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Reviewed, UniProtKB/Swiss-Prot P96994 (GALT_STRMU)

Last modified November 3, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene names
Name: galT
Ordered Locus Names: SMU_887
OrganismStreptococcus mutans [Complete proteome] [HAMAP]
Taxonomic identifier1309 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

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Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571

Pathway

Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Galactose metabolism
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgalactose metabolic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionUDP-glucose:hexose-1-phosphate uridylyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Galactose-1-phosphate uridylyltransferase HAMAP MF_00571
PRO_0000169913

Experimental info

Sequence conflict271S → R in AAB49737. Ref.1
Sequence conflict481L → R in AAB49737. Ref.1
Sequence conflict981N → Y in AAB49737. Ref.1
Sequence conflict1171N → D in AAB49737. Ref.1
Sequence conflict2861R → H in AAB49737. Ref.1
Sequence conflict3831I → V in AAB49737. Ref.1
Sequence conflict4521I → V in AAB49737. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P96994-1 [UniParc].

Last modified November 28, 2002. Version 2.
Checksum: 25A5981BB50BF9A0

FASTA49155,445
        10         20         30         40         50         60 
MTALLDTFVS KIIENSDYAE LDATYLSNRI LALVGEDNAQ QDTNQSNLIA LKDELVDLAV 

        70         80         90        100        110        120 
VNGKVGDLAE EKDCLGAELM NFITPIPSQV NKAFWDTNAK SPQKAIKDFY ELSKRNNYIK 

       130        140        150        160        170        180 
VTAIAKNIAF TTSSVYGDID ITINLSKPEK DPKAIAAAKL AKTSNYPKCQ LCMENEGYQG 

       190        200        210        220        230        240 
RINYPARANH RIIRMNLGDE KWGFQYSPYA YFNEHCIFLN TEHVPMVISQ NTFRQLLDIV 

       250        260        270        280        290        300 
DIFPGYFAGS NSDLPIVGGS ILSHNHYQGG RHIFPMEIAE LDSVFRFKDF PDVTAGIVKW 

       310        320        330        340        350        360 
PMSVIRLRGA NKYSLVELAE IIRLAWRNYS DDTMNILAFT GDTPHHTVTP IARKRDGQFE 

       370        380        390        400        410        420 
LDIVLRDNHT TAEYPDGVYH PHIDVQHIKK ENIGLIEVMG LAILPPRLKK ELAEVEKYVL 

       430        440        450        460        470        480 
NQYNEMADYH KDWADAIKAS HPETSSETVS EIVKQAVGRT FVRVLEDAGV YKRNRQGQAA 

       490 
FMRFVESIGV K

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References

« Hide 'large scale' references
[1]"Organization and nucleotide sequence of the Streptococcus mutans galactose operon."
Ajdic D., Sutcliffe I.C., Russell R.R.B., Ferretti J.J.
Gene 180:137-144(1996) [PubMed: 8973358] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Ingbritt.
[2]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159 / Serotype c.

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Cross-references

Sequence databases

U21942 Genomic DNA. Translation: AAB49737.1.
AE014133 Genomic DNA. Translation: AAN58601.1.
PIRJC5312.
RefSeqNP_721295.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1028252.
GenomeReviewsGene locus SMU_887 in contig AE014133_GR.
KEGGsmu:SMU.887.
NMPDRfig|210007.1.peg.808.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP96994.
OMAEHYQGGR.

Enzyme and pathway databases

BioCycSMUT210007:SMU_887-MON.
BRENDA2.7.7.12. 20716.

Family and domain databases

HAMAPMF_00571.
[Tree]
InterProIPR000766. GalP_uridyl_Trfase_II.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
[Graphical view]
PfamPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFPIRSF006005. GalT_BS. 1 hit.
TIGRFAMsTIGR01239. galT_2. 1 hit.
PROSITEPS01163. GAL_P_UDP_TRANSF_II. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGALT_STRMU
AccessionPrimary (citable) accession number: P96994
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: November 3, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents