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P97291 (CADH8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-8
Gene names
Name:Cdh8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 6132 Potential
PRO_0000003775
Chain62 – 799738Cadherin-8
PRO_0000003776

Regions

Topological domain62 – 621560Extracellular Potential
Transmembrane622 – 64221Helical; Potential
Topological domain643 – 799157Cytoplasmic Potential
Domain62 – 167106Cadherin 1
Domain168 – 276109Cadherin 2
Domain277 – 391115Cadherin 3
Domain392 – 494103Cadherin 4
Domain495 – 616122Cadherin 5

Amino acid modifications

Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential
Glycosylation5441N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2471K → I in CAA64857. Ref.1

Secondary structure

........................... 799
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P97291 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 0EF1285E5DD67F76

FASTA79988,215
        10         20         30         40         50         60 
MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS EDMRILSRSK 

        70         80         90        100        110        120 
RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDITGDIHA 

       130        140        150        160        170        180 
IKRLDREEKA EYTLTAQAVD FETNKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 

       190        200        210        220        230        240 
ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 

       250        260        270        280        290        300 
LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 

       310        320        330        340        350        360 
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS YTLKVEAANI 

       370        380        390        400        410        420 
HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 

       430        440        450        460        470        480 
TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV 

       490        500        510        520        530        540 
PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV 

       550        560        570        580        590        600 
NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS 

       610        620        630        640        650        660 
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 

       670        680        690        700        710        720 
RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 

       730        740        750        760        770        780 
VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 

       790 
PRFKRLGELY SVGESDKET 

« Hide

References

« Hide 'large scale' references
[1]"Restricted expression of cadherin-8 in segmental and functional subdivisions of the embryonic mouse brain."
Korematsu K., Redies C.
Dev. Dyn. 208:178-189(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss Webster / NIH.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95600 mRNA. Translation: CAA64857.1.
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1.
RefSeqNP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.1.
UniGeneMm.441131.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B63-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortalP97291.
SMRP97291. Positions 63-597, 697-790.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46028N.

PTM databases

PhosphoSiteP97291.

Proteomic databases

PaxDbP97291.
PRIDEP97291.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
GeneID12564.
KEGGmmu:12564.
UCSCuc009mzo.1. mouse.

Organism-specific databases

CTD1006.
MGIMGI:107434. Cdh8.

Phylogenomic databases

eggNOGNOG330572.
GeneTreeENSGT00700000104267.
HOGENOMHOG000231252.
HOVERGENHBG005217.
InParanoidP97291.
KOK06800.
OMAGIVQSCN.
TreeFamTF329887.

Gene expression databases

ArrayExpressP97291.
CleanExMM_CDH8.
GenevestigatorP97291.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP97291.
NextBio281644.
PROP97291.
SOURCESearch...

Entry information

Entry nameCADH8_MOUSE
AccessionPrimary (citable) accession number: P97291
Secondary accession number(s): G3UVU4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot