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P97302 (BACH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
Gene names
Name:Bach1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK. Ref.3

Subunit structure

Heterodimer of BACH1 and MAFK.

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the bZIP family. CNC subfamily.

Contains 1 BTB (POZ) domain.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Transcription regulator protein BACH1
PRO_0000076455

Regions

Domain34 – 10067BTB
Domain560 – 62364bZIP
Region565 – 58117Basic motif By similarity
Region585 – 5928Leucine-zipper By similarity

Amino acid modifications

Modified residue4481Phosphoserine By similarity

Secondary structure

..................... 739
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P97302 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: CE2DE606B05F6E32

FASTA73981,374
        10         20         30         40         50         60 
MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS VLAACSSYFH 

        70         80         90        100        110        120 
SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK DNVDEVCRCV EFLSVHNIEE 

       130        140        150        160        170        180 
SCFQFLKFKF LDSTSEQQEC ARKKCFSSHC QKADFKFSFS EQKDLEIDEA DEFLEKKRVQ 

       190        200        210        220        230        240 
TPQCDSRRCQ GSVKASPPLQ DSVSQACQSL CTDKDGALAL PSLCPKYRKF QKAFGTDKIR 

       250        260        270        280        290        300 
TLESGVRDVH TASVQPNETS ELECFGGAQG CADLHVILKC EGMKAAMESE DTEGQDPSPQ 

       310        320        330        340        350        360 
CPAEQPQGTP LPQDSAGPHG LYSLSALHTY EQSGDVAFAG VQSKTVKTEK PLSRPDAQDE 

       370        380        390        400        410        420 
KPSENQDLYL KSSMGPKEDS SSLASEDRSS VEREVAEHLA KGFWSDICST DSPCQMQLSP 

       430        440        450        460        470        480 
TVAKDGPEQG YSQRRSECPW LGIRISESPE PGQRTFTTLS SVNCPFISTL SSEGCSSNLE 

       490        500        510        520        530        540 
IGNYDYVSEP QQEPCPYACV ISLGDDSETD TEGDSESCSA REQDCEVKLP FNAQRIISLS 

       550        560        570        580        590        600 
RNDFQSLLKM HKLTPEQLDC IHDIRRRSKN RIAAQRCRKR KLDCIQNLES EIEKLQSEKE 

       610        620        630        640        650        660 
SLLKERDHIL STLGETKQNL TGLCQQVCKE AALSPEQIQI LAKYSASDCP LSFLISEKGK 

       670        680        690        700        710        720 
STPDGELAFT SVFSVSDVPP TAPPPCGRGS SAASQELVQE SPPTTAAAPE QATLLEPCRQ 

       730 
SAGISDFCQQ MSDKCTTDE 

« Hide

References

« Hide 'large scale' references
[1]"Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site."
Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
Mol. Cell. Biol. 16:6083-6095(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI.
Tissue: Mammary gland.
[3]"Crystal structure of the Bach1 BTB domain and its regulation of homodimerization."
Ito N., Watanabe-Matsui M., Igarashi K., Murayama K.
Genes Cells 14:167-178(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-135, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86603 mRNA. Translation: BAA13137.1.
BC057894 mRNA. Translation: AAH57894.1.
CCDSCCDS28293.1.
RefSeqNP_031546.1. NM_007520.2.
XP_006522942.1. XM_006522879.1.
UniGeneMm.26147.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z8HX-ray2.50A1-135[»]
ProteinModelPortalP97302.
SMRP97302. Positions 1-135, 527-620.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198294. 14 interactions.
DIPDIP-46342N.
IntActP97302. 10 interactions.
MINTMINT-4088990.

PTM databases

PhosphoSiteP97302.

Proteomic databases

PaxDbP97302.
PRIDEP97302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
GeneID12013.
KEGGmmu:12013.
UCSCuc007zup.1. mouse.

Organism-specific databases

CTD571.
MGIMGI:894680. Bach1.

Phylogenomic databases

eggNOGNOG308993.
HOGENOMHOG000231712.
HOVERGENHBG099852.
InParanoidP97302.
KOK09042.
OMAENKNVQT.
OrthoDBEOG73V6JP.
PhylomeDBP97302.
TreeFamTF326681.

Gene expression databases

ArrayExpressP97302.
BgeeP97302.
CleanExMM_BACH1.
GenevestigatorP97302.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP97302.
NextBio280221.
PROP97302.
SOURCESearch...

Entry information

Entry nameBACH1_MOUSE
AccessionPrimary (citable) accession number: P97302
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot