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Protein

ADM

Gene

Adm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:Adm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108058 Adm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000000096522 – 41Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST20
PropeptideiPRO_000000096645 – 92By similarityAdd BLAST48
PeptideiPRO_000000096795 – 144AdrenomedullinBy similarityAdd BLAST50
PropeptideiPRO_0000000968151 – 184PreproAM C-terminal fragmentBy similarityAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amideBy similarity1
Disulfide bondi108 ↔ 113By similarity
Modified residuei144Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiP97297
PaxDbiP97297
PeptideAtlasiP97297
PRIDEiP97297

PTM databases

iPTMnetiP97297
PhosphoSitePlusiP97297

Expressioni

Gene expression databases

BgeeiENSMUSG00000030790
CleanExiMM_ADM
GenevisibleiP97297 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033054

Structurei

3D structure databases

ProteinModelPortaliP97297
SMRiP97297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C Eukaryota
ENOG41120TV LUCA
GeneTreeiENSGT00390000000451
HOGENOMiHOG000033821
HOVERGENiHBG004181
InParanoidiP97297
KOiK12333
OMAiRNKISPQ
TreeFamiTF333447

Family and domain databases

InterProiView protein in InterPro
IPR001710 Adrenomedullin
IPR021116 Calcitonin/adrenomedullin
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00801 ADRENOMEDULN

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS
60 70 80 90 100
SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN
110 120 130 140 150
QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR
160 170 180
SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI
Length:184
Mass (Da):20,750
Last modified:June 28, 2011 - v2
Checksum:iC88C9903C479C898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173G → A in BAA11367 (PubMed:8938454).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78349 Genomic DNA Translation: BAA11367.1
U77630 mRNA Translation: AAB36535.1
AK144181 mRNA Translation: BAE25751.1
AK144600 mRNA Translation: BAE25959.1
AK144649 mRNA Translation: BAE25989.1
AK171066 mRNA Translation: BAE42225.1
CH466531 Genomic DNA Translation: EDL16987.1
BC052665 mRNA Translation: AAH52665.1
CCDSiCCDS21745.1
RefSeqiNP_033757.1, NM_009627.1
UniGeneiMm.1408

Genome annotation databases

EnsembliENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790
GeneIDi11535
KEGGimmu:11535
UCSCiuc009jfj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADML_MOUSE
AccessioniPrimary (citable) accession number: P97297
Secondary accession number(s): P97453, Q6GTK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: February 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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