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Protein

SH3 and cysteine-rich domain-containing protein

Gene

Stac

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in a neuron-specific signal transduction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

  • cellular response to heat Source: MGI
  • intracellular signal transduction Source: InterPro
  • muscle contraction Source: MGI
  • regulation of voltage-gated calcium channel activity Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:Stac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201400. Stac.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722361 – 403SH3 and cysteine-rich domain-containing proteinAdd BLAST403

Proteomic databases

PaxDbiP97306.
PRIDEiP97306.

PTM databases

iPTMnetiP97306.
PhosphoSitePlusiP97306.

Expressioni

Tissue specificityi

Expressed predominantly in brain and neurons, more specifically in hippocampus, cerebellum and inferior olive. Weak expression is found in heart, liver, lung and kidney. Found as well in some cell lines.

Developmental stagei

Expression in brain started at late E13.5 and continued to adult (8W) with a peak around P10.

Gene expression databases

BgeeiENSMUSG00000032502.
CleanExiMM_STAC.
ExpressionAtlasiP97306. baseline and differential.
GenevisibleiP97306. MM.

Structurei

3D structure databases

ProteinModelPortaliP97306.
SMRiP97306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 345SH3PROSITE-ProRule annotationAdd BLAST60

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
GeneTreeiENSGT00390000008822.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiP97306.
OMAiPKGFRRY.
OrthoDBiEOG091G085P.
PhylomeDBiP97306.
TreeFamiTF332878.

Family and domain databases

CDDicd00029. C1. 1 hit.
InterProiView protein in InterPro
IPR002219. PE/DAG-bd.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR035508. STAC1.
PANTHERiPTHR15135:SF3. PTHR15135:SF3. 1 hit.
PfamiView protein in Pfam
PF00130. C1_1. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00109. C1. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P97306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPSGARED SGDGLTGEAT GTEQPPSPAS TSSLESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FPRTNSDVKP QADLLAKASP GPSPIAIPGS PASMPTKAGL
110 120 130 140 150
HPGSNSKLHA FQEHVFKKPT FCDVCNHMIV GTHAKHGLRC GACKMSIHHK
160 170 180 190 200
CADGLAPQRC MGKLPKGFRR YYSSPLLIHE QFGCIKEVMP IACGNKVDPV
210 220 230 240 250
YEALRFGTSL AQRTKKGGSG SGSDSPPRTS TSELVDVPEE ADGPGDGSDM
260 270 280 290 300
RTRSNSVFTY PENGMDDFRD QMKTTNHQGP LSKDPLQMNT YVALYRFIPQ
310 320 330 340 350
ENEDLEMRPG DMITLLEDSN EDWWKGKIQD RVGFFPANFV QRVEEHEKIY
360 370 380 390 400
RCVRTFIGCK DQGQITLKEN QICVTSEEEQ DGFIRVLSGK KRGLVPLDVL

VDV
Length:403
Mass (Da):44,319
Last modified:May 1, 1997 - v1
Checksum:i2B6CAEBFBCFF9982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86639 mRNA. Translation: BAA13151.1.
CCDSiCCDS23586.1.
PIRiJC5269.
RefSeqiNP_058549.1. NM_016853.3.
UniGeneiMm.1414.

Genome annotation databases

EnsembliENSMUST00000035083; ENSMUSP00000035083; ENSMUSG00000032502.
GeneIDi20840.
KEGGimmu:20840.
UCSCiuc009rvw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSTAC_MOUSE
AccessioniPrimary (citable) accession number: P97306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot