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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciLINT189518:GJBB-153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:LA_0178
OrganismiLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifieri189518 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001408 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalUniRule annotationAdd
BLAST
Transmembranei417 – 43721HelicalUniRule annotationAdd
BLAST
Transmembranei488 – 50821HelicalUniRule annotationAdd
BLAST
Transmembranei536 – 55621HelicalUniRule annotationAdd
BLAST
Transmembranei575 – 59521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Membrane protein insertase YidCPRO_0000124721Add
BLAST

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

STRINGi189518.LA_0178.

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000040197.
InParanoidiP97041.
KOiK03217.
OMAiNEYTDID.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

P97041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDRQTRLFL ALILSMGIWM GVNYFFFPNT STKKNTETKQ TQSDKTSENT
60 70 80 90 100
KQQITSGKTK ESNSADPVVQ KEKITPFDTK KSFIVTDSYI VEFSSLGGKI
110 120 130 140 150
SKFYMKDFTG PNGELIQVAR KNPETVVVDG KSYQAVELSR DKGFDFNFSD
160 170 180 190 200
SLVEISDSPW NYIQFSLTED KINHSISFSA VSPDRSYQLK KEFRFYPSEN
210 220 230 240 250
YFKLSISIIN FSKEKLSFAS QKNVRYLRTF GSLGPYPKDR PLSDRDTANF
260 270 280 290 300
FRFYYLGGSF QDTLDGSSSV GFWSSVGNFF TGNSGTDESF SIKTDKESGV
310 320 330 340 350
DFAGTGSRYF IAVADPLDHK PHGIVLDNRP KNESGAVLVY DNILLNPGEN
360 370 380 390 400
YNLDFASYIG IRESEGMAFK NPELDPSQSK NSPFVGLSSD LNKSFNQGIT
410 420 430 440 450
TPFRNGIIWI LKQIYRFTIP NYGWSIIIFA ILFKLVFYPL NQKQADSMKK
460 470 480 490 500
MQELSPQLKT INEKFANDPK MRQQKTMELY KKNNVNPVGG CLPMVIQIPI
510 520 530 540 550
FIALYTAFSD TIDLWNSPFL WVKDLSEPDV IWTSPAIPYF TQTGIGLNLL
560 570 580 590 600
ALLMVGTQVF QTRMTSVSMD PNQKMLMYVM PVMMLYIFWN MPSGVTLYWT
610 620
FQNVLSIGQQ WITNHLKKTE EKKKAKV
Length:627
Mass (Da):71,456
Last modified:November 21, 2003 - v2
Checksum:i9D4DAD8A68E00723
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741L → F in BAA19448 (PubMed:9666070).Curated
Sequence conflicti374 – 3741L → F in BAA24371 (PubMed:9666070).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001721 Genomic DNA. Translation: BAA19448.1.
AB010203 Genomic DNA. Translation: BAA24371.1.
AE010300 Genomic DNA. Translation: AAN47377.1.
PIRiT00124.
RefSeqiNP_710359.1. NC_004342.2.
WP_000390191.1. NC_004342.2.

Genome annotation databases

EnsemblBacteriaiAAN47377; AAN47377; LA_0178.
GeneIDi1149521.
KEGGilil:LA_0178.
PATRICi22381195. VBILepInt91350_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001721 Genomic DNA. Translation: BAA19448.1.
AB010203 Genomic DNA. Translation: BAA24371.1.
AE010300 Genomic DNA. Translation: AAN47377.1.
PIRiT00124.
RefSeqiNP_710359.1. NC_004342.2.
WP_000390191.1. NC_004342.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189518.LA_0178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN47377; AAN47377; LA_0178.
GeneIDi1149521.
KEGGilil:LA_0178.
PATRICi22381195. VBILepInt91350_0177.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000040197.
InParanoidiP97041.
KOiK03217.
OMAiNEYTDID.

Enzyme and pathway databases

BioCyciLINT189518:GJBB-153-MONOMER.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIDC_LEPIN
AccessioniPrimary (citable) accession number: P97041
Secondary accession number(s): Q8F9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.