Reviewed, UniProtKB/Swiss-Prot P97014 (DHPH_SPOUR)

Names and origin

Protein names

Recommended name:
    Phenylalanine dehydrogenase
      Short name=PheDH
    EC=1.4.1.20

Gene names

Name:

pdh

Organism

Sporosarcina ureae

Taxonomic identifier

1571 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Planococcaceae › Sporosarcina

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-phenylalanine + H(2)O + NAD(+) = phenylpyruvate + NH(3) + NADH.
Pathway	Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from phenylpyruvate (PDH route): step 1/1.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro phenylalanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Phenylalanine dehydrogenase		PRO_0000182808
Regions
	Nucleotide binding	192 – 198	7	NAD Potential
Sites
	Active site	92	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97014-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 3764391A07B4C0A8	FASTA	379	41,329
	10 20 30 40 50 60 MILVTLEQTL QDDKASVLDK MVEHEQILFC HDKATGLQAI IAVHDTTMGP ALGGCRMAPY 70 80 90 100 110 120 KTMDLALKDV LRLSKGMTYK CAAADVDFGG GKSVIIGDPL KDKTPEKFRA FGQFIESLNG 130 140 150 160 170 180 RFYTGTDMGT TLEDFVHAMK ETNYIVGKPV EYGGGGDSSI PTALGVFYGI KATNQNLFGD 190 200 210 220 230 240 DKVEGRKYSI QGLGKVGYKV AEHIINEGGN VIVTDINEQA IADIQKLGGS AVRVVSSEEI 250 260 270 280 290 300 YSQQADVFVP CAFGGVINDD TLKVLKVRGI SGSANNQLAE SRHGELLREK GILYAPDYIV 310 320 330 340 350 360 NGGGLIQVAD ELYGTNPARV LAKTENIYTS LLEVFHQAEQ DHMTTATAAD RMCEKRIADA 370 KNRNSFFTQS NRPKWNFHQ

References

[1]	"Phenylalanine dehydrogenase." Asano Y. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: R04.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB001031 Genomic DNA. Translation: BAA19221.1.
3D structure databases
HSSP	HSSP built from PDB template 1C1D based on UniProtKB Q59771.
ModBase	Search...
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DHase. IPR006096. Glu/Leu/Phe/Val_DHase_C. IPR006097. Glu/Leu/Phe/Val_DHase_dimer. IPR016211. Glu/Phe/Leu/Val_DHase_bac/arc. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000188. Phe_leu_dh. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHPH_SPOUR

Accession

Primary (citable) accession number: P97014

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1997
Last modified:	November 25, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)