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P97292

- HRH2_MOUSE

UniProt

P97292 - HRH2_MOUSE

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Protein
Histamine H2 receptor
Gene
Hrh2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for histamine binding By similarity
Sitei185 – 1851Essential for tiotidine binding and implicated in histamine binding By similarity
Sitei189 – 1891Implicated in histamine binding By similarity

GO - Molecular functioni

  1. histamine receptor activity Source: InterPro

GO - Biological processi

  1. digestive tract development Source: MGI
  2. epithelial cell morphogenesis Source: MGI
  3. gastric acid secretion Source: MGI
  4. gastrin-induced gastric acid secretion Source: MGI
  5. gland development Source: MGI
  6. histamine-induced gastric acid secretion Source: MGI
  7. memory Source: MGI
  8. positive regulation of vasoconstriction Source: InterPro
  9. regulation of synaptic plasticity Source: MGI
  10. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H2 receptor
Short name:
H2R
Short name:
HH2R
Alternative name(s):
Gastric receptor I
Gene namesi
Name:Hrh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:108482. Hrh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Extracellular Reviewed prediction
Add
BLAST
Transmembranei23 – 4422Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini45 – 5713Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei58 – 8124Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini82 – 9211Extracellular Reviewed prediction
Add
BLAST
Transmembranei93 – 11422Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini115 – 13420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei135 – 15925Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini160 – 17920Extracellular Reviewed prediction
Add
BLAST
Transmembranei180 – 20324Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini204 – 23330Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25724Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini258 – 2669Extracellular Reviewed prediction
Transmembranei267 – 28822Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini289 – 397109Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Histamine H2 receptor
PRO_0000069685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi91 ↔ 173 By similarity
Lipidationi304 – 3041S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP97292.

PTM databases

PhosphoSiteiP97292.

Expressioni

Gene expression databases

CleanExiMM_HRH2.
GenevestigatoriP97292.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170.

Structurei

3D structure databases

ProteinModelPortaliP97292.
SMRiP97292. Positions 21-303.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283797.
GeneTreeiENSGT00750000117368.
HOVERGENiHBG106962.
InParanoidiP97292.
KOiK04150.
OMAiQVWSGTE.
OrthoDBiEOG7QC7W8.
PhylomeDBiP97292.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97292-1 [UniParc]FASTAAdd to Basket

« Hide

MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR    50
SLTNCFIVSL AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM 100
LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS 150
FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGMVTF YLPLLIMCVT 200
YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIVCWFPYF 250
TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ 300
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT 350
HPQGSPVRTR LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA 397
Length:397
Mass (Da):44,794
Last modified:October 16, 2013 - v2
Checksum:iBB4719084F4BDD59
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851S → R in BAA08792. 1 Publication
Sequence conflicti263 – 2631A → P in BAA08792. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
CCDSiCCDS26526.1.
RefSeqiNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.1.
UniGeneiMm.57243.

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneIDi15466.
KEGGimmu:15466.
UCSCiuc007qob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020259 mRNA. Translation: BAB32044.1 .
AK163760 mRNA. Translation: BAE37484.1 .
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1 .
CCDSi CCDS26526.1.
RefSeqi NP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.1.
UniGenei Mm.57243.

3D structure databases

ProteinModelPortali P97292.
SMRi P97292. Positions 21-303.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000038170.

Chemistry

ChEMBLi CHEMBL2245.
GuidetoPHARMACOLOGYi 263.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97292.

Proteomic databases

PRIDEi P97292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038101 ; ENSMUSP00000038170 ; ENSMUSG00000034987 .
GeneIDi 15466.
KEGGi mmu:15466.
UCSCi uc007qob.1. mouse.

Organism-specific databases

CTDi 3274.
MGIi MGI:108482. Hrh2.

Phylogenomic databases

eggNOGi NOG283797.
GeneTreei ENSGT00750000117368.
HOVERGENi HBG106962.
InParanoidi P97292.
KOi K04150.
OMAi QVWSGTE.
OrthoDBi EOG7QC7W8.
PhylomeDBi P97292.
TreeFami TF316350.

Miscellaneous databases

NextBioi 288294.
PROi P97292.
SOURCEi Search...

Gene expression databases

CleanExi MM_HRH2.
Genevestigatori P97292.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Corpus striatum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene."
    Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
    Genomics 37:390-394(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
    Strain: 129/Ola.

Entry informationi

Entry nameiHRH2_MOUSE
AccessioniPrimary (citable) accession number: P97292
Secondary accession number(s): Q9D282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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