ID   HRH2_MOUSE              Reviewed;         397 AA.
AC   P97292; Q9D282;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 2.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Histamine H2 receptor;
DE            Short=H2R;
DE            Short=HH2R;
DE   AltName: Full=Gastric receptor I;
GN   Name=Hrh2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cecum, and Corpus striatum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
RC   STRAIN=129/Ola;
RX   PubMed=8938453; DOI=10.1006/geno.1996.0575;
RA   Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA   Watanabe T.;
RT   "Cloning, RNA expression, and chromosomal location of a mouse histamine H2
RT   receptor gene.";
RL   Genomics 37:390-394(1996).
CC   -!- FUNCTION: The H2 subclass of histamine receptors mediates gastric acid
CC       secretion. The activity of this receptor is mediated by G proteins
CC       which activate adenylyl cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AK020259; BAB32044.1; -; mRNA.
DR   EMBL; AK163760; BAE37484.1; -; mRNA.
DR   EMBL; AC163343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC164086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D50096; BAA08792.1; -; Genomic_DNA.
DR   CCDS; CCDS26526.1; -.
DR   RefSeq; NP_001010973.1; NM_001010973.2.
DR   RefSeq; NP_032312.2; NM_008286.2.
DR   RefSeq; XP_006516915.1; XM_006516852.2.
DR   RefSeq; XP_017170886.1; XM_017315397.1.
DR   AlphaFoldDB; P97292; -.
DR   SMR; P97292; -.
DR   STRING; 10090.ENSMUSP00000038170; -.
DR   BindingDB; P97292; -.
DR   ChEMBL; CHEMBL2245; -.
DR   GlyCosmos; P97292; 1 site, No reported glycans.
DR   GlyGen; P97292; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; P97292; -.
DR   PhosphoSitePlus; P97292; -.
DR   PaxDb; 10090-ENSMUSP00000038170; -.
DR   ProteomicsDB; 267158; -.
DR   Antibodypedia; 2931; 370 antibodies from 39 providers.
DR   DNASU; 15466; -.
DR   Ensembl; ENSMUST00000038101.4; ENSMUSP00000038170.4; ENSMUSG00000034987.5.
DR   GeneID; 15466; -.
DR   KEGG; mmu:15466; -.
DR   UCSC; uc007qob.1; mouse.
DR   AGR; MGI:108482; -.
DR   CTD; 3274; -.
DR   MGI; MGI:108482; Hrh2.
DR   VEuPathDB; HostDB:ENSMUSG00000034987; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000158761; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; P97292; -.
DR   OMA; SQKRMDF; -.
DR   OrthoDB; 2900736at2759; -.
DR   PhylomeDB; P97292; -.
DR   TreeFam; TF316350; -.
DR   Reactome; R-MMU-390650; Histamine receptors.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   BioGRID-ORCS; 15466; 2 hits in 78 CRISPR screens.
DR   ChiTaRS; Dhx15; mouse.
DR   PRO; PR:P97292; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; P97292; Protein.
DR   Bgee; ENSMUSG00000034987; Expressed in granulocyte and 41 other cell types or tissues.
DR   ExpressionAtlas; P97292; baseline and differential.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR   GO; GO:1901363; F:heterocyclic compound binding; ISO:MGI.
DR   GO; GO:0004969; F:histamine receptor activity; ISO:MGI.
DR   GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0048565; P:digestive tract development; IMP:MGI.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR   GO; GO:0001696; P:gastric acid secretion; IGI:MGI.
DR   GO; GO:0001698; P:gastrin-induced gastric acid secretion; IMP:MGI.
DR   GO; GO:0048732; P:gland development; IMP:MGI.
DR   GO; GO:0001697; P:histamine-induced gastric acid secretion; IMP:MGI.
DR   GO; GO:0007613; P:memory; IMP:MGI.
DR   GO; GO:1900139; P:negative regulation of arachidonic acid secretion; ISO:MGI.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
DR   GO; GO:0008542; P:visual learning; IMP:MGI.
DR   CDD; cd15051; 7tmA_Histamine_H2R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000503; Histamine_H2_rcpt.
DR   PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR   PANTHER; PTHR24247:SF276; HISTAMINE H2 RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00531; HISTAMINEH2R.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P97292; MM.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..397
FT                   /note="Histamine H2 receptor"
FT                   /id="PRO_0000069685"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..81
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..92
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..114
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..203
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..288
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..397
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   SITE            98
FT                   /note="Essential for histamine binding"
FT                   /evidence="ECO:0000250"
FT   SITE            185
FT                   /note="Essential for tiotidine binding and implicated in
FT                   histamine binding"
FT                   /evidence="ECO:0000250"
FT   SITE            189
FT                   /note="Implicated in histamine binding"
FT                   /evidence="ECO:0000250"
FT   LIPID           304
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..173
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        85
FT                   /note="S -> R (in Ref. 3; BAA08792)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        263
FT                   /note="A -> P (in Ref. 3; BAA08792)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   397 AA;  44794 MW;  BB4719084F4BDD59 CRC64;
     MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR SLTNCFIVSL
     AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM LCTASILNLF MISLDRYCAV
     TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV
     YGLVDGMVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG
     AFIVCWFPYF TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ
     LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT HPQGSPVRTR
     LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA
//