P96994 (GALT_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	SMU_887

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_0000169913
Experimental info
	Sequence conflict	27	1	S → R in AAB49737. Ref.1
	Sequence conflict	48	1	L → R in AAB49737. Ref.1
	Sequence conflict	98	1	N → Y in AAB49737. Ref.1
	Sequence conflict	117	1	N → D in AAB49737. Ref.1
	Sequence conflict	286	1	R → H in AAB49737. Ref.1
	Sequence conflict	383	1	I → V in AAB49737. Ref.1
	Sequence conflict	452	1	I → V in AAB49737. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P96994 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 25A5981BB50BF9A0	FASTA	491	55,445
	10 20 30 40 50 60 MTALLDTFVS KIIENSDYAE LDATYLSNRI LALVGEDNAQ QDTNQSNLIA LKDELVDLAV 70 80 90 100 110 120 VNGKVGDLAE EKDCLGAELM NFITPIPSQV NKAFWDTNAK SPQKAIKDFY ELSKRNNYIK 130 140 150 160 170 180 VTAIAKNIAF TTSSVYGDID ITINLSKPEK DPKAIAAAKL AKTSNYPKCQ LCMENEGYQG 190 200 210 220 230 240 RINYPARANH RIIRMNLGDE KWGFQYSPYA YFNEHCIFLN TEHVPMVISQ NTFRQLLDIV 250 260 270 280 290 300 DIFPGYFAGS NSDLPIVGGS ILSHNHYQGG RHIFPMEIAE LDSVFRFKDF PDVTAGIVKW 310 320 330 340 350 360 PMSVIRLRGA NKYSLVELAE IIRLAWRNYS DDTMNILAFT GDTPHHTVTP IARKRDGQFE 370 380 390 400 410 420 LDIVLRDNHT TAEYPDGVYH PHIDVQHIKK ENIGLIEVMG LAILPPRLKK ELAEVEKYVL 430 440 450 460 470 480 NQYNEMADYH KDWADAIKAS HPETSSETVS EIVKQAVGRT FVRVLEDAGV YKRNRQGQAA 490 FMRFVESIGV K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization and nucleotide sequence of the Streptococcus mutans galactose operon." Ajdic D., Sutcliffe I.C., Russell R.R.B., Ferretti J.J. Gene 180:137-144(1996) [PubMed: 8973358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Ingbritt.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U21942 Genomic DNA. Translation: AAB49737.1. AE014133 Genomic DNA. Translation: AAN58601.1.
PIR	JC5312.
RefSeq	NP_721295.1. NC_004350.2.
3D structure databases
ProteinModelPortal	P96994.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000014081; EBSTRP00000013563; EBSTRG00000014081.
GeneID	1028252.
GenomeReviews	Gene locus SMU_887 in contig AE014133_GR.
KEGG	smu:SMU_887.
NMPDR	fig|210007.1.peg.808.
PATRIC	19663923. VBIStrMut61772_0794.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027103.
HOGENOM	HBG337915.
OMA	HYFIGSN.
ProtClustDB	PRK05270.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_887-MONOMER.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_STRMU

Accession

Primary (citable) accession number: P96994

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 28, 2002
Last modified:	January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program