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P97303

- BACH2_MOUSE

UniProt

P97303 - BACH2_MOUSE

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Protein

Transcription regulator protein BACH2

Gene

Bach2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  2. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH2
Alternative name(s):
BTB and CNC homolog 2
Gene namesi
Name:Bach2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:894679. Bach2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation
Note: Nucleocytoplasmic shuttling is controlled by phosphorylation.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Transcription regulator protein BACH2PRO_0000076457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 – 20Interchain; redox-activeBy similarity
Modified residuei520 – 5201Phosphoserine; by RPS6KB1By similarity

Post-translational modificationi

The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses.By similarity
Phosphorylation at Ser-520 downstream of the PI-3K pathway promotes nuclear export.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP97303.
PRIDEiP97303.

PTM databases

PhosphoSiteiP97303.

Expressioni

Tissue specificityi

Expression restricted to monocytes and neuronal cells.

Gene expression databases

BgeeiP97303.
CleanExiMM_BACH2.
ExpressionAtlasiP97303. baseline and differential.
GenevestigatoriP97303.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Heterodimer of BACH2 and Maf-related transcription factors.By similarity

Protein-protein interaction databases

IntActiP97303. 1 interaction.
MINTiMINT-1728942.
STRINGi10090.ENSMUSP00000103815.

Structurei

3D structure databases

ProteinModelPortaliP97303.
SMRiP97303. Positions 8-129, 608-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 10367BTBPROSITE-ProRule annotationAdd
BLAST
Domaini645 – 70864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni650 – 66617Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni670 – 6778Leucine-zipperPROSITE-ProRule annotation

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi819 – 83921Nuclear export signalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1687Poly-Glu

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276808.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000231712.
HOVERGENiHBG050655.
InParanoidiP97303.
KOiK09042.
OMAiLHRYCPV.
OrthoDBiEOG7WMCHX.
PhylomeDBiP97303.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97303) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDEKPGSP MYVYESTVHC ANILLGLNDQ RKKDILCDVT LIVERKEFRA
60 70 80 90 100
HRAVLAACSE YFWQALVGQT KDDLVVSLPE EVTARGFGPL LQFAYTAKLL
110 120 130 140 150
LSRENIREVI RCAEFLRMHN LEDSCFSFLQ TQLLNREDGL FVCRKDSACQ
160 170 180 190 200
RPQEDHGNSA GEEEEEEETM DSETARMACA TDQMLPDPIS FEATAIPVAE
210 220 230 240 250
KEEALLPESE VPTDTKENSE KGALTQYPRY KKYQLACTKN VYSAPSHGTS
260 270 280 290 300
GFASTFSEDS PGNSLKPGLP MGQIKSEPPS EETEEESITL CLSGDETDIK
310 320 330 340 350
DRPGDVEMDR KQPSPAPTPS TPTGAACLDR SRSVSSPSCL RSLFGITKGV
360 370 380 390 400
ESTGLPSTSQ QPLVRSSACP FNKGISQGDL KTDYTPLAGN YGQPHVGQKD
410 420 430 440 450
VSNFAMGSPL RGPGPETLCK QEGELDRRSV IFSASACDQP NTPVHSYSAV
460 470 480 490 500
SNLDKDLSEP VPKSLWVGAG QSLPSSQAYS HSGLMADHLP GRIRPNTSCP
510 520 530 540 550
VPIKVCPRSP PLETRTRTSS SCSSYSYAED GSGGSPCSLP LCEFSSSPCS
560 570 580 590 600
QGARFLATEH QEPGLMGDGM YNQVRPQIKC EQSYGTNSSD ESGSFSEADS
610 620 630 640 650
ESCPVQDRGQ EVKLPFPVDQ ITDLPRNDFQ MMIKMHKLTS EQLEFIHDIR
660 670 680 690 700
RRSKNRIAAQ RCRKRKLDCI QNLECEIRKL VCEKEKLLSE RNHLKACMGE
710 720 730 740 750
LLDNFSCLSQ EVCRDIQSPE QIQALHRYCP VLIPMDLPGA SVNPPPVGVE
760 770 780 790 800
QSLAPSPCAV GGSVPCCLEP GAAPPGLPWV PSNTSENCTS GRRLEGSDPG
810 820 830
TFSERGPPLE ARSQSVTVDF CQEMTEKCTT DEQPRKDYA
Length:839
Mass (Da):91,836
Last modified:September 18, 2013 - v3
Checksum:i8A5321A68A07653D
GO
Isoform 2 (identifier: P97303-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-543: Missing.

Show »
Length:716
Mass (Da):78,817
Checksum:i703BCE4305A70352
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201E → G in AAI31643. (PubMed:15489334)Curated
Sequence conflicti317 – 3171P → R in BAA13138. (PubMed:8887638)Curated
Sequence conflicti322 – 3221P → R in BAA13138. (PubMed:8887638)Curated
Sequence conflicti420 – 4201K → E in BAA13138. (PubMed:8887638)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei421 – 543123Missing in isoform 2. 1 PublicationVSP_047933Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86604 mRNA. Translation: BAA13138.1.
AL732547 Genomic DNA. No translation available.
AL831746 Genomic DNA. Translation: CAM26623.1.
BC131642 mRNA. Translation: AAI31643.1.
CCDSiCCDS51135.1. [P97303-1]
RefSeqiNP_001103131.1. NM_001109661.1. [P97303-1]
XP_006537630.1. XM_006537567.1. [P97303-1]
UniGeneiMm.491223.

Genome annotation databases

EnsembliENSMUST00000037416; ENSMUSP00000043693; ENSMUSG00000040270. [P97303-2]
ENSMUST00000108180; ENSMUSP00000103815; ENSMUSG00000040270. [P97303-1]
ENSMUST00000171600; ENSMUSP00000131592; ENSMUSG00000040270. [P97303-1]
GeneIDi12014.
KEGGimmu:12014.
UCSCiuc012dbf.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86604 mRNA. Translation: BAA13138.1 .
AL732547 Genomic DNA. No translation available.
AL831746 Genomic DNA. Translation: CAM26623.1 .
BC131642 mRNA. Translation: AAI31643.1 .
CCDSi CCDS51135.1. [P97303-1 ]
RefSeqi NP_001103131.1. NM_001109661.1. [P97303-1 ]
XP_006537630.1. XM_006537567.1. [P97303-1 ]
UniGenei Mm.491223.

3D structure databases

ProteinModelPortali P97303.
SMRi P97303. Positions 8-129, 608-705.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97303. 1 interaction.
MINTi MINT-1728942.
STRINGi 10090.ENSMUSP00000103815.

PTM databases

PhosphoSitei P97303.

Proteomic databases

MaxQBi P97303.
PRIDEi P97303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037416 ; ENSMUSP00000043693 ; ENSMUSG00000040270 . [P97303-2 ]
ENSMUST00000108180 ; ENSMUSP00000103815 ; ENSMUSG00000040270 . [P97303-1 ]
ENSMUST00000171600 ; ENSMUSP00000131592 ; ENSMUSG00000040270 . [P97303-1 ]
GeneIDi 12014.
KEGGi mmu:12014.
UCSCi uc012dbf.1. mouse.

Organism-specific databases

CTDi 60468.
MGIi MGI:894679. Bach2.

Phylogenomic databases

eggNOGi NOG276808.
GeneTreei ENSGT00550000074399.
HOGENOMi HOG000231712.
HOVERGENi HBG050655.
InParanoidi P97303.
KOi K09042.
OMAi LHRYCPV.
OrthoDBi EOG7WMCHX.
PhylomeDBi P97303.
TreeFami TF326681.

Miscellaneous databases

NextBioi 280225.
PROi P97303.
SOURCEi Search...

Gene expression databases

Bgeei P97303.
CleanExi MM_BACH2.
ExpressionAtlasi P97303. baseline and differential.
Genevestigatori P97303.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site."
    Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
    Mol. Cell. Biol. 16:6083-6095(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element."
    Hoshino H., Kobayashi A., Yoshida M., Kudo N., Oyake T., Motohashi H., Hayashi N., Yamamoto M., Igarashi K.
    J. Biol. Chem. 275:15370-15376(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBACH2_MOUSE
AccessioniPrimary (citable) accession number: P97303
Secondary accession number(s): A2ANU8, A2ANU9, A2RRI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3