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Protein

DNA-directed RNA polymerases I and III subunit RPAC2

Gene

Polr1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I and III subunit RPAC2
Short name:
RNA polymerases I and III subunit AC2
Alternative name(s):
AC19
DNA-directed RNA polymerase I subunit D
RNA polymerase I 16 kDa subunit
Short name:
RPA16
Gene namesi
Name:Polr1d
Synonyms:Rpo1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108403. Polr1d.

Subcellular locationi

GO - Cellular componenti

  • DNA-directed RNA polymerase I complex Source: MGI
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133DNA-directed RNA polymerases I and III subunit RPAC2PRO_0000149317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP97304.
PaxDbiP97304.
PRIDEiP97304.

PTM databases

iPTMnetiP97304.
PhosphoSiteiP97304.

Expressioni

Gene expression databases

BgeeiP97304.
ExpressionAtlasiP97304. baseline and differential.
GenevisibleiP97304. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

IntActiP97304. 2 interactions.
MINTiMINT-4133004.
STRINGi10090.ENSMUSP00000058355.

Structurei

3D structure databases

ProteinModelPortaliP97304.
SMRiP97304. Positions 22-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3438. Eukaryota.
COG1761. LUCA.
HOGENOMiHOG000179862.
HOVERGENiHBG001176.
InParanoidiP97304.
KOiK03020.
OMAiSSFSIME.
OrthoDBiEOG7J9VRX.
PhylomeDBiP97304.
TreeFamiTF103035.

Family and domain databases

InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRQCV TFVLHEEDHT
60 70 80 90 100
LGNCLRYIIM KNPEVEFCGY TTTHPSESKI NLRIQTRGAL PAVEPFQKGL
110 120 130
NELLNVCQHV LVKFEASIKD YKAKKASKKE PTF
Length:133
Mass (Da):15,072
Last modified:May 1, 1997 - v1
Checksum:iD355055B67C7388B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86609 mRNA. Translation: BAA13139.1.
CCDSiCCDS19876.1.
RefSeqiNP_033113.1. NM_009087.2.
UniGeneiMm.317557.

Genome annotation databases

EnsembliENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642.
GeneIDi20018.
KEGGimmu:20018.
UCSCiuc009anu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86609 mRNA. Translation: BAA13139.1.
CCDSiCCDS19876.1.
RefSeqiNP_033113.1. NM_009087.2.
UniGeneiMm.317557.

3D structure databases

ProteinModelPortaliP97304.
SMRiP97304. Positions 22-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97304. 2 interactions.
MINTiMINT-4133004.
STRINGi10090.ENSMUSP00000058355.

PTM databases

iPTMnetiP97304.
PhosphoSiteiP97304.

Proteomic databases

EPDiP97304.
PaxDbiP97304.
PRIDEiP97304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642.
GeneIDi20018.
KEGGimmu:20018.
UCSCiuc009anu.2. mouse.

Organism-specific databases

CTDi51082.
MGIiMGI:108403. Polr1d.

Phylogenomic databases

eggNOGiKOG3438. Eukaryota.
COG1761. LUCA.
HOGENOMiHOG000179862.
HOVERGENiHBG001176.
InParanoidiP97304.
KOiK03020.
OMAiSSFSIME.
OrthoDBiEOG7J9VRX.
PhylomeDBiP97304.
TreeFamiTF103035.

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiPolr1d. mouse.
NextBioi297525.
PROiP97304.
SOURCEiSearch...

Gene expression databases

BgeeiP97304.
ExpressionAtlasiP97304. baseline and differential.
GenevisibleiP97304. MM.

Family and domain databases

InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III."
    Yao Y., Yamamoto K., Nishi Y., Nogi Y., Muramatsu M.
    J. Biol. Chem. 271:32881-32885(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiRPAC2_MOUSE
AccessioniPrimary (citable) accession number: P97304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.