Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine and glycine-rich protein 1

Gene

Csrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in neuronal development.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • platelet aggregation Source: MGI
  • response to metal ion Source: Reactome

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5660489. MTF1 activates gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Gene namesi
Name:Csrp1
Synonyms:Crp1, Csrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88549. Csrp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757161 – 193Cysteine and glycine-rich protein 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1
Modified residuei84N6-acetyllysineCombined sources1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysineCombined sources1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei161N6-acetyllysineCombined sources1
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97315.
PaxDbiP97315.
PeptideAtlasiP97315.
PRIDEiP97315.

PTM databases

iPTMnetiP97315.
PhosphoSitePlusiP97315.
SwissPalmiP97315.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026421.
CleanExiMM_CSRP1.
ExpressionAtlasiP97315. baseline and differential.
GenevisibleiP97315. MM.

Interactioni

Subunit structurei

Interacts with ASCC1; ASCC2 AND TRIP4.By similarity

Protein-protein interaction databases

BioGridi198952. 3 interactors.
IntActiP97315. 4 interactors.
MINTiMINT-4092312.
STRINGi10090.ENSMUSP00000027677.

Structurei

3D structure databases

ProteinModelPortaliP97315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP97315.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP97315.
TreeFamiTF313758.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 2 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P97315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP
110 120 130 140 150
TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KSCFRCAKCG
160 170 180 190
KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
Length:193
Mass (Da):20,583
Last modified:January 23, 2007 - v3
Checksum:iAC69703ABD68C97A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88793 mRNA. Translation: BAA13723.1.
AF092921 mRNA. Translation: AAD19352.1.
AK077787 mRNA. Translation: BAC37009.1.
AK087436 mRNA. Translation: BAC39873.1.
BC006912 mRNA. Translation: AAH06912.1.
CCDSiCCDS15320.1.
RefSeqiNP_031817.1. NM_007791.5.
UniGeneiMm.196484.

Genome annotation databases

EnsembliENSMUST00000027677; ENSMUSP00000027677; ENSMUSG00000026421.
ENSMUST00000097561; ENSMUSP00000095169; ENSMUSG00000026421.
GeneIDi13007.
KEGGimmu:13007.
UCSCiuc007cto.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCSRP1_MOUSE
AccessioniPrimary (citable) accession number: P97315
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot