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Protein

Transcription regulator protein BACH1

Gene

Bach1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
Gene namesi
Name:Bach1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:894680. Bach1.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764551 – 739Transcription regulator protein BACH1Add BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97302.
PeptideAtlasiP97302.
PRIDEiP97302.

PTM databases

iPTMnetiP97302.
PhosphoSitePlusiP97302.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000025612.
CleanExiMM_BACH1.
ExpressionAtlasiP97302. baseline and differential.
GenevisibleiP97302. MM.

Interactioni

Subunit structurei

Heterodimer of BACH1 and MAFK.

Protein-protein interaction databases

BioGridi198294. 27 interactors.
DIPiDIP-46342N.
IntActiP97302. 23 interactors.
MINTiMINT-4088990.
STRINGi10090.ENSMUSP00000026703.

Structurei

Secondary structure

1739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 30Combined sources15
Beta strandi36 – 40Combined sources5
Beta strandi43 – 47Combined sources5
Helixi49 – 55Combined sources7
Helixi57 – 63Combined sources7
Beta strandi71 – 74Combined sources4
Helixi81 – 93Combined sources13
Turni100 – 102Combined sources3
Helixi103 – 113Combined sources11
Helixi116 – 118Combined sources3
Helixi119 – 125Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortaliP97302.
SMRiP97302.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97302.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100BTBPROSITE-ProRule annotationAdd BLAST67
Domaini560 – 623bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni565 – 581Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni585 – 592Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISV2. Eukaryota.
ENOG410Z743. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiP97302.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG091G02EB.
PhylomeDBiP97302.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
1.20.5.370. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR011333. SKP1/BTB/POZ.
IPR008917. TF_DNA-bd.
IPR014751. XRCC4_C.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
DNVDEVCRCV EFLSVHNIEE SCFQFLKFKF LDSTSEQQEC ARKKCFSSHC
160 170 180 190 200
QKADFKFSFS EQKDLEIDEA DEFLEKKRVQ TPQCDSRRCQ GSVKASPPLQ
210 220 230 240 250
DSVSQACQSL CTDKDGALAL PSLCPKYRKF QKAFGTDKIR TLESGVRDVH
260 270 280 290 300
TASVQPNETS ELECFGGAQG CADLHVILKC EGMKAAMESE DTEGQDPSPQ
310 320 330 340 350
CPAEQPQGTP LPQDSAGPHG LYSLSALHTY EQSGDVAFAG VQSKTVKTEK
360 370 380 390 400
PLSRPDAQDE KPSENQDLYL KSSMGPKEDS SSLASEDRSS VEREVAEHLA
410 420 430 440 450
KGFWSDICST DSPCQMQLSP TVAKDGPEQG YSQRRSECPW LGIRISESPE
460 470 480 490 500
PGQRTFTTLS SVNCPFISTL SSEGCSSNLE IGNYDYVSEP QQEPCPYACV
510 520 530 540 550
ISLGDDSETD TEGDSESCSA REQDCEVKLP FNAQRIISLS RNDFQSLLKM
560 570 580 590 600
HKLTPEQLDC IHDIRRRSKN RIAAQRCRKR KLDCIQNLES EIEKLQSEKE
610 620 630 640 650
SLLKERDHIL STLGETKQNL TGLCQQVCKE AALSPEQIQI LAKYSASDCP
660 670 680 690 700
LSFLISEKGK STPDGELAFT SVFSVSDVPP TAPPPCGRGS SAASQELVQE
710 720 730
SPPTTAAAPE QATLLEPCRQ SAGISDFCQQ MSDKCTTDE
Length:739
Mass (Da):81,374
Last modified:May 1, 1997 - v1
Checksum:iCE2DE606B05F6E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86603 mRNA. Translation: BAA13137.1.
BC057894 mRNA. Translation: AAH57894.1.
CCDSiCCDS28293.1.
RefSeqiNP_031546.1. NM_007520.2.
XP_006522942.1. XM_006522879.3.
UniGeneiMm.26147.

Genome annotation databases

EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
GeneIDi12013.
KEGGimmu:12013.
UCSCiuc007zup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86603 mRNA. Translation: BAA13137.1.
BC057894 mRNA. Translation: AAH57894.1.
CCDSiCCDS28293.1.
RefSeqiNP_031546.1. NM_007520.2.
XP_006522942.1. XM_006522879.3.
UniGeneiMm.26147.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortaliP97302.
SMRiP97302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198294. 27 interactors.
DIPiDIP-46342N.
IntActiP97302. 23 interactors.
MINTiMINT-4088990.
STRINGi10090.ENSMUSP00000026703.

PTM databases

iPTMnetiP97302.
PhosphoSitePlusiP97302.

Proteomic databases

PaxDbiP97302.
PeptideAtlasiP97302.
PRIDEiP97302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
GeneIDi12013.
KEGGimmu:12013.
UCSCiuc007zup.1. mouse.

Organism-specific databases

CTDi571.
MGIiMGI:894680. Bach1.

Phylogenomic databases

eggNOGiENOG410ISV2. Eukaryota.
ENOG410Z743. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiP97302.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG091G02EB.
PhylomeDBiP97302.
TreeFamiTF326681.

Miscellaneous databases

EvolutionaryTraceiP97302.
PROiP97302.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025612.
CleanExiMM_BACH1.
ExpressionAtlasiP97302. baseline and differential.
GenevisibleiP97302. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
1.20.5.370. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR011333. SKP1/BTB/POZ.
IPR008917. TF_DNA-bd.
IPR014751. XRCC4_C.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBACH1_MOUSE
AccessioniPrimary (citable) accession number: P97302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.