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Protein

Chloride channel protein

Gene

CLC-3

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

ChlorideUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
Gene namesi
Name:CLC-3Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 9225HelicalUniRule annotationAdd
BLAST
Transmembranei156 – 17823HelicalUniRule annotationAdd
BLAST
Transmembranei198 – 21922HelicalUniRule annotationAdd
BLAST
Transmembranei226 – 24318HelicalUniRule annotationAdd
BLAST
Transmembranei255 – 27925HelicalUniRule annotationAdd
BLAST
Transmembranei328 – 35023HelicalUniRule annotationAdd
BLAST
Transmembranei370 – 38920HelicalUniRule annotationAdd
BLAST
Transmembranei441 – 46222HelicalUniRule annotationAdd
BLAST
Transmembranei474 – 49522HelicalUniRule annotationAdd
BLAST
Transmembranei515 – 54026HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000000815.

Structurei

3D structure databases

ProteinModelPortaliP97274.
SMRiP97274. Positions 592-753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini600 – 66465CBSInterPro annotationAdd
BLAST
Domaini697 – 75458CBSInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotationSAAS annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0475. Eukaryota.
COG0038. LUCA.
HOVERGENiHBG050984.

Family and domain databases

Gene3Di1.10.3080.10. 3 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002245. Cl_channel-3.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01114. CLCHANNEL3.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 3 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNGGSINSS THLLDLLDEP IPGVGTYDDF HTIDWVREKC KDRERHRRIN
60 70 80 90 100
SKKKESAWEM TKSLYDAWSG WLVVTLTGLA SGALAGLIDI AADWMTDLKE
110 120 130 140 150
GICLSALWYN HEQCCWGSNE TTFEERDKCP QWKTWAELII GQAEGPGSYI
160 170 180 190 200
MNYIMYIFWA LSFAFLAVSL VKVFAPYACG SGIPEIKTIL SGFIIRGYLG
210 220 230 240 250
KWTLMIKTIT LVLAVASGLS LGKEGPLVHV ACCCGNIFSY LFPKYSTNEA
260 270 280 290 300
KKREVLSAAS AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LGRSFFAALV
310 320 330 340 350
AAFVLRSINP FGNSRLVLFY VEYHTPWYLF ELFPFILLGV FGGLWGAFFI
360 370 380 390 400
RANIAWCRRR KSTKFGKYPV LEVIIVAAIT AVIAFPNPYT RLNTSELIKE
410 420 430 440 450
LFTDCGPLES SSLCDYRNDM NASKIVDDIP DRPAGVGVYS AIWQLCLALI
460 470 480 490 500
FKIIMTVFTF GIKVPSGLFI PSMAIGAIAG RIVGIAVEQL AYFHHDWFIF
510 520 530 540 550
KEWCEVGADC ITPGLYAMVG AAACLGGVTR MTVSLVVIVF ELTGGLEYIV
560 570 580 590 600
PLMAAVMTSK WVGDAFGREG IYEAHIRLNG YPFLDAKEEF THTTLAADVM
610 620 630 640 650
RPRRNDPPLA VLTQDNMTVD DIENMINETS YNGFPVIMSK ESQRLVGFAL
660 670 680 690 700
RRDLTIAIES ARKKQEGIVG SSRVCFAQHT PSLPAESPRP LKLRSILDMS
710 720 730 740 750
PFTVTDHTPM EIVVDIFRKL GLRQCLVTHN GRLLGIITKK DILRHMAQTA
760
NQDPASIMFN
Length:760
Mass (Da):84,357
Last modified:November 1, 1999 - v2
Checksum:iDF8D017D1881A531
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83464 mRNA. Translation: AAB88634.2.
RefSeqiNP_001166164.1. NM_001172693.1.

Genome annotation databases

GeneIDi100135501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83464 mRNA. Translation: AAB88634.2.
RefSeqiNP_001166164.1. NM_001172693.1.

3D structure databases

ProteinModelPortaliP97274.
SMRiP97274. Positions 592-753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000000815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135501.

Organism-specific databases

CTDi1182.

Phylogenomic databases

eggNOGiKOG0475. Eukaryota.
COG0038. LUCA.
HOVERGENiHBG050984.

Family and domain databases

Gene3Di1.10.3080.10. 3 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002245. Cl_channel-3.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01114. CLCHANNEL3.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 3 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular identification of a volume-regulated chloride channel."
    Duan D., Winter C., Cowley S., Hume J.R., Horowitz B.
    Nature 390:417-421(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Duan D., Winter C., Hume J.R., Horowitz B.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP97274_CAVPO
AccessioniPrimary (citable) accession number: P97274
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.