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P96989

- OMPB_RICTY

UniProt

P96989 - OMPB_RICTY

Protein

Outer membrane protein B

Gene

ompB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    The 120 kDa surface-exposed protein is a major structural protein which may play a role as a rickettsial virulence factor and/or immunogen during infection.
    The 32 kDa beta peptide may serve as a membrane anchor.

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-733-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein B
    Alternative name(s):
    168 kDa surface-layer protein
    Cell surface antigen 5
    Short name:
    Sca5
    Surface protein antigen
    rOmp B
    Short name:
    rOmpB
    Cleaved into the following 2 chains:
    Alternative name(s):
    120 kDa outer membrane protein OmpB
    Surface protein antigen
    p120
    Gene namesi
    Name:ompB
    Synonyms:slp
    Ordered Locus Names:RT0699
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Chain 120 kDa surface-exposed protein : Secreted. Cell surface
    Note: Surface exposed. This bacterium is covered by a S-layer with hexagonal symmetry.
    Chain 32 kDa beta peptide : Cell outer membrane Curated; Multi-pass membrane protein Curated
    Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. cell surface Source: UniProtKB-SubCell
    3. extracellular region Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane, Periplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16451645Outer membrane protein BPRO_0000387583Add
    BLAST
    Chaini1 – 13281328120 kDa surface-exposed proteinPRO_0000032660Add
    BLAST
    Propeptidei1329 – 135224Sequence AnalysisPRO_0000032661Add
    BLAST
    Chaini1353 – 164529332 kDa beta peptidePRO_0000032662Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0699.

    Structurei

    3D structure databases

    ProteinModelPortaliP96989.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1357 – 1645289AutotransporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rickettsiae OmpA/OmpB family.Curated
    Contains 1 autotransporter (TC 1.B.12) domain. [View classification]PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000010784.
    OMAiAMNINDI.
    OrthoDBiEOG63NMCR.

    Family and domain databases

    Gene3Di2.40.128.130. 1 hit.
    InterProiIPR005546. Auto_transptbeta.
    IPR006315. OM_autotransptr_brl.
    IPR022095. rOmpB.
    [Graphical view]
    PfamiPF03797. Autotransporter. 1 hit.
    PF12334. rOmpB. 1 hit.
    [Graphical view]
    SMARTiSM00869. Autotransporter. 1 hit.
    [Graphical view]
    SUPFAMiSSF103515. SSF103515. 2 hits.
    TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
    PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P96989-1 [UniParc]FASTAAdd to Basket

