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P96989 (OMPB_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane protein B
Alternative name(s):
168 kDa surface-layer protein
Cell surface antigen 5
Short name=Sca5
Surface protein antigen
rOmp B
Short name=rOmpB

Cleaved into the following 2 chains:

  1. 120 kDa surface-exposed protein
    Alternative name(s):
    120 kDa outer membrane protein OmpB
    Surface protein antigen
    p120
  2. 32 kDa beta peptide
Gene names
Name:ompB
Synonyms:slp
Ordered Locus Names:RT0699
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length1645 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The 120 kDa surface-exposed protein is a major structural protein which may play a role as a rickettsial virulence factor and/or immunogen during infection.

The 32 kDa beta peptide may serve as a membrane anchor.

Subcellular location

Outer membrane protein B: Periplasm By similarity.

120 kDa surface-exposed protein: Secreted. Cell surface. Note: Surface exposed. This bacterium is covered by a S-layer with hexagonal symmetry.

32 kDa beta peptide: Cell outer membrane; Multi-pass membrane protein Potential. Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.

Sequence similarities

Belongs to the rickettsiae OmpA/OmpB family.

Contains 1 autotransporter (TC 1.B.12) domain. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16451645Outer membrane protein B
PRO_0000387583
Chain1 – 13281328120 kDa surface-exposed protein
PRO_0000032660
Propeptide1329 – 135224 Potential
PRO_0000032661
Chain1353 – 164529332 kDa beta peptide
PRO_0000032662

Regions

Domain1357 – 1645289Autotransporter

Experimental info

Sequence conflict6571H → N AA sequence Ref.3
Sequence conflict8421V → I AA sequence Ref.3
Sequence conflict10711G → A AA sequence Ref.3
Sequence conflict13061G → S AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
P96989 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0CB5641C7EB185EE

FASTA1,645169,698
        10         20         30         40         50         60 
MAQKPNFLKK IISAGLVTAS TATIVAGFSG VAMGAVMQYN RTTNAAATTV DGAGFDQTGA 

        70         80         90        100        110        120 
GVNLPVATNS VITANSNNAI TFNTPNGNLN SLFLDTANTL AVTINENTTL GFVTNVTKQG 

       130        140        150        160        170        180 
NFFNFTIGAG KSLTITGHGI TAQQAATTKS AQNVVSKVNA GAAINDNDLS GVGSIDFTAA 

       190        200        210        220        230        240 
PSVLEFNLIN PTTQEAPLTL GDNAKIVNGA NGILNITNGF VKVSDKTFAG IKTINIGDNQ 

       250        260        270        280        290        300 
GLMFNTTPDA ANALNLQGGG NTINFNGRDG TGKLVLVSKN GNATEFNVTG SLGGNLKGVI 

       310        320        330        340        350        360 
EFDTTAAAGK LIANGGAANA VIGTDNGAGR AAGFIVSVDN GNAATISGQV YAKDIVIQSA 

       370        380        390        400        410        420 
NAGGQVTFEH LVDVGLGGKT NFKTADSKVI ITENASFGST DFGNLAVQIV VPNNKILTGN 

       430        440        450        460        470        480 
FIGDAKNNGN TAGVITFNAN GTLVSGNTDP NIVVTNIKAI EVEGAGIVQL SGIHGAELRL 

       490        500        510        520        530        540 
GNAGSIFKLA DGTVINGPVN QNPLVNNNAL AAGSIQLDGS AIITGDIGNG AVNAALQDIT 

       550        560        570        580        590        600 
LANDASKILT LSGANIIGAN AGGAIHFQAN GGTIQLTSTQ NNILVDFDLD VTTDQTGVVD 

       610        620        630        640        650        660 
ASSLTNNQTL TINGSIGTIG ANTKTLGRFN VGSSKTILNA GDVAINELVM ENDGSVHLTH 

       670        680        690        700        710        720 
NTYLITKTIN AANQGKIIVA ADPINTDTAL ADGTNLGSAE SPLSNIHFAT KAANGDSILH 

       730        740        750        760        770        780 
IGKGVNLYAN NITTTDANVG SLHFRSGGTS IVSGTVGGQQ GLKLNNLILD NGTTVKFLGD 

       790        800        810        820        830        840 
ITFNGGTKIE GKSILQISSN YITDHIESAD NTGTLEFVNT DPITVTLNKQ GAYFGVLKQV 

