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P96989

- OMPB_RICTY

UniProt

P96989 - OMPB_RICTY

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Protein

Outer membrane protein B

Gene

ompB

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The 120 kDa surface-exposed protein is a major structural protein which may play a role as a rickettsial virulence factor and/or immunogen during infection.
The 32 kDa beta peptide may serve as a membrane anchor.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein B
Alternative name(s):
168 kDa surface-layer protein
Cell surface antigen 5
Short name:
Sca5
Surface protein antigen
rOmp B
Short name:
rOmpB
Cleaved into the following 2 chains:
Alternative name(s):
120 kDa outer membrane protein OmpB
Surface protein antigen
p120
Gene namesi
Name:ompB
Synonyms:slp
Ordered Locus Names:RT0699
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Chain 120 kDa surface-exposed protein : Secreted. Cell surface
Note: Surface exposed. This bacterium is covered by a S-layer with hexagonal symmetry.
Chain 32 kDa beta peptide : Cell outer membrane Curated; Multi-pass membrane protein Curated
Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. periplasmic space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16451645Outer membrane protein BPRO_0000387583Add
BLAST
Chaini1 – 13281328120 kDa surface-exposed proteinPRO_0000032660Add
BLAST
Propeptidei1329 – 135224Sequence AnalysisPRO_0000032661Add
BLAST
Chaini1353 – 164529332 kDa beta peptidePRO_0000032662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0699.

Structurei

3D structure databases

ProteinModelPortaliP96989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1357 – 1645289AutotransporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the rickettsiae OmpA/OmpB family.Curated
Contains 1 autotransporter (TC 1.B.12) domain. [View classification]PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000010784.
OMAiAMNINDI.
OrthoDBiEOG63NMCR.

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR022095. rOmpB.
[Graphical view]
PfamiPF03797. Autotransporter. 1 hit.
PF12334. rOmpB. 1 hit.
[Graphical view]
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 2 hits.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P96989-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQKPNFLKK IISAGLVTAS TATIVAGFSG VAMGAVMQYN RTTNAAATTV
60 70 80 90 100
DGAGFDQTGA GVNLPVATNS VITANSNNAI TFNTPNGNLN SLFLDTANTL
110 120 130 140 150
AVTINENTTL GFVTNVTKQG NFFNFTIGAG KSLTITGHGI TAQQAATTKS
160 170 180 190 200
AQNVVSKVNA GAAINDNDLS GVGSIDFTAA PSVLEFNLIN PTTQEAPLTL
210 220 230 240 250
GDNAKIVNGA NGILNITNGF VKVSDKTFAG IKTINIGDNQ GLMFNTTPDA
260 270 280 290 300
ANALNLQGGG NTINFNGRDG TGKLVLVSKN GNATEFNVTG SLGGNLKGVI
310 320 330 340 350
EFDTTAAAGK LIANGGAANA VIGTDNGAGR AAGFIVSVDN GNAATISGQV
360 370 380 390 400
YAKDIVIQSA NAGGQVTFEH LVDVGLGGKT NFKTADSKVI ITENASFGST
410 420 430 440 450
DFGNLAVQIV VPNNKILTGN FIGDAKNNGN TAGVITFNAN GTLVSGNTDP
460 470 480 490 500
NIVVTNIKAI EVEGAGIVQL SGIHGAELRL GNAGSIFKLA DGTVINGPVN
510 520 530 540 550
QNPLVNNNAL AAGSIQLDGS AIITGDIGNG AVNAALQDIT LANDASKILT
560 570 580 590 600
LSGANIIGAN AGGAIHFQAN GGTIQLTSTQ NNILVDFDLD VTTDQTGVVD
610 620 630 640 650
ASSLTNNQTL TINGSIGTIG ANTKTLGRFN VGSSKTILNA GDVAINELVM
660 670 680 690 700
ENDGSVHLTH NTYLITKTIN AANQGKIIVA ADPINTDTAL ADGTNLGSAE
710 720 730 740 750
SPLSNIHFAT KAANGDSILH IGKGVNLYAN NITTTDANVG SLHFRSGGTS
760 770 780 790 800
IVSGTVGGQQ GLKLNNLILD NGTTVKFLGD ITFNGGTKIE GKSILQISSN
810 820 830 840 850
YITDHIESAD NTGTLEFVNT DPITVTLNKQ GAYFGVLKQV MVSGPGNIAF
860 870 880 890 900
NEIGNGVAHA IAVDSISFEN ASLGASLFLL SGTPLDVLTI KSTVGNGTVD
910 920 930 940 950
NFNAPILVVS GIDSMINNGQ VIGDQKNIIA LSLGSDNSIT VNSNTLYAGI
960 970 980 990 1000
RTTKTNQGTV TLSGGIPNNP GTIYGLGLEN GDPKLKQVTF TTDYNNLGSI
1010 1020 1030 1040 1050
IATNVTINDD VTLTTGGIAG TDFDGKITLG SINGNANVKF VDRTFSHPTS
1060 1070 1080 1090 1100
MIVSTKANQG TVTYLGNALV GNIGSSDIPV ASVRFTGNDS GVGLQGNIHS
1110 1120 1130 1140 1150
QNIDFGTYNL TILNSDVILG GGTTAINGEI DLLTNNLIFA NGTSTWGNNT
1160 1170 1180 1190 1200
SLSTTLNVSN GNVGQIVIAE GAQVNATTTG TTTIKIQDNA NANFSGTQTY
1210 1220 1230 1240 1250
TLIQGGARFN GTLGAPNFDV TGNNIFVKYE LIRDANQDYV LTRTNDVLNV
1260 1270 1280 1290 1300
VTTAVGNSAI ANAPGVHQNI AICLESTDTA AYNNMLLAKD SSDVATFIGA
1310 1320 1330 1340 1350
IATDTGAAVA TVNLNDTQKT QDLLGNRLGA LRYLSNSETA DVGGSETGAV
1360 1370 1380 1390 1400
SSGDEAIDQV SYGVWAKPFY NIAEQDKKGG LAGYKAKTAG VVVGLDTLAN
1410 1420 1430 1440 1450
DNLMIGAAIG ITKTDIKHQD YKKGDKTDIK GLSFSLYGAQ QLVKNFFAQG
1460 1470 1480 1490 1500
SAIFTLNKVK SKSQRYFFDA NGKMNKQIAA GNYDNITFGG NLMFGYDYNA
1510 1520 1530 1540 1550
LQGVLVTPMA GLSYLKSSNE NYKETGTTVA NKRIHSKFSD RIDLIVGAKV
1560 1570 1580 1590 1600
TGSAMNINDI VIYPEIHSFV VHKVNGKLSK AQSMLDGQTA PFISQPDRTA
1610 1620 1630 1640
KTSYNIGLSA NIRSDAKMEY GIGYDFNAAS KYTAHQGTLK VRINF
Length:1,645
Mass (Da):169,698
Last modified:May 1, 1997 - v1
Checksum:i0CB5641C7EB185EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti657 – 6571H → N AA sequence (PubMed:1370573)Curated
Sequence conflicti842 – 8421V → I AA sequence (PubMed:1370573)Curated
Sequence conflicti1071 – 10711G → A AA sequence (PubMed:1370573)Curated
Sequence conflicti1306 – 13061G → S AA sequence (PubMed:1370573)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04661 Unassigned DNA. Translation: AAB48987.1.
AE017197 Genomic DNA. Translation: AAU04158.1.
PIRiJN0896.
RefSeqiYP_067640.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04158; AAU04158; RT0699.
GeneIDi2959181.
KEGGirty:RT0699.
PATRICi17910646. VBIRicTyp34752_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04661 Unassigned DNA. Translation: AAB48987.1 .
AE017197 Genomic DNA. Translation: AAU04158.1 .
PIRi JN0896.
RefSeqi YP_067640.1. NC_006142.1.

