Skip Header

Contribute Send feedback
Read comments (?) or add your own

P97324 (G6PD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase 2
Short name=G6PD
EC=1.1.1.49
Gene names
Name:G6pd2
Synonyms:G6pd-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Subunit structure

Homotetramer.

Tissue specificity

Testis.

Miscellaneous

Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 513512Glucose-6-phosphate 1-dehydrogenase 2
PRO_0000068086

Sites

Active site2631Proton acceptor By similarity
Binding site401NADP By similarity
Binding site721NADP By similarity
Binding site2011Substrate By similarity
Binding site2051Substrate By similarity
Binding site2381NADP By similarity
Binding site3571NADP By similarity
Binding site4871NADP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
P97324 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 655830EB767B6C53

FASTA51359,126
        10         20         30         40         50         60 
MAEQVTLSRT QVCGILREEL YQNDAFHQAD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 

        70         80         90        100        110        120 
LPKETFIVGY ARSQLTVDDI QKQSEPFFKA TPEERPKLEE FFTRNSYVVG QYDDPASYKH 

       130        140        150        160        170        180 
LNSYINALHQ GMQANHLFYL ALPPTVYEAV TKNIQETCMS QTGFNRIIVE KPFGRDLQSS 

       190        200        210        220        230        240 
NQLSNHISSL FREDQIYRID HYLDKEMVQN LMVLRFANRI FGPIWNGDNI VCVILTFKEP 

       250        260        270        280        290        300 
FGTEGRGGYF DEFGIIRDVM QSHLLQMLCL VAMEKPATTD SDDVRNEKVK VLKCISEVET 

       310        320        330        340        350        360 
DNVILGQYVG NPNGEGEAAN GYLDDPTVPR GSTTATFAAA VLYVKNERWD GVPFILRCGK 

       370        380        390        400        410        420 
ALNERKAEVR LQFRDIPGDI FHQKCKRNEL VIRMQPNEAV YTTMMTKKPG MFFNPEESEL 

       430        440        450        460        470        480 
DLTYGNKYKN VKLPGAYERL ILDVFCGCQM HFVRTDELRE GWRIFTPLLH KIEREKPQPF 

       490        500        510 
PYVYGSRGPT EADELMRRVG FQYKGTYKGT HKH

« Hide

References

« Hide 'large scale' references
[1]"Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse."
Hendriksen P.J.M., Hoogerbrugge J.W., Baarends W.M., de Boer P., Vreeburg J.T.M., Vos E.A., van der Lende T., Grootegoed A.J.
Genomics 41:350-359(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Swiss.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z84471 Genomic DNA. Translation: CAB06476.1.
BC120827 mRNA. Translation: AAI20828.1.
BC137684 mRNA. Translation: AAI37685.1.
IPIIPI00228867.
RefSeqNP_062341.2. NM_019468.2.
UniGeneMm.347430.

3D structure databases

ProteinModelPortalP97324.
SMRP97324. Positions 28-505.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000113269.

PTM databases

PhosphoSiteP97324.

Proteomic databases

PaxDbP97324.
PRIDEP97324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID14380.
KEGGmmu:14380.

Organism-specific databases

CTD14380.
MGIMGI:105977. G6pd2.

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046192.
HOVERGENHBG000856.
InParanoidQ0VB18.
KOK00036.
OrthoDBEOG4VHK69.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Gene expression databases

CleanExMM_G6PD2.
GenevestigatorP97324.
GermOnlineENSMUSG00000045120. Mus musculus.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
ProtoNetSearch...

Other

NextBio285889.
SOURCESearch...

Entry information

Entry nameG6PD2_MOUSE
AccessionPrimary (citable) accession number: P97324
Secondary accession number(s): Q0VB18
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 29, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents