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P97272

- CCL5_CAVPO

UniProt

P97272 - CCL5_CAVPO

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Protein
C-C motif chemokine 5
Gene
CCL5, SCYA5
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils By similarity.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. phosphatidylinositol phospholipase C activity Source: Ensembl
  3. phospholipase activator activity Source: Ensembl
  4. protein kinase activity Source: Ensembl
  5. receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. activation of phospholipase D activity Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cell-cell signaling Source: Ensembl
  5. cellular calcium ion homeostasis Source: Ensembl
  6. cellular protein complex assembly Source: Ensembl
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to organic cyclic compound Source: Ensembl
  11. cellular response to tumor necrosis factor Source: Ensembl
  12. eosinophil chemotaxis Source: Ensembl
  13. exocytosis Source: Ensembl
  14. inflammatory response Source: UniProtKB-KW
  15. leukocyte cell-cell adhesion Source: Ensembl
  16. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  19. negative regulation of T cell apoptotic process Source: Ensembl
  20. negative regulation of chemokine-mediated signaling pathway Source: Ensembl
  21. negative regulation of macrophage apoptotic process Source: Ensembl
  22. negative regulation of viral genome replication Source: Ensembl
  23. neutrophil activation Source: Ensembl
  24. positive regulation of T cell apoptotic process Source: Ensembl
  25. positive regulation of T cell chemotaxis Source: Ensembl
  26. positive regulation of T cell proliferation Source: Ensembl
  27. positive regulation of calcium ion transport Source: Ensembl
  28. positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
  29. positive regulation of cellular biosynthetic process Source: Ensembl
  30. positive regulation of epithelial cell proliferation Source: Ensembl
  31. positive regulation of homotypic cell-cell adhesion Source: Ensembl
  32. positive regulation of macrophage chemotaxis Source: Ensembl
  33. positive regulation of monocyte chemotaxis Source: Ensembl
  34. positive regulation of natural killer cell chemotaxis Source: Ensembl
  35. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  36. positive regulation of smooth muscle cell migration Source: Ensembl
  37. positive regulation of smooth muscle cell proliferation Source: Ensembl
  38. positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  39. protein kinase B signaling Source: Ensembl
  40. protein tetramerization Source: Ensembl
  41. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9168C-C motif chemokine 5
PRO_0000005172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57 By similarity
Disulfide bondi34 ↔ 73 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP97272.
SMRiP97272. Positions 24-91.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97272.
OMAiCSIPAVV.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97272-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSAAALCV ILTTAALCVP ASASPYASDT TPCCFAYISR ALPRTHIKEY   50
FYTSSKCSNL AVVFVTRKNR QVCANPEKKW VREYINSLEM S 91
Length:91
Mass (Da):10,088
Last modified:May 1, 1997 - v1
Checksum:i7F6A31B751237DB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77037 mRNA. Translation: AAC53293.1.
AB002662 mRNA. Translation: BAA19604.1.
RefSeqiNP_001166398.1. NM_001172927.1.

Genome annotation databases

EnsembliENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
GeneIDi100135495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77037 mRNA. Translation: AAC53293.1 .
AB002662 mRNA. Translation: BAA19604.1 .
RefSeqi NP_001166398.1. NM_001172927.1.

3D structure databases

ProteinModelPortali P97272.
SMRi P97272. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000008932 ; ENSCPOP00000007949 ; ENSCPOG00000008852 .
GeneIDi 100135495.

Organism-specific databases

CTDi 6352.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P97272.
OMAi CSIPAVV.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Campbell E.M., Proudfoot A.E.I., Yoshimura T., Allet B., Wells T.N.C., White A.M., Westwick J., Watson M.L.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dunkin-Hartley.
  2. Asano K., Nakamura M., Oguma T., Fukunaga K., Ishizaka A., Yamaguchi K., Kanazawa M.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL5_CAVPO
AccessioniPrimary (citable) accession number: P97272
Secondary accession number(s): O09076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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