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Protein

Phenylalanine dehydrogenase

Gene

pdh

Organism
Sporosarcina ureae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible, NAD-dependent deamination of L-phenylalanine to phenyl pyruvate, ammonia and NADH.By similarity

Catalytic activityi

L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH.By similarity

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Phenylalanine dehydrogenase (pdh)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from phenylpyruvate (PDH route), the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56NADBy similarity1
Binding sitei80SubstrateBy similarity1
Active sitei92PROSITE-ProRule annotationBy similarity1
Binding sitei127NADBy similarity1
Binding sitei158NADBy similarity1
Binding sitei162NADBy similarity1
Binding sitei275SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 198NADBy similarity7
Nucleotide bindingi215 – 216NADBy similarity2
Nucleotide bindingi252 – 253NADBy similarity2
Nucleotide bindingi273 – 275NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00121; UER00346

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine dehydrogenase1 Publication (EC:1.4.1.20By similarity)
Short name:
PheDH
Gene namesi
Name:pdh
OrganismiSporosarcina ureae
Taxonomic identifieri1571 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPlanococcaceaeSporosarcina

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001828081 – 379Phenylalanine dehydrogenaseAdd BLAST379

Proteomic databases

PRIDEiP97014

Structurei

3D structure databases

ProteinModelPortaliP97014
SMRiP97014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR016211 Glu/Phe/Leu/Val_DH_bac/arc
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR42722 PTHR42722, 1 hit
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000188 Phe_leu_dh, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P97014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVTLEQTL QDDKASVLDK MVEHEQILFC HDKATGLQAI IAVHDTTMGP
60 70 80 90 100
ALGGCRMAPY KTMDLALKDV LRLSKGMTYK CAAADVDFGG GKSVIIGDPL
110 120 130 140 150
KDKTPEKFRA FGQFIESLNG RFYTGTDMGT TLEDFVHAMK ETNYIVGKPV
160 170 180 190 200
EYGGGGDSSI PTALGVFYGI KATNQNLFGD DKVEGRKYSI QGLGKVGYKV
210 220 230 240 250
AEHIINEGGN VIVTDINEQA IADIQKLGGS AVRVVSSEEI YSQQADVFVP
260 270 280 290 300
CAFGGVINDD TLKVLKVRGI SGSANNQLAE SRHGELLREK GILYAPDYIV
310 320 330 340 350
NGGGLIQVAD ELYGTNPARV LAKTENIYTS LLEVFHQAEQ DHMTTATAAD
360 370
RMCEKRIADA KNRNSFFTQS NRPKWNFHQ
Length:379
Mass (Da):41,329
Last modified:May 1, 1997 - v1
Checksum:i3764391A07B4C0A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001031 Genomic DNA Translation: BAA19221.1

Similar proteinsi

Entry informationi

Entry nameiDHPH_SPOUR
AccessioniPrimary (citable) accession number: P97014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health