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Protein

Transcription regulator protein BACH1

Gene

Bach1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
Gene namesi
Name:Bach1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:894680 Bach1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764551 – 739Transcription regulator protein BACH1Add BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineBy similarity1
Modified residuei448PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97302
PeptideAtlasiP97302
PRIDEiP97302

PTM databases

iPTMnetiP97302
PhosphoSitePlusiP97302

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000025612
CleanExiMM_BACH1
ExpressionAtlasiP97302 baseline and differential
GenevisibleiP97302 MM

Interactioni

Subunit structurei

Heterodimer of BACH1 and MAFK.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi19829427 interactors.
DIPiDIP-46342N
IntActiP97302 29 interactors.
MINTiP97302
STRINGi10090.ENSMUSP00000026703

Structurei

Secondary structure

1739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 30Combined sources15
Beta strandi36 – 40Combined sources5
Beta strandi43 – 47Combined sources5
Helixi49 – 55Combined sources7
Helixi57 – 63Combined sources7
Beta strandi71 – 74Combined sources4
Helixi81 – 93Combined sources13
Turni100 – 102Combined sources3
Helixi103 – 113Combined sources11
Helixi116 – 118Combined sources3
Helixi119 – 125Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortaliP97302
SMRiP97302
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97302

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100BTBPROSITE-ProRule annotationAdd BLAST67
Domaini560 – 623bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni565 – 581Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni585 – 592Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISV2 Eukaryota
ENOG410Z743 LUCA
GeneTreeiENSGT00850000132251
HOGENOMiHOG000231712
HOVERGENiHBG099852
InParanoidiP97302
KOiK09042
OMAiCQMQLSP
OrthoDBiEOG091G02EB
PhylomeDBiP97302
TreeFamiTF326681

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR011333 SKP1/BTB/POZ_sf
IPR008917 TF_DNA-bd_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P97302-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
DNVDEVCRCV EFLSVHNIEE SCFQFLKFKF LDSTSEQQEC ARKKCFSSHC
160 170 180 190 200
QKADFKFSFS EQKDLEIDEA DEFLEKKRVQ TPQCDSRRCQ GSVKASPPLQ
210 220 230 240 250
DSVSQACQSL CTDKDGALAL PSLCPKYRKF QKAFGTDKIR TLESGVRDVH
260 270 280 290 300
TASVQPNETS ELECFGGAQG CADLHVILKC EGMKAAMESE DTEGQDPSPQ
310 320 330 340 350
CPAEQPQGTP LPQDSAGPHG LYSLSALHTY EQSGDVAFAG VQSKTVKTEK
360 370 380 390 400
PLSRPDAQDE KPSENQDLYL KSSMGPKEDS SSLASEDRSS VEREVAEHLA
410 420 430 440 450
KGFWSDICST DSPCQMQLSP TVAKDGPEQG YSQRRSECPW LGIRISESPE
460 470 480 490 500
PGQRTFTTLS SVNCPFISTL SSEGCSSNLE IGNYDYVSEP QQEPCPYACV
510 520 530 540 550
ISLGDDSETD TEGDSESCSA REQDCEVKLP FNAQRIISLS RNDFQSLLKM
560 570 580 590 600
HKLTPEQLDC IHDIRRRSKN RIAAQRCRKR KLDCIQNLES EIEKLQSEKE
610 620 630 640 650
SLLKERDHIL STLGETKQNL TGLCQQVCKE AALSPEQIQI LAKYSASDCP
660 670 680 690 700
LSFLISEKGK STPDGELAFT SVFSVSDVPP TAPPPCGRGS SAASQELVQE
710 720 730
SPPTTAAAPE QATLLEPCRQ SAGISDFCQQ MSDKCTTDE
Length:739
Mass (Da):81,374
Last modified:May 1, 1997 - v1
Checksum:iCE2DE606B05F6E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86603 mRNA Translation: BAA13137.1
BC057894 mRNA Translation: AAH57894.1
CCDSiCCDS28293.1
RefSeqiNP_031546.1, NM_007520.2
XP_006522942.1, XM_006522879.3
UniGeneiMm.26147

Genome annotation databases

EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612
GeneIDi12013
KEGGimmu:12013
UCSCiuc007zup.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBACH1_MOUSE
AccessioniPrimary (citable) accession number: P97302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome