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P97297

- ADML_MOUSE

UniProt

P97297 - ADML_MOUSE

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Protein
ADM
Gene
Adm
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Biological processi

  1. G-protein coupled receptor internalization Source: Ensembl
  2. aging Source: Ensembl
  3. androgen metabolic process Source: Ensembl
  4. branching involved in labyrinthine layer morphogenesis Source: MGI
  5. cAMP biosynthetic process Source: Ensembl
  6. cAMP-mediated signaling Source: Ensembl
  7. developmental growth Source: MGI
  8. female pregnancy Source: Ensembl
  9. heart development Source: UniProtKB
  10. hormone secretion Source: Ensembl
  11. negative regulation of cell proliferation Source: Ensembl
  12. negative regulation of vascular permeability Source: UniProtKB
  13. negative regulation of vasoconstriction Source: Ensembl
  14. neural tube closure Source: MGI
  15. neuron projection regeneration Source: Ensembl
  16. odontogenesis of dentin-containing tooth Source: Ensembl
  17. organ regeneration Source: Ensembl
  18. positive regulation of angiogenesis Source: UniProtKB
  19. positive regulation of apoptotic process Source: Ensembl
  20. positive regulation of cAMP biosynthetic process Source: Ensembl
  21. positive regulation of cell proliferation Source: MGI
  22. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  23. positive regulation of heart rate Source: Ensembl
  24. positive regulation of vasculogenesis Source: UniProtKB
  25. positive regulation of vasodilation Source: Ensembl
  26. regulation of the force of heart contraction Source: Ensembl
  27. response to cold Source: Ensembl
  28. response to glucocorticoid Source: Ensembl
  29. response to hypoxia Source: Ensembl
  30. response to insulin Source: Ensembl
  31. response to lipopolysaccharide Source: Ensembl
  32. response to starvation Source: Ensembl
  33. response to wounding Source: Ensembl
  34. spongiotrophoblast layer development Source: MGI
  35. vascular smooth muscle cell development Source: UniProtKB
  36. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:Adm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:108058. Adm.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Peptidei22 – 4120Proadrenomedullin N-20 terminal peptide
PRO_0000000965Add
BLAST
Propeptidei45 – 9248 By similarity
PRO_0000000966Add
BLAST
Peptidei95 – 14450Adrenomedullin
PRO_0000000967Add
BLAST
Propeptidei151 – 18434PreproAM C-terminal fragment By similarity
PRO_0000000968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Arginine amide By similarity
Disulfide bondi108 ↔ 113 By similarity
Modified residuei144 – 1441Tyrosine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP97297.

PTM databases

PhosphoSiteiP97297.

Expressioni

Gene expression databases

BgeeiP97297.
CleanExiMM_ADM.
GenevestigatoriP97297.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054.

Structurei

3D structure databases

ProteinModelPortaliP97297.
SMRiP97297. Positions 95-144.

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46109.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiQ6GTK2.
KOiK12333.
OMAiVAPRNKI.
OrthoDBiEOG7DC266.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97297-1 [UniParc]FASTAAdd to Basket

« Hide

MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS    50
SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN 100
QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR 150
SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI 184
Length:184
Mass (Da):20,750
Last modified:June 28, 2011 - v2
Checksum:iC88C9903C479C898
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731G → A in BAA11367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSiCCDS21745.1.
RefSeqiNP_033757.1. NM_009627.1.
UniGeneiMm.1408.

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneIDi11535.
KEGGimmu:11535.
UCSCiuc009jfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1 .
U77630 mRNA. Translation: AAB36535.1 .
AK144181 mRNA. Translation: BAE25751.1 .
AK144600 mRNA. Translation: BAE25959.1 .
AK144649 mRNA. Translation: BAE25989.1 .
AK171066 mRNA. Translation: BAE42225.1 .
CH466531 Genomic DNA. Translation: EDL16987.1 .
BC052665 mRNA. Translation: AAH52665.1 .
CCDSi CCDS21745.1.
RefSeqi NP_033757.1. NM_009627.1.
UniGenei Mm.1408.

3D structure databases

ProteinModelPortali P97297.
SMRi P97297. Positions 95-144.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033054.

PTM databases

PhosphoSitei P97297.

Proteomic databases

PRIDEi P97297.

Protocols and materials databases

DNASUi 11535.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033054 ; ENSMUSP00000033054 ; ENSMUSG00000030790 .
GeneIDi 11535.
KEGGi mmu:11535.
UCSCi uc009jfj.1. mouse.

Organism-specific databases

CTDi 133.
MGIi MGI:108058. Adm.

Phylogenomic databases

eggNOGi NOG46109.
GeneTreei ENSGT00390000000451.
HOGENOMi HOG000033821.
HOVERGENi HBG004181.
InParanoidi Q6GTK2.
KOi K12333.
OMAi VAPRNKI.
OrthoDBi EOG7DC266.
TreeFami TF333447.

Miscellaneous databases

NextBioi 278978.
PROi P97297.
SOURCEi Search...

Gene expression databases

Bgeei P97297.
CleanExi MM_ADM.
Genevestigatori P97297.

Family and domain databases

InterProi IPR001710. Adrenomedullin.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view ]
Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view ]
PRINTSi PR00801. ADRENOMEDULN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene."
    Okazaki T., Ogawa Y., Tamura N., Mori Y., Isse N., Aoki T., Rochelle J.M., Taketo M.M., Seldin M.F., Nakao K.
    Genomics 37:395-399(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse."
    Yotsumoto S., Shimada T., Cui C.Y., Nakashima H., Fujiwara H., Ko M.S.H.
    Dev. Biol. 203:264-275(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Kidney and Lung.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiADML_MOUSE
AccessioniPrimary (citable) accession number: P97297
Secondary accession number(s): P97453, Q6GTK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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