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P96989

- OMPB_RICTY

UniProt

P96989 - OMPB_RICTY

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Protein

Outer membrane protein B

Gene
ompB, slp, RT0699
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The 120 kDa surface-exposed protein is a major structural protein which may play a role as a rickettsial virulence factor and/or immunogen during infection.
The 32 kDa beta peptide may serve as a membrane anchor.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein B
Alternative name(s):
168 kDa surface-layer protein
Cell surface antigen 5
Short name:
Sca5
Surface protein antigen
rOmp B
Short name:
rOmpB
Cleaved into the following 2 chains:
Alternative name(s):
120 kDa outer membrane protein OmpB
Surface protein antigen
p120
Gene namesi
Name:ompB
Synonyms:slp
Ordered Locus Names:RT0699
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Chain 120 kDa surface-exposed protein : Secreted. Cell surface
Note: Surface exposed. This bacterium is covered by a S-layer with hexagonal symmetry.
Chain 32 kDa beta peptide : Cell outer membrane; Multi-pass membrane protein Reviewed prediction
Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. cell surface Source: UniProtKB-SubCell
  3. extracellular region Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16451645Outer membrane protein BPRO_0000387583Add
BLAST
Chaini1 – 13281328120 kDa surface-exposed proteinPRO_0000032660Add
BLAST
Propeptidei1329 – 135224 Reviewed predictionPRO_0000032661Add
BLAST
Chaini1353 – 164529332 kDa beta peptidePRO_0000032662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0699.

Structurei

3D structure databases

ProteinModelPortaliP96989.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1357 – 1645289AutotransporterAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000010784.
OMAiAMNINDI.
OrthoDBiEOG63NMCR.

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR022095. rOmpB.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF12334. rOmpB. 1 hit.
[Graphical view]
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 2 hits.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96989-1 [UniParc]FASTAAdd to Basket

« Hide

MAQKPNFLKK IISAGLVTAS TATIVAGFSG VAMGAVMQYN RTTNAAATTV     50
DGAGFDQTGA GVNLPVATNS VITANSNNAI TFNTPNGNLN SLFLDTANTL 100
AVTINENTTL GFVTNVTKQG NFFNFTIGAG KSLTITGHGI TAQQAATTKS 150
AQNVVSKVNA GAAINDNDLS GVGSIDFTAA PSVLEFNLIN PTTQEAPLTL 200
GDNAKIVNGA NGILNITNGF VKVSDKTFAG IKTINIGDNQ GLMFNTTPDA 250
ANALNLQGGG NTINFNGRDG TGKLVLVSKN GNATEFNVTG SLGGNLKGVI 300
EFDTTAAAGK LIANGGAANA VIGTDNGAGR AAGFIVSVDN GNAATISGQV 350
YAKDIVIQSA NAGGQVTFEH LVDVGLGGKT NFKTADSKVI ITENASFGST 400
DFGNLAVQIV VPNNKILTGN FIGDAKNNGN TAGVITFNAN GTLVSGNTDP 450
NIVVTNIKAI EVEGAGIVQL SGIHGAELRL GNAGSIFKLA DGTVINGPVN 500
QNPLVNNNAL AAGSIQLDGS AIITGDIGNG AVNAALQDIT LANDASKILT 550
LSGANIIGAN AGGAIHFQAN GGTIQLTSTQ NNILVDFDLD VTTDQTGVVD 600
ASSLTNNQTL TINGSIGTIG ANTKTLGRFN VGSSKTILNA GDVAINELVM 650
ENDGSVHLTH NTYLITKTIN AANQGKIIVA ADPINTDTAL ADGTNLGSAE 700
SPLSNIHFAT KAANGDSILH IGKGVNLYAN NITTTDANVG SLHFRSGGTS 750
IVSGTVGGQQ GLKLNNLILD NGTTVKFLGD ITFNGGTKIE GKSILQISSN 800
YITDHIESAD NTGTLEFVNT DPITVTLNKQ GAYFGVLKQV MVSGPGNIAF 850
NEIGNGVAHA IAVDSISFEN ASLGASLFLL SGTPLDVLTI KSTVGNGTVD 900
NFNAPILVVS GIDSMINNGQ VIGDQKNIIA LSLGSDNSIT VNSNTLYAGI 950
RTTKTNQGTV TLSGGIPNNP GTIYGLGLEN GDPKLKQVTF TTDYNNLGSI 1000
IATNVTINDD VTLTTGGIAG TDFDGKITLG SINGNANVKF VDRTFSHPTS 1050
MIVSTKANQG TVTYLGNALV GNIGSSDIPV ASVRFTGNDS GVGLQGNIHS 1100
QNIDFGTYNL TILNSDVILG GGTTAINGEI DLLTNNLIFA NGTSTWGNNT 1150
SLSTTLNVSN GNVGQIVIAE GAQVNATTTG TTTIKIQDNA NANFSGTQTY 1200
TLIQGGARFN GTLGAPNFDV TGNNIFVKYE LIRDANQDYV LTRTNDVLNV 1250
VTTAVGNSAI ANAPGVHQNI AICLESTDTA AYNNMLLAKD SSDVATFIGA 1300
IATDTGAAVA TVNLNDTQKT QDLLGNRLGA LRYLSNSETA DVGGSETGAV 1350
SSGDEAIDQV SYGVWAKPFY NIAEQDKKGG LAGYKAKTAG VVVGLDTLAN 1400
DNLMIGAAIG ITKTDIKHQD YKKGDKTDIK GLSFSLYGAQ QLVKNFFAQG 1450
SAIFTLNKVK SKSQRYFFDA NGKMNKQIAA GNYDNITFGG NLMFGYDYNA 1500
LQGVLVTPMA GLSYLKSSNE NYKETGTTVA NKRIHSKFSD RIDLIVGAKV 1550
TGSAMNINDI VIYPEIHSFV VHKVNGKLSK AQSMLDGQTA PFISQPDRTA 1600
KTSYNIGLSA NIRSDAKMEY GIGYDFNAAS KYTAHQGTLK VRINF 1645
Length:1,645
Mass (Da):169,698
Last modified:May 1, 1997 - v1
Checksum:i0CB5641C7EB185EE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti657 – 6571H → N AA sequence 1 Publication
Sequence conflicti842 – 8421V → I AA sequence 1 Publication
Sequence conflicti1071 – 10711G → A AA sequence 1 Publication
Sequence conflicti1306 – 13061G → S AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04661 Unassigned DNA. Translation: AAB48987.1.
AE017197 Genomic DNA. Translation: AAU04158.1.
PIRiJN0896.
RefSeqiYP_067640.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04158; AAU04158; RT0699.
GeneIDi2959181.
KEGGirty:RT0699.
PATRICi17910646. VBIRicTyp34752_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04661 Unassigned DNA. Translation: AAB48987.1 .
AE017197 Genomic DNA. Translation: AAU04158.1 .
PIRi JN0896.
RefSeqi YP_067640.1. NC_006142.1.

3D structure databases

ProteinModelPortali P96989.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04158 ; AAU04158 ; RT0699 .
GeneIDi 2959181.
KEGGi rty:RT0699.
PATRICi 17910646. VBIRicTyp34752_0718.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000010784.
OMAi AMNINDI.
OrthoDBi EOG63NMCR.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-733-MONOMER.

Family and domain databases

Gene3Di 2.40.128.130. 1 hit.
InterProi IPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR022095. rOmpB.
[Graphical view ]
Pfami PF03797. Autotransporter. 1 hit.
PF12334. rOmpB. 1 hit.
[Graphical view ]
SMARTi SM00869. Autotransporter. 1 hit.
[Graphical view ]
SUPFAMi SSF103515. SSF103515. 2 hits.
TIGRFAMsi TIGR01414. autotrans_barl. 1 hit.
PROSITEi PS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the gene encoding the crystalline surface layer protein of Rickettsia typhi."
    Hahn M.-J., Kim K.-K., Kim I., Chang W.-H.
    Gene 133:129-133(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.
  3. "Mapping of monoclonal antibody binding sites on CNBr fragments of the S-layer protein antigens of Rickettsia typhi and Rickettsia prowazekii."
    Ching W.M., Carl M., Dasch G.A.
    Mol. Immunol. 29:95-105(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC VR-144 / Wilmington.
  4. "Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing."
    Hackstadt T., Messer R., Cieplak W. Jr., Peacock M.G.
    Infect. Immun. 60:159-165(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1353-1371, IDENTIFICATION OF CLEAVAGE SITE.
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiOMPB_RICTY
AccessioniPrimary (citable) accession number: P96989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi