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Protein

Plasma protease C1 inhibitor

Gene

Serping1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei470 – 471Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.
R-MMU-977606. Regulation of Complement cascade.

Protein family/group databases

MEROPSiI04.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma protease C1 inhibitor
Short name:
C1 Inh
Short name:
C1Inh
Alternative name(s):
C1 esterase inhibitor
C1-inhibiting factor
Serpin G1
Gene namesi
Name:Serping1
Synonyms:C1nh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:894696. Serping1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003251523 – 504Plasma protease C1 inhibitorAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 432By similarity
Disulfide bondi135 ↔ 210By similarity
Glycosylationi243N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP97290.
PaxDbiP97290.
PeptideAtlasiP97290.
PRIDEiP97290.

PTM databases

iPTMnetiP97290.
PhosphoSitePlusiP97290.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023224.
ExpressionAtlasiP97290. baseline and differential.
GenevisibleiP97290. MM.

Interactioni

Subunit structurei

Interacts with MASP1.By similarity

Protein-protein interaction databases

IntActiP97290. 1 interactor.
MINTiMINT-1858614.
STRINGi10090.ENSMUSP00000023994.

Structurei

3D structure databases

ProteinModelPortaliP97290.
SMRiP97290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000231936.
HOVERGENiHBG104060.
InParanoidiP97290.
KOiK04001.
OMAiIYLSAKW.
OrthoDBiEOG091G03BW.
TreeFamiTF317350.

Family and domain databases

InterProiView protein in InterPro
IPR015553. C1-inh.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF269. PTHR11461:SF269. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLTPLTL LLLLLAGDRA FSDPEATSHS TQDPLEAQAK SRESFPERDD
60 70 80 90 100
SWSPPEPTVL PSTWPTTSVA ITITNDTMGK VANESFSQHS QPAAQLPTDS
110 120 130 140 150
PGQPPLNSSS QPSTASDLPT QATTEPFCPE PLAQCSDSDR DSSEAKLSEA
160 170 180 190 200
LTDFSVKLYH AFSATKMAKT NMAFSPFSIA SLLTQVLLGA GDSTKSNLES
210 220 230 240 250
ILSYPKDFAC VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG
260 270 280 290 300
SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL
310 320 330 340 350
SAKWKITFEP KKMMAPFFYK NSMIKVPMMS SVKYPVAQFD DHTLKAKVGQ
360 370 380 390 400
LQLSHNLSFV IVVPVFPKHQ LKDVEKALNP TVFKAIMKKL ELSKFLPTYL
410 420 430 440 450
TMPHIKVKSS QDMLSVMEKL EFFDFTYDLN LCGLTEDPDL QVSAMKHETV
460 470 480 490 500
LELTESGVEA AAASAISFGR SLPIFEVQRP FLFLLWDQQH RFPVFMGRVY

DPRG
Length:504
Mass (Da):55,585
Last modified:July 27, 2011 - v3
Checksum:iB27BBDC05D318E62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291C → R in AAC40136 (PubMed:9652403).Curated1
Sequence conflicti421E → K in CAA71412 (PubMed:9199246).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10386 mRNA. Translation: CAA71412.1.
AF010254 mRNA. Translation: AAC40136.1.
AF052039 Genomic DNA. Translation: AAC40149.1.
AL928914 Genomic DNA. Translation: CAM23311.1.
BC002026 mRNA. Translation: AAH02026.1.
CCDSiCCDS16193.1.
RefSeqiNP_033906.2. NM_009776.3.
XP_006498686.1. XM_006498623.3.
UniGeneiMm.38888.

Genome annotation databases

EnsembliENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224.
GeneIDi12258.
KEGGimmu:12258.
UCSCiuc008kjd.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiIC1_MOUSE
AccessioniPrimary (citable) accession number: P97290
Secondary accession number(s): A2ATR7
, O88330, Q99M43, Q9QX09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families