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Protein

Cysteine and glycine-rich protein 2

Gene

Csrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name:
CRP2
Double LIM protein 1
Short name:
DLP-1
Gene namesi
Name:Csrp2
Synonyms:Dlp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1202907. Csrp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757221 – 193Cysteine and glycine-rich protein 2Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei137N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP97314.
MaxQBiP97314.
PaxDbiP97314.
PeptideAtlasiP97314.
PRIDEiP97314.

PTM databases

iPTMnetiP97314.
PhosphoSitePlusiP97314.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020186.
CleanExiMM_CSRP2.
GenevisibleiP97314. MM.

Interactioni

Subunit structurei

Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction (By similarity). Interacts with GLRX3.By similarity1 Publication

Protein-protein interaction databases

BioGridi198953. 1 interactor.
IntActiP97314. 2 interactors.
MINTiMINT-4092329.

Structurei

3D structure databases

ProteinModelPortaliP97314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI2. Eukaryota.
ENOG4111F44. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP97314.
KOiK09377.
OMAiFHKCCFL.
OrthoDBiEOG091G11RX.
PhylomeDBiP97314.
TreeFamiTF313758.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 2 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P97314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESAQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Length:193
Mass (Da):20,926
Last modified:January 23, 2007 - v3
Checksum:iBF792F284C9597E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30F → Y in BAB28379 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88792 mRNA. Translation: BAA13722.1.
AK010626 mRNA. Translation: BAB27072.1.
AK012647 mRNA. Translation: BAB28379.1.
BC012663 mRNA. Translation: AAH12663.1.
CCDSiCCDS24165.1.
RefSeqiNP_031818.3. NM_007792.4.
UniGeneiMm.2020.

Genome annotation databases

EnsembliENSMUST00000020403; ENSMUSP00000020403; ENSMUSG00000020186.
GeneIDi13008.
KEGGimmu:13008.
UCSCiuc007gzs.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCSRP2_MOUSE
AccessioniPrimary (citable) accession number: P97314
Secondary accession number(s): Q9CZG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot