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Protein

Transcription regulator protein BACH1

Gene

Bach1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
Gene namesi
Name:Bach1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:894680. Bach1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Transcription regulator protein BACH1PRO_0000076455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei448 – 4481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97302.
PaxDbiP97302.
PRIDEiP97302.

PTM databases

PhosphoSiteiP97302.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP97302.
CleanExiMM_BACH1.
ExpressionAtlasiP97302. baseline and differential.
GenevisibleiP97302. MM.

Interactioni

Subunit structurei

Heterodimer of BACH1 and MAFK.

Protein-protein interaction databases

BioGridi198294. 14 interactions.
DIPiDIP-46342N.
IntActiP97302. 10 interactions.
MINTiMINT-4088990.
STRINGi10090.ENSMUSP00000026703.

Structurei

Secondary structure

1
739
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 3015Combined sources
Beta strandi36 – 405Combined sources
Beta strandi43 – 475Combined sources
Helixi49 – 557Combined sources
Helixi57 – 637Combined sources
Beta strandi71 – 744Combined sources
Helixi81 – 9313Combined sources
Turni100 – 1023Combined sources
Helixi103 – 11311Combined sources
Helixi116 – 1183Combined sources
Helixi119 – 1257Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortaliP97302.
SMRiP97302. Positions 1-135, 527-620.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97302.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10067BTBPROSITE-ProRule annotationAdd
BLAST
Domaini560 – 62364bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni565 – 58117Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni585 – 5928Leucine-zipperPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG308993.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiP97302.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG73V6JP.
PhylomeDBiP97302.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
DNVDEVCRCV EFLSVHNIEE SCFQFLKFKF LDSTSEQQEC ARKKCFSSHC
160 170 180 190 200
QKADFKFSFS EQKDLEIDEA DEFLEKKRVQ TPQCDSRRCQ GSVKASPPLQ
210 220 230 240 250
DSVSQACQSL CTDKDGALAL PSLCPKYRKF QKAFGTDKIR TLESGVRDVH
260 270 280 290 300
TASVQPNETS ELECFGGAQG CADLHVILKC EGMKAAMESE DTEGQDPSPQ
310 320 330 340 350
CPAEQPQGTP LPQDSAGPHG LYSLSALHTY EQSGDVAFAG VQSKTVKTEK
360 370 380 390 400
PLSRPDAQDE KPSENQDLYL KSSMGPKEDS SSLASEDRSS VEREVAEHLA
410 420 430 440 450
KGFWSDICST DSPCQMQLSP TVAKDGPEQG YSQRRSECPW LGIRISESPE
460 470 480 490 500
PGQRTFTTLS SVNCPFISTL SSEGCSSNLE IGNYDYVSEP QQEPCPYACV
510 520 530 540 550
ISLGDDSETD TEGDSESCSA REQDCEVKLP FNAQRIISLS RNDFQSLLKM
560 570 580 590 600
HKLTPEQLDC IHDIRRRSKN RIAAQRCRKR KLDCIQNLES EIEKLQSEKE
610 620 630 640 650
SLLKERDHIL STLGETKQNL TGLCQQVCKE AALSPEQIQI LAKYSASDCP
660 670 680 690 700
LSFLISEKGK STPDGELAFT SVFSVSDVPP TAPPPCGRGS SAASQELVQE
710 720 730
SPPTTAAAPE QATLLEPCRQ SAGISDFCQQ MSDKCTTDE
Length:739
Mass (Da):81,374
Last modified:May 1, 1997 - v1
Checksum:iCE2DE606B05F6E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86603 mRNA. Translation: BAA13137.1.
BC057894 mRNA. Translation: AAH57894.1.
CCDSiCCDS28293.1.
RefSeqiNP_031546.1. NM_007520.2.
XP_006522942.1. XM_006522879.2.
UniGeneiMm.26147.

Genome annotation databases

EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
GeneIDi12013.
KEGGimmu:12013.
UCSCiuc007zup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86603 mRNA. Translation: BAA13137.1.
BC057894 mRNA. Translation: AAH57894.1.
CCDSiCCDS28293.1.
RefSeqiNP_031546.1. NM_007520.2.
XP_006522942.1. XM_006522879.2.
UniGeneiMm.26147.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortaliP97302.
SMRiP97302. Positions 1-135, 527-620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198294. 14 interactions.
DIPiDIP-46342N.
IntActiP97302. 10 interactions.
MINTiMINT-4088990.
STRINGi10090.ENSMUSP00000026703.

PTM databases

PhosphoSiteiP97302.

Proteomic databases

MaxQBiP97302.
PaxDbiP97302.
PRIDEiP97302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
GeneIDi12013.
KEGGimmu:12013.
UCSCiuc007zup.1. mouse.

Organism-specific databases

CTDi571.
MGIiMGI:894680. Bach1.

Phylogenomic databases

eggNOGiNOG308993.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiP97302.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG73V6JP.
PhylomeDBiP97302.
TreeFamiTF326681.

Miscellaneous databases

EvolutionaryTraceiP97302.
NextBioi280221.
PROiP97302.
SOURCEiSearch...

Gene expression databases

BgeeiP97302.
CleanExiMM_BACH1.
ExpressionAtlasiP97302. baseline and differential.
GenevisibleiP97302. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site."
    Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
    Mol. Cell. Biol. 16:6083-6095(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary gland.
  3. "Crystal structure of the Bach1 BTB domain and its regulation of homodimerization."
    Ito N., Watanabe-Matsui M., Igarashi K., Murayama K.
    Genes Cells 14:167-178(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-135, FUNCTION.

Entry informationi

Entry nameiBACH1_MOUSE
AccessioniPrimary (citable) accession number: P97302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.