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Protein

Histamine H2 receptor

Gene

Hrh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei98Essential for histamine bindingBy similarity1
Sitei185Essential for tiotidine binding and implicated in histamine bindingBy similarity1
Sitei189Implicated in histamine bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

  • digestive tract development Source: MGI
  • epithelial cell morphogenesis Source: MGI
  • gastric acid secretion Source: MGI
  • gastrin-induced gastric acid secretion Source: MGI
  • gland development Source: MGI
  • histamine-induced gastric acid secretion Source: MGI
  • immune response Source: GO_Central
  • memory Source: MGI
  • positive regulation of vasoconstriction Source: InterPro
  • regulation of synaptic plasticity Source: MGI
  • toxin transport Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H2 receptor
Short name:
H2R
Short name:
HH2R
Alternative name(s):
Gastric receptor I
Gene namesi
Name:Hrh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:108482. Hrh2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 44Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini45 – 57CytoplasmicSequence analysisAdd BLAST13
Transmembranei58 – 81Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini82 – 92ExtracellularSequence analysisAdd BLAST11
Transmembranei93 – 114Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini115 – 134CytoplasmicSequence analysisAdd BLAST20
Transmembranei135 – 159Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini160 – 179ExtracellularSequence analysisAdd BLAST20
Transmembranei180 – 203Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini204 – 233CytoplasmicSequence analysisAdd BLAST30
Transmembranei234 – 257Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini258 – 266ExtracellularSequence analysis9
Transmembranei267 – 288Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini289 – 397CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696851 – 397Histamine H2 receptorAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 173PROSITE-ProRule annotation
Lipidationi304S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP97292.
PRIDEiP97292.

PTM databases

iPTMnetiP97292.
PhosphoSitePlusiP97292.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034987.
CleanExiMM_HRH2.
GenevisibleiP97292. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170.

Chemistry databases

BindingDBiP97292.

Structurei

3D structure databases

ProteinModelPortaliP97292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP97292.
KOiK04150.
OMAiCKVQVNL.
OrthoDBiEOG091G06VI.
PhylomeDBiP97292.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR
60 70 80 90 100
SLTNCFIVSL AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM
110 120 130 140 150
LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS
160 170 180 190 200
FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGMVTF YLPLLIMCVT
210 220 230 240 250
YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIVCWFPYF
260 270 280 290 300
TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ
310 320 330 340 350
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT
360 370 380 390
HPQGSPVRTR LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA
Length:397
Mass (Da):44,794
Last modified:October 16, 2013 - v2
Checksum:iBB4719084F4BDD59
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85S → R in BAA08792 (PubMed:8938453).Curated1
Sequence conflicti263A → P in BAA08792 (PubMed:8938453).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
CCDSiCCDS26526.1.
RefSeqiNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.2.
XP_017170886.1. XM_017315397.1.
UniGeneiMm.57243.

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneIDi15466.
KEGGimmu:15466.
UCSCiuc007qob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
CCDSiCCDS26526.1.
RefSeqiNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.2.
XP_017170886.1. XM_017315397.1.
UniGeneiMm.57243.

3D structure databases

ProteinModelPortaliP97292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170.

Chemistry databases

BindingDBiP97292.
ChEMBLiCHEMBL2245.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97292.
PhosphoSitePlusiP97292.

Proteomic databases

PaxDbiP97292.
PRIDEiP97292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneIDi15466.
KEGGimmu:15466.
UCSCiuc007qob.1. mouse.

Organism-specific databases

CTDi3274.
MGIiMGI:108482. Hrh2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP97292.
KOiK04150.
OMAiCKVQVNL.
OrthoDBiEOG091G06VI.
PhylomeDBiP97292.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP97292.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034987.
CleanExiMM_HRH2.
GenevisibleiP97292. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRH2_MOUSE
AccessioniPrimary (citable) accession number: P97292
Secondary accession number(s): Q9D282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.