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P97291

- CADH8_MOUSE

UniProt

P97291 - CADH8_MOUSE

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Protein

Cadherin-8

Gene

Cdh8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. response to cold Source: MGI
  3. synaptic transmission Source: MGI
  4. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:Cdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:107434. Cdh8.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. synaptic cleft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 6132Sequence AnalysisPRO_0000003775Add
BLAST
Chaini62 – 799738Cadherin-8PRO_0000003776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP97291.
PaxDbiP97291.
PRIDEiP97291.

PTM databases

PhosphoSiteiP97291.

Expressioni

Gene expression databases

CleanExiMM_CDH8.
ExpressionAtlasiP97291. baseline and differential.
GenevestigatoriP97291.

Interactioni

Protein-protein interaction databases

DIPiDIP-46028N.

Structurei

Secondary structure

1
799
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704
Helixi72 – 743
Beta strandi76 – 783
Beta strandi80 – 845
Beta strandi96 – 1027
Turni106 – 1083
Beta strandi109 – 1113
Turni113 – 1153
Beta strandi117 – 1204
Turni126 – 1283
Beta strandi130 – 14011
Turni141 – 1433
Beta strandi146 – 1483
Beta strandi151 – 1577

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B62-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortaliP97291.
SMRiP97291. Positions 63-597, 729-790.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97291.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini62 – 621560ExtracellularSequence AnalysisAdd
BLAST
Topological domaini643 – 799157CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei622 – 64221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 167106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 276109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 391115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 494103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini495 – 616122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330572.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97291.
KOiK06800.
OMAiSIEPHTA.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97291 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS
60 70 80 90 100
EDMRILSRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL
110 120 130 140 150
SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD FETNKPLEPP
160 170 180 190 200
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG
210 220 230 240 250
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG
260 270 280 290 300
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA
310 320 330 340 350
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS
360 370 380 390 400
YTLKVEAANI HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV
410 420 430 440 450
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL
460 470 480 490 500
ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY
510 520 530 540 550
EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN
560 570 580 590 600
EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS
610 620 630 640 650
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE
660 670 680 690 700
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI
710 720 730 740 750
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE
760 770 780 790
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET
Length:799
Mass (Da):88,215
Last modified:October 3, 2012 - v2
Checksum:i0EF1285E5DD67F76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471K → I in CAA64857. (PubMed:9022055)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95600 mRNA. Translation: CAA64857.1.
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1.
CCDSiCCDS40448.1.
RefSeqiNP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.1.
UniGeneiMm.441131.

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
GeneIDi12564.
KEGGimmu:12564.
UCSCiuc009mzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95600 mRNA. Translation: CAA64857.1 .
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1 .
CCDSi CCDS40448.1.
RefSeqi NP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.1.
UniGenei Mm.441131.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZXK X-ray 2.00 A/B 62-159 [» ]
2A62 X-ray 4.50 A 63-383 [» ]
ProteinModelPortali P97291.
SMRi P97291. Positions 63-597, 729-790.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46028N.

PTM databases

PhosphoSitei P97291.

Proteomic databases

MaxQBi P97291.
PaxDbi P97291.
PRIDEi P97291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000128860 ; ENSMUSP00000117326 ; ENSMUSG00000036510 .
GeneIDi 12564.
KEGGi mmu:12564.
UCSCi uc009mzo.1. mouse.

Organism-specific databases

CTDi 1006.
MGIi MGI:107434. Cdh8.

Phylogenomic databases

eggNOGi NOG330572.
GeneTreei ENSGT00760000118954.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P97291.
KOi K06800.
OMAi SIEPHTA.
TreeFami TF329887.

Miscellaneous databases

EvolutionaryTracei P97291.
NextBioi 281644.
PROi P97291.
SOURCEi Search...

Gene expression databases

CleanExi MM_CDH8.
ExpressionAtlasi P97291. baseline and differential.
Genevestigatori P97291.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Restricted expression of cadherin-8 in segmental and functional subdivisions of the embryonic mouse brain."
    Korematsu K., Redies C.
    Dev. Dyn. 208:178-189(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCADH8_MOUSE
AccessioniPrimary (citable) accession number: P97291
Secondary accession number(s): G3UVU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3