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P97298

- PEDF_MOUSE

UniProt

P97298 - PEDF_MOUSE

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Protein

Pigment epithelium-derived factor

Gene

Serpinf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. aging Source: Ensembl
  2. kidney development Source: Ensembl
  3. negative regulation of angiogenesis Source: UniProtKB
  4. negative regulation of endopeptidase activity Source: RefGenome
  5. negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  6. negative regulation of inflammatory response Source: Ensembl
  7. positive regulation of neurogenesis Source: UniProtKB
  8. regulation of proteolysis Source: RefGenome
  9. response to glucocorticoid Source: Ensembl
  10. response to retinoic acid Source: Ensembl
  11. short-term memory Source: Ensembl
Complete GO annotation...

Protein family/group databases

MEROPSiI04.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Pigment epithelium-derived factor
Short name:
PEDF
Alternative name(s):
Caspin
Serpin F1
Stromal cell-derived factor 3
Short name:
SDF-3
Gene namesi
Name:Serpinf1
Synonyms:Pedf, Sdf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:108080. Serpinf1.

Subcellular locationi

Secreted. Melanosome By similarity

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 417398Pigment epithelium-derived factorPRO_0000032509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP97298.
PaxDbiP97298.
PRIDEiP97298.

PTM databases

PhosphoSiteiP97298.

Expressioni

Tissue specificityi

Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes.2 Publications

Developmental stagei

First detected at 12.5 dpc in cartilage primordium, it is present in the osseous matrix of developing limbs, vertebrae, ribs and skull. At 16.5 dpc it is detected in bone matrix and smooth muscle, and at lower levels in connective tissue, bronchial epithelial cells, metanephron microtubules, and skin.1 Publication

Gene expression databases

BgeeiP97298.
ExpressionAtlasiP97298. baseline and differential.
GenevestigatoriP97298.

Structurei

3D structure databases

ProteinModelPortaliP97298.
SMRiP97298. Positions 35-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000115489.
HOVERGENiHBG106911.
InParanoidiP97298.
OMAiLNCKIAQ.
OrthoDBiEOG7K3TMD.
PhylomeDBiP97298.
TreeFamiTF317350.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97298-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQALVLLLWT GALLGHGSSQ NVPSSSEGSP VPDSTGEPVE EEDPFFKVPV
60 70 80 90 100
NKLAAAVSNF GYDLYRLRSS ASPTGNVLLS PLSVATALSA LSLGAEHRTE
110 120 130 140 150
SVIHRALYYD LITNPDIHST YKELLASVTA PEKNLKSASR IVFERKLRVK
160 170 180 190 200
SSFVAPLEKS YGTRPRILTG NPRVDLQEIN NWVQAQMKGK IARSTREMPS
210 220 230 240 250
ALSILLLGVA YFKGQWVTKF DSRKTTLQDF HLDEDRTVRV PMMSDPKAIL
260 270 280 290 300
RYGLDSDLNC KIAQLPLTGS MSIIFFLPLT VTQNLTMIEE SLTSEFIHDI
310 320 330 340 350
DRELKTIQAV LTVPKLKLSF EGELTKSLQD MKLQSLFESP DFSKITGKPV
360 370 380 390 400
KLTQVEHRAA FEWNEEGAGS SPSPGLQPVR LTFPLDYHLN QPFLFVLRDT
410
DTGALLFIGR ILDPSST
Length:417
Mass (Da):46,234
Last modified:March 29, 2004 - v2
Checksum:iECD360FE6AA74D25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701S → G in AAC69271. 1 PublicationCurated
Sequence conflicti136 – 1361K → N in BAA31978. (PubMed:9614124)Curated
Sequence conflicti137 – 1371S → R in AAC69271. 1 PublicationCurated
Sequence conflicti280 – 2801T → A in BAA09051. (PubMed:8938438)Curated
Sequence conflicti377 – 3771Q → L in AAC69271. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50460 mRNA. Translation: BAA09051.1.
AF036164 mRNA. Translation: AAC69271.1.
D87975 mRNA. Translation: BAA31978.1.
AF017055
, AF017051, AF017052, AF017053, AF017054 Genomic DNA. Translation: AAC05733.1.
AF017057 mRNA. Translation: AAC05731.1.
BC019852 mRNA. Translation: AAH19852.1.
CCDSiCCDS25045.1.
RefSeqiNP_035470.3. NM_011340.3.
UniGeneiMm.2044.

Genome annotation databases

EnsembliENSMUST00000000769; ENSMUSP00000000769; ENSMUSG00000000753.
GeneIDi20317.
KEGGimmu:20317.
UCSCiuc007kdp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50460 mRNA. Translation: BAA09051.1 .
AF036164 mRNA. Translation: AAC69271.1 .
D87975 mRNA. Translation: BAA31978.1 .
AF017055
, AF017051 , AF017052 , AF017053 , AF017054 Genomic DNA. Translation: AAC05733.1 .
AF017057 mRNA. Translation: AAC05731.1 .
BC019852 mRNA. Translation: AAH19852.1 .
CCDSi CCDS25045.1.
RefSeqi NP_035470.3. NM_011340.3.
UniGenei Mm.2044.

3D structure databases

ProteinModelPortali P97298.
SMRi P97298. Positions 35-414.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.979.

PTM databases

PhosphoSitei P97298.

Proteomic databases

MaxQBi P97298.
PaxDbi P97298.
PRIDEi P97298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000769 ; ENSMUSP00000000769 ; ENSMUSG00000000753 .
GeneIDi 20317.
KEGGi mmu:20317.
UCSCi uc007kdp.1. mouse.

Organism-specific databases

CTDi 5176.
MGIi MGI:108080. Serpinf1.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118839.
HOGENOMi HOG000115489.
HOVERGENi HBG106911.
InParanoidi P97298.
OMAi LNCKIAQ.
OrthoDBi EOG7K3TMD.
PhylomeDBi P97298.
TreeFami TF317350.

Miscellaneous databases

ChiTaRSi SERPINF1. mouse.
NextBioi 298103.
PROi P97298.
SOURCEi Search...

Gene expression databases

Bgeei P97298.
ExpressionAtlasi P97298. baseline and differential.
Genevestigatori P97298.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method."
    Shirozu M., Tada H., Tashiro K., Nakamura T., Lopez N.D., Nazarea M., Hamada T., Sato T., Nakano T., Honjo T.
    Genomics 37:273-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation, purification and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells."
    Kozaki K., Miyaishi O., Koiwai O., Yasui Y., Kashiwai A., Nishikawa Y., Shimizu S., Saga S.
    J. Biol. Chem. 273:15125-15130(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 53-66; 252-261; 333-344 AND 359-372, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Liver.
  3. "Structural and comparative analysis of the mouse gene for pigment epithelium-derived factor (PEDF)."
    Singh V.K., Chader G.J., Rodriguez I.R.
    Mol. Vis. 4:7-7(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: FVB/N.
    Tissue: Liver.
  4. Tombran-Tink J.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  6. "Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model."
    Abramson L.P., Stellmach V., Doll J.A., Cornwell M., Arensman R.M., Crawford S.E.
    J. Pediatr. Surg. 38:336-342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPEDF_MOUSE
AccessioniPrimary (citable) accession number: P97298
Secondary accession number(s): O70629, O88691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 29, 2004
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3