Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-directed RNA polymerases I and III subunit RPAC2

Gene

Polr1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I and III subunit RPAC2
Short name:
RNA polymerases I and III subunit AC2
Alternative name(s):
AC19
DNA-directed RNA polymerase I subunit D
RNA polymerase I 16 kDa subunit
Short name:
RPA16
Gene namesi
Name:Polr1d
Synonyms:Rpo1-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108403 Polr1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493171 – 133DNA-directed RNA polymerases I and III subunit RPAC2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP97304
PaxDbiP97304
PeptideAtlasiP97304
PRIDEiP97304

PTM databases

iPTMnetiP97304
PhosphoSitePlusiP97304

Expressioni

Gene expression databases

BgeeiENSMUSG00000029642
ExpressionAtlasiP97304 baseline and differential
GenevisibleiP97304 MM

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97304, 2 interactors
MINTiP97304
STRINGi10090.ENSMUSP00000058355

Structurei

3D structure databases

ProteinModelPortaliP97304
SMRiP97304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3438 Eukaryota
COG1761 LUCA
GeneTreeiENSGT00550000075160
HOGENOMiHOG000179862
HOVERGENiHBG001176
InParanoidiP97304
KOiK03020
OMAiDEVEFCG
OrthoDBiEOG091G0STX
PhylomeDBiP97304
TreeFamiTF103035

Family and domain databases

CDDicd07029 RNAP_I_III_AC19, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR036603 RBP11-like
IPR009025 RBP11-like_dimer
IPR008193 RNA_pol_Rpb11_13-16kDa_CS
IPR033898 RNAP_AC19
PfamiView protein in Pfam
PF13656 RNA_pol_L_2, 1 hit
SUPFAMiSSF55257 SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154 RNA_POL_L_13KD, 1 hit

Sequencei

Sequence statusi: Complete.

P97304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRQCV TFVLHEEDHT
60 70 80 90 100
LGNCLRYIIM KNPEVEFCGY TTTHPSESKI NLRIQTRGAL PAVEPFQKGL
110 120 130
NELLNVCQHV LVKFEASIKD YKAKKASKKE PTF
Length:133
Mass (Da):15,072
Last modified:May 1, 1997 - v1
Checksum:iD355055B67C7388B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86609 mRNA Translation: BAA13139.1
CCDSiCCDS19876.1
RefSeqiNP_033113.1, NM_009087.2
UniGeneiMm.317557

Genome annotation databases

EnsembliENSMUST00000050970; ENSMUSP00000058355; ENSMUSG00000029642
GeneIDi20018
KEGGimmu:20018
UCSCiuc009anu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRPAC2_MOUSE
AccessioniPrimary (citable) accession number: P97304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health