3D structure databases

ProteinModelPortali P96989.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04158 ; AAU04158 ; RT0699 .
GeneIDi 2959181.
KEGGi rty:RT0699.
PATRICi 17910646. VBIRicTyp34752_0718.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000010784.
OMAi AMNINDI.
OrthoDBi EOG63NMCR.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-733-MONOMER.

Family and domain databases

Gene3Di 2.40.128.130. 1 hit.
InterProi IPR005546. Auto_transptbeta.
IPR006315. OM_autotransptr_brl.
IPR022095. rOmpB.
[Graphical view ]
Pfami PF03797. Autotransporter. 1 hit.
PF12334. rOmpB. 1 hit.
[Graphical view ]
SMARTi SM00869. Autotransporter. 1 hit.
[Graphical view ]
SUPFAMi SSF103515. SSF103515. 2 hits.
TIGRFAMsi TIGR01414. autotrans_barl. 1 hit.
PROSITEi PS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of the gene encoding the crystalline surface layer protein of Rickettsia typhi."
    Hahn M.-J., Kim K.-K., Kim I., Chang W.-H.
    Gene 133:129-133(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.
  3. "Mapping of monoclonal antibody binding sites on CNBr fragments of the S-layer protein antigens of Rickettsia typhi and Rickettsia prowazekii."
    Ching W.M., Carl M., Dasch G.A.
    Mol. Immunol. 29:95-105(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Strain: ATCC VR-144 / Wilmington.
  4. "Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing."
    Hackstadt T., Messer R., Cieplak W. Jr., Peacock M.G.
    Infect. Immun. 60:159-165(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1353-1371, IDENTIFICATION OF CLEAVAGE SITE.
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiOMPB_RICTY
AccessioniPrimary (citable) accession number: P96989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3