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Protein

ADM

Gene

Adm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:Adm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108058. Adm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000000096522 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
PropeptideiPRO_000000096645 – 92By similarityAdd BLAST48
PeptideiPRO_000000096795 – 144AdrenomedullinBy similarityAdd BLAST50
PropeptideiPRO_0000000968151 – 184PreproAM C-terminal fragmentBy similarityAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amideBy similarity1
Disulfide bondi108 ↔ 113By similarity
Modified residuei144Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiP97297.
PaxDbiP97297.
PeptideAtlasiP97297.
PRIDEiP97297.

PTM databases

iPTMnetiP97297.
PhosphoSitePlusiP97297.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030790.
CleanExiMM_ADM.
GenevisibleiP97297. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054.

Structurei

3D structure databases

ProteinModelPortaliP97297.
SMRiP97297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP97297.
KOiK12333.
TreeFamiTF333447.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS
60 70 80 90 100
SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN
110 120 130 140 150
QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR
160 170 180
SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI
Length:184
Mass (Da):20,750
Last modified:June 28, 2011 - v2
Checksum:iC88C9903C479C898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173G → A in BAA11367 (PubMed:8938454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSiCCDS21745.1.
RefSeqiNP_033757.1. NM_009627.1.
UniGeneiMm.1408.

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneIDi11535.
KEGGimmu:11535.
UCSCiuc009jfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78349 Genomic DNA. Translation: BAA11367.1.
U77630 mRNA. Translation: AAB36535.1.
AK144181 mRNA. Translation: BAE25751.1.
AK144600 mRNA. Translation: BAE25959.1.
AK144649 mRNA. Translation: BAE25989.1.
AK171066 mRNA. Translation: BAE42225.1.
CH466531 Genomic DNA. Translation: EDL16987.1.
BC052665 mRNA. Translation: AAH52665.1.
CCDSiCCDS21745.1.
RefSeqiNP_033757.1. NM_009627.1.
UniGeneiMm.1408.

3D structure databases

ProteinModelPortaliP97297.
SMRiP97297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054.

PTM databases

iPTMnetiP97297.
PhosphoSitePlusiP97297.

Proteomic databases

MaxQBiP97297.
PaxDbiP97297.
PeptideAtlasiP97297.
PRIDEiP97297.

Protocols and materials databases

DNASUi11535.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
GeneIDi11535.
KEGGimmu:11535.
UCSCiuc009jfj.1. mouse.

Organism-specific databases

CTDi133.
MGIiMGI:108058. Adm.

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP97297.
KOiK12333.
TreeFamiTF333447.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiP97297.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030790.
CleanExiMM_ADM.
GenevisibleiP97297. MM.

Family and domain databases

InterProiIPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
[Graphical view]
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00801. ADRENOMEDULN.
ProtoNetiSearch...

Entry informationi

Entry nameiADML_MOUSE
AccessioniPrimary (citable) accession number: P97297
Secondary accession number(s): P97453, Q6GTK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.