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Protein

Phenylalanine dehydrogenase

Gene

pdh

Organism
Sporosarcina ureae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible, NAD-dependent deamination of L-phenylalanine to phenyl pyruvate, ammonia and NADH.By similarity

Catalytic activityi

L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH.By similarity

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Phenylalanine dehydrogenase (pdh)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route), the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561NADBy similarity
Binding sitei80 – 801SubstrateBy similarity
Active sitei92 – 921PROSITE-ProRule annotationBy similarity
Binding sitei127 – 1271NADBy similarity
Binding sitei158 – 1581NADBy similarity
Binding sitei162 – 1621NADBy similarity
Binding sitei275 – 2751SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi192 – 1987NADBy similarity
Nucleotide bindingi215 – 2162NADBy similarity
Nucleotide bindingi252 – 2532NADBy similarity
Nucleotide bindingi273 – 2753NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00121; UER00346.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine dehydrogenase1 Publication (EC:1.4.1.20By similarity)
Short name:
PheDH
Gene namesi
Name:pdh
OrganismiSporosarcina ureae
Taxonomic identifieri1571 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPlanococcaceaeSporosarcina

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Phenylalanine dehydrogenasePRO_0000182808Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP97014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVTLEQTL QDDKASVLDK MVEHEQILFC HDKATGLQAI IAVHDTTMGP
60 70 80 90 100
ALGGCRMAPY KTMDLALKDV LRLSKGMTYK CAAADVDFGG GKSVIIGDPL
110 120 130 140 150
KDKTPEKFRA FGQFIESLNG RFYTGTDMGT TLEDFVHAMK ETNYIVGKPV
160 170 180 190 200
EYGGGGDSSI PTALGVFYGI KATNQNLFGD DKVEGRKYSI QGLGKVGYKV
210 220 230 240 250
AEHIINEGGN VIVTDINEQA IADIQKLGGS AVRVVSSEEI YSQQADVFVP
260 270 280 290 300
CAFGGVINDD TLKVLKVRGI SGSANNQLAE SRHGELLREK GILYAPDYIV
310 320 330 340 350
NGGGLIQVAD ELYGTNPARV LAKTENIYTS LLEVFHQAEQ DHMTTATAAD
360 370
RMCEKRIADA KNRNSFFTQS NRPKWNFHQ
Length:379
Mass (Da):41,329
Last modified:May 1, 1997 - v1
Checksum:i3764391A07B4C0A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001031 Genomic DNA. Translation: BAA19221.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001031 Genomic DNA. Translation: BAA19221.1.

3D structure databases

ProteinModelPortaliP97014.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00121; UER00346.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phenylalanine dehydrogenase."
    Asano Y.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: R04.

Entry informationi

Entry nameiDHPH_SPOUR
AccessioniPrimary (citable) accession number: P97014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.