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    MAQKPNFLKK IISAGLVTAS TATIVAGFSG VAMGAVMQYN RTTNAAATTV     50
    DGAGFDQTGA GVNLPVATNS VITANSNNAI TFNTPNGNLN SLFLDTANTL 100
    AVTINENTTL GFVTNVTKQG NFFNFTIGAG KSLTITGHGI TAQQAATTKS 150
    AQNVVSKVNA GAAINDNDLS GVGSIDFTAA PSVLEFNLIN PTTQEAPLTL 200
    GDNAKIVNGA NGILNITNGF VKVSDKTFAG IKTINIGDNQ GLMFNTTPDA 250
    ANALNLQGGG NTINFNGRDG TGKLVLVSKN GNATEFNVTG SLGGNLKGVI 300
    EFDTTAAAGK LIANGGAANA VIGTDNGAGR AAGFIVSVDN GNAATISGQV 350
    YAKDIVIQSA NAGGQVTFEH LVDVGLGGKT NFKTADSKVI ITENASFGST 400
    DFGNLAVQIV VPNNKILTGN FIGDAKNNGN TAGVITFNAN GTLVSGNTDP 450
    NIVVTNIKAI EVEGAGIVQL SGIHGAELRL GNAGSIFKLA DGTVINGPVN 500
    QNPLVNNNAL AAGSIQLDGS AIITGDIGNG AVNAALQDIT LANDASKILT 550
    LSGANIIGAN AGGAIHFQAN GGTIQLTSTQ NNILVDFDLD VTTDQTGVVD 600
    ASSLTNNQTL TINGSIGTIG ANTKTLGRFN VGSSKTILNA GDVAINELVM 650
    ENDGSVHLTH NTYLITKTIN AANQGKIIVA ADPINTDTAL ADGTNLGSAE 700
    SPLSNIHFAT KAANGDSILH IGKGVNLYAN NITTTDANVG SLHFRSGGTS 750
    IVSGTVGGQQ GLKLNNLILD NGTTVKFLGD ITFNGGTKIE GKSILQISSN 800
    YITDHIESAD NTGTLEFVNT DPITVTLNKQ GAYFGVLKQV MVSGPGNIAF 850
    NEIGNGVAHA IAVDSISFEN ASLGASLFLL SGTPLDVLTI KSTVGNGTVD 900
    NFNAPILVVS GIDSMINNGQ VIGDQKNIIA LSLGSDNSIT VNSNTLYAGI 950
    RTTKTNQGTV TLSGGIPNNP GTIYGLGLEN GDPKLKQVTF TTDYNNLGSI 1000
    IATNVTINDD VTLTTGGIAG TDFDGKITLG SINGNANVKF VDRTFSHPTS 1050
    MIVSTKANQG TVTYLGNALV GNIGSSDIPV ASVRFTGNDS GVGLQGNIHS 1100
    QNIDFGTYNL TILNSDVILG GGTTAINGEI DLLTNNLIFA NGTSTWGNNT 1150
    SLSTTLNVSN GNVGQIVIAE GAQVNATTTG TTTIKIQDNA NANFSGTQTY 1200
    TLIQGGARFN GTLGAPNFDV TGNNIFVKYE LIRDANQDYV LTRTNDVLNV 1250
    VTTAVGNSAI ANAPGVHQNI AICLESTDTA AYNNMLLAKD SSDVATFIGA 1300
    IATDTGAAVA TVNLNDTQKT QDLLGNRLGA LRYLSNSETA DVGGSETGAV 1350
    SSGDEAIDQV SYGVWAKPFY NIAEQDKKGG LAGYKAKTAG VVVGLDTLAN 1400
    DNLMIGAAIG ITKTDIKHQD YKKGDKTDIK GLSFSLYGAQ QLVKNFFAQG 1450
    SAIFTLNKVK SKSQRYFFDA NGKMNKQIAA GNYDNITFGG NLMFGYDYNA 1500
    LQGVLVTPMA GLSYLKSSNE NYKETGTTVA NKRIHSKFSD RIDLIVGAKV 1550
    TGSAMNINDI VIYPEIHSFV VHKVNGKLSK AQSMLDGQTA PFISQPDRTA 1600
    KTSYNIGLSA NIRSDAKMEY GIGYDFNAAS KYTAHQGTLK VRINF 1645
    Length:1,645
    Mass (Da):169,698
    Last modified:May 1, 1997 - v1
    Checksum:i0CB5641C7EB185EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti657 – 6571H → N AA sequence (PubMed:1370573)Curated
    Sequence conflicti842 – 8421V → I AA sequence (PubMed:1370573)Curated
    Sequence conflicti1071 – 10711G → A AA sequence (PubMed:1370573)Curated
    Sequence conflicti1306 – 13061G → S AA sequence (PubMed:1370573)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04661 Unassigned DNA. Translation: AAB48987.1.
    AE017197 Genomic DNA. Translation: AAU04158.1.
    PIRiJN0896.
    RefSeqiYP_067640.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04158; AAU04158; RT0699.
    GeneIDi2959181.
    KEGGirty:RT0699.
    PATRICi17910646. VBIRicTyp34752_0718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04661 Unassigned DNA. Translation: AAB48987.1 .
    AE017197 Genomic DNA. Translation: AAU04158.1 .
    PIRi JN0896.
    RefSeqi YP_067640.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali P96989.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04158 ; AAU04158 ; RT0699 .
    GeneIDi 2959181.
    KEGGi rty:RT0699.
    PATRICi 17910646. VBIRicTyp34752_0718.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000010784.
    OMAi AMNINDI.
    OrthoDBi EOG63NMCR.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-733-MONOMER.

    Family and domain databases

    Gene3Di 2.40.128.130. 1 hit.
    InterProi IPR005546. Auto_transptbeta.
    IPR006315. OM_autotransptr_brl.
    IPR022095. rOmpB.
    [Graphical view ]
    Pfami PF03797. Autotransporter. 1 hit.
    PF12334. rOmpB. 1 hit.
    [Graphical view ]
    SMARTi SM00869. Autotransporter. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103515. SSF103515. 2 hits.
    TIGRFAMsi TIGR01414. autotrans_barl. 1 hit.
    PROSITEi PS51208. AUTOTRANSPORTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the gene encoding the crystalline surface layer protein of Rickettsia typhi."
      Hahn M.-J., Kim K.-K., Kim I., Chang W.-H.
      Gene 133:129-133(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.
    3. "Mapping of monoclonal antibody binding sites on CNBr fragments of the S-layer protein antigens of Rickettsia typhi and Rickettsia prowazekii."
      Ching W.M., Carl M., Dasch G.A.
      Mol. Immunol. 29:95-105(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Strain: ATCC VR-144 / Wilmington.
    4. "Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing."
      Hackstadt T., Messer R., Cieplak W. Jr., Peacock M.G.
      Infect. Immun. 60:159-165(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1353-1371, IDENTIFICATION OF CLEAVAGE SITE.
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiOMPB_RICTY
    AccessioniPrimary (citable) accession number: P96989
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3