
QREQWCSERL DNQKELMEEL YEEKLKILKE SLTTFYQEQI QERDEKIEEL ETLLQEAKQQ 

       670        680        690        700        710        720 
PAAQQSGGLS LLRRSQRLAA SASTQQFQEV KAELEQCKTE LSSTTAELHK YQQVLKPPPP 

       730        740        750        760        770        780 
AKPFTIDVDK KLEEGQKNIR LLRTELQKLG QSLQSAERAC CHSTGAGKLR QALTNCDDIL 

       790        800        810        820        830        840 
IKQNQTLAEL QNNMVLVKLD LQKKAACIAE QYHTVLKLQG QASAKKRLGA NQENQQPNHQ 

       850        860        870        880 
PPGKKPFLRN LLPRTPTCQS STDSSPYARI LRSRHSPLLK SPFGKKY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction of a Golgi-associated kinesin-like protein with Rab6." Echard A., Jollivet F., Martinez O., Lacapere J.-J., Rousselet A., Janoueix-Lerosey I., Goud B. Science 279:580-585(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Testis.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Heart and Lung.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09632 mRNA. Translation: CAA70845.1. AK083412 mRNA. Translation: BAC38906.1. AK084732 mRNA. Translation: BAC39267.1. AK144844 mRNA. Translation: BAE26095.1. BC060608 mRNA. Translation: AAH60608.1.
IPI	IPI00123947.
RefSeq	NP_001159878.1. NM_001166406.1. NP_001159879.1. NM_001166407.1. NP_033030.1. NM_009004.4.
UniGene	Mm.258846.
3D structure databases
ProteinModelPortal	P97329.
SMR	P97329. Positions 58-233, 295-541.
ModBase	Search...
Protein-protein interaction databases
IntAct	P97329. 1 interaction.
STRING	10090.ENSMUSP00000003877.
PTM databases
PhosphoSite	P97329.
Proteomic databases
PaxDb	P97329.
PRIDE	P97329.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000166044; ENSMUSP00000132659; ENSMUSG00000003779. ENSMUST00000167161; ENSMUSP00000130045; ENSMUSG00000003779.
GeneID	19348.
KEGG	mmu:19348.
UCSC	uc008ela.2. mouse.
Organism-specific databases
CTD	10112.
MGI	MGI:1201682. Kif20a.
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00530000063172.
HOGENOM	HOG000054207.
HOVERGEN	HBG052246.
InParanoid	P97329.
KO	K10402.
OMA	VKVYLRV.
OrthoDB	EOG4VT5WT.
Gene expression databases
Bgee	P97329.
CleanEx	MM_KIF20A.
Genevestigator	P97329.
GermOnline	ENSMUSG00000003779. Mus musculus.
Family and domain databases
Gene3D	3.40.850.10. 2 hits.
InterPro	IPR027326. KIF20A. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
PANTHER	PTHR24115:SF227. PTHR24115:SF227. 1 hit.
Pfam	PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296373.
SOURCE	Search...

Entry information

Entry name

KI20A_MOUSE

Accession

Primary (citable) accession number: P97329
Secondary accession number(s): Q542M4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents