Reviewed, UniProtKB/Swiss-Prot P97324 (G6PD2_MOUSE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase 2
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	G6pd2
Synonyms:	G6pd-2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Subunit structure	Homotetramer.
Tissue specificity	Testis.
Miscellaneous	Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 513	512	Glucose-6-phosphate 1-dehydrogenase 2		PRO_0000068086
Sites
	Active site	263	1	Proton acceptor By similarity
	Binding site	40	1	NADP By similarity
	Binding site	72	1	NADP By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
	Binding site	238	1	NADP By similarity
	Binding site	357	1	NADP By similarity
	Binding site	487	1	NADP By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97324-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 655830EB767B6C53	FASTA	513	59,126
	10 20 30 40 50 60 MAEQVTLSRT QVCGILREEL YQNDAFHQAD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 70 80 90 100 110 120 LPKETFIVGY ARSQLTVDDI QKQSEPFFKA TPEERPKLEE FFTRNSYVVG QYDDPASYKH 130 140 150 160 170 180 LNSYINALHQ GMQANHLFYL ALPPTVYEAV TKNIQETCMS QTGFNRIIVE KPFGRDLQSS 190 200 210 220 230 240 NQLSNHISSL FREDQIYRID HYLDKEMVQN LMVLRFANRI FGPIWNGDNI VCVILTFKEP 250 260 270 280 290 300 FGTEGRGGYF DEFGIIRDVM QSHLLQMLCL VAMEKPATTD SDDVRNEKVK VLKCISEVET 310 320 330 340 350 360 DNVILGQYVG NPNGEGEAAN GYLDDPTVPR GSTTATFAAA VLYVKNERWD GVPFILRCGK 370 380 390 400 410 420 ALNERKAEVR LQFRDIPGDI FHQKCKRNEL VIRMQPNEAV YTTMMTKKPG MFFNPEESEL 430 440 450 460 470 480 DLTYGNKYKN VKLPGAYERL ILDVFCGCQM HFVRTDELRE GWRIFTPLLH KIEREKPQPF 490 500 510 PYVYGSRGPT EADELMRRVG FQYKGTYKGT HKH

References

[1]	"Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse." Hendriksen P.J.M., Hoogerbrugge J.W., Baarends W.M., de Boer P., Vreeburg J.T.M., Vos E.A., van der Lende T., Grootegoed A.J. Genomics 41:350-359(1997) [PubMed: 9169132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Swiss.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z84471 Genomic DNA. Translation: CAB06476.1.
RefSeq	NP_062341.1.
UniGene	Mm.347430
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
SMR	P97324. Positions 28-513.
ModBase	Search...
PTM databases
PhosphoSite	P97324.
Genome annotation databases
Ensembl	ENSMUSG00000031400. Mus musculus. [Contig view]
GeneID	14380.
KEGG	mmu:14380.
Organism-specific databases
MGI	MGI:105977. G6pd2.
Phylogenomic databases
HOGENOM	P97324.
HOVERGEN	P97324.
Gene expression databases
ArrayExpress	P97324.
CleanEx	MM_G6PD2.
GermOnline	ENSMUSG00000045120. Mus musculus.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	285889.
SOURCE	Search...

Entry information

Entry name

G6PD2_MOUSE

Accession

Primary (citable) accession number: P97324

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)