       850        860        870        880        890        900 
MVSGPGNIAF NEIGNGVAHA IAVDSISFEN ASLGASLFLL SGTPLDVLTI KSTVGNGTVD 

       910        920        930        940        950        960 
NFNAPILVVS GIDSMINNGQ VIGDQKNIIA LSLGSDNSIT VNSNTLYAGI RTTKTNQGTV 

       970        980        990       1000       1010       1020 
TLSGGIPNNP GTIYGLGLEN GDPKLKQVTF TTDYNNLGSI IATNVTINDD VTLTTGGIAG 

      1030       1040       1050       1060       1070       1080 
TDFDGKITLG SINGNANVKF VDRTFSHPTS MIVSTKANQG TVTYLGNALV GNIGSSDIPV 

      1090       1100       1110       1120       1130       1140 
ASVRFTGNDS GVGLQGNIHS QNIDFGTYNL TILNSDVILG GGTTAINGEI DLLTNNLIFA 

      1150       1160       1170       1180       1190       1200 
NGTSTWGNNT SLSTTLNVSN GNVGQIVIAE GAQVNATTTG TTTIKIQDNA NANFSGTQTY 

      1210       1220       1230       1240       1250       1260 
TLIQGGARFN GTLGAPNFDV TGNNIFVKYE LIRDANQDYV LTRTNDVLNV VTTAVGNSAI 

      1270       1280       1290       1300       1310       1320 
ANAPGVHQNI AICLESTDTA AYNNMLLAKD SSDVATFIGA IATDTGAAVA TVNLNDTQKT 

      1330       1340       1350       1360       1370       1380 
QDLLGNRLGA LRYLSNSETA DVGGSETGAV SSGDEAIDQV SYGVWAKPFY NIAEQDKKGG 

      1390       1400       1410       1420       1430       1440 
LAGYKAKTAG VVVGLDTLAN DNLMIGAAIG ITKTDIKHQD YKKGDKTDIK GLSFSLYGAQ 

      1450       1460       1470       1480       1490       1500 
QLVKNFFAQG SAIFTLNKVK SKSQRYFFDA NGKMNKQIAA GNYDNITFGG NLMFGYDYNA 

      1510       1520       1530       1540       1550       1560 
LQGVLVTPMA GLSYLKSSNE NYKETGTTVA NKRIHSKFSD RIDLIVGAKV TGSAMNINDI 

      1570       1580       1590       1600       1610       1620 
VIYPEIHSFV VHKVNGKLSK AQSMLDGQTA PFISQPDRTA KTSYNIGLSA NIRSDAKMEY 

      1630       1640 
GIGYDFNAAS KYTAHQGTLK VRINF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of the gene encoding the crystalline surface layer protein of Rickettsia typhi."
Hahn M.-J., Kim K.-K., Kim I., Chang W.-H.
Gene 133:129-133(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.
[2]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.
[3]"Mapping of monoclonal antibody binding sites on CNBr fragments of the S-layer protein antigens of Rickettsia typhi and Rickettsia prowazekii."
Ching W.M., Carl M., Dasch G.A.
Mol. Immunol. 29:95-105(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
Strain: ATCC VR-144 / Wilmington.
[4]"Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing."
Hackstadt T., Messer R., Cieplak W. Jr., Peacock M.G.
Infect. Immun. 60:159-165(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1353-1371, IDENTIFICATION OF CLEAVAGE SITE.
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04661 Unassigned DNA. Translation: AAB48987.1.
AE017197 Genomic DNA. Translation: AAU04158.1.
PIRJN0896.
RefSeqYP_067640.1. NC_006142.1.

3D structure databases

ProteinModelPortalP96989.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04158; AAU04158; RT0699.
GeneID2959181.
KEGGrty:RT0699.
PATRIC17910646. VBIRicTyp34752_0718.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000010784.
OMADITVGQD.
OrthoDBEOG63NMCR.
ProtClustDBCLSK871043.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-733-MONOMER.

Family and domain databases

Gene3D2.40.128.130. 1 hit.
InterProIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR022095. rOmpB.
[Graphical view]
PfamPF03797. Autotransporter. 1 hit.
PF12334. rOmpB. 1 hit.
[Graphical view]
SMARTSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMSSF103515. SSF103515. 2 hits.
TIGRFAMsTIGR01414. autotrans_barl. 1 hit.
PROSITEPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOMPB_RICTY
AccessionPrimary (citable) accession number: P96989
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names