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Protein

Cadherin-6

Gene

Cdh6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-6
Alternative name(s):
Kidney cadherin
Short name:
K-cadherin
Gene namesi
Name:Cdh6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107435. Cdh6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 615ExtracellularSequence analysisAdd BLAST562
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 790CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000376319 – 53Sequence analysisAdd BLAST35
ChainiPRO_000000376454 – 790Cadherin-6Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi399N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi536N-linked (GlcNAc...)Sequence analysis1
Modified residuei786PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97326.
PaxDbiP97326.
PeptideAtlasiP97326.
PRIDEiP97326.

PTM databases

iPTMnetiP97326.
PhosphoSitePlusiP97326.

Expressioni

Developmental stagei

Expressed in fetal, newborn and 7-day-old testis but not in 21-day-old or adult testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039385.
CleanExiMM_CDH6.
GenevisibleiP97326. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113.

Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 64Combined sources5
Beta strandi68 – 70Combined sources3
Beta strandi72 – 76Combined sources5
Beta strandi94 – 97Combined sources4
Turni98 – 100Combined sources3
Beta strandi101 – 103Combined sources3
Turni105 – 107Combined sources3
Beta strandi109 – 112Combined sources4
Helixi118 – 120Combined sources3
Beta strandi123 – 125Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi132 – 135Combined sources4
Beta strandi146 – 150Combined sources5
Beta strandi158 – 160Combined sources3
Beta strandi162 – 171Combined sources10
Beta strandi177 – 180Combined sources4
Beta strandi191 – 193Combined sources3
Beta strandi198 – 204Combined sources7
Helixi205 – 207Combined sources3
Beta strandi208 – 210Combined sources3
Turni212 – 214Combined sources3
Beta strandi216 – 219Combined sources4
Beta strandi231 – 240Combined sources10
Helixi241 – 243Combined sources3
Beta strandi248 – 259Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LNDX-ray2.82A/B/C/D58-260[»]
ProteinModelPortaliP97326.
SMRiP97326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 608Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97326.
KOiK06798.
OMAiYNRHEMS.
OrthoDBiEOG091G0298.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTYRYFLLL FWVGQPYPTF SNPLSKRTSG FPAKRKALEL SANSRNELSR
60 70 80 90 100
SKRSWMWNQF FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL
110 120 130 140 150
FIINENTGDI QATKRLDREE KPVYILRAQA VNRRTGRPVE PESEFIIKIH
160 170 180 190 200
DINDNEPIFT KDVYTATVPE MADVGTFVVQ VTATDADDPT YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN
310 320 330 340 350
AEIEYSITDG EGHEMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS
360 370 380 390 400
NPHVEPRFLY LGPFKDSATV RIVVDDVDEP PVFSKLAYIL QIREDARINT
410 420 430 440 450
TIGSVAAQDP DAARNPVKYS VDRHTDMDRI FNIDSGNGSI FTSKLLDRET
460 470 480 490 500
LLWHNITVIA TEINNPKQSS RVPLYIKVLD VNDNAPEFAE FYETFVCEKA
510 520 530 540 550
KADQLIQTLR AVDKDDPYSG HQFSFSLAPE AASSSNFTIQ DNKDNTAGIL
560 570 580 590 600
TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC
610 620 630 640 650
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE
660 670 680 690 700
DIRDNIVSYN DEGGGEEDTQ AFDIGTLRNP EAMEDSKSRR DIVPEALFLP
710 720 730 740 750
RRTPTARDNT DVRDFINQRL KENDTDPTAP PYDSLATYAY EGTGSVADSL
760 770 780 790
SSLESVTTDG DQDYDYLSDW GPRFKKLADM YGGMDSDKDS
Length:790
Mass (Da):88,355
Last modified:July 27, 2011 - v2
Checksum:i14389434D23B2A8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → D in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti54S → G in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti65E → G in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti106N → H in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti346 – 348KVE → RWK in BAA11516 (PubMed:9126293).Curated3
Sequence conflicti403G → V in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti464N → K in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti534S → G in AAB07550 (Ref. 3) Curated1
Sequence conflicti536N → T in AAB07550 (Ref. 3) Curated1
Sequence conflicti597 – 598MQ → IE in BAA11516 (PubMed:9126293).Curated2
Sequence conflicti613T → S in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti640R → E in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti777L → V in BAA11516 (PubMed:9126293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA. Translation: BAA11516.1.
BC107013 mRNA. Translation: AAI07014.1.
U67399 mRNA. Translation: AAB07550.1.
CCDSiCCDS27393.1.
RefSeqiNP_031692.2. NM_007666.4.
XP_006520080.1. XM_006520017.1.
UniGeneiMm.458225.
Mm.57048.

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385.
GeneIDi12563.
KEGGimmu:12563.
UCSCiuc007vif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA. Translation: BAA11516.1.
BC107013 mRNA. Translation: AAI07014.1.
U67399 mRNA. Translation: AAB07550.1.
CCDSiCCDS27393.1.
RefSeqiNP_031692.2. NM_007666.4.
XP_006520080.1. XM_006520017.1.
UniGeneiMm.458225.
Mm.57048.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LNDX-ray2.82A/B/C/D58-260[»]
ProteinModelPortaliP97326.
SMRiP97326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113.

PTM databases

iPTMnetiP97326.
PhosphoSitePlusiP97326.

Proteomic databases

MaxQBiP97326.
PaxDbiP97326.
PeptideAtlasiP97326.
PRIDEiP97326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385.
GeneIDi12563.
KEGGimmu:12563.
UCSCiuc007vif.1. mouse.

Organism-specific databases

CTDi1004.
MGIiMGI:107435. Cdh6.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97326.
KOiK06798.
OMAiYNRHEMS.
OrthoDBiEOG091G0298.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTraceiP97326.
PROiP97326.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039385.
CleanExiMM_CDH6.
GenevisibleiP97326. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH6_MOUSE
AccessioniPrimary (citable) accession number: P97326
Secondary accession number(s): P70393, Q3KNY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.