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P97324

- G6PD2_MOUSE

UniProt

P97324 - G6PD2_MOUSE

Protein

Glucose-6-phosphate 1-dehydrogenase 2

Gene

G6pd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.1 Publication

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721NADP 1By similarity
    Binding sitei147 – 1471NADP 1By similarity
    Binding sitei171 – 1711NADP 1; via carbonyl oxygenBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei239 – 2391SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei263 – 2631Proton acceptorBy similarity
    Binding sitei357 – 3571NADP 2By similarity
    Binding sitei360 – 3601SubstrateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity
    Binding sitei366 – 3661NADP 2By similarity
    Binding sitei370 – 3701NADP 2By similarity
    Binding sitei393 – 3931NADP 2By similarity
    Binding sitei395 – 3951SubstrateBy similarity
    Binding sitei487 – 4871NADP 2By similarity
    Binding sitei503 – 5031NADP 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 458NADP 1By similarity
    Nucleotide bindingi401 – 4033NADP 2By similarity
    Nucleotide bindingi421 – 4233NADP 2By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: UniProtKB
    2. NADP metabolic process Source: UniProtKB
    3. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase 2 (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:G6pd2
    Synonyms:G6pd-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:105977. G6pd2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Glucose-6-phosphate 1-dehydrogenase 2PRO_0000068086Add
    BLAST

    Post-translational modificationi

    Acetylated by ELP3; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2; deacetylation stimulates its enzyme activity By similarity.By similarity

    Proteomic databases

    MaxQBiP97324.
    PaxDbiP97324.
    PRIDEiP97324.

    PTM databases

    PhosphoSiteiP97324.

    Expressioni

    Tissue specificityi

    Testis.1 Publication

    Gene expression databases

    CleanExiMM_G6PD2.
    GenevestigatoriP97324.

    Interactioni

    Subunit structurei

    Interacts with SIRT2; the interaction is enhanced by H2O2 treatment By similarity. Homotetramer; dimer of dimers.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113269.

    Structurei

    3D structure databases

    ProteinModelPortaliP97324.
    SMRiP97324. Positions 28-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 2055Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    HOVERGENiHBG000856.
    InParanoidiQ0VB18.
    KOiK00036.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P97324-1 [UniParc]FASTAAdd to Basket

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    MAEQVTLSRT QVCGILREEL YQNDAFHQAD THIFIIMGAS GDLAKKKIYP    50
    TIWWLFRDGL LPKETFIVGY ARSQLTVDDI QKQSEPFFKA TPEERPKLEE 100
    FFTRNSYVVG QYDDPASYKH LNSYINALHQ GMQANHLFYL ALPPTVYEAV 150
    TKNIQETCMS QTGFNRIIVE KPFGRDLQSS NQLSNHISSL FREDQIYRID 200
    HYLDKEMVQN LMVLRFANRI FGPIWNGDNI VCVILTFKEP FGTEGRGGYF 250
    DEFGIIRDVM QSHLLQMLCL VAMEKPATTD SDDVRNEKVK VLKCISEVET 300
    DNVILGQYVG NPNGEGEAAN GYLDDPTVPR GSTTATFAAA VLYVKNERWD 350
    GVPFILRCGK ALNERKAEVR LQFRDIPGDI FHQKCKRNEL VIRMQPNEAV 400
    YTTMMTKKPG MFFNPEESEL DLTYGNKYKN VKLPGAYERL ILDVFCGCQM 450
    HFVRTDELRE GWRIFTPLLH KIEREKPQPF PYVYGSRGPT EADELMRRVG 500
    FQYKGTYKGT HKH 513
    Length:513
    Mass (Da):59,126
    Last modified:January 23, 2007 - v3
    Checksum:i655830EB767B6C53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z84471 Genomic DNA. Translation: CAB06476.1.
    BC120827 mRNA. Translation: AAI20828.1.
    BC137684 mRNA. Translation: AAI37685.1.
    CCDSiCCDS19297.1.
    RefSeqiNP_062341.2. NM_019468.2.
    UniGeneiMm.347430.

    Genome annotation databases

    GeneIDi14380.
    KEGGimmu:14380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z84471 Genomic DNA. Translation: CAB06476.1 .
    BC120827 mRNA. Translation: AAI20828.1 .
    BC137684 mRNA. Translation: AAI37685.1 .
    CCDSi CCDS19297.1.
    RefSeqi NP_062341.2. NM_019468.2.
    UniGenei Mm.347430.

    3D structure databases

    ProteinModelPortali P97324.
    SMRi P97324. Positions 28-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113269.

    PTM databases

    PhosphoSitei P97324.

    Proteomic databases

    MaxQBi P97324.
    PaxDbi P97324.
    PRIDEi P97324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14380.
    KEGGi mmu:14380.

    Organism-specific databases

    CTDi 14380.
    MGIi MGI:105977. G6pd2.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    HOVERGENi HBG000856.
    InParanoidi Q0VB18.
    KOi K00036.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Miscellaneous databases

    NextBioi 285889.
    PROi P97324.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_G6PD2.
    Genevestigatori P97324.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse."
      Hendriksen P.J.M., Hoogerbrugge J.W., Baarends W.M., de Boer P., Vreeburg J.T.M., Vos E.A., van der Lende T., Grootegoed A.J.
      Genomics 41:350-359(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY.
      Strain: Swiss.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiG6PD2_MOUSE
    AccessioniPrimary (citable) accession number: P97324
    Secondary accession number(s): Q0VB18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3