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P97324

- G6PD2_MOUSE

UniProt

P97324 - G6PD2_MOUSE

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Protein

Glucose-6-phosphate 1-dehydrogenase 2

Gene
G6pd2, G6pd-2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.1 Publication

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721NADP 1 By similarity
Binding sitei147 – 1471NADP 1 By similarity
Binding sitei171 – 1711NADP 1; via carbonyl oxygen By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei239 – 2391Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei263 – 2631Proton acceptor By similarity
Binding sitei357 – 3571NADP 2 By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei365 – 3651Substrate By similarity
Binding sitei366 – 3661NADP 2 By similarity
Binding sitei370 – 3701NADP 2 By similarity
Binding sitei393 – 3931NADP 2 By similarity
Binding sitei395 – 3951Substrate By similarity
Binding sitei487 – 4871NADP 2 By similarity
Binding sitei503 – 5031NADP 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458NADP 1 By similarity
Nucleotide bindingi401 – 4033NADP 2 By similarity
Nucleotide bindingi421 – 4233NADP 2 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: UniProtKB
  2. NADP metabolic process Source: UniProtKB
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 2 (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:G6pd2
Synonyms:G6pd-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:105977. G6pd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Glucose-6-phosphate 1-dehydrogenase 2UniRule annotationPRO_0000068086Add
BLAST

Post-translational modificationi

Acetylated by ELP3; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2; deacetylation stimulates its enzyme activity By similarity.

Proteomic databases

MaxQBiP97324.
PaxDbiP97324.
PRIDEiP97324.

PTM databases

PhosphoSiteiP97324.

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

CleanExiMM_G6PD2.
GenevestigatoriP97324.

Interactioni

Subunit structurei

Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity. Homotetramer; dimer of dimers.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113269.

Structurei

3D structure databases

ProteinModelPortaliP97324.
SMRiP97324. Positions 28-505.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2055Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
HOVERGENiHBG000856.
InParanoidiQ0VB18.
KOiK00036.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

P97324-1 [UniParc]FASTAAdd to Basket

« Hide

MAEQVTLSRT QVCGILREEL YQNDAFHQAD THIFIIMGAS GDLAKKKIYP    50
TIWWLFRDGL LPKETFIVGY ARSQLTVDDI QKQSEPFFKA TPEERPKLEE 100
FFTRNSYVVG QYDDPASYKH LNSYINALHQ GMQANHLFYL ALPPTVYEAV 150
TKNIQETCMS QTGFNRIIVE KPFGRDLQSS NQLSNHISSL FREDQIYRID 200
HYLDKEMVQN LMVLRFANRI FGPIWNGDNI VCVILTFKEP FGTEGRGGYF 250
DEFGIIRDVM QSHLLQMLCL VAMEKPATTD SDDVRNEKVK VLKCISEVET 300
DNVILGQYVG NPNGEGEAAN GYLDDPTVPR GSTTATFAAA VLYVKNERWD 350
GVPFILRCGK ALNERKAEVR LQFRDIPGDI FHQKCKRNEL VIRMQPNEAV 400
YTTMMTKKPG MFFNPEESEL DLTYGNKYKN VKLPGAYERL ILDVFCGCQM 450
HFVRTDELRE GWRIFTPLLH KIEREKPQPF PYVYGSRGPT EADELMRRVG 500
FQYKGTYKGT HKH 513
Length:513
Mass (Da):59,126
Last modified:January 23, 2007 - v3
Checksum:i655830EB767B6C53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z84471 Genomic DNA. Translation: CAB06476.1.
BC120827 mRNA. Translation: AAI20828.1.
BC137684 mRNA. Translation: AAI37685.1.
CCDSiCCDS19297.1.
RefSeqiNP_062341.2. NM_019468.2.
UniGeneiMm.347430.

Genome annotation databases

GeneIDi14380.
KEGGimmu:14380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z84471 Genomic DNA. Translation: CAB06476.1 .
BC120827 mRNA. Translation: AAI20828.1 .
BC137684 mRNA. Translation: AAI37685.1 .
CCDSi CCDS19297.1.
RefSeqi NP_062341.2. NM_019468.2.
UniGenei Mm.347430.

3D structure databases

ProteinModelPortali P97324.
SMRi P97324. Positions 28-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000113269.

PTM databases

PhosphoSitei P97324.

Proteomic databases

MaxQBi P97324.
PaxDbi P97324.
PRIDEi P97324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14380.
KEGGi mmu:14380.

Organism-specific databases

CTDi 14380.
MGIi MGI:105977. G6pd2.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
HOVERGENi HBG000856.
InParanoidi Q0VB18.
KOi K00036.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

NextBioi 285889.
PROi P97324.
SOURCEi Search...

Gene expression databases

CleanExi MM_G6PD2.
Genevestigatori P97324.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse."
    Hendriksen P.J.M., Hoogerbrugge J.W., Baarends W.M., de Boer P., Vreeburg J.T.M., Vos E.A., van der Lende T., Grootegoed A.J.
    Genomics 41:350-359(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY.
    Strain: Swiss.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiG6PD2_MOUSE
AccessioniPrimary (citable) accession number: P97324
Secondary accession number(s): Q0VB18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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