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Protein

C-C motif chemokine 5

Gene

CCL5

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:CCL5
Synonyms:SCYA5
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168C-C motif chemokine 5PRO_0000005172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007949.

Structurei

3D structure databases

ProteinModelPortaliP97272.
SMRiP97272. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97272.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAAALCV ILTTAALCVP ASASPYASDT TPCCFAYISR ALPRTHIKEY
60 70 80 90
FYTSSKCSNL AVVFVTRKNR QVCANPEKKW VREYINSLEM S
Length:91
Mass (Da):10,088
Last modified:May 1, 1997 - v1
Checksum:i7F6A31B751237DB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77037 mRNA. Translation: AAC53293.1.
AB002662 mRNA. Translation: BAA19604.1.
RefSeqiNP_001166398.1. NM_001172927.1.

Genome annotation databases

EnsembliENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
GeneIDi100135495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77037 mRNA. Translation: AAC53293.1.
AB002662 mRNA. Translation: BAA19604.1.
RefSeqiNP_001166398.1. NM_001172927.1.

3D structure databases

ProteinModelPortaliP97272.
SMRiP97272. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000007949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000008932; ENSCPOP00000007949; ENSCPOG00000008852.
GeneIDi100135495.

Organism-specific databases

CTDi6352.

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97272.
OMAiQEYFYTS.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR030595. CCL5.
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF82. PTHR12015:SF82. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Campbell E.M., Proudfoot A.E.I., Yoshimura T., Allet B., Wells T.N.C., White A.M., Westwick J., Watson M.L.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dunkin-Hartley.
  2. Asano K., Nakamura M., Oguma T., Fukunaga K., Ishizaka A., Yamaguchi K., Kanazawa M.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL5_CAVPO
AccessioniPrimary (citable) accession number: P97272
Secondary accession number(s): O09076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.