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P97292 (HRH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histamine H2 receptor

Short name=H2R
Short name=HH2R
Alternative name(s):
Gastric receptor I
Gene names
Name:Hrh2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Histamine H2 receptor
PRO_0000069685

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4422Helical; Name=1; Potential
Topological domain45 – 5713Cytoplasmic Potential
Transmembrane58 – 8124Helical; Name=2; Potential
Topological domain82 – 9211Extracellular Potential
Transmembrane93 – 11422Helical; Name=3; Potential
Topological domain115 – 13420Cytoplasmic Potential
Transmembrane135 – 15925Helical; Name=4; Potential
Topological domain160 – 17920Extracellular Potential
Transmembrane180 – 20324Helical; Name=5; Potential
Topological domain204 – 23330Cytoplasmic Potential
Transmembrane234 – 25724Helical; Name=6; Potential
Topological domain258 – 2669Extracellular Potential
Transmembrane267 – 28822Helical; Name=7; Potential
Topological domain289 – 35870Cytoplasmic Potential

Sites

Site981Essential for histamine binding By similarity
Site1851Essential for tiotidine binding and implicated in histamine binding By similarity
Site1891Implicated in histamine binding By similarity

Amino acid modifications

Lipidation3041S-palmitoyl cysteine By similarity
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond91 ↔ 173 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97292 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: D3DBA81D71B6D927

FASTA35840,379
        10         20         30         40         50         60 
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR SLTNCFIVSL 

        70         80         90        100        110        120 
AATDLLLGLL VMPFSAIYQL SFKWRFGQVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 

       130        140        150        160        170        180 
TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV 

       190        200        210        220        230        240 
YGLVDGMVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG 

       250        260        270        280        290        300 
AFIVCWFPYF TAFVYRGLRG DDPVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ 

       310        320        330        340        350 
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT HPQGSPVR 

« Hide

References

[1]"Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene."
Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
Genomics 37:390-394(1996) [PubMed: 8938453] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Ola.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50096 Genomic DNA. Translation: BAA08792.1.
IPIIPI00467449.
UniGeneMm.57243.

3D structure databases

ProteinModelPortalP97292.
SMRP97292. Positions 14-302.
ModBaseSearch...

Protein-protein interaction databases

STRINGP97292.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP97292.

Proteomic databases

PRIDEP97292.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:108482. Hrh2.

Phylogenomic databases

eggNOGroNOG12936.
HOVERGENHBG106962.
InParanoidP97292.
OrthoDBEOG418BP4.

Gene expression databases

ArrayExpressP97292.
BgeeP97292.
CleanExMM_HRH2.
GenevestigatorP97292.
GermOnlineENSMUSG00000034987. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR000503. Histamine_H2_recept.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameHRH2_MOUSE
AccessionPrimary (citable) accession number: P97292
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 21, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families