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Protein

60 kDa chaperonin

Gene

groL

Organism
Tsukamurella tyrosinosolvens
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Heat shock protein 60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, hsp60
OrganismiTsukamurella tyrosinosolvens
Taxonomic identifieri57704 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesTsukamurellaceaeTsukamurella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 53953960 kDa chaperoninPRO_0000063592Add
BLAST

Proteomic databases

PRIDEiP97086.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTIAFDKK ARRGLERGLN ALADAVKVTL GPKGRNVVLE KKWGAPTITN
60 70 80 90 100
DGVSIAKEIE LEDPYEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVR
110 120 130 140 150
EGLRNVAAGA NPLGLKRGIE KAVEAVTEHL LKAAKEVETK DQIAATAGIS
160 170 180 190 200
AGDPAIGELI AEAMDKVGKE GVITVEESNT FGLQLELTEG MRFDKGFISG
210 220 230 240 250
YFATDAERQE AVLEDPYVLL VSGKISTVKD LLPLLEKVIQ SGKPLAIIAE
260 270 280 290 300
DVEGEALVTL IVNKIRGTFK SVAIKAPGFG DRRKAMLQDM AILTGGQVIS
310 320 330 340 350
EEIGLSLDTA GLEVLGQARQ VVVTKDETTI VDGAGSKEQI AGRVSQIRAE
360 370 380 390 400
IENSDSDYDR EKLQERLAKL AGGVAVIKAG AATEDLKERK HRIEDAVRNA
410 420 430 440 450
KAAVEEGIVA GGGSSLAQSG TVFDSXALEG DEATGANIVK VALDAPVKQI
460 470 480 490 500
AVNAGLEPGV VAEKVRNSPA GTGLNAATGV YEDLLAAGIN DPVKVTRSAL
510 520 530
QNAASIAALF LTTEAVVADK PEKAGAPVDP TGGMGGMDF
Length:539
Mass (Da):56,138
Last modified:May 1, 1997 - v1
Checksum:i6335314830C9B662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90204 Genomic DNA. Translation: AAB49990.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90204 Genomic DNA. Translation: AAB49990.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP97086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tsukamurella tyrosinosolvens sp. nov. hsp60 gene for heat shock protein 60."
    Zimmermann O., Pinkenburg O., Koechel H.G.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IMMIB D-1411.

Entry informationi

Entry nameiCH60_TSUTY
AccessioniPrimary (citable) accession number: P97086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.