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P97299

- SFRP2_MOUSE

UniProt

P97299 - SFRP2_MOUSE

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Protein

Secreted frizzled-related protein 2

Gene
Sfrp2, Sarp1, Sdf5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  1. endopeptidase activator activity Source: MGI
  2. metalloenzyme activator activity Source: MGI
  3. PDZ domain binding Source: RefGenome
  4. protein binding Source: MGI
  5. receptor agonist activity Source: BHF-UCL
  6. Wnt-activated receptor activity Source: RefGenome
  7. Wnt-protein binding Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. apoptotic process Source: MGI
  3. bone morphogenesis Source: MGI
  4. brain development Source: RefGenome
  5. cardiac left ventricle morphogenesis Source: Ensembl
  6. cartilage development Source: MGI
  7. cellular response to extracellular stimulus Source: MGI
  8. cellular response to X-ray Source: UniProtKB
  9. chondrocyte development Source: MGI
  10. collagen fibril organization Source: MGI
  11. convergent extension involved in axis elongation Source: MGI
  12. development of primary male sexual characteristics Source: MGI
  13. digestive tract morphogenesis Source: MGI
  14. embryonic digit morphogenesis Source: MGI
  15. hematopoietic stem cell proliferation Source: UniProtKB
  16. male gonad development Source: MGI
  17. negative regulation of BMP signaling pathway Source: MGI
  18. negative regulation of canonical Wnt signaling pathway Source: MGI
  19. negative regulation of cardiac muscle cell apoptotic process Source: MGI
  20. negative regulation of cell growth Source: Ensembl
  21. negative regulation of cell migration Source: UniProtKB
  22. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  23. negative regulation of dermatome development Source: BHF-UCL
  24. negative regulation of epithelial cell proliferation Source: Ensembl
  25. negative regulation of epithelial to mesenchymal transition Source: Ensembl
  26. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  27. negative regulation of gene expression Source: UniProtKB
  28. negative regulation of JUN kinase activity Source: MGI
  29. negative regulation of mesodermal cell fate specification Source: MGI
  30. negative regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  31. negative regulation of planar cell polarity pathway involved in axis elongation Source: MGI
  32. negative regulation of transcription, DNA-templated Source: Ensembl
  33. negative regulation of Wnt signaling pathway Source: BHF-UCL
  34. neural tube closure Source: MGI
  35. neural tube development Source: MGI
  36. outflow tract morphogenesis Source: Ensembl
  37. patterning of blood vessels Source: BHF-UCL
  38. planar cell polarity pathway involved in neural tube closure Source: MGI
  39. positive regulation of angiogenesis Source: BHF-UCL
  40. positive regulation of apoptotic process Source: Ensembl
  41. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  42. positive regulation of catenin import into nucleus Source: BHF-UCL
  43. positive regulation of cell growth Source: UniProtKB
  44. positive regulation of cell proliferation Source: UniProtKB
  45. positive regulation of endopeptidase activity Source: MGI
  46. positive regulation of fat cell differentiation Source: MGI
  47. positive regulation of osteoblast differentiation Source: MGI
  48. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  49. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  50. post-anal tail morphogenesis Source: MGI
  51. regulation of apoptotic process Source: MGI
  52. regulation of cell proliferation Source: MGI
  53. regulation of establishment of planar polarity Source: MGI
  54. regulation of stem cell division Source: UniProtKB
  55. regulation of Wnt signaling pathway Source: UniProtKB
  56. response to drug Source: UniProtKB
  57. response to nutrient Source: Ensembl
  58. sclerotome development Source: BHF-UCL
  59. somitogenesis Source: MGI
  60. Wnt signaling pathway involved in somitogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Alternative name(s):
Protein SDF5
Secreted apoptosis-related protein 1
Short name:
SARP-1
Gene namesi
Name:Sfrp2
Synonyms:Sarp1, Sdf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:108078. Sfrp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: UniProtKB
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 295271Secreted frizzled-related protein 2PRO_0000032543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 103 By similarity
Disulfide bondi50 ↔ 96 By similarity
Disulfide bondi87 ↔ 125 By similarity
Disulfide bondi114 ↔ 152 By similarity
Disulfide bondi118 ↔ 142 By similarity
Disulfide bondi172 ↔ 245 By similarity
Disulfide bondi175 ↔ 247 By similarity
Disulfide bondi190 ↔ 295 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP97299.

PTM databases

PhosphoSiteiP97299.

