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Protein

Histamine H2 receptor

Gene

Hrh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Essential for histamine bindingBy similarity
Sitei185 – 1851Essential for tiotidine binding and implicated in histamine bindingBy similarity
Sitei189 – 1891Implicated in histamine bindingBy similarity

GO - Molecular functioni

  1. histamine receptor activity Source: InterPro

GO - Biological processi

  1. digestive tract development Source: MGI
  2. epithelial cell morphogenesis Source: MGI
  3. gastric acid secretion Source: MGI
  4. gastrin-induced gastric acid secretion Source: MGI
  5. gland development Source: MGI
  6. histamine-induced gastric acid secretion Source: MGI
  7. memory Source: MGI
  8. positive regulation of vasoconstriction Source: InterPro
  9. regulation of synaptic plasticity Source: MGI
  10. toxin transport Source: MGI
  11. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_257161. Histamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H2 receptor
Short name:
H2R
Short name:
HH2R
Alternative name(s):
Gastric receptor I
Gene namesi
Name:Hrh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:108482. Hrh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei23 – 4422Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 5713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei58 – 8124Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 9211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei93 – 11422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini115 – 13420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei135 – 15925Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 17920ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20324Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini204 – 23330CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25724Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 2669ExtracellularSequence Analysis
Transmembranei267 – 28822Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini289 – 397109CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Histamine H2 receptorPRO_0000069685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi91 ↔ 173PROSITE-ProRule annotation
Lipidationi304 – 3041S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP97292.

PTM databases

PhosphoSiteiP97292.

Expressioni

Gene expression databases

CleanExiMM_HRH2.
ExpressionAtlasiP97292. baseline and differential.
GenevestigatoriP97292.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170.

Structurei

3D structure databases

ProteinModelPortaliP97292.
SMRiP97292. Positions 21-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283797.
GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiP97292.
KOiK04150.
OMAiQVWSGTE.
OrthoDBiEOG7QC7W8.
PhylomeDBiP97292.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR
60 70 80 90 100
SLTNCFIVSL AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM
110 120 130 140 150
LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS
160 170 180 190 200
FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGMVTF YLPLLIMCVT
210 220 230 240 250
YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIVCWFPYF
260 270 280 290 300
TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ
310 320 330 340 350
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT
360 370 380 390
HPQGSPVRTR LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA
Length:397
Mass (Da):44,794
Last modified:October 16, 2013 - v2
Checksum:iBB4719084F4BDD59
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851S → R in BAA08792 (PubMed:8938453).Curated
Sequence conflicti263 – 2631A → P in BAA08792 (PubMed:8938453).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
CCDSiCCDS26526.1.
RefSeqiNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.1.
UniGeneiMm.57243.

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneIDi15466.
KEGGimmu:15466.
UCSCiuc007qob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA. Translation: BAB32044.1.
AK163760 mRNA. Translation: BAE37484.1.
AC163343 Genomic DNA. No translation available.
AC164086 Genomic DNA. No translation available.
D50096 Genomic DNA. Translation: BAA08792.1.
CCDSiCCDS26526.1.
RefSeqiNP_001010973.1. NM_001010973.2.
NP_032312.2. NM_008286.2.
XP_006516915.1. XM_006516852.1.
UniGeneiMm.57243.

3D structure databases

ProteinModelPortaliP97292.
SMRiP97292. Positions 21-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170.

Chemistry

ChEMBLiCHEMBL2245.
GuidetoPHARMACOLOGYi263.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP97292.

Proteomic databases

PRIDEiP97292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
GeneIDi15466.
KEGGimmu:15466.
UCSCiuc007qob.1. mouse.

Organism-specific databases

CTDi3274.
MGIiMGI:108482. Hrh2.

Phylogenomic databases

eggNOGiNOG283797.
GeneTreeiENSGT00760000118774.
HOVERGENiHBG106962.
InParanoidiP97292.
KOiK04150.
OMAiQVWSGTE.
OrthoDBiEOG7QC7W8.
PhylomeDBiP97292.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_257161. Histamine receptors.

Miscellaneous databases

NextBioi288294.
PROiP97292.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HRH2.
ExpressionAtlasiP97292. baseline and differential.
GenevestigatoriP97292.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000503. Histamine_H2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00531. HISTAMINEH2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Corpus striatum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene."
    Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
    Genomics 37:390-394(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
    Strain: 129/Ola.

Entry informationi

Entry nameiHRH2_MOUSE
AccessioniPrimary (citable) accession number: P97292
Secondary accession number(s): Q9D282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: January 7, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.