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Protein

Cadherin-6

Gene

Cdh6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-6
Alternative name(s):
Kidney cadherin
Short name:
K-cadherin
Gene namesi
Name:Cdh6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107435. Cdh6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 615562ExtracellularSequence analysisAdd
BLAST
Transmembranei616 – 63621HelicalSequence analysisAdd
BLAST
Topological domaini637 – 790154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 5335Sequence analysisPRO_0000003763Add
BLAST
Chaini54 – 790737Cadherin-6PRO_0000003764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence analysis
Modified residuei786 – 7861PhosphoserineCombined sources
Modified residuei790 – 7901PhosphoserineCombined sources

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97326.
PaxDbiP97326.
PRIDEiP97326.

PTM databases

iPTMnetiP97326.
PhosphoSiteiP97326.

Expressioni

Developmental stagei

Expressed in fetal, newborn and 7-day-old testis but not in 21-day-old or adult testis.1 Publication

Gene expression databases

BgeeiP97326.
CleanExiMM_CDH6.
GenevisibleiP97326. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113.

Structurei

Secondary structure

1
790
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi60 – 645Combined sources
Beta strandi68 – 703Combined sources
Beta strandi72 – 765Combined sources
Beta strandi94 – 974Combined sources
Turni98 – 1003Combined sources
Beta strandi101 – 1033Combined sources
Turni105 – 1073Combined sources
Beta strandi109 – 1124Combined sources
Helixi118 – 1203Combined sources
Beta strandi123 – 1253Combined sources
Beta strandi127 – 1304Combined sources
Beta strandi132 – 1354Combined sources
Beta strandi146 – 1505Combined sources
Beta strandi158 – 1603Combined sources
Beta strandi162 – 17110Combined sources
Beta strandi177 – 1804Combined sources
Beta strandi191 – 1933Combined sources
Beta strandi198 – 2047Combined sources
Helixi205 – 2073Combined sources
Beta strandi208 – 2103Combined sources
Turni212 – 2143Combined sources
Beta strandi216 – 2194Combined sources
Beta strandi231 – 24010Combined sources
Helixi241 – 2433Combined sources
Beta strandi248 – 25912Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNDX-ray2.82A/B/C/D58-260[»]
ProteinModelPortaliP97326.
SMRiP97326. Positions 54-589, 688-783.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97326.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 608122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97326.
KOiK06798.
OMAiYNRHEMS.
OrthoDBiEOG7GBFW7.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTYRYFLLL FWVGQPYPTF SNPLSKRTSG FPAKRKALEL SANSRNELSR
60 70 80 90 100
SKRSWMWNQF FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL
110 120 130 140 150
FIINENTGDI QATKRLDREE KPVYILRAQA VNRRTGRPVE PESEFIIKIH
160 170 180 190 200
DINDNEPIFT KDVYTATVPE MADVGTFVVQ VTATDADDPT YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN
310 320 330 340 350
AEIEYSITDG EGHEMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS
360 370 380 390 400
NPHVEPRFLY LGPFKDSATV RIVVDDVDEP PVFSKLAYIL QIREDARINT
410 420 430 440 450
TIGSVAAQDP DAARNPVKYS VDRHTDMDRI FNIDSGNGSI FTSKLLDRET
460 470 480 490 500
LLWHNITVIA TEINNPKQSS RVPLYIKVLD VNDNAPEFAE FYETFVCEKA
510 520 530 540 550
KADQLIQTLR AVDKDDPYSG HQFSFSLAPE AASSSNFTIQ DNKDNTAGIL
560 570 580 590 600
TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC
610 620 630 640 650
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE
660 670 680 690 700
DIRDNIVSYN DEGGGEEDTQ AFDIGTLRNP EAMEDSKSRR DIVPEALFLP
710 720 730 740 750
RRTPTARDNT DVRDFINQRL KENDTDPTAP PYDSLATYAY EGTGSVADSL
760 770 780 790
SSLESVTTDG DQDYDYLSDW GPRFKKLADM YGGMDSDKDS
Length:790
Mass (Da):88,355
Last modified:July 27, 2011 - v2
Checksum:i14389434D23B2A8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431N → D in BAA11516 (PubMed:9126293).Curated
Sequence conflicti54 – 541S → G in BAA11516 (PubMed:9126293).Curated
Sequence conflicti65 – 651E → G in BAA11516 (PubMed:9126293).Curated
Sequence conflicti106 – 1061N → H in BAA11516 (PubMed:9126293).Curated
Sequence conflicti346 – 3483KVE → RWK in BAA11516 (PubMed:9126293).Curated
Sequence conflicti403 – 4031G → V in BAA11516 (PubMed:9126293).Curated
Sequence conflicti464 – 4641N → K in BAA11516 (PubMed:9126293).Curated
Sequence conflicti534 – 5341S → G in AAB07550 (Ref. 3) Curated
Sequence conflicti536 – 5361N → T in AAB07550 (Ref. 3) Curated
Sequence conflicti597 – 5982MQ → IE in BAA11516 (PubMed:9126293).Curated
Sequence conflicti613 – 6131T → S in BAA11516 (PubMed:9126293).Curated
Sequence conflicti640 – 6401R → E in BAA11516 (PubMed:9126293).Curated
Sequence conflicti777 – 7771L → V in BAA11516 (PubMed:9126293).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA. Translation: BAA11516.1.
BC107013 mRNA. Translation: AAI07014.1.
U67399 mRNA. Translation: AAB07550.1.
CCDSiCCDS27393.1.
RefSeqiNP_031692.2. NM_007666.4.
XP_006520080.1. XM_006520017.1.
UniGeneiMm.458225.
Mm.57048.

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385.
GeneIDi12563.
KEGGimmu:12563.
UCSCiuc007vif.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA. Translation: BAA11516.1.
BC107013 mRNA. Translation: AAI07014.1.
U67399 mRNA. Translation: AAB07550.1.
CCDSiCCDS27393.1.
RefSeqiNP_031692.2. NM_007666.4.
XP_006520080.1. XM_006520017.1.
UniGeneiMm.458225.
Mm.57048.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LNDX-ray2.82A/B/C/D58-260[»]
ProteinModelPortaliP97326.
SMRiP97326. Positions 54-589, 688-783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113.

PTM databases

iPTMnetiP97326.
PhosphoSiteiP97326.

Proteomic databases

MaxQBiP97326.
PaxDbiP97326.
PRIDEiP97326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385.
GeneIDi12563.
KEGGimmu:12563.
UCSCiuc007vif.1. mouse.

Organism-specific databases

CTDi1004.
MGIiMGI:107435. Cdh6.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97326.
KOiK06798.
OMAiYNRHEMS.
OrthoDBiEOG7GBFW7.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTraceiP97326.
NextBioi281640.
PROiP97326.
SOURCEiSearch...

Gene expression databases

BgeeiP97326.
CleanExiMM_CDH6.
GenevisibleiP97326. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos."
    Inoue T., Chisaka O., Matsunami H., Takeichi M.
    Dev. Biol. 183:183-194(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Faulkner-Jones B.E., Dziadek M.A.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 479-666.
    Strain: C57BL/6 X CBA.
    Tissue: Kidney.
  4. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Testis.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786 AND SER-790, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiCADH6_MOUSE
AccessioniPrimary (citable) accession number: P97326
Secondary accession number(s): P70393, Q3KNY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: January 20, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.