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Protein

SH3 and cysteine-rich domain-containing protein

Gene

Stac

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in a neuron-specific signal transduction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri108 – 16053Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: MGI
  • intracellular signal transduction Source: InterPro
  • muscle contraction Source: MGI
  • regulation of voltage-gated calcium channel activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:Stac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201400. Stac.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • T-tubule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403SH3 and cysteine-rich domain-containing proteinPRO_0000072236Add
BLAST

Proteomic databases

PaxDbiP97306.
PRIDEiP97306.

PTM databases

iPTMnetiP97306.
PhosphoSiteiP97306.

Expressioni

Tissue specificityi

Expressed predominantly in brain and neurons, more specifically in hippocampus, cerebellum and inferior olive. Weak expression is found in heart, liver, lung and kidney. Found as well in some cell lines.

Developmental stagei

Expression in brain started at late E13.5 and continued to adult (8W) with a peak around P10.

Gene expression databases

BgeeiP97306.
CleanExiMM_STAC.
ExpressionAtlasiP97306. baseline and differential.
GenevisibleiP97306. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035083.

Structurei

3D structure databases

ProteinModelPortaliP97306.
SMRiP97306. Positions 105-162, 289-343, 348-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 34560SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri108 – 16053Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiP97306.
OMAiNSVFTYP.
OrthoDBiEOG7XM2ZF.
PhylomeDBiP97306.
TreeFamiTF332878.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPSGARED SGDGLTGEAT GTEQPPSPAS TSSLESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FPRTNSDVKP QADLLAKASP GPSPIAIPGS PASMPTKAGL
110 120 130 140 150
HPGSNSKLHA FQEHVFKKPT FCDVCNHMIV GTHAKHGLRC GACKMSIHHK
160 170 180 190 200
CADGLAPQRC MGKLPKGFRR YYSSPLLIHE QFGCIKEVMP IACGNKVDPV
210 220 230 240 250
YEALRFGTSL AQRTKKGGSG SGSDSPPRTS TSELVDVPEE ADGPGDGSDM
260 270 280 290 300
RTRSNSVFTY PENGMDDFRD QMKTTNHQGP LSKDPLQMNT YVALYRFIPQ
310 320 330 340 350
ENEDLEMRPG DMITLLEDSN EDWWKGKIQD RVGFFPANFV QRVEEHEKIY
360 370 380 390 400
RCVRTFIGCK DQGQITLKEN QICVTSEEEQ DGFIRVLSGK KRGLVPLDVL

VDV
Length:403
Mass (Da):44,319
Last modified:May 1, 1997 - v1
Checksum:i2B6CAEBFBCFF9982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86639 mRNA. Translation: BAA13151.1.
CCDSiCCDS23586.1.
PIRiJC5269.
RefSeqiNP_058549.1. NM_016853.3.
UniGeneiMm.1414.

Genome annotation databases

EnsembliENSMUST00000035083; ENSMUSP00000035083; ENSMUSG00000032502.
GeneIDi20840.
KEGGimmu:20840.
UCSCiuc009rvw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86639 mRNA. Translation: BAA13151.1.
CCDSiCCDS23586.1.
PIRiJC5269.
RefSeqiNP_058549.1. NM_016853.3.
UniGeneiMm.1414.

3D structure databases

ProteinModelPortaliP97306.
SMRiP97306. Positions 105-162, 289-343, 348-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035083.

PTM databases

iPTMnetiP97306.
PhosphoSiteiP97306.

Proteomic databases

PaxDbiP97306.
PRIDEiP97306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035083; ENSMUSP00000035083; ENSMUSG00000032502.
GeneIDi20840.
KEGGimmu:20840.
UCSCiuc009rvw.1. mouse.

Organism-specific databases

CTDi6769.
MGIiMGI:1201400. Stac.

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiP97306.
OMAiNSVFTYP.
OrthoDBiEOG7XM2ZF.
PhylomeDBiP97306.
TreeFamiTF332878.

Miscellaneous databases

PROiP97306.
SOURCEiSearch...

Gene expression databases

BgeeiP97306.
CleanExiMM_STAC.
ExpressionAtlasiP97306. baseline and differential.
GenevisibleiP97306. MM.

Family and domain databases

InterProiIPR002219. PE/DAG-bd.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Stac, a novel neuron-specific protein with cysteine-rich and SH3 domains."
    Suzuki H., Kawai J., Taga C., Yaoi T., Hara A., Hirose K., Hayashizaki Y., Watanabe S.
    Biochem. Biophys. Res. Commun. 229:902-909(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeJ.
    Tissue: Brain.

Entry informationi

Entry nameiSTAC_MOUSE
AccessioniPrimary (citable) accession number: P97306
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.