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P97272

- CCL5_CAVPO

UniProt

P97272 - CCL5_CAVPO

Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.By similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. phosphatidylinositol phospholipase C activity Source: Ensembl
    3. phospholipase activator activity Source: Ensembl
    4. protein kinase activity Source: Ensembl
    5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase D activity Source: Ensembl
    2. calcium ion transport Source: Ensembl
    3. cell-cell signaling Source: Ensembl
    4. cellular calcium ion homeostasis Source: Ensembl
    5. cellular protein complex assembly Source: Ensembl
    6. cellular response to fibroblast growth factor stimulus Source: Ensembl
    7. cellular response to interferon-gamma Source: Ensembl
    8. cellular response to interleukin-1 Source: Ensembl
    9. cellular response to organic cyclic compound Source: Ensembl
    10. cellular response to tumor necrosis factor Source: Ensembl
    11. eosinophil chemotaxis Source: Ensembl
    12. exocytosis Source: Ensembl
    13. inflammatory response Source: UniProtKB-KW
    14. leukocyte cell-cell adhesion Source: Ensembl
    15. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    16. MAPK cascade Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
    19. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    20. negative regulation of macrophage apoptotic process Source: Ensembl
    21. negative regulation of T cell apoptotic process Source: Ensembl
    22. negative regulation of viral genome replication Source: Ensembl
    23. neutrophil activation Source: Ensembl
    24. positive regulation of calcium ion transport Source: Ensembl
    25. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
    26. positive regulation of cellular biosynthetic process Source: Ensembl
    27. positive regulation of epithelial cell proliferation Source: Ensembl
    28. positive regulation of homotypic cell-cell adhesion Source: Ensembl
    29. positive regulation of macrophage chemotaxis Source: Ensembl
    30. positive regulation of monocyte chemotaxis Source: Ensembl
    31. positive regulation of natural killer cell chemotaxis Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    33. positive regulation of smooth muscle cell migration Source: Ensembl
    34. positive regulation of smooth muscle cell proliferation Source: Ensembl
    35. positive regulation of T cell apoptotic process Source: Ensembl
    36. positive regulation of T cell chemotaxis Source: Ensembl
    37. positive regulation of T cell proliferation Source: Ensembl
    38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
    39. protein kinase B signaling Source: Ensembl
    40. protein tetramerization Source: Ensembl
    41. response to toxic substance Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 5
    Alternative name(s):
    SIS-delta
    Small-inducible cytokine A5
    T-cell-specific protein RANTES
    Gene namesi
    Name:CCL5
    Synonyms:SCYA5
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168C-C motif chemokine 5PRO_0000005172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 57By similarity
    Disulfide bondi34 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP97272.
    SMRiP97272. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP97272.
    OMAiCSIPAVV.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97272-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAAALCV ILTTAALCVP ASASPYASDT TPCCFAYISR ALPRTHIKEY   50
    FYTSSKCSNL AVVFVTRKNR QVCANPEKKW VREYINSLEM S 91
    Length:91
    Mass (Da):10,088
    Last modified:May 1, 1997 - v1
    Checksum:i7F6A31B751237DB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77037 mRNA. Translation: AAC53293.1.
    AB002662 mRNA. Translation: BAA19604.1.
    RefSeqiNP_001166398.1. NM_001172927.1.

    Genome annotation databases

    EnsembliENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
    GeneIDi100135495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77037 mRNA. Translation: AAC53293.1 .
    AB002662 mRNA. Translation: BAA19604.1 .
    RefSeqi NP_001166398.1. NM_001172927.1.

    3D structure databases

    ProteinModelPortali P97272.
    SMRi P97272. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000008932 ; ENSCPOP00000007949 ; ENSCPOG00000008852 .
    GeneIDi 100135495.

    Organism-specific databases

    CTDi 6352.

    Phylogenomic databases

    eggNOGi NOG38896.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P97272.
    OMAi CSIPAVV.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Campbell E.M., Proudfoot A.E.I., Yoshimura T., Allet B., Wells T.N.C., White A.M., Westwick J., Watson M.L.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Dunkin-Hartley.
    2. Asano K., Nakamura M., Oguma T., Fukunaga K., Ishizaka A., Yamaguchi K., Kanazawa M.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL5_CAVPO
    AccessioniPrimary (citable) accession number: P97272
    Secondary accession number(s): O09076
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3