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P97287

- MCL1_MOUSE

UniProt

P97287 - MCL1_MOUSE

Protein

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Gene

Mcl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei108 – 1092Cleavage; by caspase-3By similarity
    Sitei138 – 1392Cleavage; by caspase-3By similarity

    GO - Molecular functioni

    1. BH3 domain binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein heterodimerization activity Source: RefGenome
    4. protein homodimerization activity Source: RefGenome

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: MGI
    2. cell differentiation Source: UniProtKB-KW
    3. execution phase of apoptosis Source: Ensembl
    4. extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
    5. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    6. multicellular organismal development Source: UniProtKB-KW
    7. negative regulation of anoikis Source: Ensembl
    8. negative regulation of apoptotic process Source: UniProtKB
    9. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    10. negative regulation of intrinsic apoptotic signaling pathway Source: RefGenome
    11. regulation of response to DNA damage stimulus Source: Ensembl
    12. response to cytokine Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Apoptosis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Alternative name(s):
    Bcl-2-related protein EAT/mcl1
    Gene namesi
    Name:Mcl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:101769. Mcl1.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity. Cytoplasm By similarity. Mitochondrion. Nucleusnucleoplasm By similarity
    Note: Cytoplasmic, associated with mitochondria.

    GO - Cellular componenti

    1. Bcl-2 family protein complex Source: Ensembl
    2. cytoplasm Source: MGI
    3. cytosol Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane Source: UniProtKB
    6. mitochondrial matrix Source: MGI
    7. mitochondrial outer membrane Source: RefGenome
    8. mitochondrion Source: MGI
    9. nucleoplasm Source: UniProtKB-SubCell
    10. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Induced myeloid leukemia cell differentiation protein Mcl-1 homologPRO_0000143081Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphoserineBy similarity
    Cross-linki117 – 117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei140 – 1401Phosphoserine; by GSK3-alpha and GSK3-beta1 Publication
    Modified residuei143 – 1431PhosphoserineBy similarity
    Modified residuei144 – 1441Phosphothreonine; by MAPKBy similarity
    Cross-linki175 – 175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki178 – 178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment.By similarity
    Rapidly degraded in the absence of phosphorylation in the PEST region.By similarity
    Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.1 Publication
    Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140 By similarity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP97287.
    PRIDEiP97287.

    PTM databases

    PhosphoSiteiP97287.

    Expressioni

    Inductioni

    Up-regulated by IL3 and CSF2. Up-regulated in murine embryonal carcinoma cells in response to retinoic acid treatment. Levels reach a maximum after 4 hours, are decreased after 8 hours and are back to maximum after 12 hours. Levels are decreased after 24 hours and back to basal levels after 48 hours. Expression remains constant in retinoic acid-treated embryonic stem cells.2 Publications

    Gene expression databases

    ArrayExpressiP97287.
    BgeeiP97287.
    CleanExiMM_MCL1.
    GenevestigatoriP97287.

    Interactioni

    Subunit structurei

    Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1. Interacts with BBC3, BFM and PMAIP1. Interacts with BOP. Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BAK1Q166113EBI-707292,EBI-519866From a different organism.
    BAXQ078122EBI-707292,EBI-516580From a different organism.
    BBC3Q9BXH15EBI-707292,EBI-519884From a different organism.
    BCL2L11O435217EBI-707292,EBI-526406From a different organism.
    Bcl2l11O549184EBI-707292,EBI-526067
    Pmaip1Q9JM544EBI-707292,EBI-709183

    Protein-protein interaction databases

    BioGridi201344. 10 interactions.
    DIPiDIP-33343N.
    IntActiP97287. 14 interactions.
    MINTiMINT-209660.

    Structurei

    Secondary structure

    1
    331
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi154 – 17219
    Turni181 – 1833
    Helixi185 – 1895
    Helixi206 – 2138
    Turni221 – 2233
    Helixi227 – 2348
    Turni235 – 2373
    Helixi242 – 26120
    Helixi265 – 2673
    Helixi268 – 28922
    Helixi292 – 3009
    Turni301 – 3033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WSXNMR-A152-308[»]
    2JM6NMR-B152-308[»]
    2NL9X-ray1.55A152-189[»]
    2NLAX-ray2.80A152-189[»]
    2ROCNMR-A152-308[»]
    2RODNMR-A152-308[»]
    3D7VX-ray2.03A152-189[»]
    3IO9X-ray2.40A152-189[»]
    4BPIX-ray1.98A152-189[»]
    4BPJX-ray1.60A152-189[»]
    4G35X-ray2.00A152-308[»]
    ProteinModelPortaliP97287.
    SMRiP97287. Positions 148-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP97287.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 15672PEST-likeBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi190 – 20415BH3Add
    BLAST
    Motifi234 – 25320BH1Add
    BLAST
    Motifi285 – 30016BH2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi149 – 1524Poly-Glu

