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P97291

- CADH8_MOUSE

UniProt

P97291 - CADH8_MOUSE

Protein

Cadherin-8

Gene

Cdh8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro
    2. response to cold Source: MGI
    3. synaptic transmission Source: MGI
    4. synaptic transmission, glutamatergic Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-8
    Gene namesi
    Name:Cdh8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:107434. Cdh8.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell
    4. synaptic cleft Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 6132Sequence AnalysisPRO_0000003775Add
    BLAST
    Chaini62 – 799738Cadherin-8PRO_0000003776Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiP97291.
    PRIDEiP97291.

    PTM databases

    PhosphoSiteiP97291.

    Expressioni

    Gene expression databases

    ArrayExpressiP97291.
    CleanExiMM_CDH8.
    GenevestigatoriP97291.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-46028N.

    Structurei

    Secondary structure

    1
    799
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi67 – 704
    Helixi72 – 743
    Beta strandi76 – 783
    Beta strandi80 – 845
    Beta strandi96 – 1027
    Turni106 – 1083
    Beta strandi109 – 1113
    Turni113 – 1153
    Beta strandi117 – 1204
    Turni126 – 1283
    Beta strandi130 – 14011
    Turni141 – 1433
    Beta strandi146 – 1483
    Beta strandi151 – 1577

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZXKX-ray2.00A/B62-159[»]
    2A62X-ray4.50A63-383[»]
    ProteinModelPortaliP97291.
    SMRiP97291. Positions 63-597, 729-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP97291.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini62 – 621560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini643 – 799157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei622 – 64221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 167106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 276109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 391115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini392 – 494103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini495 – 616122Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330572.
    GeneTreeiENSGT00700000104267.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiP97291.
    KOiK06800.
    OMAiSIEPHTA.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97291-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS    50
    EDMRILSRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL 100
    SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD FETNKPLEPP 150
    SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG 200
    NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG 250
    GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 300
    NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS 350
    YTLKVEAANI HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV 400
    HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL 450
    ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY 500
    EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN 550
    EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS 600
    NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE 650
    PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI 700
    KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE 750
    GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET 799
    Length:799
    Mass (Da):88,215
    Last modified:October 3, 2012 - v2
    Checksum:i0EF1285E5DD67F76
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471K → I in CAA64857. (PubMed:9022055)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95600 mRNA. Translation: CAA64857.1.
    AC102643 Genomic DNA. No translation available.
    AC103397 Genomic DNA. No translation available.
    AC162519 Genomic DNA. No translation available.
    AC162867 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL11191.1.
    CCDSiCCDS40448.1.
    RefSeqiNP_031693.2. NM_007667.3.
    XP_006530694.1. XM_006530631.1.
    UniGeneiMm.441131.

    Genome annotation databases

    EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
    GeneIDi12564.
    KEGGimmu:12564.
    UCSCiuc009mzo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95600 mRNA. Translation: CAA64857.1 .
    AC102643 Genomic DNA. No translation available.
    AC103397 Genomic DNA. No translation available.
    AC162519 Genomic DNA. No translation available.
    AC162867 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL11191.1 .
    CCDSi CCDS40448.1.
    RefSeqi NP_031693.2. NM_007667.3.
    XP_006530694.1. XM_006530631.1.
    UniGenei Mm.441131.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZXK X-ray 2.00 A/B 62-159 [» ]
    2A62 X-ray 4.50 A 63-383 [» ]
    ProteinModelPortali P97291.
    SMRi P97291. Positions 63-597, 729-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46028N.

    PTM databases

    PhosphoSitei P97291.

    Proteomic databases

    PaxDbi P97291.
    PRIDEi P97291.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000128860 ; ENSMUSP00000117326 ; ENSMUSG00000036510 .
    GeneIDi 12564.
    KEGGi mmu:12564.
    UCSCi uc009mzo.1. mouse.

    Organism-specific databases

    CTDi 1006.
    MGIi MGI:107434. Cdh8.

    Phylogenomic databases

    eggNOGi NOG330572.
    GeneTreei ENSGT00700000104267.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi P97291.
    KOi K06800.
    OMAi SIEPHTA.
    TreeFami TF329887.

    Miscellaneous databases

    EvolutionaryTracei P97291.
    NextBioi 281644.
    PROi P97291.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97291.
    CleanExi MM_CDH8.
    Genevestigatori P97291.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Restricted expression of cadherin-8 in segmental and functional subdivisions of the embryonic mouse brain."
      Korematsu K., Redies C.
      Dev. Dyn. 208:178-189(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster / NIH.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCADH8_MOUSE
    AccessioniPrimary (citable) accession number: P97291
    Secondary accession number(s): G3UVU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3