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Reviewed, UniProtKB/Swiss-Prot P97318 (DAB1_MOUSE)

Last modified November 4, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Disabled homolog 1
Gene names
Name: Dab1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Adapter molecule functioning in neural development. May regulate SIAH1 activity.

Subunit structure

Interacts with LRP1 By similarity. Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1.

Tissue specificity

Expressed mainly in brain.

Domain

The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.

Post-translational modification

Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.

Sequence similarities

Contains 1 PID domain.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform DAB588 (identifier: P97318-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Notes: No experimental confirmation available.
Isoform DAB197 (identifier: P97318-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2-23: STETELQVAVKTSAKKDSRKKG → LC
     200-217: YIVFEAGHEPIRDPETEE → VISEPRQGFACSCEGSFD
     218-588: Missing.
Notes: No experimental confirmation available.
Isoform DAB204 (identifier: P97318-5)

The sequence of this isoform differs from the canonical sequence as follows:
     200-204: YIVFE → NLQKN
     205-588: Missing.
Notes: No experimental confirmation available.
Isoform DAB217 (identifier: P97318-6)

The sequence of this isoform differs from the canonical sequence as follows:
     200-217: YIVFEAGHEPIRDPETEE → VISEPRQGFACSCEGSFD
     218-588: Missing.
Isoform DAB271 (identifier: P97318-3)

The sequence of this isoform differs from the canonical sequence as follows:
     240-272: Missing.
     275-304: AVTQLELFGDMSTPPDITSPPTPATPGDAF → SLVQSPAAERAEAESRTGPAEPGSILRPLG
     305-588: Missing.
Isoform DAB553 (identifier: P97318-8)

The sequence of this isoform differs from the canonical sequence as follows:
     187-221: Missing.
Notes: No experimental confirmation available.
Isoform DAB555 (identifier: P97318-2)

The sequence of this isoform differs from the canonical sequence as follows:
     240-272: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Disabled homolog 1
PRO_0000079769

Regions

Domain36 – 189154PID

Amino acid modifications

Modified residue1981Phosphotyrosine
Modified residue2201Phosphotyrosine
Modified residue5241Phosphoserine; by CDK5

Natural variations

Alternative sequence2 – 2322STETE…SRKKG → LC in isoform DAB197.
VSP_026205
Alternative sequence187 – 22135Missing in isoform DAB553.
VSP_026206
Alternative sequence200 – 21718YIVFE…PETEE → VISEPRQGFACSCEGSFD in isoform DAB197 and isoform DAB217.
VSP_003841
Alternative sequence200 – 2045YIVFE → NLQKN in isoform DAB204.
VSP_026208
Alternative sequence205 – 588384Missing in isoform DAB204.
VSP_026209
Alternative sequence218 – 588371Missing in isoform DAB197 and isoform DAB217.
VSP_003842
Alternative sequence240 – 27233Missing in isoform DAB555 and isoform DAB271.
VSP_003843
Alternative sequence275 – 30430AVTQL…PGDAF → SLVQSPAAERAEAESRTGPA EPGSILRPLG in isoform DAB271.
VSP_003844
Alternative sequence305 – 588284Missing in isoform DAB271.
VSP_003845

Experimental info

Sequence conflict291A → R in BAB24163. Ref.2
Sequence conflict2391P → PVS in CAM17685 and CAM26758. Ref.3
Sequence conflict2481E → D in CAM17685 and CAM26758. Ref.3

Secondary structure

............................ 588
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform DAB588 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: 08404220792B1DB4

FASTA58863,578
        10         20         30         40         50         60 
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL 

        70         80         90        100        110        120 
CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 

       130        140        150        160        170        180 
TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 

       190        200        210        220        230        240 
EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPN 

       250        260        270        280        290        300 
SQPLEDFESR FAAATPNRNL SMDFDELLEA TKVSAVTQLE LFGDMSTPPD ITSPPTPATP 

       310        320        330        340        350        360 
GDAFLPSSSQ TLPGSADVFG SMSFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQIAMGAQP 

       370        380        390        400        410        420 
PVAQVIPGAQ PIAWGQPGLF PATQQAWPTV AGQFPPAAFM PTQTVMPLAA AMFQGPLTPL 

       430        440        450        460        470        480 
ATVPGTNDSA RSSPQSDKPR QKMGKESFKD FQMVQPPPVP SRKPDQPSLT CTSEAFSSYF 

       490        500        510        520        530        540 
NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHVSDPTADD 

       550        560        570        580 
IFEEGFESPS KSEEQEAPDG SQASSTSDPF GEPSGEPSGD NISPQDGS 

« Hide

Isoform DAB197 [UniParc].

Checksum: 6AF789B4EC7FF6E9
Show »

19722,236
Isoform DAB204 [UniParc].

Checksum: 36271043EFC36BB4
Show »

20423,077
Isoform DAB217 [UniParc].

Checksum: 17E7E398F5D1DC01
Show »

21724,394
Isoform DAB271 [UniParc].

Checksum: FA4A8CE9812EB55C
Show »

27130,296
Isoform DAB553 [UniParc].

Checksum: 8B281EE7C3CFD2F2
Show »

55359,415
Isoform DAB555 [UniParc].

Checksum: 57A7130311954FE0
Show »

55559,838

References

« Hide 'large scale' references
[1]"Mouse disabled (mDab1): a Src binding protein implicated in neuronal development."
Howell B.W., Gertler F.B., Cooper J.A.
EMBO J. 16:121-132(1997) [PubMed: 9009273] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS DAB217; DAB271 AND DAB555), FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
Tissue: Embryonic brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DAB197).
Strain: C57BL/6J.
Tissue: Testis.
[3]The mouse genome sequencing consortium
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1."
Keshvara L., Benhayon D., Magdaleno S., Curran T.
J. Biol. Chem. 276:16008-16014(2001) [PubMed: 11279201] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-198 AND TYR-220.
[5]"Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of reelin signaling."
Keshvara L., Magdaleno S., Benhayon D., Curran T.
J. Neurosci. 22:4869-4877(2002) [PubMed: 12077184] [Abstract]
Cited for: PHOSPHORYLATION AT SER-524.
[6]"Inhibition of ubiquitin ligase Siah-1A by disabled-1."
Park T.-J., Hamanaka H., Ohshima T., Watanabe N., Mikoshiba K., Nukina N.
Biochem. Biophys. Res. Commun. 302:671-678(2003) [PubMed: 12646221] [Abstract]
Cited for: INTERACTION WITH SIAH1.
+Additional computationally mapped references.

Cross-references

Sequence databases

Y08380 mRNA. Translation: CAA69663.1.
Y08379 mRNA. Translation: CAA69662.1.
Y08381 mRNA. Translation: CAA69664.1.
Y08383 Genomic DNA. No translation available.
AK005640 mRNA. Translation: BAB24163.1.
AL627134, AL645483 Genomic DNA. Translation: CAM26758.1.
AL627134, AL645483, AL669938 Genomic DNA. Translation: CAM26759.1.
AL627134, AL645483, AL669938 Genomic DNA. Translation: CAM26760.1.
AL627134, AL645483, AL669938 Genomic DNA. Translation: CAM26762.1.
AL627134, AL645483, AL669938 Genomic DNA. Translation: CAM26765.1.
AL645483, AL627134 Genomic DNA. Translation: CAM17685.1.
AL645483, AL627134, AL669938 Genomic DNA. Translation: