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P97292

- HRH2_MOUSE

UniProt

P97292 - HRH2_MOUSE

Protein

Histamine H2 receptor

Gene

Hrh2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei98 – 981Essential for histamine bindingBy similarity
    Sitei185 – 1851Essential for tiotidine binding and implicated in histamine bindingBy similarity
    Sitei189 – 1891Implicated in histamine bindingBy similarity

    GO - Molecular functioni

    1. histamine receptor activity Source: InterPro

    GO - Biological processi

    1. digestive tract development Source: MGI
    2. epithelial cell morphogenesis Source: MGI
    3. gastric acid secretion Source: MGI
    4. gastrin-induced gastric acid secretion Source: MGI
    5. gland development Source: MGI
    6. histamine-induced gastric acid secretion Source: MGI
    7. memory Source: MGI
    8. positive regulation of vasoconstriction Source: InterPro
    9. regulation of synaptic plasticity Source: MGI
    10. visual learning Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine H2 receptor
    Short name:
    H2R
    Short name:
    HH2R
    Alternative name(s):
    Gastric receptor I
    Gene namesi
    Name:Hrh2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:108482. Hrh2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Histamine H2 receptorPRO_0000069685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi91 ↔ 173PROSITE-ProRule annotation
    Lipidationi304 – 3041S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP97292.

    PTM databases

    PhosphoSiteiP97292.

    Expressioni

    Gene expression databases

    CleanExiMM_HRH2.
    GenevestigatoriP97292.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000038170.

    Structurei

    3D structure databases

    ProteinModelPortaliP97292.
    SMRiP97292. Positions 21-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 5713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 9211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini115 – 13420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 17920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 23330CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2669ExtracellularSequence Analysis
    Topological domaini289 – 397109CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4422Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 8124Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei135 – 15925Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20324Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25724Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28822Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283797.
    GeneTreeiENSGT00750000117368.
    HOVERGENiHBG106962.
    InParanoidiP97292.
    KOiK04150.
    OMAiQVWSGTE.
    OrthoDBiEOG7QC7W8.
    PhylomeDBiP97292.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000503. Histamine_H2_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00531. HISTAMINEH2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR    50
    SLTNCFIVSL AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM 100
    LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS 150
    FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGMVTF YLPLLIMCVT 200
    YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIVCWFPYF 250
    TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ 300
    LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT 350
    HPQGSPVRTR LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA 397
    Length:397
    Mass (Da):44,794
    Last modified:October 16, 2013 - v2
    Checksum:iBB4719084F4BDD59
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851S → R in BAA08792. (PubMed:8938453)Curated
    Sequence conflicti263 – 2631A → P in BAA08792. (PubMed:8938453)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020259 mRNA. Translation: BAB32044.1.
    AK163760 mRNA. Translation: BAE37484.1.
    AC163343 Genomic DNA. No translation available.
    AC164086 Genomic DNA. No translation available.
    D50096 Genomic DNA. Translation: BAA08792.1.
    CCDSiCCDS26526.1.
    RefSeqiNP_001010973.1. NM_001010973.2.
    NP_032312.2. NM_008286.2.
    XP_006516915.1. XM_006516852.1.
    UniGeneiMm.57243.

    Genome annotation databases

    EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
    GeneIDi15466.
    KEGGimmu:15466.
    UCSCiuc007qob.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020259 mRNA. Translation: BAB32044.1 .
    AK163760 mRNA. Translation: BAE37484.1 .
    AC163343 Genomic DNA. No translation available.
    AC164086 Genomic DNA. No translation available.
    D50096 Genomic DNA. Translation: BAA08792.1 .
    CCDSi CCDS26526.1.
    RefSeqi NP_001010973.1. NM_001010973.2.
    NP_032312.2. NM_008286.2.
    XP_006516915.1. XM_006516852.1.
    UniGenei Mm.57243.

    3D structure databases

    ProteinModelPortali P97292.
    SMRi P97292. Positions 21-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000038170.

    Chemistry

    ChEMBLi CHEMBL2245.
    GuidetoPHARMACOLOGYi 263.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97292.

    Proteomic databases

    PRIDEi P97292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038101 ; ENSMUSP00000038170 ; ENSMUSG00000034987 .
    GeneIDi 15466.
    KEGGi mmu:15466.
    UCSCi uc007qob.1. mouse.

    Organism-specific databases

    CTDi 3274.
    MGIi MGI:108482. Hrh2.

    Phylogenomic databases

    eggNOGi NOG283797.
    GeneTreei ENSGT00750000117368.
    HOVERGENi HBG106962.
    InParanoidi P97292.
    KOi K04150.
    OMAi QVWSGTE.
    OrthoDBi EOG7QC7W8.
    PhylomeDBi P97292.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 288294.
    PROi P97292.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HRH2.
    Genevestigatori P97292.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000503. Histamine_H2_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00531. HISTAMINEH2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum and Corpus striatum.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene."
      Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
      Genomics 37:390-394(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
      Strain: 129/Ola.

    Entry informationi

    Entry nameiHRH2_MOUSE
    AccessioniPrimary (citable) accession number: P97292
    Secondary accession number(s): Q9D282
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3