Expressioni

Tissue specificityi

Highly expressed in the eye. Weaker expression in heart and lung.1 Publication

Developmental stagei

During kidney development, expressed at E10.5 in the mesonephric tubules, and at E12.5 strongly expressed in the comma shaped bodies and surrounding ureter stalk. In E14.5 kidney, expressed in the S-shaped bodies. In the developing nervous system, expressed in the presumptive hindbrain and the ventral part of the neural tube from E8.0 onwards. At E9.5, expression is additionally detected in the mesonephros and the optic vesicle. E10 expression is found in the second and third branchial cleft, in the eye, the ventral neural tube and specific rhombomeres and prosomers. E10.5 brain shows specific expression in the basal and alar plate. In developing eye, expressed at E9.0 in the optic placode, and at E9.5 in the optic vesicle. By E10.5, expression found in the lens vesicle and the inner layer of the invaginating optic vesicle. Strong expression at E14.5 in the anterior lens epithelium, decreasing thereafter. Expression also found in the prospective neural retina. In developing limbs, expression found at E11.5 in the shoulder and at the distal end of the cartilaginous condensation. At E12.5, expressed in the foot and hand paddle extending along the digital rays. Expressed, at E13.5 and E14.5, in the forelimb and hindlimb where the interphalangeal joints will develop. Also expressed at E14.5 between the sternal bands and where the ribs contact the sternum. In other developing structures, expression found at E11.5, in the maxillary and mandibular component of the first branchial arch, and later, in the loose mesenchyme surrounding cartilage and epithelia of the skull as well as in the whisker follicles. Also expressed in developing teeth, with the highest levels at E15.5 and E16.5 in the mesenchyme and the dental epithelium of the developing molars. Expressed in development smooth muscle surrounding the esophagus at E11.5, the dorsal aorta and the ductus arteriosus at E14.5, and the ureter stalk at E15.5.2 Publications

Gene expression databases

ArrayExpressiP97299.
BgeeiP97299.
CleanExiMM_SFRP2.
GenevestigatoriP97299.

Interactioni

Protein-protein interaction databases

BioGridi203142. 9 interactions.
DIPiDIP-59486N.

Structurei

3D structure databases

ProteinModelPortaliP97299.
SMRiP97299. Positions 49-150.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 155121FZAdd
BLAST
Domaini172 – 295124NTRAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiP97299.
KOiK02176.
OMAiTSLKRWQ.
OrthoDBiEOG789CBZ.
PhylomeDBiP97299.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97299-1 [UniParc]FASTAAdd to Basket

« Hide

MPRGPASLLL LVLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC    50
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA 100
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND 150
LCIPLASSDH LLPATEEAPK VCEACKTKNE DDNDIMETLC KNDFALKIKV 200
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM 250
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC 295
Length:295
Mass (Da):33,469
Last modified:March 15, 2005 - v2
Checksum:i2D287C177C974C62
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381S → T in AAB70795. 1 Publication
Sequence conflicti119 – 1191V → M in BAA09053. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50462 mRNA. Translation: BAA09053.1.
U88567 mRNA. Translation: AAC53146.1.
AF017989 mRNA. Translation: AAB70795.1.
BC014722 mRNA. Translation: AAH14722.1.
CCDSiCCDS17434.1.
RefSeqiNP_033170.1. NM_009144.2.
UniGeneiMm.19155.

Genome annotation databases

EnsembliENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996.
GeneIDi20319.
KEGGimmu:20319.
UCSCiuc008ppl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50462 mRNA. Translation: BAA09053.1 .
U88567 mRNA. Translation: AAC53146.1 .
AF017989 mRNA. Translation: AAB70795.1 .
BC014722 mRNA. Translation: AAH14722.1 .
CCDSi CCDS17434.1.
RefSeqi NP_033170.1. NM_009144.2.
UniGenei Mm.19155.

3D structure databases

ProteinModelPortali P97299.
SMRi P97299. Positions 49-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203142. 9 interactions.
DIPi DIP-59486N.

Protein family/group databases

MEROPSi I93.001.

PTM databases

PhosphoSitei P97299.

Proteomic databases

PRIDEi P97299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029625 ; ENSMUSP00000029625 ; ENSMUSG00000027996 .
GeneIDi 20319.
KEGGi mmu:20319.
UCSCi uc008ppl.2. mouse.

Organism-specific databases

CTDi 6423.
MGIi MGI:108078. Sfrp2.

Phylogenomic databases

eggNOGi NOG240950.
HOGENOMi HOG000231058.
HOVERGENi HBG052928.
InParanoidi P97299.
KOi K02176.
OMAi TSLKRWQ.
OrthoDBi EOG789CBZ.
PhylomeDBi P97299.
TreeFami TF350133.

Enzyme and pathway databases

Reactomei REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

ChiTaRSi SFRP2. mouse.
NextBioi 298111.
PROi P97299.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97299.
Bgeei P97299.
CleanExi MM_SFRP2.
Genevestigatori P97299.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR026558. SFRP2.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF45. PTHR11309:SF45. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method."
    Shirozu M., Tada H., Tashiro K., Nakamura T., Lopez N.D., Nazarea M., Hamada T., Sato T., Nakano T., Honjo T.
    Genomics 37:273-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow stroma.
  2. "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors."
    Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Embryonic eye.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family."
    Leimeister C., Bach A., Gessler M.
    Mech. Dev. 75:29-42(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSFRP2_MOUSE
AccessioniPrimary (citable) accession number: P97299
Secondary accession number(s): O08862, O35297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi