Reviewed, UniProtKB/Swiss-Prot P97295 (NPY2R_MOUSE)

Names and origin

Protein names

Recommended name:
    Neuropeptide Y receptor type 2
      Short name=NPY2-R
Alternative name(s):
    NPY-Y2 receptor
      Short name=Y2 receptor

Gene names

Name:

Npy2r

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide YY receptor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Neuropeptide Y receptor type 2		PRO_0000069930
Regions
	Topological domain	1 – 55	55	Extracellular Potential
	Transmembrane	56 – 76	21	1 Potential
	Topological domain	77 – 90	14	Cytoplasmic Potential
	Transmembrane	91 – 111	21	2 Potential
	Topological domain	112 – 128	17	Extracellular Potential
	Transmembrane	129 – 149	21	3 Potential
	Topological domain	150 – 169	20	Cytoplasmic Potential
	Transmembrane	170 – 190	21	4 Potential
	Topological domain	191 – 220	30	Extracellular Potential
	Transmembrane	221 – 241	21	5 Potential
	Topological domain	242 – 272	31	Cytoplasmic Potential
	Transmembrane	273 – 293	21	6 Potential
	Topological domain	294 – 308	15	Extracellular Potential
	Transmembrane	309 – 329	21	7 Potential
	Topological domain	330 – 385	56	Cytoplasmic Potential
Amino acid modifications
	Lipidation	346	1	S-palmitoyl cysteine Potential
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Disulfide bond	127 ↔ 207		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97295-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 5AD7E4C9B7077085	FASTA	385	43,100
	10 20 30 40 50 60 MVLKMGPVGA EADENQTVEV KVEPYGPGHT TPRGELPPDP EPELIDSTKL VEVQVILILA 70 80 90 100 110 120 YCSIILLGVV GNSLVIHVVI KFKSMRTVTN FFIANLAVAD LLVNTLCLPF TLTYTLMGEW 130 140 150 160 170 180 KMGPVLCHLV PYAQGLAVQV STITLTVIAL DRHRCIVYHL ESKISKRISF LIIGLAWGIS 190 200 210 220 230 240 ALLASPLAIF REYSLIEIIP DFEIVACTEK WPGEEKSVYG TVYSLSTLLI LYVLPLGIIS 250 260 270 280 290 300 FSYTRIWSKL RNHVSPGAAS DHYHQRRHKM TKMLVCVVVV FAVSWLPLHA FQLAVDIDSH 310 320 330 340 350 360 VLDLKEYKLI FTVFHIIAMC STFANPLLYG WMNSNYRKAF LSAFRCEQRL DAIHSEVSMT 370 380 FKAKKNLEVK KNNGPTDSFS EATNV

References

[1]	"Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor." Nakamura M., Aoki Y., Hirano D. Biochim. Biophys. Acta 1284:134-137(1996) [PubMed: 8914576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D86238 mRNA. Translation: BAA13050.1.
IPI	IPI00122993.
UniGene	Mm.1433 Mm.454539
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000028004. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:108418. Npy2r.
Phylogenomic databases
HOGENOM	P97295.
HOVERGEN	P97295.
Gene expression databases
ArrayExpress	P97295.
Bgee	P97295.
CleanEx	MM_NPY2R.
GermOnline	ENSMUSG00000028004. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001358. NPY2_rcpt. IPR000611. NPY_rcpt. [Graphical view]
PANTHER	PTHR19264:SF119. NPY2_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01014. NRPEPTIDEY2R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

NPY2R_MOUSE

Accession

Primary (citable) accession number: P97295

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)