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P97292 (HRH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine H2 receptor

Short name=H2R
Short name=HH2R
Alternative name(s):
Gastric receptor I
Gene names
Name:Hrh2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdigestive tract development

Inferred from mutant phenotype PubMed 10862789PubMed 15476751. Source: MGI

epithelial cell morphogenesis

Inferred from mutant phenotype PubMed 10862789. Source: MGI

gastric acid secretion

Inferred from genetic interaction PubMed 15476751. Source: MGI

gastrin-induced gastric acid secretion

Inferred from mutant phenotype PubMed 10862789PubMed 15476751. Source: MGI

gland development

Inferred from mutant phenotype PubMed 15476751. Source: MGI

histamine-induced gastric acid secretion

Inferred from mutant phenotype PubMed 10862789PubMed 15476751. Source: MGI

memory

Inferred from mutant phenotype PubMed 17145090. Source: MGI

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 17145090. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 17145090. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistamine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Histamine H2 receptor
PRO_0000069685

Regions

Topological domain1 – 2222Extracellular Potential
Transmembrane23 – 4422Helical; Name=1; Potential
Topological domain45 – 5713Cytoplasmic Potential
Transmembrane58 – 8124Helical; Name=2; Potential
Topological domain82 – 9211Extracellular Potential
Transmembrane93 – 11422Helical; Name=3; Potential
Topological domain115 – 13420Cytoplasmic Potential
Transmembrane135 – 15925Helical; Name=4; Potential
Topological domain160 – 17920Extracellular Potential
Transmembrane180 – 20324Helical; Name=5; Potential
Topological domain204 – 23330Cytoplasmic Potential
Transmembrane234 – 25724Helical; Name=6; Potential
Topological domain258 – 2669Extracellular Potential
Transmembrane267 – 28822Helical; Name=7; Potential
Topological domain289 – 397109Cytoplasmic Potential

Sites

Site981Essential for histamine binding By similarity
Site1851Essential for tiotidine binding and implicated in histamine binding By similarity
Site1891Implicated in histamine binding By similarity

Amino acid modifications

Lipidation3041S-palmitoyl cysteine By similarity
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond91 ↔ 173 By similarity

Experimental info

Sequence conflict851S → R in BAA08792. Ref.3
Sequence conflict2631A → P in BAA08792. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P97292 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: BB4719084F4BDD59

FASTA39744,794
        10         20         30         40         50         60 
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR SLTNCFIVSL 

        70         80         90        100        110        120 
AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM LCTASILNLF MISLDRYCAV 

       130        140        150        160        170        180 
TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV 

       190        200        210        220        230        240 
YGLVDGMVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG 

       250        260        270        280        290        300 
AFIVCWFPYF TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ 

       310        320        330        340        350        360 
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT HPQGSPVRTR 

       370        380        390 
LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cecum and Corpus striatum.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene."
Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
Genomics 37:390-394(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
Strain: 129/Ola.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
RefSeqNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.1.
UniGeneMm.57243.

3D structure databases

ProteinModelPortalP97292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000038170.

Chemistry

ChEMBLCHEMBL2245.
GuidetoPHARMACOLOGY263.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP97292.

Proteomic databases

PRIDEP97292.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneID15466.
KEGGmmu:15466.
UCSCuc007qob.1. mouse.

Organism-specific databases

CTD3274.
MGIMGI:108482. Hrh2.

Phylogenomic databases

eggNOGNOG283797.
GeneTreeENSGT00750000117368.
HOVERGENHBG106962.
InParanoidP97292.
KOK04150.
OrthoDBEOG7QC7W8.
PhylomeDBP97292.
TreeFamTF316350.

Gene expression databases

CleanExMM_HRH2.
GenevestigatorP97292.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PANTHERPTHR24249:SF29. PTHR24249:SF29. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288294.
PROP97292.
SOURCESearch...

Entry information

Entry nameHRH2_MOUSE
AccessionPrimary (citable) accession number: P97292
Secondary accession number(s): Q9D282
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries