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Protein

DNA-directed RNA polymerases I and III subunit RPAC2

Gene

Polr1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I and III subunit RPAC2
Short name:
RNA polymerases I and III subunit AC2
Alternative name(s):
AC19
DNA-directed RNA polymerase I subunit D
RNA polymerase I 16 kDa subunit
Short name:
RPA16
Gene namesi
Name:Polr1d
Synonyms:Rpo1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108403. Polr1d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493171 – 133DNA-directed RNA polymerases I and III subunit RPAC2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP97304.
PaxDbiP97304.
PeptideAtlasiP97304.
PRIDEiP97304.

PTM databases

iPTMnetiP97304.
PhosphoSitePlusiP97304.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029642.
ExpressionAtlasiP97304. baseline and differential.
GenevisibleiP97304. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

IntActiP97304. 2 interactors.
MINTiMINT-4133004.
STRINGi10090.ENSMUSP00000058355.

Structurei

3D structure databases

ProteinModelPortaliP97304.
SMRiP97304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3438. Eukaryota.
COG1761. LUCA.
GeneTreeiENSGT00550000075160.
HOGENOMiHOG000179862.
HOVERGENiHBG001176.
InParanoidiP97304.
KOiK03020.
OMAiNELMDVC.
OrthoDBiEOG091G0STX.
PhylomeDBiP97304.
TreeFamiTF103035.

Family and domain databases

CDDicd07029. RNAP_I_III_AC19. 1 hit.
InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
IPR033898. RNAP_AC19.
[Graphical view]
PfamiPF13656. RNA_pol_L_2. 1 hit.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRQCV TFVLHEEDHT
60 70 80 90 100
LGNCLRYIIM KNPEVEFCGY TTTHPSESKI NLRIQTRGAL PAVEPFQKGL
110 120 130
NELLNVCQHV LVKFEASIKD YKAKKASKKE PTF
Length:133
Mass (Da):15,072
Last modified:May 1, 1997 - v1
Checksum:iD355055B67C7388B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86609 mRNA. Translation: BAA13139.1.
CCDSiCCDS19876.1.
RefSeqiNP_033113.1. NM_009087.2.
UniGeneiMm.317557.

Genome annotation databases

EnsembliENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642.
GeneIDi20018.
KEGGimmu:20018.
UCSCiuc009anu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86609 mRNA. Translation: BAA13139.1.
CCDSiCCDS19876.1.
RefSeqiNP_033113.1. NM_009087.2.
UniGeneiMm.317557.

3D structure databases

ProteinModelPortaliP97304.
SMRiP97304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97304. 2 interactors.
MINTiMINT-4133004.
STRINGi10090.ENSMUSP00000058355.

PTM databases

iPTMnetiP97304.
PhosphoSitePlusiP97304.

Proteomic databases

EPDiP97304.
PaxDbiP97304.
PeptideAtlasiP97304.
PRIDEiP97304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642.
GeneIDi20018.
KEGGimmu:20018.
UCSCiuc009anu.2. mouse.

Organism-specific databases

CTDi51082.
MGIiMGI:108403. Polr1d.

Phylogenomic databases

eggNOGiKOG3438. Eukaryota.
COG1761. LUCA.
GeneTreeiENSGT00550000075160.
HOGENOMiHOG000179862.
HOVERGENiHBG001176.
InParanoidiP97304.
KOiK03020.
OMAiNELMDVC.
OrthoDBiEOG091G0STX.
PhylomeDBiP97304.
TreeFamiTF103035.

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5250924. B-WICH complex positively regulates rRNA expression.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiPolr1d. mouse.
PROiP97304.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029642.
ExpressionAtlasiP97304. baseline and differential.
GenevisibleiP97304. MM.

Family and domain databases

CDDicd07029. RNAP_I_III_AC19. 1 hit.
InterProiIPR009025. RBP11-like_dimer.
IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
IPR033898. RNAP_AC19.
[Graphical view]
PfamiPF13656. RNA_pol_L_2. 1 hit.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 1 hit.
PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPAC2_MOUSE
AccessioniPrimary (citable) accession number: P97304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.