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Protein

ADM

Gene

Adm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Biological processi

  • aging Source: Ensembl
  • androgen metabolic process Source: Ensembl
  • branching involved in labyrinthine layer morphogenesis Source: MGI
  • cAMP biosynthetic process Source: MGI
  • cAMP-mediated signaling Source: Ensembl
  • developmental growth Source: MGI
  • female pregnancy Source: Ensembl
  • G-protein coupled receptor internalization Source: MGI
  • heart development Source: UniProtKB
  • hormone secretion Source: Ensembl
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of vascular permeability Source: UniProtKB
  • negative regulation of vasoconstriction Source: MGI
  • neural tube closure Source: MGI
  • neuron projection regeneration Source: Ensembl
  • odontogenesis of dentin-containing tooth Source: Ensembl
  • organ regeneration Source: Ensembl
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of heart rate Source: Ensembl
  • positive regulation of vasculogenesis Source: UniProtKB
  • positive regulation of vasodilation Source: Ensembl
  • receptor internalization Source: MGI
  • regulation of the force of heart contraction Source: Ensembl
  • response to cold Source: Ensembl
  • response to glucocorticoid Source: Ensembl
  • response to hypoxia Source: Ensembl
  • response to insulin Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to starvation Source: Ensembl
  • response to wounding Source: Ensembl
  • spongiotrophoblast layer development Source: MGI
  • vascular smooth muscle cell development Source: UniProtKB
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:Adm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108058. Adm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Peptidei22 – 4120Proadrenomedullin N-20 terminal peptidePRO_0000000965Add
BLAST
Propeptidei45 – 9248By similarityPRO_0000000966Add
BLAST
Peptidei95 – 14450AdrenomedullinPRO_0000000967Add
BLAST
Propeptidei151 – 18434PreproAM C-terminal fragmentBy similarityPRO_0000000968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411Arginine amideBy similarity
Disulfide bondi108 ↔ 113By similarity
Modified residuei144 – 1441Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP97297.

PTM databases

PhosphoSiteiP97297.

Expressioni

Gene expression databases

BgeeiP97297.
CleanExiMM_ADM.
GenevisibleiP97297. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054.

Structurei

3D structure databases

ProteinModelPortaliP97297.
SMRiP97297. Positions 95-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46109.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP97297.
KOiK12333.
OMAiRNKISPQ.
OrthoDBiEOG7DC266.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS
60 70 80 90 100
SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN
110 120 130 140 150
QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR
160 170 180
SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI
Length:184
Mass (Da):20,750
Last modified:June 28, 2011 - v2
Checksum:iC88C9903C479C898
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731G → A in BAA11367 (PubMed:8938454).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSiCCDS21745.1.
RefSeqiNP_033757.1. NM_009627.1.
UniGeneiMm.1408.

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneIDi11535.
KEGGimmu:11535.
UCSCiuc009jfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSiCCDS21745.1.
RefSeqiNP_033757.1. NM_009627.1.
UniGeneiMm.1408.

3D structure databases

ProteinModelPortaliP97297.
SMRiP97297. Positions 95-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054.

PTM databases

PhosphoSiteiP97297.

Proteomic databases

PRIDEiP97297.

Protocols and materials databases

DNASUi11535.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneIDi11535.
KEGGimmu:11535.
UCSCiuc009jfj.1. mouse.

Organism-specific databases

CTDi133.
MGIiMGI:108058. Adm.

Phylogenomic databases

eggNOGiNOG46109.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP97297.
KOiK12333.
OMAiRNKISPQ.
OrthoDBiEOG7DC266.
TreeFamiTF333447.

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi278978.
PROiP97297.
SOURCEiSearch...

Gene expression databases

BgeeiP97297.
CleanExiMM_ADM.
GenevisibleiP97297. MM.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene."
    Okazaki T., Ogawa Y., Tamura N., Mori Y., Isse N., Aoki T., Rochelle J.M., Taketo M.M., Seldin M.F., Nakao K.
    Genomics 37:395-399(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse."
    Yotsumoto S., Shimada T., Cui C.Y., Nakashima H., Fujiwara H., Ko M.S.H.
    Dev. Biol. 203:264-275(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Kidney and Lung.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiADML_MOUSE
AccessioniPrimary (citable) accession number: P97297
Secondary accession number(s): P97453, Q6GTK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.