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P97303

- BACH2_MOUSE

UniProt

P97303 - BACH2_MOUSE

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Protein
Transcription regulator protein BACH2
Gene
Bach2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: MGI
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
Gene namesi
Name:Bach2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:894679. Bach2.

Subcellular locationi

Cytoplasm. Nucleus
Note: Nucleocytoplasmic shuttling is controlled by phosphorylation By similarity.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Transcription regulator protein BACH2
PRO_0000076457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 – 20Interchain; redox-active By similarity
Modified residuei520 – 5201Phosphoserine; by RPS6KB1 By similarity

Post-translational modificationi

The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses By similarity.
Phosphorylation at Ser-520 downstream of the PI-3K pathway promotes nuclear export By similarity.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP97303.

PTM databases

PhosphoSiteiP97303.

Expressioni

Tissue specificityi

Expression restricted to monocytes and neuronal cells.

Gene expression databases

ArrayExpressiP97303.
BgeeiP97303.
CleanExiMM_BACH2.
GenevestigatoriP97303.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity. Heterodimer of BACH2 and Maf-related transcription factors.

Protein-protein interaction databases

IntActiP97303. 1 interaction.
MINTiMINT-1728942.
STRINGi10090.ENSMUSP00000103815.

Structurei

3D structure databases

ProteinModelPortaliP97303.
SMRiP97303. Positions 8-129, 608-705.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 10367BTB
Add
BLAST
Domaini645 – 70864bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni650 – 66617Basic motif By similarity
Add
BLAST
Regioni670 – 6778Leucine-zipper By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi819 – 83921Nuclear export signal
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1687Poly-Glu

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.
Contains 1 BTB (POZ) domain.

Phylogenomic databases

eggNOGiNOG276808.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000231712.
HOVERGENiHBG050655.
KOiK09042.
OMAiLHRYCPV.
OrthoDBiEOG7WMCHX.
PhylomeDBiP97303.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97303-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVDEKPGSP MYVYESTVHC ANILLGLNDQ RKKDILCDVT LIVERKEFRA    50
HRAVLAACSE YFWQALVGQT KDDLVVSLPE EVTARGFGPL LQFAYTAKLL 100
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNREDGL FVCRKDSACQ 150
RPQEDHGNSA GEEEEEEETM DSETARMACA TDQMLPDPIS FEATAIPVAE 200
KEEALLPESE VPTDTKENSE KGALTQYPRY KKYQLACTKN VYSAPSHGTS 250
GFASTFSEDS PGNSLKPGLP MGQIKSEPPS EETEEESITL CLSGDETDIK 300
DRPGDVEMDR KQPSPAPTPS TPTGAACLDR SRSVSSPSCL RSLFGITKGV 350
ESTGLPSTSQ QPLVRSSACP FNKGISQGDL KTDYTPLAGN YGQPHVGQKD 400
VSNFAMGSPL RGPGPETLCK QEGELDRRSV IFSASACDQP NTPVHSYSAV 450
SNLDKDLSEP VPKSLWVGAG QSLPSSQAYS HSGLMADHLP GRIRPNTSCP 500
VPIKVCPRSP PLETRTRTSS SCSSYSYAED GSGGSPCSLP LCEFSSSPCS 550
QGARFLATEH QEPGLMGDGM YNQVRPQIKC EQSYGTNSSD ESGSFSEADS 600
ESCPVQDRGQ EVKLPFPVDQ ITDLPRNDFQ MMIKMHKLTS EQLEFIHDIR 650
RRSKNRIAAQ RCRKRKLDCI QNLECEIRKL VCEKEKLLSE RNHLKACMGE 700
LLDNFSCLSQ EVCRDIQSPE QIQALHRYCP VLIPMDLPGA SVNPPPVGVE 750
QSLAPSPCAV GGSVPCCLEP GAAPPGLPWV PSNTSENCTS GRRLEGSDPG 800
TFSERGPPLE ARSQSVTVDF CQEMTEKCTT DEQPRKDYA 839
Length:839
Mass (Da):91,836
Last modified:September 18, 2013 - v3
Checksum:i8A5321A68A07653D
GO
Isoform 2 (identifier: P97303-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-543: Missing.

