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P97297 (ADML_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADM

Cleaved into the following 2 chains:

  1. Adrenomedullin
    Short name=AM
  2. Proadrenomedullin N-20 terminal peptide
    Alternative name(s):
    ProAM N-terminal 20 peptide
    Short name=PAMP
    Short name=ProAM-N20
Gene names
Name:Adm
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

AM and PAMP are potent hypotensive and vasodilatator agents.

Subcellular location

Secreted.

Sequence similarities

Belongs to the adrenomedullin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor internalization

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

androgen metabolic process

Inferred from electronic annotation. Source: Ensembl

branching involved in labyrinthine layer morphogenesis

Inferred from mutant phenotype PubMed 16981008. Source: MGI

cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

cAMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

developmental growth

Inferred from mutant phenotype PubMed 16981008. Source: MGI

female pregnancy

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from mutant phenotype PubMed 18097473. Source: UniProtKB

hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of vascular permeability

Inferred from mutant phenotype PubMed 18097473. Source: UniProtKB

negative regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

neural tube closure

Inferred from mutant phenotype PubMed 16981008. Source: MGI

neuron projection regeneration

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from mutant phenotype PubMed 18097473. Source: UniProtKB

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 16537897. Source: MGI

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasculogenesis

Inferred from mutant phenotype PubMed 18097473. Source: UniProtKB

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

regulation of the force of heart contraction

Inferred from electronic annotation. Source: Ensembl

response to cold

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to starvation

Inferred from electronic annotation. Source: Ensembl

response to wounding

Inferred from electronic annotation. Source: Ensembl

spongiotrophoblast layer development

Inferred from mutant phenotype PubMed 16981008. Source: MGI

vascular smooth muscle cell development

Inferred from mutant phenotype PubMed 18097473. Source: UniProtKB

vasculogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Peptide22 – 4120Proadrenomedullin N-20 terminal peptide
PRO_0000000965
Propeptide45 – 9248 By similarity
PRO_0000000966
Peptide95 – 14450Adrenomedullin
PRO_0000000967
Propeptide151 – 18434PreproAM C-terminal fragment By similarity
PRO_0000000968

Amino acid modifications

Modified residue411Arginine amide By similarity
Modified residue1441Tyrosine amide By similarity
Disulfide bond108 ↔ 113 By similarity

Experimental info

Sequence conflict1731G → A in BAA11367. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P97297 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: C88C9903C479C898

FASTA18420,750
        10         20         30         40         50         60 
MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS SYPTGLADET 

        70         80         90        100        110        120 
TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN QGSRSNGCRF GTCTFQKLAH 

       130        140        150        160        170        180 
QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR SLLEVLRSRT VESSQEQTHT APGPWAHISR 


LFRI 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene."
Okazaki T., Ogawa Y., Tamura N., Mori Y., Isse N., Aoki T., Rochelle J.M., Taketo M.M., Seldin M.F., Nakao K.
Genomics 37:395-399(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse."
Yotsumoto S., Shimada T., Cui C.Y., Nakashima H., Fujiwara H., Ko M.S.H.
Dev. Biol. 203:264-275(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Kidney and Lung.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Egg.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSCCDS21745.1.
RefSeqNP_033757.1. NM_009627.1.
UniGeneMm.1408.

3D structure databases

ProteinModelPortalP97297.
SMRP97297. Positions 95-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033054.

PTM databases

PhosphoSiteP97297.

Proteomic databases

PRIDEP97297.

Protocols and materials databases

DNASU11535.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneID11535.
KEGGmmu:11535.
UCSCuc009jfj.1. mouse.

Organism-specific databases

CTD133.
MGIMGI:108058. Adm.

Phylogenomic databases

eggNOGNOG46109.
GeneTreeENSGT00390000000451.
HOGENOMHOG000033821.
HOVERGENHBG004181.
InParanoidQ6GTK2.
KOK12333.
OMAVAPRNKI.
OrthoDBEOG7DC266.
TreeFamTF333447.

Gene expression databases

BgeeP97297.
CleanExMM_ADM.
GenevestigatorP97297.

Family and domain databases

InterProIPR001710. Adrenomedullin.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00801. ADRENOMEDULN.
ProtoNetSearch...

Other

NextBio278978.
PROP97297.
SOURCESearch...

Entry information

Entry nameADML_MOUSE
AccessionPrimary (citable) accession number: P97297
Secondary accession number(s): P97453, Q6GTK2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot