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Protein

Cadherin-8

Gene

Cdh8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • response to cold Source: MGI
  • synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:Cdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:107434. Cdh8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini62 – 621ExtracellularSequence analysisAdd BLAST560
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 799CytoplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

  • axon terminus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • synaptic cleft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000377530 – 61Sequence analysisAdd BLAST32
ChainiPRO_000000377662 – 799Cadherin-8Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi544N-linked (GlcNAc...)Sequence analysis1
Modified residuei795PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97291.
PaxDbiP97291.
PRIDEiP97291.

PTM databases

iPTMnetiP97291.
PhosphoSitePlusiP97291.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036510.
CleanExiMM_CDH8.
ExpressionAtlasiP97291. baseline and differential.
GenevisibleiP97291. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-46028N.
STRINGi10090.ENSMUSP00000117326.

Structurei

Secondary structure

1799
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Helixi72 – 74Combined sources3
Beta strandi76 – 78Combined sources3
Beta strandi80 – 84Combined sources5
Beta strandi96 – 102Combined sources7
Turni106 – 108Combined sources3
Beta strandi109 – 111Combined sources3
Turni113 – 115Combined sources3
Beta strandi117 – 120Combined sources4
Turni126 – 128Combined sources3
Beta strandi130 – 140Combined sources11
Turni141 – 143Combined sources3
Beta strandi146 – 148Combined sources3
Beta strandi151 – 157Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B62-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortaliP97291.
SMRiP97291.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97291.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 167Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini168 – 276Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini277 – 391Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini392 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini495 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97291.
KOiK06800.
OMAiEEYFVVI.
OrthoDBiEOG091G0241.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS
60 70 80 90 100
EDMRILSRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL
110 120 130 140 150
SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD FETNKPLEPP
160 170 180 190 200
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG
210 220 230 240 250
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG
260 270 280 290 300
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA
310 320 330 340 350
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS
360 370 380 390 400
YTLKVEAANI HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV
410 420 430 440 450
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL
460 470 480 490 500
ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY
510 520 530 540 550
EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN
560 570 580 590 600
EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS
610 620 630 640 650
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE
660 670 680 690 700
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI
710 720 730 740 750
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE
760 770 780 790
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET
Length:799
Mass (Da):88,215
Last modified:October 3, 2012 - v2
Checksum:i0EF1285E5DD67F76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247K → I in CAA64857 (PubMed:9022055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95600 mRNA. Translation: CAA64857.1.
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1.
CCDSiCCDS40448.1.
RefSeqiNP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.2.
UniGeneiMm.441131.

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
GeneIDi12564.
KEGGimmu:12564.
UCSCiuc009mzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95600 mRNA. Translation: CAA64857.1.
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1.
CCDSiCCDS40448.1.
RefSeqiNP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.2.
UniGeneiMm.441131.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B62-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortaliP97291.
SMRiP97291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46028N.
STRINGi10090.ENSMUSP00000117326.

PTM databases

iPTMnetiP97291.
PhosphoSitePlusiP97291.

Proteomic databases

MaxQBiP97291.
PaxDbiP97291.
PRIDEiP97291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
GeneIDi12564.
KEGGimmu:12564.
UCSCiuc009mzo.2. mouse.

Organism-specific databases

CTDi1006.
MGIiMGI:107434. Cdh8.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97291.
KOiK06800.
OMAiEEYFVVI.
OrthoDBiEOG091G0241.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTraceiP97291.
PROiP97291.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036510.
CleanExiMM_CDH8.
ExpressionAtlasiP97291. baseline and differential.
GenevisibleiP97291. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH8_MOUSE
AccessioniPrimary (citable) accession number: P97291
Secondary accession number(s): G3UVU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.