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282183.
    GeneTreeiENSGT00510000048923.
    HOGENOMiHOG000232116.
    HOVERGENiHBG003527.
    InParanoidiP97287.
    KOiK02539.
    OMAiKDTKPMG.
    OrthoDBiEOG7S2209.
    PhylomeDBiP97287.
    TreeFamiTF315834.

    Family and domain databases

    InterProiIPR013281. Apop_reg_Mc1.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF6. PTHR11256:SF6. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PRINTSiPR01866. APOPREGMCL1.
    PR01862. BCL2FAMILY.
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P97287-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFGLRRNAVI GLNLYCGGAS LGAGGGSPAG ARLVAEEAKA RREGGGEAAL    50
    LPGARVVARP PPVGAEDPDV TASAERRLHK SPGLLAVPPE EMAASAAAAI 100
    VSPEEELDGC EPEAIGKRPA VLPLLERVSE AAKSSGADGS LPSTPPPPEE 150
    EEDDLYRQSL EIISRYLREQ ATGSKDSKPL GEAGAAGRRA LETLRRVGDG 200
    VQRNHETAFQ GMLRKLDIKN EGDVKSFSRV MVHVFKDGVT NWGRIVTLIS 250
    FGAFVAKHLK SVNQESFIEP LAETITDVLV RTKRDWLVKQ RGWDGFVEFF 300
    HVQDLEGGIR NVLLAFAGVA GVGAGLAYLI R 331
    Length:331
    Mass (Da):35,217
    Last modified:November 1, 1998 - v3
    Checksum:iE4FD369DB0EC6723
    GO
    Isoform 2 (identifier: P97287-2) [UniParc]FASTAAdd to Basket

    Also known as: Mck-1V

    The sequence of this isoform differs from the canonical sequence as follows:
         18-63: Missing.

    Note: This isoform is more stable than isoform 1 in cells undergoing apoptosis.

    Show »
    Length:285
    Mass (Da):30,930
    Checksum:i73643EE7EE849B27
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 6346Missing in isoform 2. 1 PublicationVSP_046443Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35623 mRNA. Translation: AAC31790.1.
    GU182318 mRNA. Translation: ACZ54910.1.
    AK010424 mRNA. Translation: BAB26927.1.
    AK159504 mRNA. Translation: BAE35137.1.
    AK160594 mRNA. Translation: BAE35901.1.
    AC092479 Genomic DNA. No translation available.
    FO082281 Genomic DNA. No translation available.
    BC003839 mRNA. Translation: AAH03839.1.
    BC005427 mRNA. Translation: AAH05427.1.
    BC021638 mRNA. Translation: AAH21638.1.
    AF063886 Genomic DNA. Translation: AAC27929.1.
    CCDSiCCDS57236.1. [P97287-1]
    RefSeqiNP_032588.1. NM_008562.3. [P97287-1]
    UniGeneiMm.1639.

    Genome annotation databases

    EnsembliENSMUST00000037947; ENSMUSP00000044048; ENSMUSG00000038612. [P97287-1]
    ENSMUST00000178686; ENSMUSP00000135915; ENSMUSG00000038612. [P97287-2]
    GeneIDi17210.
    KEGGimmu:17210.
    UCSCiuc029unp.1. mouse. [P97287-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35623 mRNA. Translation: AAC31790.1 .
    GU182318 mRNA. Translation: ACZ54910.1 .
    AK010424 mRNA. Translation: BAB26927.1 .
    AK159504 mRNA. Translation: BAE35137.1 .
    AK160594 mRNA. Translation: BAE35901.1 .
    AC092479 Genomic DNA. No translation available.
    FO082281 Genomic DNA. No translation available.
    BC003839 mRNA. Translation: AAH03839.1 .
    BC005427 mRNA. Translation: AAH05427.1 .
    BC021638 mRNA. Translation: AAH21638.1 .
    AF063886 Genomic DNA. Translation: AAC27929.1 .
    CCDSi CCDS57236.1. [P97287-1 ]
    RefSeqi NP_032588.1. NM_008562.3. [P97287-1 ]
    UniGenei Mm.1639.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WSX NMR - A 152-308 [» ]
    2JM6 NMR - B 152-308 [» ]
    2NL9 X-ray 1.55 A 152-189 [» ]
    2NLA X-ray 2.80 A 152-189 [» ]
    2ROC NMR - A 152-308 [» ]
    2ROD NMR - A 152-308 [» ]
    3D7V X-ray 2.03 A 152-189 [» ]
    3IO9 X-ray 2.40 A 152-189 [» ]
    4BPI X-ray 1.98 A 152-189 [» ]
    4BPJ X-ray 1.60 A 152-189 [» ]
    4G35 X-ray 2.00 A 152-308 [» ]
    ProteinModelPortali P97287.
    SMRi P97287. Positions 148-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201344. 10 interactions.
    DIPi DIP-33343N.
    IntActi P97287. 14 interactions.
    MINTi MINT-209660.

    Chemistry

    BindingDBi P97287.
    ChEMBLi CHEMBL5768.

    PTM databases

    PhosphoSitei P97287.

    Proteomic databases

    PaxDbi P97287.
    PRIDEi P97287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037947 ; ENSMUSP00000044048 ; ENSMUSG00000038612 . [P97287-1 ]
    ENSMUST00000178686 ; ENSMUSP00000135915 ; ENSMUSG00000038612 . [P97287-2 ]
    GeneIDi 17210.
    KEGGi mmu:17210.
    UCSCi uc029unp.1. mouse. [P97287-1 ]

    Organism-specific databases

    CTDi 4170.
    MGIi MGI:101769. Mcl1.

    Phylogenomic databases

    eggNOGi NOG282183.
    GeneTreei ENSGT00510000048923.
    HOGENOMi HOG000232116.
    HOVERGENi HBG003527.
    InParanoidi P97287.
    KOi K02539.
    OMAi KDTKPMG.
    OrthoDBi EOG7S2209.
    PhylomeDBi P97287.
    TreeFami TF315834.

    Miscellaneous databases

    ChiTaRSi MCL1. mouse.
    EvolutionaryTracei P97287.
    NextBioi 291598.
    PROi P97287.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97287.
    Bgeei P97287.
    CleanExi MM_MCL1.
    Genevestigatori P97287.

    Family and domain databases

    InterProi IPR013281. Apop_reg_Mc1.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF6. PTHR11256:SF6. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01866. APOPREGMCL1.
    PR01862. BCL2FAMILY.
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells."
      Okita H., Umezawa A., Suzuki A., Hata J.
      Biochim. Biophys. Acta 1398:335-341(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
      Tissue: Fetus.
    2. "MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair."
      Kojima S., Hyakutake A., Koshikawa N., Nakagawara A., Takenaga K.
      Biochem. Biophys. Res. Commun. 391:492-497(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCALIZATION.
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo and Embryonic stem cell.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor and Salivary gland.
    6. "Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response."
      Chao J.-R., Wang J.-M., Lee S.-F., Peng H.-W., Lin Y.-H., Chou C.-H., Li J.-C., Huang H.-M., Chou C.-K., Kuo M.-L., Yen J.J.-Y., Yang-Yen H.-F.
      Mol. Cell. Biol. 18:4883-4898(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65, INDUCTION.
      Strain: 129/SvJ.
    7. "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
      Maurer U., Charvet C., Wagman A.S., Dejardin E., Green D.R.
      Mol. Cell 21:749-760(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS INHIBITOR OF APOPTOSIS, PHOSPHORYLATION AT SER-140 BY GSK3-ALPHA AND GSK3-BETA, INTERACTION WITH BCL2L11.
    8. "Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands."
      Day C.L., Chen L., Richardson S.J., Harrison P.J., Huang D.C.S., Hinds M.G.
      J. Biol. Chem. 280:4738-4744(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 152-308, INTERACTION WITH BCL2L11; BMF AND PMAIP.
    9. "Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1."
      Day C.L., Smits C., Fan F.C., Lee E.F., Fairlie W.D., Hinds M.G.
      J. Mol. Biol. 380:958-971(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 148-308 IN COMPLEXES WITH WITH BBC3 AND PMAIP1.

    Entry informationi

    Entry nameiMCL1_MOUSE
    AccessioniPrimary (citable) accession number: P97287
    Secondary accession number(s): D2K6L9
    , Q3TUS0, Q792P0, Q9CRI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3