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P97291

- CADH8_MOUSE

UniProt

P97291 - CADH8_MOUSE

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Protein

Cadherin-8

Gene
Cdh8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
  2. response to cold Source: MGI
  3. synaptic transmission Source: MGI
  4. synaptic transmission, glutamatergic Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:Cdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:107434. Cdh8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini62 – 621560Extracellular Reviewed predictionAdd
BLAST
Transmembranei622 – 64221Helical; Reviewed predictionAdd
BLAST
Topological domaini643 – 799157Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. synaptic cleft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Propeptidei30 – 6132 Reviewed predictionPRO_0000003775Add
BLAST
Chaini62 – 799738Cadherin-8PRO_0000003776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi463 – 4631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi473 – 4731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP97291.
PRIDEiP97291.

PTM databases

PhosphoSiteiP97291.

Expressioni

Gene expression databases

ArrayExpressiP97291.
CleanExiMM_CDH8.
GenevestigatoriP97291.

Interactioni

Protein-protein interaction databases

DIPiDIP-46028N.

Structurei

Secondary structure

1
799
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704
Helixi72 – 743
Beta strandi76 – 783
Beta strandi80 – 845
Beta strandi96 – 1027
Turni106 – 1083
Beta strandi109 – 1113
Turni113 – 1153
Beta strandi117 – 1204
Turni126 – 1283
Beta strandi130 – 14011
Turni141 – 1433
Beta strandi146 – 1483
Beta strandi151 – 1577

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B62-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortaliP97291.
SMRiP97291. Positions 63-597, 729-790.

Miscellaneous databases

EvolutionaryTraceiP97291.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 167106Cadherin 1Add
BLAST
Domaini168 – 276109Cadherin 2Add
BLAST
Domaini277 – 391115Cadherin 3Add
BLAST
Domaini392 – 494103Cadherin 4Add
BLAST
Domaini495 – 616122Cadherin 5Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330572.
GeneTreeiENSGT00700000104267.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP97291.
KOiK06800.
OMAiSIEPHTA.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97291-1 [UniParc]FASTAAdd to Basket

« Hide

MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS    50
EDMRILSRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL 100
SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD FETNKPLEPP 150
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG 200
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG 250
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 300
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS 350
YTLKVEAANI HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV 400
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL 450
ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY 500
EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN 550
EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS 600
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE 650
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI 700
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE 750
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET 799
Length:799
Mass (Da):88,215
Last modified:October 3, 2012 - v2
Checksum:i0EF1285E5DD67F76
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471K → I in CAA64857. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95600 mRNA. Translation: CAA64857.1.
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1.
CCDSiCCDS40448.1.
RefSeqiNP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.1.
UniGeneiMm.441131.

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510.
GeneIDi12564.
KEGGimmu:12564.
UCSCiuc009mzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95600 mRNA. Translation: CAA64857.1 .
AC102643 Genomic DNA. No translation available.
AC103397 Genomic DNA. No translation available.
AC162519 Genomic DNA. No translation available.
AC162867 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11191.1 .
CCDSi CCDS40448.1.
RefSeqi NP_031693.2. NM_007667.3.
XP_006530694.1. XM_006530631.1.
UniGenei Mm.441131.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZXK X-ray 2.00 A/B 62-159 [» ]
2A62 X-ray 4.50 A 63-383 [» ]
ProteinModelPortali P97291.
SMRi P97291. Positions 63-597, 729-790.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46028N.

PTM databases

PhosphoSitei P97291.

Proteomic databases

PaxDbi P97291.
PRIDEi P97291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000128860 ; ENSMUSP00000117326 ; ENSMUSG00000036510 .
GeneIDi 12564.
KEGGi mmu:12564.
UCSCi uc009mzo.1. mouse.

Organism-specific databases

CTDi 1006.
MGIi MGI:107434. Cdh8.

Phylogenomic databases

eggNOGi NOG330572.
GeneTreei ENSGT00700000104267.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P97291.
KOi K06800.
OMAi SIEPHTA.
TreeFami TF329887.

Miscellaneous databases

EvolutionaryTracei P97291.
NextBioi 281644.
PROi P97291.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97291.
CleanExi MM_CDH8.
Genevestigatori P97291.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Restricted expression of cadherin-8 in segmental and functional subdivisions of the embryonic mouse brain."
    Korematsu K., Redies C.
    Dev. Dyn. 208:178-189(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCADH8_MOUSE
AccessioniPrimary (citable) accession number: P97291
Secondary accession number(s): G3UVU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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