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P97302

- BACH1_MOUSE

UniProt

P97302 - BACH1_MOUSE

Protein

Transcription regulator protein BACH1

Gene

Bach1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    7. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
    5. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
    6. regulation of transcription involved in G2/M transition of mitotic cell cycle Source: Ensembl

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription regulator protein BACH1
    Alternative name(s):
    BTB and CNC homolog 1
    Gene namesi
    Name:Bach1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:894680. Bach1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Transcription regulator protein BACH1PRO_0000076455Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei448 – 4481PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP97302.
    PRIDEiP97302.

    PTM databases

    PhosphoSiteiP97302.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP97302.
    BgeeiP97302.
    CleanExiMM_BACH1.
    GenevestigatoriP97302.

    Interactioni

    Subunit structurei

    Heterodimer of BACH1 and MAFK.

    Protein-protein interaction databases

    BioGridi198294. 14 interactions.
    DIPiDIP-46342N.
    IntActiP97302. 10 interactions.
    MINTiMINT-4088990.

    Structurei

    Secondary structure

    1
    739
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 3015
    Beta strandi36 – 405
    Beta strandi43 – 475
    Helixi49 – 557
    Helixi57 – 637
    Beta strandi71 – 744
    Helixi81 – 9313
    Turni100 – 1023
    Helixi103 – 11311
    Helixi116 – 1183
    Helixi119 – 1257

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Z8HX-ray2.50A1-135[»]
    ProteinModelPortaliP97302.
    SMRiP97302. Positions 1-135, 527-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP97302.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10067BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini560 – 62364bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni565 – 58117Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni585 – 5928Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family. CNC subfamily.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG308993.
    HOGENOMiHOG000231712.
    HOVERGENiHBG099852.
    InParanoidiP97302.
    KOiK09042.
    OMAiENKNVQT.
    OrthoDBiEOG73V6JP.
    PhylomeDBiP97302.
    TreeFamiTF326681.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97302-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSESAVFA YESSVHSTNV LLSLNDQRKK DVLCDVTVLV EGQRFRAHRS    50
    VLAACSSYFH SRIVGQTDAE LTVTLPEEVT VKGFEPLIQF AYTAKLILSK 100
    DNVDEVCRCV EFLSVHNIEE SCFQFLKFKF LDSTSEQQEC ARKKCFSSHC 150
    QKADFKFSFS EQKDLEIDEA DEFLEKKRVQ TPQCDSRRCQ GSVKASPPLQ 200
    DSVSQACQSL CTDKDGALAL PSLCPKYRKF QKAFGTDKIR TLESGVRDVH 250
    TASVQPNETS ELECFGGAQG CADLHVILKC EGMKAAMESE DTEGQDPSPQ 300
    CPAEQPQGTP LPQDSAGPHG LYSLSALHTY EQSGDVAFAG VQSKTVKTEK 350
    PLSRPDAQDE KPSENQDLYL KSSMGPKEDS SSLASEDRSS VEREVAEHLA 400
    KGFWSDICST DSPCQMQLSP TVAKDGPEQG YSQRRSECPW LGIRISESPE 450
    PGQRTFTTLS SVNCPFISTL SSEGCSSNLE IGNYDYVSEP QQEPCPYACV 500
    ISLGDDSETD TEGDSESCSA REQDCEVKLP FNAQRIISLS RNDFQSLLKM 550
    HKLTPEQLDC IHDIRRRSKN RIAAQRCRKR KLDCIQNLES EIEKLQSEKE 600
    SLLKERDHIL STLGETKQNL TGLCQQVCKE AALSPEQIQI LAKYSASDCP 650
    LSFLISEKGK STPDGELAFT SVFSVSDVPP TAPPPCGRGS SAASQELVQE 700
    SPPTTAAAPE QATLLEPCRQ SAGISDFCQQ MSDKCTTDE 739
    Length:739
    Mass (Da):81,374
    Last modified:May 1, 1997 - v1
    Checksum:iCE2DE606B05F6E32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86603 mRNA. Translation: BAA13137.1.
    BC057894 mRNA. Translation: AAH57894.1.
    CCDSiCCDS28293.1.
    RefSeqiNP_031546.1. NM_007520.2.
    XP_006522942.1. XM_006522879.1.
    UniGeneiMm.26147.

    Genome annotation databases

    EnsembliENSMUST00000026703; ENSMUSP00000026703; ENSMUSG00000025612.
    GeneIDi12013.
    KEGGimmu:12013.
    UCSCiuc007zup.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86603 mRNA. Translation: BAA13137.1 .
    BC057894 mRNA. Translation: AAH57894.1 .
    CCDSi CCDS28293.1.
    RefSeqi NP_031546.1. NM_007520.2.
    XP_006522942.1. XM_006522879.1.
    UniGenei Mm.26147.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Z8H X-ray 2.50 A 1-135 [» ]
    ProteinModelPortali P97302.
    SMRi P97302. Positions 1-135, 527-620.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198294. 14 interactions.
    DIPi DIP-46342N.
    IntActi P97302. 10 interactions.
    MINTi MINT-4088990.

    PTM databases

    PhosphoSitei P97302.

    Proteomic databases

    PaxDbi P97302.
    PRIDEi P97302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026703 ; ENSMUSP00000026703 ; ENSMUSG00000025612 .
    GeneIDi 12013.
    KEGGi mmu:12013.
    UCSCi uc007zup.1. mouse.

    Organism-specific databases

    CTDi 571.
    MGIi MGI:894680. Bach1.

    Phylogenomic databases

    eggNOGi NOG308993.
    HOGENOMi HOG000231712.
    HOVERGENi HBG099852.
    InParanoidi P97302.
    KOi K09042.
    OMAi ENKNVQT.
    OrthoDBi EOG73V6JP.
    PhylomeDBi P97302.
    TreeFami TF326681.

    Miscellaneous databases

    EvolutionaryTracei P97302.
    NextBioi 280221.
    PROi P97302.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97302.
    Bgeei P97302.
    CleanExi MM_BACH1.
    Genevestigatori P97302.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site."
      Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
      Mol. Cell. Biol. 16:6083-6095(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRI.
      Tissue: Mammary gland.
    3. "Crystal structure of the Bach1 BTB domain and its regulation of homodimerization."
      Ito N., Watanabe-Matsui M., Igarashi K., Murayama K.
      Genes Cells 14:167-178(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-135, FUNCTION.

    Entry informationi

    Entry nameiBACH1_MOUSE
    AccessioniPrimary (citable) accession number: P97302
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3