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P97272 (CCL5_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene names
Name:CCL5
Synonyms:SCYA5
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

activation of phospholipase D activity

Inferred from electronic annotation. Source: Ensembl

calcium ion transport

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Inferred from electronic annotation. Source: Ensembl

cellular calcium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

cellular protein complex assembly

Inferred from electronic annotation. Source: Ensembl

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

eosinophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

exocytosis

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

leukocyte cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation by host of viral transcription

Inferred from electronic annotation. Source: Ensembl

negative regulation of G-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of chemokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of macrophage apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of viral genome replication

Inferred from electronic annotation. Source: Ensembl

neutrophil activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of homotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of STAT protein

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

protein tetramerization

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

phospholipase activator activity

Inferred from electronic annotation. Source: Ensembl

protein kinase activity

Inferred from electronic annotation. Source: Ensembl

receptor signaling protein tyrosine kinase activator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9168C-C motif chemokine 5
PRO_0000005172

Amino acid modifications

Disulfide bond33 ↔ 57 By similarity
Disulfide bond34 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97272 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 7F6A31B751237DB9

FASTA9110,088
        10         20         30         40         50         60 
MKVSAAALCV ILTTAALCVP ASASPYASDT TPCCFAYISR ALPRTHIKEY FYTSSKCSNL 

        70         80         90 
AVVFVTRKNR QVCANPEKKW VREYINSLEM S 

« Hide

References

[1]Campbell E.M., Proudfoot A.E.I., Yoshimura T., Allet B., Wells T.N.C., White A.M., Westwick J., Watson M.L.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Dunkin-Hartley.
[2]Asano K., Nakamura M., Oguma T., Fukunaga K., Ishizaka A., Yamaguchi K., Kanazawa M.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77037 mRNA. Translation: AAC53293.1.
AB002662 mRNA. Translation: BAA19604.1.
RefSeqNP_001166398.1. NM_001172927.1.

3D structure databases

ProteinModelPortalP97272.
SMRP97272. Positions 24-91.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
GeneID100135495.

Organism-specific databases

CTD6352.

Phylogenomic databases

eggNOGNOG38896.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP97272.
OMAQEYFYTS.
OrthoDBEOG7CVQ1F.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL5_CAVPO
AccessionPrimary (citable) accession number: P97272
Secondary accession number(s): O09076
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families