Show »
Length:716
Mass (Da):78,817
Checksum:i703BCE4305A70352
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei421 – 543123Missing in isoform 2.
VSP_047933Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201E → G in AAI31643. 1 Publication
Sequence conflicti317 – 3171P → R in BAA13138. 1 Publication
Sequence conflicti322 – 3221P → R in BAA13138. 1 Publication
Sequence conflicti420 – 4201K → E in BAA13138. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86604 mRNA. Translation: BAA13138.1.
AL732547 Genomic DNA. No translation available.
AL831746 Genomic DNA. Translation: CAM26623.1.
BC131642 mRNA. Translation: AAI31643.1.
CCDSiCCDS51135.1. [P97303-1]
RefSeqiNP_001103131.1. NM_001109661.1. [P97303-1]
XP_006537630.1. XM_006537567.1. [P97303-1]
UniGeneiMm.491223.

Genome annotation databases

EnsembliENSMUST00000037416; ENSMUSP00000043693; ENSMUSG00000040270. [P97303-2]
ENSMUST00000108180; ENSMUSP00000103815; ENSMUSG00000040270. [P97303-1]
ENSMUST00000171600; ENSMUSP00000131592; ENSMUSG00000040270. [P97303-1]
GeneIDi12014.
KEGGimmu:12014.
UCSCiuc012dbf.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86604 mRNA. Translation: BAA13138.1 .
AL732547 Genomic DNA. No translation available.
AL831746 Genomic DNA. Translation: CAM26623.1 .
BC131642 mRNA. Translation: AAI31643.1 .
CCDSi CCDS51135.1. [P97303-1 ]
RefSeqi NP_001103131.1. NM_001109661.1. [P97303-1 ]
XP_006537630.1. XM_006537567.1. [P97303-1 ]
UniGenei Mm.491223.

3D structure databases

ProteinModelPortali P97303.
SMRi P97303. Positions 8-129, 608-705.
ModBasei Search...

Protein-protein interaction databases

IntActi P97303. 1 interaction.
MINTi MINT-1728942.
STRINGi 10090.ENSMUSP00000103815.

PTM databases

PhosphoSitei P97303.

Proteomic databases

PRIDEi P97303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037416 ; ENSMUSP00000043693 ; ENSMUSG00000040270 . [P97303-2 ]
ENSMUST00000108180 ; ENSMUSP00000103815 ; ENSMUSG00000040270 . [P97303-1 ]
ENSMUST00000171600 ; ENSMUSP00000131592 ; ENSMUSG00000040270 . [P97303-1 ]
GeneIDi 12014.
KEGGi mmu:12014.
UCSCi uc012dbf.1. mouse.

Organism-specific databases

CTDi 60468.
MGIi MGI:894679. Bach2.

Phylogenomic databases

eggNOGi NOG276808.
GeneTreei ENSGT00550000074399.
HOGENOMi HOG000231712.
HOVERGENi HBG050655.
KOi K09042.
OMAi LHRYCPV.
OrthoDBi EOG7WMCHX.
PhylomeDBi P97303.
TreeFami TF326681.

Miscellaneous databases

NextBioi 280225.
PROi P97303.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97303.
Bgeei P97303.
CleanExi MM_BACH2.
Genevestigatori P97303.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site."
    Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
    Mol. Cell. Biol. 16:6083-6095(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element."
    Hoshino H., Kobayashi A., Yoshida M., Kudo N., Oyake T., Motohashi H., Hayashi N., Yamamoto M., Igarashi K.
    J. Biol. Chem. 275:15370-15376(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBACH2_MOUSE
AccessioniPrimary (citable) accession number: P97303
Secondary accession number(s): A2ANU8, A2ANU9, A2RRI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi