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P97297

- ADML_MOUSE

UniProt

P97297 - ADML_MOUSE

Protein

ADM

Gene

Adm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    AM and PAMP are potent hypotensive and vasodilatator agents.

    GO - Biological processi

    1. aging Source: Ensembl
    2. androgen metabolic process Source: Ensembl
    3. branching involved in labyrinthine layer morphogenesis Source: MGI
    4. cAMP biosynthetic process Source: Ensembl
    5. cAMP-mediated signaling Source: Ensembl
    6. developmental growth Source: MGI
    7. female pregnancy Source: Ensembl
    8. G-protein coupled receptor internalization Source: Ensembl
    9. heart development Source: UniProtKB
    10. hormone secretion Source: Ensembl
    11. negative regulation of cell proliferation Source: Ensembl
    12. negative regulation of vascular permeability Source: UniProtKB
    13. negative regulation of vasoconstriction Source: Ensembl
    14. neural tube closure Source: MGI
    15. neuron projection regeneration Source: Ensembl
    16. odontogenesis of dentin-containing tooth Source: Ensembl
    17. organ regeneration Source: Ensembl
    18. positive regulation of angiogenesis Source: UniProtKB
    19. positive regulation of apoptotic process Source: Ensembl
    20. positive regulation of cAMP biosynthetic process Source: Ensembl
    21. positive regulation of cell proliferation Source: MGI
    22. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    23. positive regulation of heart rate Source: Ensembl
    24. positive regulation of vasculogenesis Source: UniProtKB
    25. positive regulation of vasodilation Source: Ensembl
    26. regulation of the force of heart contraction Source: Ensembl
    27. response to cold Source: Ensembl
    28. response to glucocorticoid Source: Ensembl
    29. response to hypoxia Source: Ensembl
    30. response to insulin Source: Ensembl
    31. response to lipopolysaccharide Source: Ensembl
    32. response to starvation Source: Ensembl
    33. response to wounding Source: Ensembl
    34. spongiotrophoblast layer development Source: MGI
    35. vascular smooth muscle cell development Source: UniProtKB
    36. vasculogenesis Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADM
    Cleaved into the following 2 chains:
    Adrenomedullin
    Short name:
    AM
    Alternative name(s):
    ProAM N-terminal 20 peptide
    Short name:
    PAMP
    Short name:
    ProAM-N20
    Gene namesi
    Name:Adm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:108058. Adm.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Peptidei22 – 4120Proadrenomedullin N-20 terminal peptidePRO_0000000965Add
    BLAST
    Propeptidei45 – 9248By similarityPRO_0000000966Add
    BLAST
    Peptidei95 – 14450AdrenomedullinPRO_0000000967Add
    BLAST
    Propeptidei151 – 18434PreproAM C-terminal fragmentBy similarityPRO_0000000968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411Arginine amideBy similarity
    Disulfide bondi108 ↔ 113By similarity
    Modified residuei144 – 1441Tyrosine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP97297.

    PTM databases

    PhosphoSiteiP97297.

    Expressioni

    Gene expression databases

    BgeeiP97297.
    CleanExiMM_ADM.
    GenevestigatoriP97297.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033054.

    Structurei

    3D structure databases

    ProteinModelPortaliP97297.
    SMRiP97297. Positions 95-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adrenomedullin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46109.
    GeneTreeiENSGT00390000000451.
    HOGENOMiHOG000033821.
    HOVERGENiHBG004181.
    InParanoidiQ6GTK2.
    KOiK12333.
    OMAiVAPRNKI.
    OrthoDBiEOG7DC266.
    TreeFamiTF333447.

    Family and domain databases

    InterProiIPR001710. Adrenomedullin.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view]
    PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view]
    PRINTSiPR00801. ADRENOMEDULN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97297-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS    50
    SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN 100
    QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR 150
    SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI 184
    Length:184
    Mass (Da):20,750
    Last modified:June 28, 2011 - v2
    Checksum:iC88C9903C479C898
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731G → A in BAA11367. (PubMed:8938454)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78349 Genomic DNA. Translation: BAA11367.1.
    U77630 mRNA. Translation: AAB36535.1.
    AK144181 mRNA. Translation: BAE25751.1.
    AK144600 mRNA. Translation: BAE25959.1.
    AK144649 mRNA. Translation: BAE25989.1.
    AK171066 mRNA. Translation: BAE42225.1.
    CH466531 Genomic DNA. Translation: EDL16987.1.
    BC052665 mRNA. Translation: AAH52665.1.
    CCDSiCCDS21745.1.
    RefSeqiNP_033757.1. NM_009627.1.
    UniGeneiMm.1408.

    Genome annotation databases

    EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790.
    GeneIDi11535.
    KEGGimmu:11535.
    UCSCiuc009jfj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78349 Genomic DNA. Translation: BAA11367.1 .
    U77630 mRNA. Translation: AAB36535.1 .
    AK144181 mRNA. Translation: BAE25751.1 .
    AK144600 mRNA. Translation: BAE25959.1 .
    AK144649 mRNA. Translation: BAE25989.1 .
    AK171066 mRNA. Translation: BAE42225.1 .
    CH466531 Genomic DNA. Translation: EDL16987.1 .
    BC052665 mRNA. Translation: AAH52665.1 .
    CCDSi CCDS21745.1.
    RefSeqi NP_033757.1. NM_009627.1.
    UniGenei Mm.1408.

    3D structure databases

    ProteinModelPortali P97297.
    SMRi P97297. Positions 95-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033054.

    PTM databases

    PhosphoSitei P97297.

    Proteomic databases

    PRIDEi P97297.

    Protocols and materials databases

    DNASUi 11535.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033054 ; ENSMUSP00000033054 ; ENSMUSG00000030790 .
    GeneIDi 11535.
    KEGGi mmu:11535.
    UCSCi uc009jfj.1. mouse.

    Organism-specific databases

    CTDi 133.
    MGIi MGI:108058. Adm.

    Phylogenomic databases

    eggNOGi NOG46109.
    GeneTreei ENSGT00390000000451.
    HOGENOMi HOG000033821.
    HOVERGENi HBG004181.
    InParanoidi Q6GTK2.
    KOi K12333.
    OMAi VAPRNKI.
    OrthoDBi EOG7DC266.
    TreeFami TF333447.

    Miscellaneous databases

    NextBioi 278978.
    PROi P97297.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97297.
    CleanExi MM_ADM.
    Genevestigatori P97297.

    Family and domain databases

    InterProi IPR001710. Adrenomedullin.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view ]
    Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view ]
    PRINTSi PR00801. ADRENOMEDULN.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene."
      Okazaki T., Ogawa Y., Tamura N., Mori Y., Isse N., Aoki T., Rochelle J.M., Taketo M.M., Seldin M.F., Nakao K.
      Genomics 37:395-399(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse."
      Yotsumoto S., Shimada T., Cui C.Y., Nakashima H., Fujiwara H., Ko M.S.H.
      Dev. Biol. 203:264-275(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Kidney and Lung.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg.

    Entry informationi

    Entry nameiADML_MOUSE
    AccessioniPrimary (citable) accession number: P97297
    Secondary accession number(s): P97453, Q6GTK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3