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Protein

Neuropeptide Y receptor type 2

Gene

Npy2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: MGI
  • peptide YY receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 2
Short name:
NPY2-R
Alternative name(s):
NPY-Y2 receptor
Short name:
Y2 receptor
Gene namesi
Name:Npy2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:108418. Npy2r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51ExtracellularSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini73 – 86CytoplasmicSequence analysisAdd BLAST14
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 124ExtracellularSequence analysisAdd BLAST17
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 216ExtracellularSequence analysisAdd BLAST30
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 268CytoplasmicSequence analysisAdd BLAST31
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 304ExtracellularSequence analysisAdd BLAST15
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 381CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • non-motile cilium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699301 – 381Neuropeptide Y receptor type 2Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 203PROSITE-ProRule annotation
Lipidationi342S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP97295.
PRIDEiP97295.

PTM databases

iPTMnetiP97295.
PhosphoSitePlusiP97295.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028004.
CleanExiMM_NPY2R.
ExpressionAtlasiP97295. baseline and differential.
GenevisibleiP97295. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096595.

Chemistry databases

BindingDBiP97295.

Structurei

3D structure databases

ProteinModelPortaliP97295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105675.
InParanoidiP97295.
KOiK04205.
OMAiEKSMYGT.
OrthoDBiEOG091G0C6Q.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVGAEADE NQTVEVKVEP YGPGHTTPRG ELPPDPEPEL IDSTKLVEVQ
60 70 80 90 100
VILILAYCSI ILLGVVGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSVYGTVYS LSTLLILYVL PLGIISFSYT RIWSKLRNHV
260 270 280 290 300
SPGAASDHYH QRRHKMTKML VCVVVVFAVS WLPLHAFQLA VDIDSHVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSMTFKAK KNLEVKKNNG PTDSFSEATN V
Length:381
Mass (Da):42,628
Last modified:November 28, 2012 - v2
Checksum:i90787C051347884A
GO

Sequence cautioni

The sequence BAA13050 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86238 mRNA. Translation: BAA13050.1. Different initiation.
AK049892 mRNA. Translation: BAC33975.1.
AC091478 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15430.1.
CH466547 Genomic DNA. Translation: EDL15431.1.
BC104490 mRNA. Translation: AAI04491.1.
BC104734 mRNA. Translation: AAI04735.1.
CCDSiCCDS59646.1.
RefSeqiNP_032757.2. NM_008731.3.
XP_006501178.1. XM_006501115.1.
XP_006501179.1. XM_006501116.1.
UniGeneiMm.1433.

Genome annotation databases

EnsembliENSMUST00000029633; ENSMUSP00000029633; ENSMUSG00000028004.
ENSMUST00000098997; ENSMUSP00000096595; ENSMUSG00000028004.
ENSMUST00000182831; ENSMUSP00000138282; ENSMUSG00000028004.
GeneIDi18167.
KEGGimmu:18167.
UCSCiuc008ppa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86238 mRNA. Translation: BAA13050.1. Different initiation.
AK049892 mRNA. Translation: BAC33975.1.
AC091478 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15430.1.
CH466547 Genomic DNA. Translation: EDL15431.1.
BC104490 mRNA. Translation: AAI04491.1.
BC104734 mRNA. Translation: AAI04735.1.
CCDSiCCDS59646.1.
RefSeqiNP_032757.2. NM_008731.3.
XP_006501178.1. XM_006501115.1.
XP_006501179.1. XM_006501116.1.
UniGeneiMm.1433.

3D structure databases

ProteinModelPortaliP97295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096595.

Chemistry databases

BindingDBiP97295.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97295.
PhosphoSitePlusiP97295.

Proteomic databases

PaxDbiP97295.
PRIDEiP97295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029633; ENSMUSP00000029633; ENSMUSG00000028004.
ENSMUST00000098997; ENSMUSP00000096595; ENSMUSG00000028004.
ENSMUST00000182831; ENSMUSP00000138282; ENSMUSG00000028004.
GeneIDi18167.
KEGGimmu:18167.
UCSCiuc008ppa.1. mouse.

Organism-specific databases

CTDi4887.
MGIiMGI:108418. Npy2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105675.
InParanoidiP97295.
KOiK04205.
OMAiEKSMYGT.
OrthoDBiEOG091G0C6Q.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP97295.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028004.
CleanExiMM_NPY2R.
ExpressionAtlasiP97295. baseline and differential.
GenevisibleiP97295. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY2R_MOUSE
AccessioniPrimary (citable) accession number: P97295
Secondary accession number(s): F7C6W7, Q8BWV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 28, 2012
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.